{"id":12236,"date":"2021-02-03T10:36:19","date_gmt":"2021-02-03T12:36:19","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12236"},"modified":"2023-01-05T13:50:12","modified_gmt":"2023-01-05T16:50:12","slug":"covid-19-pets","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lt\/covid-19-pets\/","title":{"rendered":"Ar j\u016bs\u0173 augintiniui gresia COVID-19?"},"content":{"rendered":"

Taip, deja, j\u016bs\u0173 augintiniui taip pat gresia pavojus u\u017esikr\u0117sti COVID-19. Kaip ir mes esame iml\u016bs SARS-CoV-2 viruso infekcijai, taip ir tam tikros gyv\u016bn\u0173 r\u016b\u0161ys. Kadangi gyv\u016bnai turi pana\u0161i\u0173 strukt\u016brini\u0173 l\u0105steli\u0173 pavir\u0161iaus baltym\u0173, esan\u010di\u0173 \u017emoni\u0173 organizme, savybi\u0173. <\/p>\n\n\n\n

Esantis specifinis baltymas veikia kaip spyna ir raktas, raktas yra viruso baltymas, atsakingas u\u017e COVID-19 infekcij\u0105, o spyna - membranos baltymas, esantis l\u0105stel\u0117s pavir\u0161iuje. <\/p>\n\n\n\n

Jei raktas - viruso baltymas - atitinka spyn\u0105 - \u0161eimininko receptoriaus baltym\u0105, virusas gali patekti \u012f vid\u0173 ir prad\u0117ti dauginimosi cikl\u0105, sukeliant\u012f \u0161eimininko infekcij\u0105. <\/p>\n\n\n\n

Tyrimas paskelbta PLOS Computational Biology<\/a>, naudojo matematin\u012f model\u012f, kad numatyt\u0173, kurios gyv\u016bn\u0173 r\u016b\u0161ys turi b\u016btin\u0173 \u0161eimininko baltymo savybi\u0173, leid\u017eian\u010di\u0173 viruso smaigalio baltymui prisijungti. <\/p>\n\n\n\n

Tyr\u0117jai prane\u0161\u0117 apie kelet\u0105 atvej\u0173 visame pasaulyje, kai naminiams gyv\u016bnams, fermoms ir zoologijos sodams nustatyti teigiami COVID-19 infekcijos rezultatai. <\/p>\n\n\n\n

Prane\u0161ama, kad u\u017esikr\u0117tusios kat\u0117s, norkos, li\u016btai ir tigrai. <\/p>\n\n\n\n

I\u0161 prad\u017ei\u0173 tyrimai parod\u0117, kad kat\u0117s, civetai ir \u0161e\u0161kai buvo iml\u016bs SARS-CoV-2, o kiaul\u0117s, vi\u0161tos ir antys - ne. <\/p>\n\n\n\n

Antruoju momentu paai\u0161k\u0117jo kitokie rezultatai: j\u016br\u0173 kiaulyt\u0117s, pel\u0117s ir \u017eiurk\u0117s pripa\u017eintos neatspariomis, o kupranugariai, galvijai, arkliai, avys ir triu\u0161iai - neatspariais SARS-CoV-2 infekcijai.<\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Reik\u0117t\u0173 prisiminti, kad SARS-CoV-2 virusas pirm\u0105 kart\u0105 buvo perduotas \u017emon\u0117ms per tarpin\u012f \u0161eiminink\u0105. <\/strong><\/p>\n\n\n\n

Du pagrindiniai \u012ftariamieji gyv\u016bnai yra \u0161ik\u0161nosparniai ir pangolinai. Jei pirm\u0105 kart\u0105 girdite apie pangolinus, jie yra naktiniai \u017einduoliai, padengti keratino \u017evynais, gyvenantys tu\u0161\u010diaviduriuose med\u017eiuose ir urvuose.<\/p>\n\n\n\n

\u010cia pateikiama pangolino iliustracija:<\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

Kad prasid\u0117t\u0173 infekcija, pirmiausia virusas turi prisijungti savo viruso smaigalio baltym\u0105 prie \u0161eimininko l\u0105stel\u0117s membranos receptoriaus baltymo. <\/p>\n\n\n\n

