{"id":12274,"date":"2021-02-10T09:13:00","date_gmt":"2021-02-10T11:13:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12274"},"modified":"2023-01-05T13:46:34","modified_gmt":"2023-01-05T16:46:34","slug":"cannabis-and-body-pain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lt\/kanapes-ir-kuno-skausmas\/","title":{"rendered":"Kanap\u0117s ir k\u016bno skausmas"},"content":{"rendered":"

Per pastar\u0105j\u012f de\u0161imtmet\u012f atlikta daugyb\u0117 klinikini\u0173 tyrim\u0173, kuri\u0173 metu gauta teigiam\u0173 ir daug \u017eadan\u010di\u0173 rezultat\u0173 naudojant kanapi\u0173 pagrindu pagamintus vaistus neuropatiniam skausmui gydyti. <\/p>\n\n\n\n

Kanap\u0117mis buvo mal\u0161inamas diabeto, chemoterapijos, i\u0161s\u0117tin\u0117s skleroz\u0117s, fibromialgijos, osteoartrito ir kit\u0173 lig\u0173 sukeltas skausmas. <\/p>\n\n\n\n

Akivaizdu, kad egzistuoja ry\u0161ys tarp egzogenini\u0173 kanabinoid\u0173 ir opioid\u0173 receptori\u0173, tod\u0117l padid\u0117ja pacient\u0173 analgezija - nesugeb\u0117jimas jausti skausmo. <\/p>\n\n\n\n

Pacientams, gydomiems opioidais kartu su kanapi\u0173 preparatais, pasirei\u0161kia medikamentinis sinerginis poveikis, kai opioid\u0173 veiksmingum\u0105 didina tetrahidrokanabinolis - THC, pagrindin\u0117 kanapi\u0173 augalo psichoaktyvioji molekul\u0117. <\/p>\n\n\n\n

Mokslininkai \u012f \u0161iuos rezultatus \u017evelgia teigiamai d\u0117l galimyb\u0117s suma\u017einti opioid\u0173 vaist\u0173 doz\u0119, o tai pagerint\u0173 skausm\u0105 ken\u010dian\u010di\u0173 pacient\u0173 gyvenimo kokyb\u0119.<\/p>\n\n\n\n

Endokanabinoid\u0173 sistema, kaip ir kiti med\u017eiag\u0173 apykaitos keliai, n\u0117ra izoliuota \u017emogaus organizmo sistema, ji gali daryti \u012ftak\u0105 ir b\u016bti veikiama kit\u0173 signalini\u0173 keli\u0173, vienas i\u0161 j\u0173, matyt, susij\u0119s su opioidais ir j\u0173 receptoriais. <\/p>\n\n\n\n

Opioid\u0173 receptoriai ne tik signalizuoja apie skausmo poj\u016bt\u012f, bet ir moduliuoja kai kurias organizmo funkcijas, pavyzd\u017eiui, \u0161ilumos reguliavim\u0105, hormon\u0173 stabilum\u0105, analgetin\u012f aktyvum\u0105 ir kt. <\/p>\n\n\n\n

Tiek kanabinoid\u0173, tiek opioid\u0173 receptoriai priklauso G baltymais susiet\u0173 receptori\u0173 \u0161eimai, t. y. baltymams, kurie gali daryti \u012ftak\u0105 neurotransmisijai, atsakingai u\u017e skausmo plitim\u0105 galvos ir nugaros smegenyse. <\/p>\n\n\n\n

Gydant l\u0117tiniu skausmu sergan\u010dius pacientus paprastai vartojamos palaipsniui did\u0117jan\u010dios opioid\u0173 doz\u0117s, kurios da\u017enai sukelia nepageidaujam\u0105 \u0161alutin\u012f poveik\u012f, pavyzd\u017eiui, sedacij\u0105, kv\u0117pavimo sutrikimus ir viduri\u0173 u\u017ekiet\u0117jim\u0105. <\/p>\n\n\n\n

Po kurio laiko pacientai pradeda toleruoti ir prie\u0161intis opioid\u0173 dozei, nepasiekia gydomojo poveikio, tod\u0117l gydytojai priversti pakartotinai didinti doz\u0119, kad pasiekt\u0173 t\u0105 pat\u012f skausmo mal\u0161inimo lyg\u012f.<\/p>\n\n\n\n

