{"id":11788,"date":"2020-10-19T09:00:00","date_gmt":"2020-10-19T11:00:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=11788"},"modified":"2022-11-21T09:55:34","modified_gmt":"2022-11-21T12:55:34","slug":"crispr-duo-wins-nobel-prize-2020-for-chemistry","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ja\/%e3%82%af%e3%83%aa%e3%82%b9%e3%83%97%e3%83%ab%e3%83%bc%e3%83%95%e3%81%8c2020%e5%b9%b4%e3%81%ae%e3%83%8e%e3%83%bc%e3%83%99%e3%83%ab%e5%8c%96%e5%ad%a6%e8%b3%9e%e3%82%92%e5%8f%97%e8%b3%9e\/","title":{"rendered":"CRISPR DUO\u304c\u30b7\u30e7\u30fc\u3092\u76d7\u307f\u51fa\u3059\u30022020\u5e74\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde"},"content":{"rendered":"

\u7cbe\u5bc6\u3055\u306f\u79d1\u5b66\u8005\u306e\u30c8\u30ec\u30fc\u30c9\u30de\u30fc\u30af\u3002\u30a8\u30de\u30cb\u30e5\u30a8\u30eb\u30fb\u30b7\u30e3\u30eb\u30d1\u30f3\u30c6\u30a3\u30a8\u3068\u30b8\u30a7\u30cb\u30d5\u30a1\u30fc\u30fb\u30c0\u30a6\u30c9\u30ca\u306f\u3001\u300c\u907a\u4f1d\u5b50\u306e\u30cf\u30b5\u30df\u300d\u3068\u547c\u3070\u308c\u308bCRISPR\/Cas9\u3068\u3044\u3046\u907a\u4f1d\u5b50\u5de5\u5b66\u306e\u9769\u547d\u7684\u30c4\u30fc\u30eb\u3092\u767a\u898b\u3057\u3001\u3042\u3089\u3086\u308b\u624b\u3092\u5c3d\u304f\u3057\u3066\u304d\u307e\u3057\u305f\u3002\u3053\u306e\u4eba\u751f\u3092\u5909\u3048\u308b\u30c4\u30fc\u30eb\u306e\u30d1\u30a4\u30aa\u30cb\u30a2\u3067\u3042\u308b\u30a8\u30de\u30cb\u30e5\u30a8\u30eb\u30fb\u30b7\u30e3\u30eb\u30d1\u30f3\u30c6\u30a3\u30a8\u3068\u30b8\u30a7\u30cb\u30d5\u30a1\u30fc\u30fb\u30c0\u30a6\u30c9\u30ca\u306f\u30012020\u5e74\u306e\u30ce\u30fc\u30d9\u30eb\u5316\u5b66\u8cde\u3092\u53d7\u8cde\u3059\u308b\u3053\u3068\u304c\u6c7a\u5b9a\u3057\u3066\u3044\u308b\u30022012\u5e74\u306e\u5f7c\u3089\u306e\u767a\u660e\u306f\u3001\u304c\u3093\u7814\u7a76\u3001\u690d\u7269\u7814\u7a76\u3001\u907a\u4f1d\u6027\u75be\u60a3\u306e\u6cbb\u7642\u6cd5\u306e\u767a\u898b\u3068\u3044\u3063\u305f\u91cd\u8981\u306a\u5206\u91ce\u3067\u6570\u3048\u5207\u308c\u306a\u3044\u307b\u3069\u306e\u767a\u898b\u306b\u3064\u306a\u304c\u3063\u305f\u3002CRISPR\/Cas9\u306f\u3001\u907a\u4f1d\u5b50\u914d\u5217\u3092\u6b63\u78ba\u306a\u4f4d\u7f6e\u306b\u3001\u3088\u308a\u77ed\u6642\u9593\u3067\u7de8\u96c6\u3059\u308b\u3053\u3068\u3092\u53ef\u80fd\u306b\u3057\u305f\u3002\u5f7c\u3089\u306e\u767a\u898b\u306b\u3088\u308a\u3001\u751f\u547d\u79d1\u5b66\u306b\u5bfe\u3059\u308b\u898b\u65b9\u304c\u4e00\u5909\u3057\u307e\u3057\u305f\u3002\u305d\u308c\u306f\u3001\u751f\u304d\u3066\u3044\u308b\u4eba\u3005\u306b\u6069\u6075\u3092\u3082\u305f\u3089\u3059\u3001\u907a\u4f1d\u5b66\u306e\u65b0\u3057\u3044\u6642\u4ee3\u3078\u306e\u8db3\u304c\u304b\u308a\u3068\u306a\u308b\u3082\u306e\u3067\u3059\u3002\u00a0<\/span><\/p>\n