\u0160eimininko receptoriaus baltymas yra angiotenzin\u0105 konvertuojan\u010dio fermento 2, paprastai vadinamo ACE2, ekstral\u0105stelinis proteaz\u0117s domenas.<\/p>\n\n\n\n

AKE2 yra vieno pra\u0117jimo transmembraninis baltymas, esantis keli\u0173 audini\u0173 pavir\u0161iuje. ACE2 neturi tik vienos strukt\u016bros, jis gali b\u016bti keli\u0173 strukt\u016br\u0173 skirting\u0173 r\u016b\u0161i\u0173, i\u0161laikydamas t\u0105 pa\u010di\u0105 funkcij\u0105. <\/p>\n\n\n\n

I\u0161 tikr\u0173j\u0173 ACE2 priskiriamas ortologiniams genams, t. y. genams, esantiems skirtingose r\u016b\u0161yse ir kilusiems i\u0161 bendro prot\u0117vi\u0173 geno.<\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

D\u0117l \u0161i\u0173 strukt\u016brini\u0173 skirtum\u0173 SARS-CoV-2 virusas gali prisijungti prie vien\u0173 r\u016b\u0161i\u0173 ACE2, o prie kit\u0173 - ne. <\/p>\n\n\n\n

Kai viruso baltymas-smaigalys prisijungia prie ACE2, virusas patenka \u012f l\u0105stel\u0117s vid\u0173 ir pradeda naudoti \u0161eimininko l\u0105stel\u0117s mechanizmus dauginimuisi, tod\u0117l u\u017esikre\u010dia.<\/p>\n\n\n\n

Tod\u0117l geriau supratus AKE2 receptori\u0173, b\u016bt\u0173 galima tiksliau paai\u0161kinti, kod\u0117l vienos gyv\u016bn\u0173 r\u016b\u0161ys yra jautrios infekcijoms, o kitos - ne. <\/p>\n\n\n\n

Be to, tai taip pat pad\u0117t\u0173 mokslininkams kurti vaistus, taikant antivirusines strategijas, pavyzd\u017eiui, gaminant netikras spinteles, prie kuri\u0173 virusas prisijungia vietoj tikrosios \u0161eimininko spintel\u0117s. <\/p>\n\n\n\n

Taip pat siekiant geriau steb\u0117ti tarpinius gyv\u016bnus \u0161eimininkus, kurie ateityje u\u017esikr\u0117s virusu. <\/p>\n\n\n\n

Taigi, ACE2 trimat\u0117s strukt\u016bros ir jos s\u0105veikos atominiame lygmenyje apib\u016bdinimas, naudojant kompiuterin\u012f modeliavim\u0105, buvo tikslas. Rodrigues ir kolegos<\/a> darbas. <\/p>\n\n\n\n

Tokio pob\u016bd\u017eio charakterizavimo tyrimai yra brang\u016bs eksperimentiniu po\u017ei\u016briu, j\u0173 negalima taikyti dideliu mastu, tod\u0117l sunku gauti galutini\u0173 duomen\u0173, tuo tarpu kompiuterinis modeliavimas yra greitas ir nebrangus, tod\u0117l labai naudingas siekiant u\u017epildyti kai kurias strukt\u016brin\u0117s strukt\u016bros \u017eini\u0173 spragas.<\/p>\n\n\n\n

Atliekant tyrim\u0105 buvo analizuojamos 28 gyv\u016bn\u0173 r\u016b\u0161ys, sukurtas 3D modelis, kuriame ACE2 sujungtas su viruso smaigalio baltymu. <\/p>\n\n\n\n

Rezultatai parod\u0117, kad ACE2 aminor\u016bg\u0161\u010di\u0173 sekoje yra pagrindini\u0173 viet\u0173, kuriose d\u0117l mutacij\u0173 viruso baltymas negali prisijungti prie l\u0105stel\u0117s \u0161eiminink\u0117s. <\/p>\n\n\n\n

Tiksliau, ACE2 sekoje tr\u016bksta vienos aminor\u016bg\u0161ties, atsakingos u\u017e tarpmolekulin\u012f drusk\u0173 tiltel\u012f, pasteb\u0117t\u0105 tarp ACE2 ir viruso baltymo prisijungimo vietos, kaip prane\u0161\u0117 Rodriguesas ir jo komanda. <\/p>\n\n\n\n

