{"id":12175,"date":"2021-01-25T09:30:00","date_gmt":"2021-01-25T11:30:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12175"},"modified":"2023-05-22T11:11:05","modified_gmt":"2023-05-22T14:11:05","slug":"molecular-control-knob-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lt\/molekuline-kontrole-knob-smegenys\/","title":{"rendered":"\"Molekulin\u0117 valdymo ranken\u0117l\u0117\" smegenyse, padedanti mokytis ir \u012fsiminti"},"content":{"rendered":"

Kiekviena ma\u0161ina turi valdymo skydel\u012f, kuriuo galima valdyti \u012fvairias funkcijas, ypa\u010d \u012fjungimo ir i\u0161jungimo mechanizm\u0105. <\/p>\n\n\n\n

Ar kada nors susim\u0105st\u0117te, kad m\u016bs\u0173 smegenys taip pat turi toki\u0105 funkcij\u0105, kuria b\u016bt\u0173 galima valdyti smegen\u0173 funkcijas? <\/p>\n\n\n\n

Na, nauji tyrimai rodo, kad \"t\u016bris molekulin\u0117 ranken\u0117l\u0117 \", kuri reguliuoja elektrinius signalus smegenyse mokymosi ir ypa\u010d su atmintimi. <\/p>\n\n\n\n

Tai gali b\u016bti pagrindinis jungiklio mechanizmas, galintis pakeisti nervini\u0173 sutrikim\u0173 situacij\u0105.<\/p>\n\n\n\n

Maiklo Hoppos ir jo komandos paskelbtame tyrime teigiama, kad elektrini\u0173 signal\u0173 reguliavimas gali b\u016bti labai svarbus. Tyrimo metu buvo nustatomos signal\u0105 reguliuojan\u010dios molekul\u0117s.<\/p>\n\n\n\n

TYRIMO ID\u0116JA<\/p>\n\n\n\n

Sinaps\u0117s - tai jungtys, per kurias tarp nervini\u0173 l\u0105steli\u0173 perduodami elektriniai signalai. <\/p>\n\n\n\n

\u0160iuos elektrinius signalus smegenys paver\u010dia cheminiais neurotransmiteriais, kurie keliauja per sinapsinius tarpus. Komanda apra\u0161\u0117, kaip elektrini\u0173 signal\u0173 formos naudingos sinapsi\u0173 veikimui. <\/p>\n\n\n\n

Neuronai, kurie suaktyv\u0117ja neurotransmisijos metu, turi skirtingus modelius. <\/p>\n\n\n\n

\u0160ie formos ir skai\u010diaus poky\u010diai lemia sinapsi\u0173 sustipr\u0117jim\u0105 arba susilpn\u0117jim\u0105 (dar vadinama sinapsiniu plasti\u0161kumu ). <\/p>\n\n\n\n

Kai abiejuose sinaps\u0117s galuose esan\u010dios smegen\u0173 l\u0105stel\u0117s nuolat kei\u010diasi cheminiais signalais, \u012fvyksta ilgalaikis potencijavimas (LTP). <\/p>\n\n\n\n

\u0160is LTP pagerina signal\u0173 perdavim\u0105 tarp l\u0105steli\u0173 ir sinapsi\u0173, taip pat sustiprina sinapses. \u0160is LTP yra mokymosi ir atsiminim\u0173 pagrindas smegenyse, vadinamoje hipokampu.<\/p>\n\n\n\n

Tyrimo metu mokslininkai daugiausia d\u0117mesio skyr\u0117 hipokampo sri\u010diai smegenyse. Jie nustat\u0117, kad \u0161ioje srityje per sinapses perduodami signalai yra analogi\u0161ki. <\/p>\n\n\n\n

Komanda nustat\u0117, kad elektriniai signalai arba \"\u0161uoliai\" buvo perduodami kaip analoginiai, o ne skaitmeniniai signalai. <\/p>\n\n\n\n