\"\"<\/a><\/p>\n

CRISPR\/Cas9\u3068\u306f\u4f55\u304b\u3001\u3069\u306e\u3088\u3046\u306b\u767a\u898b\u3055\u308c\u305f\u306e\u304b\uff1f<\/span><\/h2>\n

CISPR\/CAS9\u306f\u3001DNA\u914d\u5217\u3092\u76ee\u7684\u306e\u4f4d\u7f6e\u3067\u6b63\u78ba\u306b\u5207\u65ad\u3059\u308b\u305f\u3081\u306b\u7528\u3044\u3089\u308c\u308b\u907a\u4f1d\u5b50\u7de8\u96c6\u30c4\u30fc\u30eb\u3067\u3042\u308b\u3002CRISPR\u306fClustered Regularly Interspaced Short Palindromic Repeats\u306e\u7565\u3067\u3001Cas9\u306f\u914d\u5217\u306e\u5207\u65ad\u3092\u652f\u63f4\u3059\u308b\u9175\u7d20\u3067\u3042\u308b\u3002CRISPR\u306b\u306f\u3001\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u30ea\u30d4\u30fc\u30bf\u30fc\u3068\u30b9\u30da\u30fc\u30b5\u30fc\u3068\u3044\u30462\u3064\u306e\u4e3b\u8981\u306a\u7279\u5fb4\u304c\u3042\u308b\u3002\u901a\u5e38\u3001CRISPR\u3067\u306f\u3001\u30cc\u30af\u30ec\u30aa\u30c1\u30c9\u914d\u5217\u304c\u92f3\u578b\u9396\u306e\u3088\u3046\u306b\u4f5c\u7528\u3057\u3066\u3001\u76f8\u88dc\u7684\u306aRNA\u3092\u8ee2\u5199\u3057\u3001\u6700\u7d42\u7684\u306bCRISPR RNA\uff08cr RNA\uff09\u3068\u547c\u3070\u308c\u308b\u3002Emmanuelle Charpentier\u3068Jennifer Doudna\u306f\u3001\u3053\u306e\u30b9\u30da\u30fc\u30b5\u30fc\u3068\u30ea\u30d4\u30fc\u30bf\u30fc\u306b\u3064\u3044\u3066\u6700\u521d\u306b\u767a\u898b\u3057\u305f\u4eba\u7269\u3067\u3042\u308b\u3002\u3055\u3089\u306b\u5f7c\u3089\u306f\u3001DNA\u914d\u5217\u306e\u5207\u65ad\u3092\u52a9\u3051\u308bCas9\u9175\u7d20\u304c\u3001\u5225\u306eRNA\u5206\u5b50\u306b\u7d50\u5408\u3057\u3066\u3044\u308b\u3053\u3068\u3082\u7a81\u304d\u6b62\u3081\u305f\u3002cr RNA\u3068trans activating cr RNA\u3068\u3044\u30462\u3064\u306e\u5206\u5b50\u304c\u3001Cas9\u304c\u4e8c\u672c\u9396DNA\u306e\u6a19\u7684\u90e8\u4f4d\u3092\u5207\u65ad\u3059\u308b\u306e\u3092\u52a9\u3051\u308b\u306e\u3067\u3042\u308b\u3002<\/span><\/p>\n