\u0160\u012f rezultat\u0105 patvirtina ir kiti paskelbti tyrimai, kuriuose eksperimenti\u0161kai \u012frodyta, kad \u0161is mutantas neturi neigiamai \u012fkrautos aminor\u016bg\u0161ties, leid\u017eian\u010dios viruso baltymui prisijungti.<\/p>\n\n\n\n

Tyrimas taip pat rodo, kad SARS-CoV-2 infekcija yra sud\u0117tingesn\u0117, nei manyta anks\u010diau, ir turi daugiau nei vien\u0105 b\u016bd\u0105 u\u017ekr\u0117sti \u0161eiminink\u0105. <\/p>\n\n\n\n

Tod\u0117l svarbu paai\u0161kinti, kad suma\u017einus AKF2 kiek\u012f gali suma\u017e\u0117ti infekcijos tikimyb\u0117, ta\u010diau tai neu\u017ekerta kelio infekcijai atsirasti.<\/p>\n\n\n\n

Be to, vien skai\u010diavimo modeliais negalima remtis norint numatyti r\u016b\u0161i\u0173 u\u017esikr\u0117timo rizik\u0105 - norint padaryti patikimesn\u0119 i\u0161vad\u0105, reikia papildom\u0173 eksperimentini\u0173 duomen\u0173.<\/p>\n\n\n\n

Taigi, manau, kad turime ir toliau laikytis pandemijos protokol\u0173 ir daryti tai, k\u0105 jau darome... Naudoti kaukes, laikytis kuo didesnio socialinio atstumo, nesilankyti u\u017edarose patalpose ir perpildytose erdv\u0117se, kad u\u017etikrintume savo ir ypa\u010d savo mylim\u0173 augintini\u0173, sav\u0119s ir savo \u0161eimos saugum\u0105.<\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

\u0160i p\u016bkuota kat\u0117 tokia gra\u017ei, ar ne? \u0160i\u0105 ir daugyb\u0119 kit\u0173 gyv\u016bn\u0173 iliustracij\u0173 rasite Mind the Graph platformoje. <\/p>\n\n\n\n

Veterinarijos<\/a>, ornitologija<\/a>, entomologija<\/a>, ir zoologija<\/a> platformoje taip pat galima rasti iliustracij\u0173, kurias galima naudoti infografikoje. Prad\u0117kite naudoti Mind the Graph dabar<\/a>!<\/p>","protected":false},"excerpt":{"rendered":"

Taip, deja, j\u016bs\u0173 augintiniui taip pat gresia pavojus u\u017esikr\u0117sti COVID-19. Kaip ir mes esame iml\u016bs SARS-CoV-2 viruso infekcijai, taip ir tam tikros gyv\u016bn\u0173 r\u016b\u0161ys. Kadangi gyv\u016bnai turi pana\u0161i\u0173 strukt\u016brini\u0173 l\u0105steli\u0173 pavir\u0161iaus baltym\u0173, esan\u010di\u0173 \u017emoni\u0173 organizme, savybi\u0173. Specifinis baltymas veikia kaip spyna ir raktas, o raktas yra viruso [...]<\/p>","protected":false},"author":4,"featured_media":12241,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[389,647,554],"yoast_head":"\nIs Your Pet in Danger of The COVID-19? - MTG<\/title>\n<meta name=\"description\" content=\"Do you know that pets also get affected by COVID-19? If you are now thinking that is your pet in danger of the COVID-19, then you're in the right place. Read this blog post to know more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/lt\/covid-19-pets\/\" \/>\n<meta property=\"og:locale\" content=\"lt_LT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Is Your Pet in Danger of The COVID-19? - MTG\" \/>\n<meta property=\"og:description\" content=\"Do you know that pets also get affected by COVID-19? If you are now thinking that is your pet in danger of the COVID-19, then you're in the right place. 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/lt\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts\/12236"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/comments?post=12236"}],"version-history":[{"count":5,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts\/12236\/revisions"}],"predecessor-version":[{"id":26012,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts\/12236\/revisions\/26012"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/media\/12241"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/media?parent=12236"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/categories?post=12236"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/tags?post=12236"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}