{"id":16636,"date":"2022-09-10T18:27:00","date_gmt":"2022-09-10T21:27:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16636"},"modified":"2023-03-17T14:47:45","modified_gmt":"2023-03-17T17:47:45","slug":"success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ja\/%e5%a4%a7%e8%85%b8%e3%81%8c%e3%82%93%e5%99%a8%e5%ae%98%e3%81%ae%e8%87%aa%e5%b7%b1%e5%86%8d%e7%94%9f%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bfgf%e3%82%b7%e3%82%b0%e3%83%8a%e3%83%aa%e3%83%b3%e3%82%b0\/","title":{"rendered":"\u5927\u8178\u304c\u3093\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u306e\u81ea\u5df1\u8907\u88fd\u306b\u304a\u3051\u308bFGF\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054 \u8ad6\u6587\u30ec\u30d3\u30e5\u30fc"},"content":{"rendered":"

\u60a3\u8005\u7531\u6765\u306eCRC\u7d30\u80de\u306b\u304a\u3051\u308bFGFR\u963b\u5bb3\u306b\u3088\u308bDisabled spheroid\u3084organoid\u5f62\u6210\u306f\u3001Mind the Graph\u306e\u30a4\u30e9\u30b9\u30c8\u3092\u4f7f\u3046\u3068\u3088\u308a\u7406\u89e3\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u306d\u3002 <\/p>\n\n\n\n

\u8457\u8005\u304c\u4f5c\u6210\u3057\u305f\u30b9\u30ad\u30fc\u30e0\u3067\u306f\u3001\u5916\u79d1\u751f\u691c\u306f\u9175\u7d20\u5206\u89e3\u3055\u308c\u3001\u5358\u7d30\u80de\u306e\u61f8\u6fc1\u6db2\u304c\u5f97\u3089\u308c\u305f\u3002\u9078\u5225\u3055\u308c\u3066\u3044\u306a\u3044\u30ca\u30a4\u30fc\u30d6\u306a\u7d30\u80de\u306f\u3001FGF2\u3092\u542b\u3080CSC-\u57f9\u5730\u307e\u305f\u306fFGFR-\u963b\u5bb3\u5264SU-5402\u3068\u3068\u3082\u306b\u57f9\u990a\u3055\u308c\u305f\u3002<\/p>\n\n\n\n

\u5927\u8178\u304c\u3093\u5e79\u7d30\u80de\u306e\u81ea\u5df1\u8907\u88fd\u306b\u304a\u3051\u308b\u7dda\u7dad\u82bd\u7d30\u80de\u5897\u6b96\u56e0\u5b502\uff08FGF2\uff09\u306e\u5f79\u5272\u3092\u8abf\u3079\u305f\u3068\u3053\u308d<\/strong><\/h2>\n\n\n\n

J\u00f6rg Otte\u3089\uff082019\uff09\u306f\u3001\u300cFGF Signalling in Self-Renewal of Colon Cancer Organoids\u300d\u306b\u304a\u3044\u3066\u3001\u30ca\u30a4\u30fc\u30d6\u306a\u5358\u7d30\u80de\u3092\u30de\u30c8\u30ea\u30b2\u30eb\u306b\u57cb\u3081\u8fbc\u3093\u3067CSC-\u57f9\u5730\u3067\u57f9\u990a\u3059\u308b\u3068\u3001\u89e3\u6790\u3057\u305f\u3059\u3079\u3066\u306e\u60a3\u8005\u3067\u3001\u3088\u308a\u8907\u96d1\u306a\u81ea\u5df1\u7d44\u7e54\u5316\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3068\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n\n\n

\u9593\u8449\u7cfb\u304a\u3088\u3073\u81ea\u5df1\u8907\u88fd\u8868\u73fe\u578b\u3068\u3068\u3082\u306bEMT\u306b\u76f4\u63a5\u95a2\u9023\u3059\u308b\u907a\u4f1d\u5b50\uff08TGFB3\u3001ID1\u3001ID2\u3001ID4\uff09\u304c\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u3067\u904e\u5270\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u3002 <\/p>\n\n\n\n

