{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ja\/%e3%82%a2%e3%83%ab%e3%83%84%e3%83%8f%e3%82%a4%e3%83%9e%e3%83%bc%e7%97%85\/","title":{"rendered":"\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u79d1\u5b66\u7684\u30a4\u30f3\u30d5\u30a9\u30b0\u30e9\u30d5\u30a3\u30c3\u30af"},"content":{"rendered":"<p style=\"text-align: justify;\">\u30e6\u30fc\u30b6\u30fc\u306e\u7d20\u6674\u3089\u3057\u3044\u4f5c\u54c1\u3092\u898b\u308b\u306e\u306f\u3001\u3044\u3064\u3082\u304a\u3081\u3067\u305f\u3044\u3053\u3068\u3067\u3059\u3002\u00a0<a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-graphical-abstracts\/#.W4WUCehKiUk\" target=\"_blank\" rel=\"noopener\">\u3059\u3067\u306b\u66f8\u3044\u305f\u304c<\/a> \u30a2\u30ec\u30c3\u30b5\u30f3\u30c9\u30e9\u30fb\u30de\u30eb\u30c6\u30a3\u30fc\u30cb\u535a\u58eb\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u306f\u3001Dr.\u00a0<a href=\"https:\/\/www.researchgate.net\/profile\/Stefania_Forner3\" target=\"_blank\" rel=\"noopener\">\u30b9\u30c6\u30d5\u30a1\u30cb\u30a2\u30fb\u30d5\u30a9\u30eb\u30ca\u30fc<\/a>\u00a0\u3068\u305d\u306e\u4ef2\u9593\u305f\u3061\u3067\u3059\u3002\u5f7c\u3089\u306f\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5927\u5b66\u306e\u535a\u58eb\u7814\u7a76\u54e1\u3067 \u30b0\u30e9\u30d5\u306e\u4f7f\u3044\u624b\u3092\u610f\u8b58\u3057\u3066\u3044\u307e\u3059\u3002  \u6570\u30f6\u6708\u524d\u3001\u79c1\u306f<a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-graphical-abstracts\/#.W4WcaOhKiUl\" target=\"_blank\" rel=\"noopener\"> \u30a4\u30f3\u30d5\u30a9\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\u30b9<\/a>\u00a0Stefania Forner\u535a\u58eb\u304c\u3001Trends in Neurosciences\u306b\u63b2\u8f09\u3055\u308c\u305f\u300cSynaptic impairment in Alzheimer's Disease\u300d\u3068\u3044\u3046\u7dcf\u8aac\u306e\u305f\u3081\u306b\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002A dysregulated symphony.<\/p>\n<p style=\"text-align: justify;\">\u672c\u65e5\u306f\u3001\u5f7c\u3089\u306e\u65b0\u3057\u3044\u30ec\u30d3\u30e5\u30fc\u8a18\u4e8b\u3067\u3042\u308b \"This is a new review article \"\u306b\u3064\u3044\u3066\u304a\u8a71\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002 <a href=\"https:\/\/www.researchgate.net\/publication\/323527342_Past_to_Future_What_Animal_Models_Have_Taught_Us_About_Alzheimer's_Disease\" target=\"_blank\" rel=\"noopener\">\u904e\u53bb\u304b\u3089\u672a\u6765\u3078\uff1a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3064\u3044\u3066\u52d5\u7269\u30e2\u30c7\u30eb\u304c\u6559\u3048\u3066\u304f\u308c\u305f\u3053\u3068\u3002<\/a><\/p>\n<p style=\"text-align: justify;\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u306f\u3001\u8a8d\u77e5\u969c\u5bb3\u3084\u8a18\u61b6\u55aa\u5931\u3092\u5f15\u304d\u8d77\u3053\u3059\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3059\u3002\u3053\u306e\u75c5\u6c17\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306f\u3001\u60a3\u8005\u3055\u3093\u306e\u751f\u6d3b\u306e\u8cea\u3092\u5411\u4e0a\u3055\u305b\u3001\u52b9\u679c\u7684\u306a\u6cbb\u7642\u6cd5\u3092\u898b\u3064\u3051\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3059\u3002\u73fe\u5728\u3001\u5b66\u8853\u754c\u3084\u88fd\u85ac\u696d\u754c\u3067\u306f\u591a\u5927\u306a\u52aa\u529b\u304c\u306a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u6709\u52b9\u306a\u6cbb\u7642\u6cd5\u306f\u3042\u308a\u307e\u305b\u3093\u3002AD\u306f\u7c73\u56fd\u306b\u304a\u3051\u308b\u6b7b\u56e0\u306e\u7b2c6\u4f4d\u3067\u3042\u308a\u3001\u5168\u4e16\u754c\u30673,500\u4e07\u4eba\u304c\u7f79\u60a3\u3057\u3066\u3044\u308b\u3068\u8a00\u308f\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n<h2 