Didel\u0117 vien THC doz\u0117 laikoma analgetiku, ta\u010diau paprastai po jos pasirei\u0161kia nepageidaujamas \u0161alutinis poveikis, pavyzd\u017eiui, nerimas, galvos skausmas, burnos d\u017ei\u016bvimas, galvos svaigimas, euforija ir tachikardija, tuo tarpu ma\u017eos doz\u0117s visi\u0161kai nesukelia analgezinio poveikio. <\/p>\n\n\n\n

Vis d\u0117lto kartu su opioidais \u0161is poveikis gali visi\u0161kai pasikeisti.<\/p>\n\n\n\n

Tyrimai, atlikti su gyv\u016bn\u0173 modeliais, parod\u0117, kad egzogeniniai kanabinoidai, tokie kaip THC, gali padidinti opioidini\u0173 vaist\u0173, toki\u0173 kaip morfinas, veiksmingum\u0105. <\/p>\n\n\n\n

Pana\u0161u, kad THC analgetinis poveikis pasirei\u0161kia per opioidinius receptorius, o kanabinoid\u0173 ir opioid\u0173 signaliniai keliai tarpusavyje s\u0105veikauja. <\/p>\n\n\n\n

Kanapi\u0173 tyr\u0117jai teigia, kad THC vartojimas gali skatinti endogenini\u0173 opioid\u0173 peptid\u0173 gamyb\u0105 organizme, kurie galiausiai prisijungia prie jau \u017einom\u0173 opioid\u0173 receptori\u0173 - delta ir kappa - ir taip tarpininkauja kanabinoid\u0173 poveikiui. <\/p>\n\n\n\n

Tre\u010diasis opioidinis receptorius mu taip pat suaktyv\u0117ja, kai vartojamas morfinas. \u0160i\u0173 trij\u0173 opioidini\u0173 receptori\u0173 suaktyv\u0117jimas gali paai\u0161kinti antinocicepcinio poveikio - analgezijos proceso, blokuojan\u010dio skausmingo dirgiklio aptikim\u0105, - veiksmingumo padid\u0117jim\u0105, palyginti su gydymo vien tik morfinu arba THC rezultatais.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

A 2004 m. \u017eurnale \"Life Sciences\" paskelbtas tyrimas<\/a> patvirtino ry\u0161\u012f tarp THC ir morfino, slopindami opioid\u0173 receptorius tam tikromis molekul\u0117mis. <\/p>\n\n\n\n

D\u0117l blokuojan\u010di\u0173 molekuli\u0173 buvimo suma\u017e\u0117jo morfino veiksmingumas, o kartu ir jo terapinis poveikis. <\/p>\n\n\n\n

\u0160is rezultatas patvirtina, koks svarbus yra \u0161i\u0173 receptori\u0173 prieinamumas ir j\u0173 aktyvinimas morfino ir THC gydymo veiksmingumui. Kitas eksperimentas, atliktas su naloksonu - opioid\u0173 antagonistu - blokavo THC aktyvum\u0105 \u012fvairiose smegen\u0173 srityse, pavyzd\u017eiui, ventralin\u0117je tegmentin\u0117je srityje, pagumburyje ir periakveduktin\u0117je pilkojoje (PAG), o tai rodo, kad \u0161ios sritys yra svarbios opioid\u0173 ir kanabinoid\u0173 s\u0105veikai. <\/p>\n\n\n\n

Be to, tyrime taip pat teigiama, kad peli\u0173 gydymas ma\u017eomis THC ir morfijaus doz\u0117mis kartu nesuk\u0117l\u0117 opioid\u0173 dozi\u0173 tolerancijos.<\/p>\n\n\n\n

\u0160is ir daugelis kit\u0173 tyrim\u0173 skelbiami patvirtinant mint\u012f, kad kanabinoid\u0173 derinys gali sustiprinti opioid\u0173 poveik\u012f. <\/p>\n\n\n\n

Pana\u0161u, kad kanabinoidai taip pat gali pakeisti opioid\u0173 tolerancij\u0105 ir priklausomyb\u0119 nuo j\u0173. <\/p>\n\n\n\n

Ilgalaikis opioid\u0173 vartojimas paprastai siejamas su pacient\u0173 priklausomybe, d\u0117l kurios jie piktnaud\u017eiauja med\u017eiaga, kuri i\u0161 prad\u017ei\u0173 tur\u0117jo tik gydom\u0105j\u0105 paskirt\u012f. <\/p>\n\n\n\n