FGFR\u3092\u963b\u5bb3\u3059\u308b\u3068MAPK\u30b7\u30b0\u30ca\u30eb\u304c\u5897\u5f37\u3055\u308c\u308b\u4e00\u65b9\u3001\u5206\u5316\u304c\u8a98\u5c0e\u3055\u308c\u3001\u307b\u3068\u3093\u3069\u306e\u5e79\u7d30\u80de\u30de\u30fc\u30ab\u30fc\u304c\u5931\u308f\u308c\u3001\u4e0a\u76ae\u306e\u8868\u73fe\u578b\u304c\u89b3\u5bdf\u3055\u308c\u305f\u3002 <\/p>\n\n\n\n

\u764c\u5e79\u7d30\u80de\u306f\u3001\u81ea\u5df1\u8907\u88fd\u304c\u53ef\u80fd\u3067\u3001\u5206\u5316\u3057\u305f\u816b\u760d\u7d30\u80de\u306e\u7d99\u7d9a\u7684\u306a\u4f9b\u7d66\u6e90\u3068\u306a\u308b\u60aa\u6027\u816b\u760d\u7d30\u80de\u306e\u4e9c\u96c6\u56e3\u3067\u3042\u308b\u3002\u304c\u3093\u5e79\u7d30\u80de\u57f9\u990a\u306e\u3044\u304f\u3064\u304b\u306e\u30d7\u30ed\u30c8\u30b3\u30fc\u30eb\u3067\u306f\u3001\u7dda\u7dad\u82bd\u7d30\u80de\u5897\u6b96\u56e0\u5b502\u304c\u5e79\u7d30\u80de\u6027\u3092\u7dad\u6301\u3059\u308b\u305f\u3081\u306e\u91cd\u8981\u306a\u6210\u5206\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002 <\/p>\n\n\n\n

\u4e00\u65b9\u3001CSC\u57f9\u5730\u57f9\u990a\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u3067\u306f\u3001TGF-\u03b2\u3068\u5206\u5316\u963b\u5bb3\u907a\u4f1d\u5b50\u30d5\u30a1\u30df\u30ea\u30fc\u306e4\u7a2e\u985e\u3059\u3079\u3066\u306e\u8a98\u5c0e\u304c\u691c\u51fa\u3055\u308c\u305f\u3002<\/p>\n\n\n\n

9\u4eba\u306e\u9023\u7d9a\u3057\u305f\u975e\u9078\u629e\u306eCRC\u60a3\u8005\u304c\u7814\u7a76\u306b\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002<\/strong><\/p>\n\n\n\n

\u3092\u78ba\u8a8d\u3057\u307e\u3059\u3002 \u30aa\u30ea\u30b8\u30ca\u30eb\u8a18\u4e8b\u306f\u3053\u3061\u3089<\/a>.<\/p>\n\n\n\n

\u30b0\u30e9\u30d5\u30a3\u30ab\u30eb\u30a2\u30d6\u30b9\u30c8\u30e9\u30af\u30c8 powered by Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
\n
\"\"<\/a>
\u3067\u4f5c\u3089\u308c\u3066\u3044\u307e\u3059\u3002 Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u5f7c\u3089\u306e\u7d50\u8ad6\u306e\u3044\u304f\u3064\u304b\u306f\u3001\u3053\u308c\u307e\u3067\u3053\u306e\u5206\u91ce\u3067\u77e5\u3089\u308c\u3066\u3044\u305f\u3053\u3068\u3092\u5f37\u5316\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u300c\u591a\u80fd\u6027\u95a2\u9023\u907a\u4f1d\u5b50\u3067\u3042\u308bNANOG\u3001LIN28\u3001SALL1\u306f\u3001hESC\u3067\u72ec\u5360\u7684\u306b\u767a\u73fe\u3057\u3066\u3044\u307e\u3057\u305f\u3002BMP\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u7d4c\u8def\u306e\u8ca0\u306e\u5236\u5fa1\u300f\u3068\u300eSMAD\u30bf\u30f3\u30d1\u30af\u8cea\u306e\u30b7\u30b0\u30ca\u30eb\u4f1d\u9054\u300f\u3068\u3044\u3046GO\u7528\u8a9e\u304c\u3001\u6211\u3005\u306ehESC\u57f9\u990a\u3067\u691c\u51fa\u3055\u308c\u307e\u3057\u305f\u300d\u3068\u3001Otte\u6c0f\u306f\u793a\u5506\u3057\u305f\u3002<\/p>\n\n\n\n

