{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/id\/kasus-keberhasilan-virus-zika-mereplikasi-dalam-jaringan-otak-manusia-dewasa-dan-merusak-sinapsis-dan-memori-pada-tikus\/","title":{"rendered":"Virus Zika bereplikasi dalam jaringan otak manusia dewasa dan merusak sinapsis dan memori pada tikus"},"content":{"rendered":"

ZIKV adalah virus berbahaya yang merusak dunia. Oleh karena itu, dalam kasus ini, penulis mempelajari replikasi virus ini di otak manusia dewasa.<\/p>\n\n\n\n

Virus Zika (ZIKV) menginfeksi jaringan otak orang dewasa dan menyebabkan gangguan memori pada tikus<\/strong><\/h2>\n\n\n\n

Sebuah kelompok dari Fakultas Farmasi yang dipimpin oleh Claudia Figueiredo (2019) mempelajari bagaimana virus zika bereplikasi dalam jaringan otak manusia dewasa dan merusak sinapsis dan memori pada tikus. Virus zika adalah arbovirus yang termasuk dalam keluarga Flaviviridae yang bertanggung jawab atas wabah besar baru-baru ini di Amerika Latin. <\/p>\n\n\n\n

ZIKV telah ditemukan di otak dan CSF pasien dewasa. Imunoreaktivitas NS2B berkolokalisasi dengan sel imunoreaktif NeuN, tetapi tidak dengan GFAP atau F4\/80, yang menunjukkan bahwa neuron menjadi target ZikV dalam jaringan manusia dewasa. Pada tikus dewasa yang memiliki imunokompeten yang terinfeksi oleh infus intracerebroventricular ZIKV, tingkat tinggi ZikV RNA terdeteksi di korteks frontal dan hipokampus, dan neuron dewasa adalah jenis sel utama yang terinfeksi. <\/p>\n\n\n\n

Peningkatan kadar TNF-\u03b1 di otak, mikrogliosis yang intens, ekspresi protein sistem komplemen yang diregulasi (C1q dan C3), dan kerusakan sinapsis hipokampus telah diverifikasi.<\/p>\n\n\n\n

Penelitian ini melibatkan 9 kuadran yang sama.<\/strong><\/p>\n\n\n\n

Periksa bagian artikel asli di sini<\/a>.<\/p>\n\n\n\n

Abstrak Grafis yang didukung oleh Mind the Graph<\/strong><\/h2>\n\n\n\n
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Dibuat dengan Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Gambar pertama mewakili kasus di mana fragmen jaringan kortikal lobus temporal manusia dipotong menjadi irisan 400 \u00b5m dan dipertahankan dalam kultur selama 4 hari sebelum diinkubasi dengan ZIKV (107 PFU) atau media tiruan selama 1 jam, diikuti dengan pencucian. <\/p>\n\n\n\n

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Dibuat dengan Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Yang kedua menunjukkan bahwa tikus dewasa menerima infus 105 PFU ZIKV, ZIKV yang dinonaktifkan dengan UV atau media tiruan ke dalam ventrikel lateral otak.<\/p>\n\n\n\n

Kesimpulan tersebut tampaknya mendukung apa yang telah diketahui sebelumnya tentang subjek ini: \"ZIKV menargetkan daerah otak yang berhubungan dengan memori terlepas dari apakah rute infeksinya melalui pusat atau perifer. Virus ini telah terdeteksi pada CSF pasien dewasa dengan komplikasi neurologis,\" klaim Figueiredo.<\/p>\n\n\n\n

Mereka mengusulkan agar penelitian di masa depan yang bertujuan untuk memeriksa dampak neurodegeneratif jangka panjang dari infeksi ZIKV diperlukan. Mengidentifikasi cara-cara untuk mencegah kelainan sinyal yang mengarah ke disfungsi otak dapat membuka jalan menuju strategi intervensi untuk menunda atau mencegah perkembangan kondisi neurologis utama.<\/p>\n\n\n\n

Dampak dan Kinerja Makalah<\/strong><\/h2>\n\n\n\n

Kita dapat menganalisis dengan Altmetric<\/a> data bahwa skor perhatian online makalah ini lebih tinggi daripada 95%<\/strong><\/strong> dari semua artikel lain yang berusia sama di Nature<\/strong> Jurnal.<\/strong><\/p>\n\n\n\n

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Sumber Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Gunakan kekuatan infografis untuk meningkatkan artikel Anda juga! Mulai kreasi di Mind the Graph.<\/p>\n\n\n\n

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Coba Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Penelitian ini adalah tentang ZIKV dalam otak manusia dewasa, virus berbahaya yang merusak dunia. Prosesnya menggunakan ilustrasi Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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