style=\"text-align: center;\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306e\u30a4\u30f3\u30d5\u30a9\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\u30b9<\/h2>\n<p>&nbsp;<\/p>\n<p style=\"text-align: justify;\">AD\u60a3\u8005\u306e\u5927\u534a\u306f\u9ad8\u9f62\u8005\u3067\u3042\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u4f75\u5b58\u75be\u60a3\u3092\u62b1\u3048\u3066\u3044\u308b\u306e\u304c\u4e00\u822c\u7684\u3067\u3059\u3002\u7cd6\u5c3f\u75c5\u3001\u9aa8\u7c97\u9b06\u75c7\u3001\u814e\u81d3\u75c5\u3001\u80a5\u6e80\u3001\u9ad8\u8840\u5727\u3001\u9ad8\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb\u8840\u75c7\u3001\u8102\u8cea\u7570\u5e38\u75c7\u3001\u8133\u5352\u4e2d\u3001\u75d9\u6523\u306a\u3069\u304cAD\u306e\u767a\u75c7\u3084\u9032\u884c\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u4e3b\u306a\u4f75\u5b58\u75be\u60a3\u3067\u3042\u308a\u3001\u75c5\u614b\u306b\u8907\u96d1\u3055\u3092\u4e0e\u3048\u3066\u3044\u308b\u3002<\/p>\n<figure id=\"attachment_8067\" aria-describedby=\"caption-attachment-8067\" style=\"width: 755px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-8067 size-full\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png\" alt=\"\u30a4\u30f3\u30d5\u30a9\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\u30fb\u30cb\u30e5\u30fc\u30ed\u30b5\u30a4\u30a8\u30f3\u30b9\" width=\"755\" height=\"487\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png 755w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience-300x194.png 300w\" sizes=\"(max-width: 755px) 100vw, 755px\" \/><figcaption id=\"caption-attachment-8067\" class=\"wp-caption-text\">\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u578b\u8a8d\u77e5\u75c7\uff08AD\uff09\u306e\u4f75\u5b58\u75be\u60a3\u3092\u793a\u3059\u30a4\u30f3\u30d5\u30a9\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\u3002\u904e\u53bb\u304b\u3089\u672a\u6765\u3078\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3064\u3044\u3066\u52d5\u7269\u30e2\u30c7\u30eb\u304c\u6559\u3048\u3066\u304f\u308c\u305f\u3053\u3068<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<blockquote>\n<p style=\"text-align: justify;\"><em>\u904e\u53bb\u6570\u5341\u5e74\u306b\u308f\u305f\u308b\u96c6\u4e2d\u7684\u306a\u7814\u7a76\u52aa\u529b\u306b\u3082\u304b\u304b\u308f\u3089\u305a\u3001\u3053\u306e\u75be\u60a3\u306e\u6700\u3082\u4e00\u822c\u7684\u306a\u578b\u3067\u3042\u308b\u6563\u767a\u6027AD\uff08sAD\uff09\u306e\u75c5\u56e0\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306f\u4f9d\u7136\u3068\u3057\u3066\u4e0d\u660e\u3067\u3042\u308b\u3002\u3053\u308c\u306f\u3001sAD\u306e\u60a3\u8005\u3055\u3093\u306e\u5927\u534a\u304c\u9ad8\u9f62\u8005\u3067\u3042\u308a\u3001\u3055\u307e\u3056\u307e\u306a\u5408\u4f75\u75c7\uff08\u8133\u5352\u4e2d\u3001\u30b9\u30c8\u30ec\u30b9\u3001\u7cd6\u5c3f\u75c5\u3001\u767a\u4f5c\u3001\u9aa8\u7c97\u9b06\u75c7\u3001\u814e\u81d3\u75c5\u306a\u3069\uff09\u3092\u62b1\u3048\u3066\u3044\u308b\u3053\u3068\u304c\u5c11\u306a\u304f\u3068\u3082\u4e00\u56e0\u3068\u8003\u3048\u3089\u308c\u307e\u3059\u3002<\/em><\/p>\n<\/blockquote>\n<p>\u6b21\u306e\u30a4\u30f3\u30d5\u30a9\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\u306f\u3001\u30bf\u30a6\u3068\u03b2-\u30a2\u30df\u30ed\u30a4\u30c9\u30aa\u30ea\u30b4\u30de\u30fc\u306e\u5f62\u6210\u3068\u30b7\u30ca\u30d7\u30b9\u6bd2\u6027\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p>\n<p>&nbsp;<\/p>\n<figure id=\"attachment_8068\" aria-describedby=\"caption-attachment-8068\" style=\"width: 