\u8457\u8005\u3089\u306f\u3001\u300c\u3053\u306e\u907a\u4f1d\u5b50\u30bb\u30c3\u30c8\u306eGO-term\u89e3\u6790\u3067\u306f\u3001\u4e00\u822c\u7684\u306b\u5236\u5fa1\u3055\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u306e\u6570\u304c\u5c11\u306a\u3044\u305f\u3081\u3001\u308f\u305a\u304b\u306a\u6709\u610f\u306a\u7d50\u679c\u3057\u304b\u5f97\u3089\u308c\u306a\u304b\u3063\u305f\u300d\u3068\u8a8d\u3081\u3066\u3044\u308b\u3002CSC-medium\u306e\u6761\u4ef6\u306b\u304a\u3051\u308b\u3053\u308c\u3089\u306eGO-terms\u306e\u307b\u3068\u3093\u3069\u306f\u3001\u6d3b\u767a\u306a\u8ee2\u5199\u3001\u7d30\u80de\u5897\u6b96\u307e\u305f\u306f\u30b0\u30eb\u30b3\u30fc\u30b9\u53d6\u308a\u8fbc\u307f\u306e\u5897\u52a0\u306b\u95a2\u9023\u3059\u308b\u3082\u306e\u3067\u3042\u3063\u305f\u3002 <\/p>\n\n\n\n

FGFR\u963b\u5bb3\u5f8c\u306f\u3001\u7d30\u80de\u5468\u671f\u5236\u5fa1\u56e0\u5b50\u3060\u3051\u3067\u306a\u304f\u3001\u300c\u4e0a\u76ae\u7d30\u80de\u5206\u5316\u300d\u300c\u6d88\u5316\u300d\u300c\u80c6\u6c41\u9178\u30fb\u80c6\u6c41\u9178\u5869\u8f38\u9001\u300d\u306a\u3069\u306b\u6ce8\u91c8\u3055\u308c\u305f\u591a\u304f\u306e\u907a\u4f1d\u5b50\u304c\u898b\u3044\u3060\u3055\u308c\u305f\u3002\"<\/p>\n\n\n\n

\u8ad6\u6587\u30a4\u30f3\u30d1\u30af\u30c8\u3068\u30d1\u30d5\u30a9\u30fc\u30de\u30f3\u30b9<\/strong><\/h2>\n\n\n\n

\u3067\u5206\u6790\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002 \u30a2\u30eb\u30c8\u30e1\u30c8\u30ea\u30c3\u30af<\/a> \u672c\u8ad6\u6587\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u6ce8\u76ee\u5ea6\u304c\u9ad8\u3044\u3068\u3044\u3046\u30c7\u30fc\u30bf \u3088\u308a 68%<\/strong><\/strong> \u306f\u3001Scientific Reports\u306b\u63b2\u8f09\u3055\u308c\u305f\u540c\u5e74\u4ee3\u306e\u4ed6\u306e\u5168\u8ad6\u6587\u306e\u3046\u3061<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
\u51fa\u5178 \u30a2\u30eb\u30c8\u30e1\u30c8\u30ea\u30af\u30b9<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u30a4\u30f3\u30d5\u30a9\u30b0\u30e9\u30d5\u30a3\u30c3\u30af\u306e\u529b\u3082\u501f\u308a\u3066\u3001\u8a18\u4e8b\u306e\u30a2\u30af\u30bb\u30b7\u30d3\u30ea\u30c6\u30a3\u3092\u5411\u4e0a\u3055\u305b\u307e\u3057\u3087\u3046\u3002<\/p>\n\n\n\n

