{"id":12121,"date":"2021-01-11T11:05:53","date_gmt":"2021-01-11T13:05:53","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12121"},"modified":"2023-01-05T14:52:03","modified_gmt":"2023-01-05T17:52:03","slug":"cause-of-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/lt\/alzheimerio-ligos-priezastis\/","title":{"rendered":"Nauja teorija bando paai\u0161kinti Alzheimerio ligos prie\u017east\u012f"},"content":{"rendered":"

\u0160iuo metu daugiau nei pus\u0117 demencijos atvej\u0173 priskiriama Alzheimerio ligai - l\u0117tinei neurodegeneracinei ligai, d\u0117l kurios palaipsniui sutrinka \u017emogaus pa\u017einimas ir atmintis. <\/p>\n\n\n\n

Iki \u0161iol buvo manoma, kad lig\u0105 sukelia genetiniai ir sen\u0117jimo veiksniai, o ligos piktadariai ir pagrindiniai kaltininkai - senatvin\u0117s plok\u0161tel\u0117s ir neurofibrilinis susipainiojimas, sukeliantis neurou\u017edegim\u0105 ir i\u0161 eil\u0117s - neuron\u0173 \u017e\u016bt\u012f. <\/p>\n\n\n\n

Ta\u010diau nauja Alzheimerio ligos prie\u017eas\u010di\u0173 teorija \u012f\u017eieb\u0117 \u0161vies\u0105 medicinos tyrim\u0173 padang\u0117je. <\/p>\n\n\n\n

Teorija teigia, kad genetika ir sen\u0117jimas n\u0117ra vieninteliai veiksniai, lemiantys amiloido gumul\u0117li\u0173 - baltymo, kuris kaupiasi tarp neuron\u0173 ir sukelia Alzheimerio lig\u0105, - susidarym\u0105, bet tai gali b\u016bti ir reakcija \u012f mikrob\u0173 infekcij\u0105.  <\/p>\n\n\n\n

Pa\u017evelkime \u012f neurologin\u0119 skal\u0119, kad suprastume vis\u0105 Alzheimerio liga sergan\u010dio \u017emogaus smegen\u0173 vaizd\u0105. Vyksta du pagrindiniai rei\u0161kiniai.<\/p>\n\n\n\n

Baltymas, vadinamas tau, yra atsakingas u\u017e stabilumo palaikym\u0105, nes palaiko neuron\u0173 viduje esan\u010dias mikrotubules. Smegenyse, sergan\u010diose \u0161ia liga, tau yra biochemi\u0161kai modifikuojamas d\u0117l reakcijos, vadinamos hiperfosforilato reakcija. <\/p>\n\n\n\n

D\u0117l \u0161io poky\u010dio neuron\u0173 viduje atsiranda netirpi\u0173 baltym\u0173 gabal\u0117li\u0173, kurie suardo vis\u0105 sistem\u0105 ir \u017eudo neuron\u0173 l\u0105steles. <\/p>\n\n\n\n

\u0160ie netirp\u016bs tau baltym\u0173 gabal\u0117liai agreguojasi tarpusavyje, sudarydami neurofibriliniai susipainiojimai.<\/strong><\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Svetain\u0117 senatvin\u0117s plok\u0161tel\u0117s<\/strong> yra pagaminti i\u0161 amiloido-\u03b2 peptidai<\/strong>. Neuron\u0173 membranose esantis baltymas (pre-amiloidas) yra skaidomas, tod\u0117l laisvi amiloido-\u03b2 gabal\u0117liai atsiduria u\u017e neuron\u0173 rib\u0173*. <\/p>\n\n\n\n

\u0160ias daleles i\u0161 i\u0161orin\u0117s neuron\u0173 terp\u0117s tur\u0117t\u0173 i\u0161valyti specialios l\u0105stel\u0117s ir fermentai per fagocitoz\u0119, ta\u010diau d\u0117l genetini\u0173 ar sen\u0117jimo veiksni\u0173 \u0161is procesas vyksta nepakankamai efektyviai, tod\u0117l lieka laisv\u0173 netirpi\u0173 amiloido-\u03b2 baltym\u0173 daleli\u0173, kurios pradeda kauptis \u012f plok\u0161teles.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Amiloidin\u0117s plok\u0161tel\u0117s yra labiausiai tiriamos ir aptarin\u0117jamos kaip Alzheimerio ligos prie\u017eastis. Ta\u010diau mokslininkai taip pat tvirtina, kad neurofibriliniai susipainiojimai yra tiesiogiai susij\u0119 su ligos progresavimu.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

