{"id":16636,"date":"2022-09-10T18:27:00","date_gmt":"2022-09-10T21:27:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16636"},"modified":"2023-03-17T14:47:45","modified_gmt":"2023-03-17T17:47:45","slug":"success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/id\/kasus-kesuksesan-fgf-memberikan-sinyal-pada-pembaharuan-diri-kanker-usus-besar-organoid\/","title":{"rendered":"Sinyal FGF dalam Pembaharuan Diri Organoid Kanker Usus Besar Ulasan Makalah"},"content":{"rendered":"

Pembentukan spheroid dan organoid yang dinonaktifkan oleh penghambatan FGFR pada sel CRC yang berasal dari pasien jauh lebih mudah dipahami dengan menggunakan ilustrasi Mind the Graph. <\/p>\n\n\n\n

Skema yang dibuat oleh penulis menunjukkan bahwa biopsi bedah dicerna secara enzimatik untuk mendapatkan suspensi sel tunggal. Sel naif yang tidak disortir dikultur dalam FGF2 yang mengandung media CSC atau dengan penghambat FGFR SU-5402.<\/p>\n\n\n\n

Peran faktor pertumbuhan fibroblast 2 (FGF2) dalam pembaruan diri sel punca kanker kolorektal telah diselidiki<\/strong><\/h2>\n\n\n\n

Dalam 'FGF Signalling in the Self-Renewal of Colon Cancer Organoids', J\u00f6rg Otte dan koleganya (2019) melaporkan bahwa ketika sel tunggal yang naif tertanam dalam Matrigel dan dikultur dalam media CSC, organisasi mandiri yang lebih kompleks diamati pada semua pasien yang dianalisis. <\/p>\n\n\n\n

Gen yang secara langsung terkait dengan EMT bersama dengan fenotipe mesenkim dan fenotipe yang memperbaharui diri (TGFB3, ID1, ID2 dan ID4) ditemukan diekspresikan secara berlebihan dalam organoid. <\/p>\n\n\n\n

Sementara penghambatan FGFR menyebabkan peningkatan sinyal MAPK, mereka mengamati diferensiasi yang diinduksi, hilangnya sebagian besar penanda sel punca dan fenotipe epitel. <\/p>\n\n\n\n

Sel punca kanker adalah subpopulasi sel ganas yang mampu memperbaharui diri dan berfungsi sebagai sumber berkelanjutan untuk sel tumor yang terdiferensiasi. Dalam beberapa protokol kultur CSC, faktor pertumbuhan Fibroblast 2 merupakan bahan penting untuk mempertahankan stemness. <\/p>\n\n\n\n

Di sisi lain, dalam organoid yang dikultur dalam media CSC, mereka mendeteksi induksi TGF-\u03b2 dan keempat anggota keluarga gen penghambat diferensiasi.<\/p>\n\n\n\n

Sembilan pasien CRC yang tidak terpilih secara berurutan dilibatkan dalam penelitian ini.<\/strong><\/p>\n\n\n\n

Periksa bagian artikel asli di sini<\/a>.<\/p>\n\n\n\n

Abstrak Grafis yang didukung oleh Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
\n
\"\"<\/a>
Dibuat dengan Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Beberapa kesimpulan mereka berpotensi memperkuat apa yang telah diketahui sebelumnya tentang bidang ini: \"Gen yang terkait dengan pluripotensi, NANOG, LIN28 dan SALL1 diekspresikan secara eksklusif oleh hESC. Istilah GO \"regulasi negatif dari jalur pensinyalan BMP\" dan \"transduksi sinyal protein SMAD\" terdeteksi dalam kultur hESC kami,\" Otte menyarankan.<\/p>\n\n\n\n

Para penulis mengakui bahwa \"analisis istilah GO dari set gen ini hanya menghasilkan beberapa hasil yang signifikan karena rendahnya jumlah gen yang diatur secara umum. Sebagian besar istilah GO untuk kondisi CSC-sedang ini dikaitkan dengan transkripsi aktif, proliferasi sel, atau peningkatan penyerapan glukosa. <\/p>\n\n\n\n

Setelah penghambatan FGFR, kami menemukan regulator siklus sel serta banyak gen yang dianotasi dengan \"diferensiasi sel epitel\", \"pencernaan\" atau \"transportasi asam empedu dan garam empedu\".\"<\/p>\n\n\n\n

Dampak dan Kinerja Makalah<\/strong><\/h2>\n\n\n\n

Kita dapat menganalisis dengan Altmetric<\/a> data bahwa skor perhatian online makalah ini lebih tinggi daripada 68%<\/strong><\/strong> dari semua artikel lain yang memiliki usia yang sama di Scientific Reports.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
Sumber Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Tingkatkan aksesibilitas artikel Anda dengan kekuatan infografis.<\/p>\n\n\n\n

\n
Coba Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Pembentukan sferoid dan organoid yang dinonaktifkan oleh penghambatan FGFR pada sel CRC yang berasal dari pasien lebih mudah dipahami dengan ilustrasi kami.<\/p>","protected":false},"author":29,"featured_media":20014,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,1],"tags":[96,554,775,963],"yoast_head":"\nFGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/id\/kasus-kesuksesan-fgf-memberikan-sinyal-pada-pembaharuan-diri-kanker-usus-besar-organoid\/\" \/>\n<meta property=\"og:locale\" content=\"id_ID\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/id\/kasus-kesuksesan-fgf-memberikan-sinyal-pada-pembaharuan-diri-kanker-usus-besar-organoid\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-10T21:27:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog","description":"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/id\/kasus-kesuksesan-fgf-memberikan-sinyal-pada-pembaharuan-diri-kanker-usus-besar-organoid\/","og_locale":"id_ID","og_type":"article","og_title":"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog","og_description":"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.","og_url":"https:\/\/mindthegraph.com\/blog\/id\/kasus-kesuksesan-fgf-memberikan-sinyal-pada-pembaharuan-diri-kanker-usus-besar-organoid\/","og_site_name":"Mind the Graph Blog","article_published_time":"2022-09-10T21:27:00+00:00","article_modified_time":"2023-03-17T17:47:45+00:00","og_image":[{"width":1125,"height":614,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg","type":"image\/jpeg"}],"author":"Artur Zignani","twitter_card":"summary_large_image","twitter_image":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg","twitter_misc":{"Written by":"Artur Zignani","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/","url":"https:\/\/mindthegraph.com\/blog\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/","name":"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2022-09-10T21:27:00+00:00","dateModified":"2023-03-17T17:47:45+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02"},"description":"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/#breadcrumb"},"inLanguage":"id-ID","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"id-ID"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02","name":"Artur Zignani","image":{"@type":"ImageObject","inLanguage":"id-ID","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","caption":"Artur Zignani"},"url":"https:\/\/mindthegraph.com\/blog\/id\/author\/artur\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/id\/wp-json\/wp\/v2\/posts\/16636"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/id\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/id\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/id\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/id\/wp-json\/wp\/v2\/comments?post=16636"}],"version-history":[{"count":5,"href":"https:\/\/mindthegraph.com\/blog\/id\/wp-json\/wp\/v2\/posts\/16636\/revisions"}],"predecessor-version":[{"id":27203,"href":"https:\/\/mindthegraph.com\/blog\/id\/wp-json\/wp\/v2\/posts\/16636\/revisions\/27203"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/id\/wp-json\/wp\/v2\/media\/20014"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/id\/wp-json\/wp\/v2\/media?parent=16636"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/id\/wp-json\/wp\/v2\/categories?post=16636"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/id\/wp-json\/wp\/v2\/tags?post=16636"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}