{"id":16636,"date":"2022-09-10T18:27:00","date_gmt":"2022-09-10T21:27:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16636"},"modified":"2023-03-17T14:47:45","modified_gmt":"2023-03-17T17:47:45","slug":"success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ko\/%ec%84%b1%ea%b3%b5-%ec%82%ac%eb%a1%80-%eb%8c%80%ec%9e%a5%ec%95%94-%ec%98%a4%ea%b0%80%eb%85%b8%ec%9d%b4%eb%93%9c%ec%9d%98-%ec%9e%90%ea%b0%80-%ec%9e%ac%ec%83%9d%ec%97%90-%eb%8c%80%ed%95%9c-fgf-%ec%8b%a0\/","title":{"rendered":"\ub300\uc7a5\uc554 \uc624\uac00\ub178\uc774\ub4dc\uc758 \uc790\uac00 \uc7ac\uc0dd\uc5d0\uc11c FGF \uc2e0\ud638 \ub17c\ubb38 \uac80\ud1a0"},"content":{"rendered":"

\ud658\uc790 \uc720\ub798 CRC \uc138\ud3ec\uc5d0\uc11c FGFR \uc800\ud574\uc5d0 \uc758\ud55c \uc7a5\uc560 \uad6c\uc0c1\uccb4 \ubc0f \uc624\uac00\ub178\uc774\ub4dc \ud615\uc131\uc740 Mind the Graph\uc758 \uadf8\ub9bc\uc744 \uc0ac\uc6a9\ud558\uba74 \ud6e8\uc52c \uc27d\uac8c \uc774\ud574\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. <\/p>\n\n\n\n

\uc800\uc790\uac00 \ub9cc\ub4e0 \uacc4\ud68d\uc5d0 \ub530\ub974\uba74 \uc218\uc220 \uc0dd\uac80\uc744 \ud6a8\uc18c \ubd84\ud574\ud558\uc5ec \ub2e8\uc77c \uc138\ud3ec\uc758 \ud604\ud0c1\uc561\uc744 \uc5bb\uc5c8\uc2b5\ub2c8\ub2e4. \ubd84\ub958\ub418\uc9c0 \uc54a\uc740 \uc21c\uc9c4\ud55c \uc138\ud3ec\ub97c CSC \ubc30\uc9c0 \ub610\ub294 FGFR \uc5b5\uc81c\uc81c SU-5402\ub97c \ud568\uc720\ud55c FGF2\uc5d0\uc11c \ubc30\uc591\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

\ub300\uc7a5\uc554 \uc904\uae30\uc138\ud3ec\uc758 \uc790\uac00 \uc7ac\uc0dd\uc5d0\uc11c \uc12c\uc720\uc544\uc138\ud3ec \uc131\uc7a5\uc778\uc790 2(FGF2)\uc758 \uc5ed\ud560\uc774 \uc5f0\uad6c\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/strong><\/h2>\n\n\n\n

'\ub300\uc7a5\uc554 \uc624\uac00\ub178\uc774\ub4dc\uc758 \uc790\uac00 \uc7ac\uc0dd\uc5d0 \uc788\uc5b4\uc11c\uc758 FGF \uc2e0\ud638'\uc5d0\uc11c J\u00f6rg Otte\uc640 \ub3d9\ub8cc\ub4e4(2019)\uc740 \uc21c\uc9c4\ud55c \ub2e8\uc77c \uc138\ud3ec\ub97c \ub9e4\ud2b8\ub9ac\uac94\uc5d0 \ub0b4\uc7a5\ud558\uace0 CSC \ubc30\uc9c0\uc5d0\uc11c \ubc30\uc591\ud588\uc744 \ub54c \ubd84\uc11d \ub300\uc0c1 \ud658\uc790 \ubaa8\ub450\uc5d0\uc11c \ub354 \ubcf5\uc7a1\ud55c \uc790\uac00 \uc870\uc9c1\uc774 \uad00\ucc30\ub418\uc5c8\ub2e4\uace0 \ubcf4\uace0\ud588\uc2b5\ub2c8\ub2e4. <\/p>\n\n\n\n

\uc911\uac04\uc5fd \ubc0f \uc790\uac00 \uc7ac\uc0dd \ud45c\ud604\ud615(TGFB3, ID1, ID2, ID4)\uacfc \ud568\uaed8 EMT\uc640 \uc9c1\uc811\uc801\uc73c\ub85c \uad00\ub828\ub41c \uc720\uc804\uc790\uac00 \uc624\uac00\ub178\uc774\ub4dc\uc5d0\uc11c \uacfc\ubc1c\ud604\ub418\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uc2b5\ub2c8\ub2e4. <\/p>\n\n\n\n