Mokslininkai amiloido gniu\u017eul\u0173 rado ir sveikose pomirtin\u0117se smegenyse. Tai rei\u0161kia, kad sveikose senose smegenyse valymo procesas taip pat vyksta ne taip efektyviai, ta\u010diau ne taip efektyviai kaip Alzheimerio liga sergan\u010diose smegenyse.<\/p>\n\n\n\n

Tod\u0117l Alzheimerio ligai b\u016bdingas didelis \u0161i\u0173 senatvini\u0173 plok\u0161teli\u0173 ir neurofibrilini\u0173 susipainiojim\u0173 skai\u010dius, kurie tampa labai toksi\u0161ki smegenims ir kei\u010dia sinapsi\u0173 efektyvum\u0105 bei kokyb\u0119. <\/p>\n\n\n\n

Sergantiesiems pasirei\u0161kia tokie simptomai kaip atminties praradimas, laiko ir vietos sumi\u0161imas, depresija, nerimas, kalbos ir bendravimo problemos, nuotaikos nestabilumas ir kt.<\/p>\n\n\n\n

Naujoje si\u016blomoje teorijoje<\/strong>, amiloido plok\u0161tel\u0117s yra smegen\u0173 apsaugos nuo mikrob\u0173 infekcijos mechanizmas. <\/p>\n\n\n\n

Amiloido-\u03b2 genas yra did\u017eiojoje stuburini\u0173 gyv\u016bn\u0173 grup\u0117je ir i\u0161liko \u012fvairiose r\u016b\u0161yse per kelias kartas, o tai rei\u0161kia, kad jis tur\u0117t\u0173 b\u016bti naudingas ir svarbus m\u016bs\u0173 organizmui, o ne tik kenksmingas - jei neb\u016bt\u0173 naudingas ar naudingas, genas evoliucijos keliu jau seniai b\u016bt\u0173 i\u0161nyk\u0119s.<\/p>\n\n\n\n

Mokslininkai i\u0161tyr\u0117 t\u016bkstan\u010dius Alzheimerio liga sergan\u010di\u0173 \u017emoni\u0173 pomirtini\u0173 smegen\u0173. <\/p>\n\n\n\n

Nors d\u0117l blog\u0173 s\u0105lyg\u0173 jie susid\u016br\u0117 su sunkumais analizuodami \u0161i\u0173 tip\u0173 smegenis, jiems pavyko i\u0161tirti ir surinkti informacij\u0105, kad v\u0117liau gal\u0117t\u0173 pasi\u016blyti kelet\u0105 galim\u0173 mikrob\u0173 sukeliam\u0173 veiksni\u0173. <\/p>\n\n\n\n

\u0160ie dirgikliai yra gynybos mechanizmai nuo kai kuri\u0173 tip\u0173 \u017emogaus herpeso virus\u0173, pavyzd\u017eiui, 1, 6A ir 7 herpeso viruso, ir trij\u0173 bakterij\u0173, Chlamidij\u0173 sukelta pneumonija<\/em>, Borrelia burgdorferi<\/em>, Porphyromonas gingivalis<\/em>.<\/p>\n\n\n\n

Teorija teigia, kad beta amiloidas i\u0161 prad\u017ei\u0173 atlieka gynybin\u0119 funkcij\u0105 - sulaiko \u012f smegenis judan\u010dius mikrobus ir sustabdo galim\u0105 infekcij\u0105 ar lig\u0105. <\/p>\n\n\n\n

Kaip min\u0117ta, d\u0117l sen\u0117jimo veiksni\u0173 smegenys praranda geb\u0117jim\u0105 veiksmingai valyti amiloidus. Taigi id\u0117ja apie amiloido funkcij\u0105 gali b\u016bti vis\u0105 laik\u0105 klaidinga; grei\u010diausiai jis dalyvauja tam tikroje antimikrobin\u0117je apsaugoje nuo smegen\u0173 u\u017epuolik\u0173, priskiriamas antimikrobini\u0173 peptid\u0173 kategorijai.<\/p>\n\n\n\n

Mokslininkai gavo teigiam\u0173 rezultat\u0173 bandydami \u012frodyti, kad \u03b2-amiloidas gali sunaikinti mikroorganizmus, sergan\u010dius keliomis paplitusiomis ligomis. <\/p>\n\n\n\n