544px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-8068 size-full\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2018\/08\/infografico-stefani1a.png\" alt=\"\u5199\u771f\uff1aStefani1a\" width=\"544\" height=\"386\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infografico-stefani1a.png 544w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infografico-stefani1a-300x213.png 300w\" sizes=\"(max-width: 544px) 100vw, 544px\" \/><figcaption id=\"caption-attachment-8068\" class=\"wp-caption-text\">\u904e\u53bb\u304b\u3089\u672a\u6765\u3078\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3064\u3044\u3066\u52d5\u7269\u30e2\u30c7\u30eb\u304c\u6559\u3048\u3066\u304f\u308c\u305f\u3053\u3068<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<blockquote>\n<p style=\"text-align: justify;\"><em>\u30bf\u30a6\u30d1\u30c1\u30fc\u306e\u9593\u3001\u6a39\u72b6\u7a81\u8d77\u30b9\u30d1\u30a4\u30f3\u306e\u6570\u304c\u6e1b\u5c11\u3059\u308b\u3002\u30bf\u30a6\u306f\u795e\u7d4c\u7d30\u80de\u306e\u6838\u306b\u5165\u308a\u8fbc\u307e\u306a\u3044\u305f\u3081\u3001DNA\u640d\u50b7\u304c\u8d77\u3053\u308b\u3002\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u306e\u6570\u304c\u6e1b\u5c11\u3057\u3001\u30b7\u30ca\u30d7\u30b9\u524d\u5c0f\u80de\u306e\u6570\u3082\u6e1b\u5c11\u3059\u308b\u305f\u3081\u3001\u30b7\u30ca\u30d7\u30b9\u304c\u5931\u308f\u308c\u308b\u3002\u3053\u306e\u3088\u3046\u306a\u640d\u5931\u306f\u3001\u6a39\u72b6\u7a81\u8d77\u3084\u30b7\u30ca\u30d7\u30b9\u5f8c\u90e8\u306b\u30bf\u30a6\u304c\u5165\u308a\u8fbc\u3080\u3053\u3068\u306b\u3082\u8d77\u56e0\u3057\u3066\u3044\u308b\u3002\u307e\u305f\u3001\u30bf\u30a6\u306f\u7d30\u80de\u5916\u306b\u51dd\u96c6\u3059\u308b\u305f\u3081\u3001\u4ed6\u306e\u795e\u7d4c\u7d30\u80de\u306b\u6355\u6349\u3055\u308c\u308b\u3053\u3068\u3082\u53ef\u80fd\u306b\u306a\u308b\u3002<\/em><\/p>\n<\/blockquote>\n<p>&nbsp;<\/p>\n<p>\u307e\u305f\u3001\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u306b\u95a2\u9023\u3059\u308b\u708e\u75c7\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u793a\u3059\u30a4\u30f3\u30d5\u30a9\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\u3092\u4f5c\u6210\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-8069\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2018\/08\/infografico-stefania.png\" alt=\"\u30b9\u30c6\u30d5\u30a1\u30cb\u30a2\u30fb\u30a4\u30f3\u30d5\u30a9\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\" width=\"503\" height=\"677\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infografico-stefania.png 503w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infografico-stefania-223x300.png 223w\" sizes=\"(max-width: 503px) 100vw, 503px\" \/><\/p>\n<p>&nbsp;<\/p>\n<blockquote>\n<p style=\"text-align: justify;\"><em>\u79c1\u305f\u3061\u306f\u3053\u3053\u6570\u5e74\u3001\u708e\u75c7\u304c\u30d9\u30fc\u30bf\u30a2\u30df\u30ed\u30a4\u30c9\u3084\u30bf\u30a6\u306e\u75c5\u7406\u306b\u3069\u306e\u3088\u3046\u306b\u5f71\u97ff\u3059\u308b\u304b\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306b\u7279\u306b\u95a2\u5fc3\u3092\u6301\u3063\u3066\u3044\u307e\u3059\u3002\u9ad8\u9f62\u8005\u306f\u30a6\u30a4\u30eb\u30b9\u3084\u7d30\u83cc\u306b\u611f\u67d3\u3057\u3084\u3059\u304f\u3001\u3053\u308c\u3089\u306e\u5fae\u751f\u7269\u304c\u8133\u306b\u5b58\u5728\u3059\u308b\u708e\u75c7\u72b6\u614b\u3092\u60aa\u5316\u3055\u305b\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u4f4e\u4e0b\u3092\u52a0\u901f\u3055\u305b\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u306e\u3067\u3059\u3002<\/em><\/p>\n<\/blockquote>\n<p