FGFR\uc744 \uc5b5\uc81c\ud558\uba74 MAPK \uc2e0\ud638\uac00 \uac15\ud654\ub418\ub294 \ubc18\uba74, \ubd84\ud654\uac00 \uc720\ub3c4\ub418\uace0 \ub300\ubd80\ubd84\uc758 \uc904\uae30\uc138\ud3ec \ub9c8\ucee4\uc640 \uc0c1\ud53c \ud45c\ud604\ud615\uc774 \uc190\uc2e4\ub418\ub294 \uac83\uc744 \uad00\ucc30\ud588\uc2b5\ub2c8\ub2e4. <\/p>\n\n\n\n

\uc554 \uc904\uae30\uc138\ud3ec\ub294 \uc790\uac00 \uc7ac\uc0dd\uc774 \uac00\ub2a5\ud558\uace0 \ubd84\ud654\ub41c \uc885\uc591 \uc138\ud3ec\uc758 \uc9c0\uc18d\uc801\uc778 \uacf5\uae09\uc6d0 \uc5ed\ud560\uc744 \ud560 \uc218 \uc788\ub294 \uc545\uc131 \uc138\ud3ec\uc758 \ud558\uc704\uc9d1\ub2e8\uc785\ub2c8\ub2e4. \uc77c\ubd80 CSC \ubc30\uc591 \ud504\ub85c\ud1a0\ucf5c\uc5d0\uc11c \uc12c\uc720\uc544\uc138\ud3ec \uc131\uc7a5 \uc778\uc790 2\ub294 \uc904\uae30\uc138\ud3ec\ub97c \uc720\uc9c0\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc131\ubd84\uc785\ub2c8\ub2e4. <\/p>\n\n\n\n

\ubc18\uba74\uc5d0 CSC \ubc30\uc9c0 \ubc30\uc591 \uc624\uac00\ub178\uc774\ub4dc\uc5d0\uc11c\ub294 TGF-\u03b2\uc640 \ubd84\ud654 \uc5b5\uc81c \uc720\uc804\uc790 \uacc4\uc5f4\uc758 \ub124 \uac00\uc9c0 \uad6c\uc131\uc6d0 \ubaa8\ub450\uc758 \uc720\ub3c4\uac00 \uac10\uc9c0\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

9\uba85\uc758 \uc5f0\uc18d \ubbf8\uc120\uc815 CRC \ud658\uc790\uac00 \uc5f0\uad6c\uc5d0 \ucc38\uc5ec\ud588\uc2b5\ub2c8\ub2e4.<\/strong><\/p>\n\n\n\n

\ud655\uc778 \uc5ec\uae30 \uc6d0\ubcf8 \uae30\uc0ac<\/a>.<\/p>\n\n\n\n

Mind the Graph \uae30\ubc18 \uadf8\ub798\ud53d \uc694\uc57d<\/strong><\/h2>\n\n\n\n
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\"\"<\/a>
\uc81c\uc791 \ub300\uc0c1 Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\uc5f0\uad6c\ud300\uc758 \uacb0\ub860 \uc911 \uc77c\ubd80\ub294 \uc774 \ubd84\uc57c\uc5d0 \ub300\ud574 \uc774\uc804\uc5d0 \uc54c\ub824\uc9c4 \ub0b4\uc6a9\uc744 \uc7a0\uc7ac\uc801\uc73c\ub85c \uac15\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4: \"\ub2e4\ub2a5\uc131 \uad00\ub828 \uc720\uc804\uc790 NANOG, LIN28 \ubc0f SALL1\uc740 hESC\uc5d0 \uc758\ud574 \ub3c5\uc810\uc801\uc73c\ub85c \ubc1c\ud604\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \"BMP \uc2e0\ud638 \uc804\ub2ec \uacbd\ub85c\uc758 \uc74c\uc131 \uc870\uc808\"\uacfc \"SMAD \ub2e8\ubc31\uc9c8 \uc2e0\ud638 \uc804\ub2ec\"\uc774\ub77c\ub294 GO \uc6a9\uc5b4\uac00 hESC \ubc30\uc591\uc5d0\uc11c \ubc1c\uacac\ub418\uc5c8\uc2b5\ub2c8\ub2e4.\"\ub77c\uace0 Otte\ub294 \uc81c\uc548\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