Be to, 2007 m. Kolumbijos universitete (Niujorkas) prad\u0117tas ir 2022 m. planuojamas baigti kitas tyrimas, kurio metu bandomas antivirusinis vaistas su pacientais, sergan\u010diais h<\/s>erpes simplex viruso 1 ir lengvos Alzheimerio ligos, siekiant i\u0161siai\u0161kinti, ar vaistas gali sul\u0117tinti ligos progresavim\u0105. <\/p>\n\n\n\n

Kol kas belieka tik\u0117tis geriausio ir laukti rezultat\u0173.<\/p>\n\n\n\n

\u0160i nauja pasi\u016blyta teorija vis dar n\u0117ra priimtina visai mokslo bendruomenei. Daugelis mokslinink\u0173 teigia, kad net jei \u0161i nauja teorija bus \u012frodyta, genetiniai veiksniai ir blogos mutacijos vis tiek bus pagrindin\u0117 ligos prie\u017eastis. <\/p>\n\n\n\n

Alzheimerio liga - tai liga, apie kurios tikr\u0105sias prie\u017eastis vis dar turima labai ma\u017eai mokslini\u0173 \u017eini\u0173, n\u0117ra vaist\u0173 ir n\u0117ra daug terapinio gydymo galimybi\u0173. Jei \u0161i teorija pasitvirtint\u0173, tai gal\u0117t\u0173 b\u016bti pirmas \u017eingsnis geresnio gydymo link. Pirmyn, mokslas!<\/p>\n\n\n\n

Nuorodos<\/strong><\/p>\n\n\n\n

ABBOTT, A. Ar infekcijos skatina kai kuriuos Alzheimerio ligos atvejus? Gamta<\/strong>, t. 587, Nr. 7832, p. 22-25, 2020 m. lapkri\u010dio 4 d.<\/p>\n\n\n\n

CEC\u00cd, K. ir kt. Alzheimerio ligos biologiniai \u017eymenys. Geriatrija, gerontologija ir sen\u0117jimas<\/strong>, t. 6, Nr. 3, p. 273-282, 2012 m.<\/p>\n\n\n\n

MAKIN, S. Amiloido hipotez\u0117s bandymas. Gamta<\/strong>, v. 559, n. 7715, p. S4-S7, 2018 m. liepos 25 d.<\/p>\n\n\n\n

YOO, K.-Y.; PARK, S.-Y. Terpenoidai kaip potencial\u016bs antialzheimerio ligos gydymo b\u016bdai. Molekul\u0117s<\/strong>, t. 17, n. 3, p. 3524-3538, kovo m\u0117n. 2012.<\/p>\n\n\n\n

___
Jei jums, kaip ir man, reikia sukurti infografik\u0105 moksliniais tikslais, \"Mind the Graph\" galite sukurti bet kokio tipo infografik\u0105, kokio tik norite. \u0160i platforma yra tam, kad mokslininkai tapt\u0173 dizaineriais ir padidint\u0173 savo poveik\u012f! Prisijunkite prie m\u016bs\u0173 platformoje, Spauskite \u010dia<\/a>!<\/p>","protected":false},"excerpt":{"rendered":"

\u0160iuo metu daugiau nei pus\u0117 demencijos atvej\u0173 priskiriama Alzheimerio ligai - l\u0117tinei neurodegeneracinei ligai, d\u0117l kurios palaipsniui sutrinka \u017emogaus pa\u017einimas ir atmintis. Iki \u0161iol buvo manoma, kad j\u0105 sukelia genetiniai ir sen\u0117jimo veiksniai, o ligos piktadariais ir pagrindiniais kaltininkais laikomi [...]<\/p>","protected":false},"author":4,"featured_media":12125,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[213,554,964,136],"yoast_head":"\nNew Theory Tries to Explain The Cause of Alzheimer\u2019s<\/title>\n<meta name=\"description\" content=\"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/lt\/cauza-bolii-alzheimer\/\" \/>\n<meta property=\"og:locale\" content=\"lt_LT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New Theory Tries to Explain The Cause of Alzheimer\u2019s\" \/>\n<meta property=\"og:description\" content=\"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. Know what scientists and researchers have found.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/lt\/cauza-bolii-alzheimer\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-11T13:05:53+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-05T17:52:03+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/new-theory-tries-to-explain-the-cause-of-alzheimers-disease.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1110\" \/>\n\t<meta property=\"og:image:height\" content=\"600\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"5 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"New Theory Tries to Explain The Cause of Alzheimer\u2019s","description":"Read this blog that discusses a new theory that tries to explain the cause of Alzheimer\u2019s disease. 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. 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