style=\"text-align: justify;\">Stefania Forner\u535a\u58eb\u3001\u7d20\u6674\u3089\u3057\u3044\u4ed5\u4e8b\u3092\u3042\u308a\u304c\u3068\u3046\u3054\u3056\u3044\u307e\u3059\u3002<\/p>\n<p style=\"text-align: justify;\">\u3082\u3057\u3042\u306a\u305f\u304c\u79d1\u5b66\u8005\u3067\u3001\u8ad6\u6587\u306e\u305f\u3081\u306b\u7f8e\u3057\u3044\u56f3\u3092\u4f5c\u308a\u305f\u3044\u306e\u3067\u3042\u308c\u3070\u3001\u4eca\u3059\u3050mind the graph\u306e\u30e6\u30fc\u30b6\u30fc\u306b\u306a\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002<\/p>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/mindthegraph.com\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter wp-image-5739\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2016\/03\/untitled-creation63724-2-1024x410.png\" alt=\"\u7121\u984c-creation63724 (2)\" width=\"500\" height=\"200\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/03\/untitled-creation63724-2-1024x410.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/03\/untitled-creation63724-2-300x120.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/03\/untitled-creation63724-2.png 1500w\" sizes=\"(max-width: 500px) 100vw, 500px\" \/><\/a><\/p>","protected":false},"excerpt":{"rendered":"<p>\u30e6\u30fc\u30b6\u30fc\u306e\u7d20\u6674\u3089\u3057\u3044\u7814\u7a76\u3092\u898b\u308b\u306e\u306f\u3001\u3044\u3064\u3082\u304a\u3081\u3067\u305f\u3044\u3053\u3068\u3067\u3059\u3002\u30a2\u30ec\u30c3\u30b5\u30f3\u30c9\u30e9\u30fb\u30de\u30eb\u30c6\u30a3\u30fc\u30cb\u535a\u58eb\u3068\u30b9\u30c6\u30d5\u30a1\u30cb\u30a2\u30fb\u30d5\u30a9\u30eb\u30ca\u30fc\u535a\u58eb\u3068\u305d\u306e\u540c\u50da\u306e\u7814\u7a76\u306b\u3064\u3044\u3066\u306f\u3001\u3059\u3067\u306b\u66f8\u304d\u307e\u3057\u305f\u3002\u5f7c\u3089\u306f\u3001\u30ab\u30ea\u30d5\u30a9\u30eb\u30cb\u30a2\u5927\u5b66\u306e\u535a\u58eb\u7814\u7a76\u54e1\u3067\u3001\u30b0\u30e9\u30d5\u306e\u30e6\u30fc\u30b6\u30fc\u3092\u610f\u8b58\u3057\u3066\u3044\u307e\u3059\u3002  \u6570\u30f6\u6708\u524d\u3001\u79c1\u306fStefania Forner\u535a\u58eb\u304cTrends in Neurosciences\u306b\u767a\u8868\u3057\u305f\u300cSynaptic impairment in Alzheimer's Disease\u300d\u3068\u3044\u3046\u7dcf\u8aac\u306e\u305f\u3081\u306b\u4f5c\u6210\u3057\u305f\u30a4\u30f3\u30d5\u30a9\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\u30b9\u3092\u7d39\u4ecb\u3057\u307e\u3057\u305f\u3002A dysregulated symphony\u300d\u3068\u984c\u3055\u308c\u305f\u7dcf\u8aac\u306e\u305f\u3081\u306bStefania Forner\u535a\u58eb\u304c\u4f5c\u6210\u3057\u305f\u30a4\u30f3\u30d5\u30a9\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\u3092\u7d39\u4ecb\u3057\u307e\u3057\u305f\u3002\u4eca\u65e5\u306f\u3001\u300c\u904e\u53bb\u304b\u3089\u672a\u6765\u3078\uff1a\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\u306b\u3064\u3044\u3066\u52d5\u7269\u30e2\u30c7\u30eb\u304c\u6559\u3048\u3066\u304f\u308c\u305f\u3053\u3068\u300d\u3068\u984c\u3057\u305f\u5f7c\u3089\u306e\u65b0\u3057\u3044\u7dcf\u8aac\u306b\u3064\u3044\u3066\u304a\u8a71\u3057\u305f\u3044\u3068\u601d\u3044\u307e\u3059\u3002\u30a2\u30eb\u30c4\u30cf\u30a4\u30de\u30fc\u75c5\uff08AD\uff09\u306f\u3001\u8a8d\u77e5\u969c\u5bb3\u3084\u8a18\u61b6\u55aa\u5931\u3092\u5f15\u304d\u8d77\u3053\u3059\u795e\u7d4c\u5909\u6027\u75be\u60a3\u3067\u3059\u3002\u3053\u306e\u75c5\u6c17\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u306f\u3001\u6cbb\u7642\u6cd5\u3092\u6539\u5584\u3059\u308b\u305f\u3081\u306b\u91cd\u8981\u3067\u3059\u3002<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"<!-- 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