{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/it\/coronavirus-covid-19-e-idrossiclorochina-la-nuova-speranza-apparentemente-si\/","title":{"rendered":"Coronavirus (Covid-19): l'idrossiclorochina \u00e8 la nuova speranza? A quanto pare, s\u00ec."},"content":{"rendered":"

Due recenti articoli che riassumono una ricerca in vitro e uno studio clinico su piccola scala sono bastati a Donald Trump per far s\u00ec che la FDA applicasse una nuova indicazione clinica per l'idrossiclorochina: migliorare i sintomi dei pazienti affetti da Coronavirus (Covid-19).<\/p>\n

Si tratta probabilmente del pi\u00f9 rapido processo di approvazione di un farmaco nella storia moderna, e a quanto pare il Presidente ha ragione. Sorprendente per un leader globale che non ha molto affetto per la scienza.<\/p>\n

\"\"<\/p>\n

La prima prova dell'azione dell'idrossiclorochina sul virus \u00e8 stata fornita da questo articolo pubblicato ieri su Cell Discovery<\/a>\u00c8 solo in vitro, con tutti i limiti del caso, ma mostra chiaramente il potenziale del farmaco nell'uccidere il virus. Al momento della presentazione del documento, in Cina erano stati confermati 80.000 casi, tra cui 2946 decessi, e oltre 10.566 casi confermati in altri 72 Paesi. All'epoca, le maggiori speranze erano riposte in un farmaco chiamato remdesivir.<\/p>\n

\"effetti
Effetti in vitro dell'idroclorochina sul coronavirus (Covid-19). La colonna a destra mostra gli effetti del farmaco efficace, rispetto alla clorochina o al gruppo di controllo a sinistra. Si vede che il farmaco ha migliorato la capacit\u00e0 delle cellule di espellere i virus... \u00e8 come aiutare a cacciare un vicino indesiderato dalla propria casa. Aiuta! \ud83d\ude42 <\/figcaption><\/figure>\n

Ma la notizia pi\u00f9 importante \u00e8 arrivata da uno studio clinico su piccola scala pubblicato il giorno prima. Il titolo \u00e8 Idrossiclorochina e azitromicina come trattamento della COVID-19: risultati di uno studio clinico non randomizzato in aperto e scaricabile nella versione \"in press\".<\/a><\/p>\n

In uno studio condotto su soli 20 pazienti, gli autori hanno dimostrato che l'idrossiclorochina era efficace contro l'infezione da coronavirus Covid-19. Infatti, ha ridotto 75% di individui infetti nel periodo di 6 giorni, il che \u00e8 impressionante. Ancora meglio, la combinazione con l'azitromicina ha migliorato l'efficacia del trattamento fino a 95%.<\/p>\n

\"La
La terapia combinata con idroclorochina e azitromicina \u00e8 efficace contro le infezioni da coronavirus (Covid-19) nei pazienti umani. Il calo \u00e8 drammatico e porta una nuova speranza ai pazienti colpiti.<\/figcaption><\/figure>\n

Il trattamento ha migliorato i sintomi e ridotto la carica virale dei pazienti. Il farmaco \u00e8 stato precedentemente approvato per la malaria, il che significa che \u00e8 considerato sicuro. Il farmaco \"gemello\", la clorochina, \u00e8 stato meno efficace. Un bene per noi, perch\u00e9 \u00e8 algo pi\u00f9 tossico.<\/p>\n

Lo studio non era randomizzato e su piccola scala, tuttavia sembra che, sebbene l'epidemia sia iniziata in Cina, la soluzione provenga da uno sforzo comunitario globale. Il documento in vitro \u00e8 in realt\u00e0 cinese, mentre quello clinico \u00e8 europeo, pi\u00f9 precisamente francese. \u00c8 interessante notare che la registrazione originale del farmaco idrossiclorochina \u00e8 dell'azienda farmaceutica francese Sanofi, mentre il recente studio clinico \u00e8 stato condotto a Marsiglia. Ale le bleu!<\/p>\n

Medscape contiene un eccellente articolo al riguardo, per chi fosse interessato a informazioni pi\u00f9 dettagliate.<\/a><\/p>\n

Si prega di citare questo lavoro come Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents - In Press 17 March 2020 - DOI : 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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