\u3053\u306e\u767a\u898b\u306f\u3001\u30a8\u30de\u30cb\u30e5\u30a8\u30eb\u30fb\u30b7\u30e3\u30eb\u30d1\u30f3\u30c6\u30a3\u30a8\u304c\u3001\u9023\u9396\u7403\u83cc\u306e\u30a6\u30a4\u30eb\u30b9\u306b\u5bfe\u3059\u308b\u514d\u75ab\u6a5f\u69cb\u3092\u89b3\u5bdf\u3057\u3066\u3044\u305f\u3068\u304d\u306b\u306a\u3055\u308c\u305f\u3082\u306e\u3067\u3042\u308b\u3002\u5f7c\u5973\u304c\u6700\u3082\u8208\u5473\u3092\u305d\u305d\u3089\u308c\u305f\u306e\u306f\u3001\u30d0\u30af\u30c6\u30ea\u30a2\u306e\u4e2d\u306b\u3042\u308bRNA\u5206\u5b50\u304c\u3001\u30d0\u30af\u30c6\u30ea\u30a2\u306eCRISPR\u3068\u975e\u5e38\u306b\u3088\u304f\u4f3c\u305f\u907a\u4f1d\u6697\u53f7\u3092\u6301\u3063\u3066\u3044\u308b\u3068\u3044\u3046\u4e8b\u5b9f\u3060\u3063\u305f\u3002 2\u3064\u306e\u914d\u5217\u3092\u89e3\u6790\u3057\u305f\u7d50\u679c\u3001RNA\u5206\u5b50\u304cCRISPR\u306e\u7e70\u308a\u8fd4\u3057\u90e8\u5206\u306b\u4e00\u81f4\u3059\u308b\u3053\u3068\u304c\u308f\u304b\u3063\u305f\u306e\u3067\u3059\u3002\u3055\u3089\u306b\u7814\u7a76\u3092\u9032\u3081\u308b\u3068\u3001\u3053\u306e\u4f4e\u5206\u5b50RNA\u304cCas9\u306e\u5b58\u5728\u4e0b\u3067RNA\u914d\u5217\u3092\u6d3b\u6027\u5316\u3059\u308b\u3053\u3068\u3092\u767a\u898b\u3057\u305f\u3002\u3053\u306eRNA\u914d\u5217\u306f\u3001CRISPR\u306e\u914d\u5217\u306e\u7d50\u679c\u3067\u3042\u3063\u305f\u3002 \u3053\u306e\u5206\u5b50\u306f\u3001\u30c8\u30e9\u30f3\u30b9\u6d3b\u6027\u5316CRISPR RNA\u3068\u547c\u3070\u308c\u308b\u3002\u7d30\u83cc\u304c\u30a6\u30a4\u30eb\u30b9\u306b\u611f\u67d3\u3059\u308b\u3068\u3001\u7d30\u83cc\u306fCRISPR\u9818\u57df\u306e\u30b2\u30ce\u30e0\u306b\u30a6\u30a4\u30eb\u30b9\u306eDNA\u3092\u8a18\u61b6\u3055\u305b\u308b\u3002\u3053\u308c\u306b\u3088\u308a\u3001\u7d30\u83cc\u306f\u65b0\u305f\u306a\u611f\u67d3\u304b\u3089\u514d\u308c\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u3002\u3053\u306eCRISPR DNA\u306f\u30b3\u30d4\u30fc\u3055\u308c\u3001CRISPR RNA\u3068\u306a\u308a\u3001\u5916\u6765\u30a6\u30a4\u30eb\u30b9DNA\u3092\u8a8d\u8b58\u3059\u308b\u306e\u306b\u5f79\u7acb\u3064\u30a6\u30a4\u30eb\u30b9DNA\u306b\u5207\u65ad\u3055\u308c\u308b\u3053\u3068\u306b\u306a\u3063\u3066\u3044\u308b\u3002\u00a0<\/span><\/p>\n