\n
Mind the Graph\u3092\u8a66\u3059<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

\u60a3\u8005\u3055\u3093\u7531\u6765\u306eCRC\u7d30\u80de\u306b\u304a\u3051\u308bFGFR\u963b\u5bb3\u306b\u3088\u308b\u7121\u52b9\u306a\u30b9\u30d5\u30a7\u30ed\u30a4\u30c9\u3084\u30aa\u30eb\u30ac\u30ce\u30a4\u30c9\u5f62\u6210\u306f\u3001\u79c1\u305f\u3061\u306e\u30a4\u30e9\u30b9\u30c8\u3067\u3088\u308a\u7406\u89e3\u3057\u3084\u3059\u304f\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>","protected":false},"author":29,"featured_media":20014,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,1],"tags":[96,554,775,963],"yoast_head":"\nFGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/ja\/\u5927\u8178\u304c\u3093\u5668\u5b98\u306e\u81ea\u5df1\u518d\u751f\u306b\u304a\u3051\u308bfgf\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\/\" \/>\n<meta property=\"og:locale\" content=\"ja_JP\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/ja\/\u5927\u8178\u304c\u3093\u5668\u5b98\u306e\u81ea\u5df1\u518d\u751f\u306b\u304a\u3051\u308bfgf\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-10T21:27:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"\u57f7\u7b46\u8005\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593\" \/>\n\t<meta name=\"twitter:data2\" content=\"3\u5206\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog","description":"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/ja\/\u5927\u8178\u304c\u3093\u5668\u5b98\u306e\u81ea\u5df1\u518d\u751f\u306b\u304a\u3051\u308bfgf\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\/","og_locale":"ja_JP","og_type":"article","og_title":"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog","og_description":"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.","og_url":"https:\/\/mindthegraph.com\/blog\/ja\/\u5927\u8178\u304c\u3093\u5668\u5b98\u306e\u81ea\u5df1\u518d\u751f\u306b\u304a\u3051\u308bfgf\u30b7\u30b0\u30ca\u30ea\u30f3\u30b0\/","og_site_name":"Mind the Graph Blog","article_published_time":"2022-09-10T21:27:00+00:00","article_modified_time":"2023-03-17T17:47:45+00:00","og_image":[{"width":1125,"height":614,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg","type":"image\/jpeg"}],"author":"Artur Zignani","twitter_card":"summary_large_image","twitter_image":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg","twitter_misc":{"\u57f7\u7b46\u8005":"Artur Zignani","\u63a8\u5b9a\u8aad\u307f\u53d6\u308a\u6642\u9593":"3\u5206"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/","url":"https:\/\/mindthegraph.com\/blog\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/","name":"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2022-09-10T21:27:00+00:00","dateModified":"2023-03-17T17:47:45+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02"},"description":"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/#breadcrumb"},"inLanguage":"ja","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"ja"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02","name":"Artur Zignani","image":{"@type":"ImageObject","inLanguage":"ja","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","caption":"Artur Zignani"},"url":"https:\/\/mindthegraph.com\/blog\/ja\/author\/artur\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/ja\/wp-json\/wp\/v2\/posts\/16636"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ja\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ja\/wp-json\/wp\/v2\/comments?post=16636"}],"version-history":[{"count":5,"href":"https:\/\/mindthegraph.com\/blog\/ja\/wp-json\/wp\/v2\/posts\/16636\/revisions"}],"predecessor-version":[{"id":27203,"href":"https:\/\/mindthegraph.com\/blog\/ja\/wp-json\/wp\/v2\/posts\/16636\/revisions\/27203"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ja\/wp-json\/wp\/v2\/media\/20014"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/ja\/wp-json\/wp\/v2\/media?parent=16636"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ja\/wp-json\/wp\/v2\/categories?post=16636"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ja\/wp-json\/wp\/v2\/tags?post=16636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}