\u0160is atradimas pad\u0117jo geriau suprasti mechanizm\u0105. \u0160ie analoginiai signalai leido lengviau reguliuoti smegen\u0173 grandin\u0117s stiprum\u0105.<\/p>\n\n\n\n

Taip pat rasta \u0161iuos elektrinius signalus reguliuojanti molekul\u0117. Kv\u03b21 molekul\u0117 i\u0161pl\u0117t\u0117 presinapsin\u012f poveik\u012f. <\/p>\n\n\n\n

\u0160i molekul\u0117 ne tik reguliuoja kalio srov\u0119, bet ir padeda formuoti elektrinius signalus. <\/p>\n\n\n\n

Anks\u010diau atlikdami eksperiment\u0105, jie atmet\u0117 Kv\u03b21 molekul\u0119 pel\u0117se. Netrukus rezultatai parod\u0117 prie\u0161ing\u0105 reakcij\u0105, buvo smarkiai paveiktas peli\u0173 miego ir atminties ciklas. <\/p>\n\n\n\n

Tai patvirtino teigiam\u0105 molekul\u0117s poveik\u012f sistemai.<\/p>\n\n\n\n

Be to, j\u0173 tyrimai atskleid\u0117, kaip vienas elektrinis impulsas gali perne\u0161ti kelis bitus informacijos, o tai leid\u017eia geriau valdyti \u017eemo da\u017enio signalus. <\/p>\n\n\n\n

Tai rei\u0161kia, kad m\u016bs\u0173 smegenys yra daug efektyvesn\u0117s, nei galima \u012fsivaizduoti. Techni\u0161kai m\u016bs\u0173 smegenys atlieka superkompiuterines u\u017eduotis esant ma\u017eam elektros signalui. <\/p>\n\n\n\n

J\u0173 tyrimai leido i\u0161matuoti \u012ftamp\u0105 ir neuromediatori\u0173 naudojant \u0161vies\u0105, kuri savo ruo\u017etu matuoja elektrinius signalus sinapsini\u0173 jung\u010di\u0173 vietose. <\/p>\n\n\n\n

Tai pakeit\u0117 po\u017ei\u016br\u012f ir i\u0161pl\u0117t\u0117 tyrim\u0173 srit\u012f molekulini\u0173 reguliatori\u0173, kurie atlieka svarb\u0173 vaidmen\u012f smegen\u0173 veikloje, srityje.<\/p>\n\n\n\n

\u0160is atradimas atveria visi\u0161kai nauj\u0105 keli\u0105 farmacijai. Tai gali pad\u0117ti atrasti nauj\u0173 vaist\u0173, skirt\u0173 demencijai ar Alzheimerio ligai gydyti. <\/p>\n\n\n\n

Molekuliniai reguliatoriai gali b\u016bti raktas \u012f vis\u0173 smegen\u0173 paj\u0117gum\u0173 panaudojim\u0105. Daugel\u012f neurologini\u0173 lig\u0173 b\u016bt\u0173 galima i\u0161gydyti, jei b\u016bt\u0173 rastas tinkamas smegen\u0173 med\u017eiag\u0173 apykaitos kelias. <\/p>\n\n\n\n

Kaip sakoma, mokymasis niekada nei\u0161semia proto, tai galia, galinti pakeisti pasaul\u012f. \u0160is atradimas, be abejo, veda \u012f visi\u0161kai nauj\u0105 mokymosi lyg\u012f ir gali\u0105 j\u012f i\u0161laikyti.<\/p>\n\n\n\n

Jei norite daugiau su\u017einoti apie j\u0173 tyrimus, per\u017ei\u016br\u0117kite toliau pateikt\u0105 nuorod\u0105.<\/p>\n\n\n\n

Nuoroda :<\/p>\n\n\n\n

In Ha Cho, Lauren C. Panzera, Morven Chin, Scott A. Alpizar, Genaro E. Olveda, Robert A. Hill, Michael B. Hoppa. Kalio kanalo Kv\u03b21 subvienetas tarnauja kaip pagrindinis sinapsinio palengvinimo valdymo ta\u0161kas. Proceedings of the National Academy of Sciences, 2020; 202000790<\/p>\n\n\n\n

