{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/id\/autophagy-memenangkan-hadiah-nobel-kedokteran\/","title":{"rendered":"Autophagy memenangkan Hadiah Nobel di bidang kedokteran"},"content":{"rendered":"

Proses autophagy terlibat dalam beberapa kondisi seperti kanker dan penyakit neurologis. Proses ini berfungsi sebagai program daur ulang internal tubuh. Namun, autophagy yang tidak berfungsi telah dikaitkan dengan penyakit Parkinson, diabetes, kanker dan gangguan yang berkaitan dengan usia.<\/p>\n

Setelah sedikit pengantar tentang pentingnya proses autophagy, tidak mengherankan jika penemuan baru dalam bidang ini dapat menghasilkan Hadiah Nobel. Memang, Senin lalu, peneliti Yoshino Ohsumi memenangkan penghargaan Penghargaan Nobel di bidang kedokteran<\/a> untuk mengidentifikasi gen esensial pertama untuk autofagi.<\/p>\n

\"Saya tidak merasa nyaman berkompetisi dengan banyak orang, dan sebaliknya, saya merasa lebih menyenangkan melakukan sesuatu yang tidak dilakukan orang lain. Di satu sisi, itulah inti dari ilmu pengetahuan, dan kegembiraan dalam menemukan sesuatu yang menginspirasi saya.\" Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Bagaimana Ohsumi melakukannya?<\/h3>\n

Di laboratoriumnya, Ohsumi telah merekayasa strain ragi yang mengakumulasi autofagosom selama kelaparan. Akumulasi ini hanya dapat terjadi jika gen-gen penting untuk autofagi tidak aktif. Oleh karena itu, Ohsumi mulai memanipulasi sel ke beberapa mutasi gen dan berhasil menginduksi autofagi.<\/p>\n

\"Autophagy<\/a><\/p>\n

Autophagy telah ada sejak dulu<\/h3>\n

Meskipun autophagy telah dikenal selama 50 tahun terakhir, namun baru pada tahun 1990-an melalui penelitian Ohsumi, proses ini baru diakui pentingnya.
\nAtas karyanya, Ohsumi sudah mendapatkan sejumlah penggemar:<\/p>\n

\"Autophagy<\/a><\/p>\n

\n

\"Saya sangat senang dia mendapatkan hadiah Nobel tahun ini, ini sangat pantas. Laboratoriumnya terutama bekerja di bidang ragi. Mereka melakukan penyaringan awal yang memungkinkan penemuan gen-gen kunci yang terlibat dalam autofagi. Begitu banyak laboratorium lain yang memanfaatkan penemuannya, secara langsung atau tidak langsung, untuk mengetahui mengapa hal ini penting dalam penyakit.\"<\/p>\n

David Rubinsztein<\/a> - wakil direktur Cambridge Institute for Medical Research<\/p>\n<\/blockquote>\n

\"Autophagy<\/a><\/p>\n

\n

\"Saya pikir sangat penting bahwa bidang ilmu pengetahuan ini diakui. Prinsip penting di sini adalah mencari mekanisme umum dalam penyakit. Hal ini membuka jalan untuk mengobati gangguan-gangguan ini yang berbeda dengan pendekatan yang lebih konvensional yang spesifik untuk penyakit tertentu.\"<\/p>\n

Giovanna Mallucci<\/a> - profesor ilmu saraf klinis di Universitas Cambridge<\/p>\n<\/blockquote>\n

\"Autophagy<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Proses autophagy terlibat dalam beberapa kondisi seperti kanker dan penyakit neurologis. Proses ini berfungsi sebagai program daur ulang internal tubuh. Namun, autophagy yang tidak berfungsi telah dikaitkan dengan penyakit Parkinson, diabetes, kanker dan gangguan yang berkaitan dengan usia. Setelah sedikit pengantar tentang pentingnya proses autophagy, tidak mengherankan jika penemuan-penemuan baru [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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