Tod\u0117l kanabinoid\u0173 ir opioid\u0173 derinys, pavyzd\u017eiui, THC ir morfijus, gal\u0117t\u0173 tapti nauja analgezinio gydymo strategija, leid\u017eian\u010dia gydytojams suma\u017einti dideles opioid\u0173 dozes savo pacientams, taip pat suma\u017einti pacient\u0173 piktnaud\u017eiavimo opioidais ir priklausomyb\u0117s nuo j\u0173 lyg\u012f. <\/p>\n\n\n\n

Be to, kanabinoidai stimuliuoja endogeninius opioidus, ta\u010diau detalus kanabinoid\u0173 ir opioid\u0173 s\u0105veikos sistemos mechanizmas vis dar lieka neai\u0161kus. <\/p>\n\n\n\n

Hipotez\u0117, kuria bandoma paai\u0161kinti galim\u0105 veikimo mechanizm\u0105, yra ta, kad kanabinoidai galb\u016bt skatina opioidini\u0173 peptid\u0173 sintez\u0119 arba i\u0161siskyrim\u0105, tod\u0117l padid\u0117ja suaktyv\u0117jusi\u0173 opioidini\u0173 receptori\u0173 skai\u010dius, o tai sukelia analgezin\u012f poveik\u012f. <\/p>\n\n\n\n

Taip pat n\u0117ra ai\u0161ku, kokie peptidai dalyvauja \u0161iame procese, tod\u0117l mokslininkams b\u016bt\u0173 labai svarbu visapusi\u0161kai suprasti \u0161i\u0173 molekuli\u0173 strukt\u016br\u0105 ir tai, kaip kanabinoidai gali b\u016bti naudojami analgeziniam poveikiui sukelti, ne tik pad\u0117ti gydant priklausomyb\u0119 nuo opioid\u0173. <\/p>\n\n\n\n

Vis d\u0117lto kanabinoidai apskritai duoda stebinan\u010di\u0173 rezultat\u0173, nuolat u\u017eima vis daugiau vietos tarp medicinos specialist\u0173, \u012frodydami, kad jie gali b\u016bti alternatyvi medicina. <\/p>\n\n\n\n

Reikia atlikti dar kelet\u0105 tyrim\u0173, kad mokslininkai gal\u0117t\u0173 visapusi\u0161kai i\u0161siai\u0161kinti tikr\u0105j\u0105 kanapi\u0173 pagrindu pagamint\u0173 vaist\u0173 naud\u0105 ir galimybes \u017emogaus organizmui, taip pat tai, kaip geriausia kanapes naudoti gydymui.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Ar jums patiko \u0161iame straipsnyje pateikta infografika? Visi piktogramos<\/a> \u0161iame straipsnyje naudojam\u0173 ir daugel\u012f kit\u0173 - galima rasti Mind the Graph. Galite per\u017ei\u016br\u0117ti turimas iliustracijas m\u016bs\u0173 galerija<\/a>.<\/p>\n\n\n\n

Be to, jums nereikia prad\u0117ti kurti infografikos nuo nulio - savo naudotojams si\u016blome redaguojamus infografikos \u0161ablonus, tod\u0117l jiems nereikia prad\u0117ti nuo tu\u0161\u010dios drob\u0117s. \u010cia galite pamatyti infografikos \u0161ablonus.<\/a><\/p>\n\n\n\n

Taip pat galite tur\u0117ti vyresni\u0173j\u0173 prenumerat\u0105 ir kurti neribot\u0105 skai\u010di\u0173, spustel\u0117kite \u010dia, kad prad\u0117tum\u0117te<\/a>!<\/p>\n\n\n\n

Nuorodos <\/strong><\/p>\n\n\n\n

BROWN, J. D.; WINTERSTEIN, A. G. Potencial\u016bs nepageidaujami rei\u0161kiniai ir vaist\u0173 s\u0105veika vartojant kanabidiol\u012f (CBD) medicinoje ir vartotojams. Journal of Clinical Medicine, v. 8, n. 7, 2019 m. liepos 8 d.<\/p>\n\n\n\n

