{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/id\/virus-korona-covid-19-adalah-hidroksi-klorokuin-harapan-baru-tampaknya-ya\/","title":{"rendered":"Virus corona (Covid-19): apakah hidroksiklorokuin merupakan harapan baru? Tampaknya, ya."},"content":{"rendered":"

Dua makalah terbaru yang merangkum satu penelitian in vitro dan studi klinis skala kecil sudah cukup bagi Donald Trump untuk membuat FDA memberlakukan indikasi klinis obat baru untuk hidroksiklorokuin: memperbaiki gejala pasien yang terkena dampak virus Corona (Covid-19).<\/p>\n

Ini mungkin merupakan jalur tercepat dalam proses persetujuan obat dalam sejarah modern, dan sang presiden rupanya benar. Mengejutkan bagi seorang pemimpin global yang tidak terlalu menyukai sains.<\/p>\n

\"\"<\/p>\n

Bukti pertama tentang hidroksiklorokuin pada virus berasal dari makalah ini diterbitkan kemarin di Cell Discovery<\/a>Penelitian ini hanya dilakukan secara in vitro, dengan segala keterbatasannya, namun jelas menunjukkan potensi obat tersebut untuk membunuh virus. Ketika mereka mengajukan makalah tersebut, 80.000 kasus telah dikonfirmasi di Cina, termasuk 2946 kematian serta lebih dari 10.566 kasus yang dikonfirmasi di 72 negara lainnya. Pada saat itu, harapan terbesar ditumpukan pada obat yang disebut remdesivir.<\/p>\n

\"efek
Efek in vitro klorokuin terhadap virus corona (Covid-19). Kolom di sebelah kanan menunjukkan efek obat yang efektif, dibandingkan dengan klorokuin atau kelompok kontrol di sebelah kiri. Ini menunjukkan bahwa obat tersebut meningkatkan kemampuan sel untuk mengusir virus... ini seperti membantu mengusir tetangga yang tidak diinginkan dari rumah Anda. Ini membantu! \ud83d\ude42. <\/figcaption><\/figure>\n

Namun berita terbesar datang dari sebuah studi klinis berskala kecil yang dipublikasikan sehari sebelumnya. Judulnya adalah Hidroksiklorokuin dan azitromisin sebagai pengobatan COVID-19: hasil uji klinis non-acak terbuka dan dapat diunduh dalam versi \"in press\"<\/a><\/p>\n

Dalam sebuah penelitian yang hanya melibatkan 20 pasien, para penulis menunjukkan bahwa hidroksiklorokuin efektif melawan infeksi virus corona Covid-19. Faktanya, obat ini mengurangi 75% orang yang terinfeksi dalam periode 6 hari, yang luar biasa. Bahkan lebih baik dari itu, kombinasi dengan azitromisin meningkatkan kemanjuran pengobatan menjadi 95%.<\/p>\n

\"Terapi
Terapi kombinasi hidroksiklorokuin dan azitromisin efektif terhadap infeksi virus corona (Covid-19) pada pasien manusia. Penurunan ini sangat dramatis dan membawa harapan baru bagi pasien yang terkena dampak.<\/figcaption><\/figure>\n

Pengobatan ini memperbaiki gejala-gejala yang ada, dan juga mengurangi viral load pada pasien. Obat ini sebelumnya telah disetujui untuk malaria, yang berarti obat ini dianggap aman. Obat \"saudaranya\", klorokuin, kurang efektif. Baik untuk kita, karena obat ini lebih beracun.<\/p>\n

Penelitian ini tidak diacak dan berskala kecil, namun, tampaknya meskipun wabah ini dimulai di Tiongkok, solusinya berasal dari upaya komunitas global. Makalah in vitro sebenarnya berasal dari Cina, sedangkan makalah klinis berasal dari Eropa, lebih tepatnya dari Prancis. Menariknya, pendaftaran obat asli untuk hidroksiklorokuin berasal dari perusahaan farmasi Perancis, Sanofi, dan studi klinis baru-baru ini dilakukan di Marseille. Ale le bleu!<\/p>\n

Medscape memiliki artikel yang sangat bagus tentang hal ini, bagi mereka yang tertarik dengan informasi yang lebih rinci.<\/a><\/p>\n

Silakan kutip karya ini sebagai Gautret dkk. (2020) Hidroksiklorokuin dan azitromisin sebagai pengobatan COVID-19: hasil uji klinis non-acak label terbuka. Jurnal Internasional Agen Antimikroba - Dalam Pers 17 Maret 2020 - DOI: 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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