\uc800\uc790\ub4e4\uc740 \"\uc774 \uc720\uc804\uc790 \uc138\ud2b8\uc5d0 \ub300\ud55c GO \uc6a9\uc5b4 \ubd84\uc11d\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \uc870\uc808\ub418\ub294 \uc720\uc804\uc790\uc758 \uc218\uac00 \uc801\uae30 \ub54c\ubb38\uc5d0 \uba87 \uac00\uc9c0 \uc911\uc694\ud55c \uacb0\uacfc\ub9cc \ub3c4\ucd9c\ud588\uc2b5\ub2c8\ub2e4. CSC \uc911\uac04 \uc0c1\ud0dc\uc5d0 \ub300\ud55c \uc774\ub7ec\ud55c GO \uc6a9\uc5b4\uc758 \ub300\ubd80\ubd84\uc740 \ud65c\uc131 \uc804\uc0ac, \uc138\ud3ec \uc99d\uc2dd \ub610\ub294 \ud3ec\ub3c4\ub2f9 \ud761\uc218 \uc99d\uac00\uc640 \uad00\ub828\uc774 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. <\/p>\n\n\n\n

FGFR \uc5b5\uc81c \ud6c4, \uc6b0\ub9ac\ub294 \uc138\ud3ec \uc8fc\uae30 \uc870\uc808\uc790\ubfd0\ub9cc \uc544\ub2c8\ub77c \"\uc0c1\ud53c \uc138\ud3ec \ubd84\ud654\", \"\uc18c\ud654\" \ub610\ub294 \"\ub2f4\uc999\uc0b0 \ubc0f \ub2f4\uc999\uc5fc \uc218\uc1a1\"\uc73c\ub85c \uc8fc\uc11d\uc774 \ub2ec\ub9b0 \ub9ce\uc740 \uc720\uc804\uc790\ub97c \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4.\"<\/p>\n\n\n\n

\ub17c\ubb38 \uc601\ud5a5\ub825 \ubc0f \uc131\uacfc<\/strong><\/h2>\n\n\n\n

\ub2e4\uc74c\uc744 \uc0ac\uc6a9\ud558\uc5ec \ubd84\uc11d\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc54c\ud2b8\uba54\ud2b8\ub9ad<\/a> \uc774 \ub17c\ubb38\uc758 \uc628\ub77c\uc778 \uad00\uc2ec\ub3c4 \uc810\uc218\uac00 \ub354 \ub192\ub2e4\ub294 \ub370\uc774\ud130 \ubcf4\ub2e4 68%<\/strong><\/strong> \uc0ac\uc774\uc5b8\ud2f0\ud53d \ub9ac\ud3ec\ud2b8\uc5d0 \uc2e4\ub9b0 \ube44\uc2b7\ud55c \uc5f0\ub3c4\uc758 \ub2e4\ub978 \ubaa8\ub4e0 \ub17c\ubb38\ubcf4\ub2e4 \ub354 \ub9ce\uc774 \uac8c\uc7ac\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/strong><\/p>\n\n\n\n

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\"\"<\/a>
\ucd9c\ucc98 Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\uc778\ud3ec\uadf8\ub798\ud53d\uc758 \uac15\ub825\ud55c \uae30\ub2a5\uc73c\ub85c \uae30\uc0ac\uc758 \uc811\uadfc\uc131\uc744 \uac1c\uc120\ud560 \uc218\ub3c4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

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Mind the Graph \uccb4\ud5d8\ud558\uae30<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

\ud658\uc790 \uc720\ub798 CRC \uc138\ud3ec\uc5d0\uc11c FGFR \uc800\ud574\uc5d0 \uc758\ud55c \uad6c\uc0c1\uccb4 \ubc0f \uc624\uac00\ub178\uc774\ub4dc \ud615\uc131 \uc7a5\uc560\ub97c \uadf8\ub9bc\uc73c\ub85c \uc27d\uac8c \uc774\ud574\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>","protected":false},"author":29,"featured_media":20014,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,1],"tags":[96,554,775,963],"yoast_head":"\nFGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/ko\/\uc131\uacf5-\uc0ac\ub840-\ub300\uc7a5\uc554-\uc624\uac00\ub178\uc774\ub4dc\uc758-\uc790\uac00-\uc7ac\uc0dd\uc5d0-\ub300\ud55c-fgf-\uc2e0\/\" \/>\n<meta property=\"og:locale\" content=\"ko_KR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - 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