CICHEWICZ, D. L. Kanabinoidini\u0173 ir opioidini\u0173 analgetik\u0173 sinergin\u0117 s\u0105veika. Life Sciences, v. 74, n. 11, p. 1317-1324, 2004 m. sausio 30 d.<\/p>\n\n\n\n

HANEY, M.; BISAGA, A.; FOLTIN, R. W. Naltreksono ir geriamojo THC s\u0105veika sunkiai r\u016bkantiems marihuan\u0105. Psychopharmacology, v. 166, n. 1, p. 77-85, 1 fev. 2003.<\/p>\n\n\n\n

KUHLEN, M. ir kt. Efektyvus spasti\u0161kumo gydymas dronabinoliu vaik\u0173 paliatyviojoje prie\u017ei\u016broje. European Journal of Paediatric Neurology, v. 20, n. 6, p. 898-903, 2016 m. lapkri\u010dio 1 d.<\/p>\n\n\n\n

L\u00d6TSCH, J. ir kt. Vaist\u0173 s\u0105veika su paciento kontroliuojama analgezija. Clinical Pharmacokinetics, t. 41, n. 1, p. 31-57, 2002 m. sausio 1 d.<\/p>\n\n\n\n

LYNCH, M. E.; CLARK, A. J. Cannabis Reduces Opioid Dose in the Treatment of Chronic Non-Cancer Pain. Journal of Pain and Symptom Management, v. 25, n. 6, p. 496-498, 2003 m. bir\u017eelio 1 d.<\/p>\n\n\n\n

MANZANARES, J. ir kt. Farmakologin\u0117 ir biochemin\u0117 opioid\u0173 ir kanabinoid\u0173 s\u0105veika. Trends in Pharmacological Sciences, v. 20, n. 7, p. 287-294, 1999 m. liepos 1 d.<\/p>\n\n\n\n

WAKLEY, A. A.; CRAFT, R. M. THC-metadono ir THC-naltreksono s\u0105veika \u017eiurki\u0173 diskriminacijos, antinocicepcijos ir lokomocijos at\u017evilgiu. Behavioural Pharmacology, t. 22, nr. 5 ir 6, p. 489-497, rinkinys. 2011.<\/p>\n\n\n\n

WELCH, S. P. Kanabinoid\u0173 ir opioid\u0173 sistem\u0173 s\u0105veika moduliuojant nocicepcij\u0105. International Review of Psychiatry, t. 21, n. 2, p. 143-151, 2009 m. sausio 1 d.<\/p>","protected":false},"excerpt":{"rendered":"

Per pastar\u0105j\u012f de\u0161imtmet\u012f atlikta daugyb\u0117 klinikini\u0173 tyrim\u0173, kuri\u0173 metu gauta teigiam\u0173 ir daug \u017eadan\u010di\u0173 rezultat\u0173 naudojant kanapi\u0173 pagrindu pagamintus vaistus neuropatiniam skausmui gydyti. Kanap\u0117mis buvo mal\u0161inamas skausmas, susij\u0119s su diabetu, chemoterapija, i\u0161s\u0117tine skleroze, fibromialgija, osteoartritu ir daugeliu kit\u0173 lig\u0173. Akivaizdu, kad egzistuoja ry\u0161ys tarp egzogenini\u0173 kanabinoid\u0173 ir opioid\u0173 receptori\u0173, d\u0117l kurio [...]<\/p>","protected":false},"author":4,"featured_media":12276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[819,51,554],"yoast_head":"\nCannabis and Body Pain - MTG<\/title>\n<meta name=\"description\" content=\"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/lt\/kanapes-ir-kuno-skausmas\/\" \/>\n<meta property=\"og:locale\" content=\"lt_LT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cannabis and Body Pain - MTG\" \/>\n<meta property=\"og:description\" content=\"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/lt\/kanapes-ir-kuno-skausmas\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-10T11:13:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-05T16:46:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/02\/cannabis-and-body-pain.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1123\" \/>\n\t<meta property=\"og:image:height\" content=\"612\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cannabis and Body Pain - MTG","description":"Do you want to know cannabis can impact the body pain? 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/lt\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts\/12274"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/comments?post=12274"}],"version-history":[{"count":3,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts\/12274\/revisions"}],"predecessor-version":[{"id":26008,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts\/12274\/revisions\/26008"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/media\/12276"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/media?parent=12274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/categories?post=12274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/tags?post=12274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}