DOI: 10.1073\/pnas.2000790117<\/p>","protected":false},"excerpt":{"rendered":"

Kiekviena ma\u0161ina turi valdymo skydel\u012f, kuriuo galima valdyti \u012fvairias funkcijas, ypa\u010d \u012fjungimo ir i\u0161jungimo mechanizm\u0105. Ar kada nors susim\u0105st\u0117te, kad ir m\u016bs\u0173 smegenys turi tok\u012f pultel\u012f, kuriuo galima valdyti smegen\u0173 funkcijas? Na, nauji tyrimai rodo, kad yra \"garsumo molekulin\u0117 ranken\u0117l\u0117\", kuri reguliuoja elektrinius signalus smegenyse mokantis ir ypa\u010d [...]<\/p>","protected":false},"author":4,"featured_media":12176,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[54,245,554],"yoast_head":"\nThe \u201cmolecular control knob\u201d that aids learning and memory - MTG<\/title>\n<meta name=\"description\" content=\"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/lt\/molekularni-nadzor-kljuc-mozgani\/\" \/>\n<meta property=\"og:locale\" content=\"lt_LT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The \u201cmolecular control knob\u201d that aids learning and memory - MTG\" \/>\n<meta property=\"og:description\" content=\"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/lt\/molekularni-nadzor-kljuc-mozgani\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-25T11:30:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-22T14:11:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/a-molecular-control-knob-in-the-brain-that-aids-in-learning-and-memory.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1123\" \/>\n\t<meta property=\"og:image:height\" content=\"612\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The \u201cmolecular control knob\u201d that aids learning and memory - MTG","description":"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/lt\/molekularni-nadzor-kljuc-mozgani\/","og_locale":"lt_LT","og_type":"article","og_title":"The \u201cmolecular control knob\u201d that aids learning and memory - MTG","og_description":"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.","og_url":"https:\/\/mindthegraph.com\/blog\/lt\/molekularni-nadzor-kljuc-mozgani\/","og_site_name":"Mind the Graph Blog","article_published_time":"2021-01-25T11:30:00+00:00","article_modified_time":"2023-05-22T14:11:05+00:00","og_image":[{"width":1123,"height":612,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/a-molecular-control-knob-in-the-brain-that-aids-in-learning-and-memory.png","type":"image\/png"}],"author":"Fabricio Pamplona","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabricio Pamplona","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/sl\/molekularni-nadzor-kljuc-mozgani\/","url":"https:\/\/mindthegraph.com\/blog\/sl\/molekularni-nadzor-kljuc-mozgani\/","name":"The \u201cmolecular control knob\u201d that aids learning and memory - MTG","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2021-01-25T11:30:00+00:00","dateModified":"2023-05-22T14:11:05+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3"},"description":"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/sl\/molekularni-nadzor-kljuc-mozgani\/#breadcrumb"},"inLanguage":"lt-LT","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/sl\/molekularni-nadzor-kljuc-mozgani\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/sl\/molekularni-nadzor-kljuc-mozgani\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"A \u201cMolecular Control Knob\u201d in The Brain That Aids in Learning and Memory"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"lt-LT"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3","name":"Fabricio Pamplona","image":{"@type":"ImageObject","inLanguage":"lt-LT","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","caption":"Fabricio Pamplona"},"description":"Fabricio Pamplona is the founder of Mind the Graph - a tool used by over 400K users in 60 countries. He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/lt\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts\/12175"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/comments?post=12175"}],"version-history":[{"count":1,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts\/12175\/revisions"}],"predecessor-version":[{"id":12177,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/posts\/12175\/revisions\/12177"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/media\/12176"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/media?parent=12175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/categories?post=12175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/lt\/wp-json\/wp\/v2\/tags?post=12175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}