{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/it\/caso-di-successo-la-microtomografia-a-raggi-x-ad-alta-risoluzione-basata-sul-sincrotrone-come-strumento-per-svelare-larchitettura-neuronale-tridimensionale-del-cervello\/","title":{"rendered":"La microtomografia a raggi X ad alta risoluzione basata sul sincrotrone come strumento per svelare l'architettura neuronale tridimensionale del cervello Rassegna cartacea"},"content":{"rendered":"

La microtomografia a raggi X \u00e8 emersa come un nuovo metodo per decifrare la citoarchitettura e la connettivit\u00e0 del cervello e qui presentiamo un metodo per l'imaging di interi neuroni.<\/p>\n\n\n\n

La microtomografia a raggi X ad alta risoluzione basata sul sincrotrone come strumento per svelare l'architettura neuronale tridimensionale del cervello<\/strong><\/h2>\n\n\n\n

In \"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain\", Matheus de Castro Fonseca et al. (2018) hanno osservato che lo studio dei neuroni come unit\u00e0 individualizzate ha avuto inizio nel XIX secolo con la creazione della dottrina del neurone. <\/p>\n\n\n\n

Negli ultimi anni sono stati compiuti grandi sforzi per comprendere l'organizzazione e la connettivit\u00e0 neuronale in campioni di cervello intatto. La tecnica di etichettatura Golgi-Cox offre un contrasto adeguato per l'etichettatura specifica dei neuroni per la microtomografia a raggi X. <\/p>\n\n\n\n

I neuroni hanno una morfologia distinta e specifici schemi di connettivit\u00e0, essenziali per il loro corretto funzionamento. I ricercatori presentano un metodo di imaging che combina la microtomografia a raggi X di sincrotrone con il protocollo di impregnazione Golgi-Cox. <\/p>\n\n\n\n

Il metodo offre un contrasto pi\u00f9 elevato e pi\u00f9 omogeneo dei neuroni interi relativamente poco distribuiti all'interno del tessuto.<\/p>\n\n\n\n

I cervelli sono stati incubati nella soluzione di colorazione Golgi-Cox per 14 giorni, al riparo dalla luce. Dopo il periodo di incubazione, i cervelli sono stati sezionati in serie con un vibratomo.<\/strong><\/p>\n\n\n\n

Controllare il articolo originale qui<\/a>.<\/p>\n\n\n\n

Astratto grafico alimentato da Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Realizzato con Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

L'autore ha utilizzato Mind the Graph<\/a> per creare un'illustrazione schematica che rappresenti un topo adulto a cui viene iniettata i.p. una soluzione salina o di pilocarpina (280 mg\/kg). Rappresentare processi complessi con le infografiche \u00e8 un buon modo per renderli facilmente comprensibili, senza tralasciare i dettagli e le informazioni cruciali.<\/p>\n\n\n\n

Alcuni dei risultati ottenuti dai ricercatori sembrano consolidare ci\u00f2 che si sapeva in precedenza su quest'area: \"L'impregnazione dei neuroni a base di mercurio qui mostrata ci ha permesso di definire chiaramente i neuroni interi, soprattutto grazie a un'impregnazione pi\u00f9 continua e omogenea delle cellule e a una densit\u00e0 molto ridotta di artefatti\", ha suggerito de Castro Fonseca.<\/p>\n\n\n\n

Impatto e prestazioni dei documenti<\/strong><\/h2>\n\n\n\n

Possiamo analizzare con Altmetric<\/a> che il punteggio di attenzione online di questo documento \u00e8 pi\u00f9 alto di 64%<\/strong><\/strong> di tutti gli altri articoli di et\u00e0 simile presenti in Scientific Reports.<\/strong><\/p>\n\n\n\n

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Fonte Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Migliorate l'accessibilit\u00e0 del vostro articolo anche con la potenza delle infografiche.<\/p>\n\n\n\n

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Prova Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Esaminate il nuovo metodo per decifrare la citoarchitettura e la connettivit\u00e0 del cervello rappresentato con le illustrazioni di Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/it\/caso-di-successo-la-microtomografia-a-raggi-x-ad-alta-risoluzione-basata-sul-sincrotrone-come-strumento-per-svelare-larchitettura-neuronale-tridimensionale-del-cervello\/\" \/>\n<meta property=\"og:locale\" content=\"it_IT\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/it\/caso-di-successo-la-microtomografia-a-raggi-x-ad-alta-risoluzione-basata-sul-sincrotrone-come-strumento-per-svelare-larchitettura-neuronale-tridimensionale-del-cervello\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-08T21:14:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Scritto da\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tempo di lettura stimato\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minuti\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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