\"\"<\/a><\/p>\n

\u305d\u306e\u5f8c\u3001\u30b8\u30a7\u30cb\u30d5\u30a1\u30fc\u30fb\u30c0\u30a6\u30c9\u30ca\u306f\u3001CRISPR RNA\u3068Cas9\u9175\u7d20\u5206\u5b50\u3092\u7528\u3044\u3066\u3001\u3053\u306e\u30a6\u30a4\u30eb\u30b9DNA\u3092\u7279\u5b9a\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u89e3\u6790\u3057\u305f\u3002\u4f55\u5ea6\u304b\u306e\u5b9f\u9a13\u306e\u5f8c\u3001\u5f7c\u3089\u306f\u307e\u3060\u305d\u308c\u3092\u7279\u5b9a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u305a\u3001\u4f55\u304b\u304c\u6b20\u3051\u3066\u3044\u308b\u3053\u3068\u306b\u6c17\u304c\u3064\u3044\u305f\u3002\u305d\u3053\u3067\u3001\u6b21\u306b\u5b9f\u9a13\u3092\u884c\u3046\u3068\u304d\u306b\u306f\u3001\u30a8\u30de\u30cb\u30e5\u30a8\u30eb\u304c\u767a\u898b\u3057\u305f\u30c8\u30e9\u30f3\u30b9\u6d3b\u6027\u5316Cr RNA\u5206\u5b50\u3082\u52a0\u3048\u3066\u307f\u305f\u3002\u3059\u308b\u3068\u3001\u306a\u3093\u3068\u30a6\u30a4\u30eb\u30b9\u306eDNA\u304c\u7279\u5b9a\u3055\u308c\u3001\u65b0\u305f\u306a\u30a4\u30aa\u30f3\u306e\u5230\u6765\u3092\u4e88\u611f\u3055\u305b\u305f\u3002\u00a0<\/span><\/p>\n

\u4eca\u65e5\u3001CRISPR\/Cas9\u306f\u3001\u751f\u6d3b\u3078\u306e\u65b0\u3057\u3044\u30a2\u30d7\u30ed\u30fc\u30c1\u306e\u5e55\u3092\u958b\u3051\u307e\u3057\u305f\u3002\u79d1\u5b66\u306e\u69d8\u3005\u306a\u5206\u91ce\u3067\u5229\u7528\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u30c4\u30fc\u30eb\u306f\u3001\u533b\u5b66\u306e\u5206\u91ce\u3067\u3082\u9032\u5316\u3092\u9042\u3052\u3066\u3044\u307e\u3059\u3002\u4eca\u65e5\u3001\u7814\u7a76\u8005\u306f\u3001\u4eba\u985e\u306b\u6700\u3082\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u907a\u4f1d\u6027\u75be\u60a3\u306e\u7d42\u7d50\u306b\u5411\u3051\u3066\u53d6\u308a\u7d44\u3093\u3067\u3044\u308b\u3002 \u3053\u306e\u30c4\u30fc\u30eb\u304c\u6d3b\u7528\u3055\u308c\u3066\u3044\u308b\u4ed6\u306e\u5206\u91ce\u306f\u3001\u8fb2\u696d\u3067\u3001\u690d\u7269\u3092\u611f\u67d3\u62b5\u6297\u6027\u306b\u5909\u66f4\u3057\u305f\u308a\u3001\u85ac\u5264\u958b\u767a\u3084\u907a\u4f1d\u5b50\u6cbb\u7642\u306a\u3069\u3001\u4ed6\u306b\u3082\u305f\u304f\u3055\u3093\u3042\u308a\u307e\u3059\u3002\u3053\u306e\u30c4\u30fc\u30eb\u3092\u898f\u5236\u7684\u3001\u502b\u7406\u7684\u306b\u4f7f\u7528\u3059\u308b\u3053\u3068\u3067\u3001\u4eba\u985e\u306f\u7121\u9650\u306e\u4e16\u754c\u3092\u7d4c\u9a13\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u306e\u3067\u3059\u3002\u00a0<\/span><\/p>\n

\u53c2\u8003\u00a0<\/span><\/p>\n

https:\/\/www.nobelprize.org\/prizes\/chemistry\/2020\/popular-information\/<\/span><\/a><\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11824,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nThe CRISPR DUO Steals The Show: Nobel Prize 2020 in Chemistry - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"In 2020, many discoveries are accoladed with Nobel Prize and CRISPR DUO in Chemistry is one of them. 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