{"id":8728,"date":"2019-04-23T16:35:01","date_gmt":"2019-04-23T19:35:01","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8728"},"modified":"2022-10-18T08:23:59","modified_gmt":"2022-10-18T11:23:59","slug":"visual-abstract-example","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/hu\/visual-abstract-example\/","title":{"rendered":"A felhaszn\u00e1l\u00f3 \u00e1ltal k\u00e9sz\u00edtett vizu\u00e1lis \u00f6sszefoglal\u00f3 a Yelena Sterlin \"Optimized Small-Molecule Pull-Downs Define MLBP1 as an Acyl-Lipid-Binding Protein\" c\u00edm\u0171 tanulm\u00e1ny\u00e1nak magyar\u00e1zat\u00e1ra."},"content":{"rendered":"

A vizu\u00e1lis absztraktot nem k\u00f6nny\u0171 l\u00e9trehozni, de itt van, hogy maradjon. Ez\u00e9rt mindig sz\u00edvesen mutatjuk be felhaszn\u00e1l\u00f3ink csod\u00e1latos munk\u00e1it, mint a vizu\u00e1lis absztrakci\u00f3 inspir\u00e1l\u00f3 p\u00e9ld\u00e1j\u00e1t. Szeretn\u00e9nk k\u00e9pess\u00e9 tenni a tud\u00f3sokat arra, hogy vizu\u00e1lisabb \u00e9s el\u00e9rhet\u0151bb tudom\u00e1nyt tegyenek lehet\u0151v\u00e9.<\/p>\n

A posztban megmutatom az eredeti kutat\u00e1s egy r\u00e9sz\u00e9t. Yelena Sterlin<\/a> \u00e9s munkat\u00e1rsai. A jeruzs\u00e1lemi H\u00e9ber Egyetem Mez\u0151gazdas\u00e1gi, \u00c9lelmiszeripari \u00e9s K\u00f6rnyezetv\u00e9delmi Kar\u00e1nak doktorandusz hallgat\u00f3ja.<\/p>\n

\u00daj tanulm\u00e1nya Optimaliz\u00e1lt kismolekul\u00e1s pull-downok defini\u00e1lj\u00e1k az MLBP1-et, mint acil-lipid-k\u00f6t\u0151 feh\u00e9rj\u00e9t<\/a> <\/strong>a feh\u00e9rje-metabolit k\u00f6lcs\u00f6nhat\u00e1sokra vil\u00e1g\u00edt r\u00e1 a n\u00f6v\u00e9nyekben, k\u00fcl\u00f6n\u00f6s tekintettel az abszcizinsav (ABA) receptorokra. \u0150 is a mind the graph el\u0151fizet\u0151je, \u00edgy k\u00e9sz\u00edtett egy infografik\u00e1t a vigy\u00e1zz a grafikonra<\/a> hogy elmagyar\u00e1zz\u00e1k m\u00f3dszertanukat.<\/p>\n

A START dom\u00e9nnel kapcsolatos feh\u00e9rj\u00e9k jelent\u0151s\u00e9ge<\/strong><\/h2>\n

 <\/p>\n

A Term\u00e9szet magazin<\/a>Az abszcizinsav (ABA) a f\u0151 n\u00f6v\u00e9nyhormon, amely r\u00e9szt vesz az abiotikus stresszre adott v\u00e1laszban \u00e9s az ahhoz val\u00f3 alkalmazkod\u00e1sban. Emellett ez egy mez\u0151gazdas\u00e1gi vegyszerjel\u00f6lt. Az ABA-t el\u0151sz\u00f6r az 1960-as \u00e9vekben fedezt\u00e9k fel. Ezt k\u00f6vet\u0151en az\u00f3ta kider\u00fclt, hogy kulcsfontoss\u00e1g\u00fa szab\u00e1lyoz\u00f3ja az olyan k\u00fcl\u00f6nb\u00f6z\u0151 folyamatoknak, mint a nyugalmi \u00e1llapot, a cs\u00edr\u00e1z\u00e1s, a magok fejl\u0151d\u00e9se, valamint a biotikus \u00e9s abiotikus stresszre adott v\u00e1laszok.<\/p>\n

Az ABA jel\u00e1tviteli \u00fatvonal legkor\u00e1bbi esem\u00e9nyei k\u00f6z\u00e9 tartozik az ABA k\u00f6t\u0151d\u00e9se a PYR\/PYL\/RCARs receptorokhoz. A receptorok a START-dom\u00e9n szupercsal\u00e1dba tartoznak.<\/p>\n

A START feh\u00e9rje dom\u00e9nek lipidk\u00f6t\u0151 dom\u00e9nek, amelyek bakt\u00e9riumok, protist\u00e1k, \u00e9leszt\u0151k, n\u00f6v\u00e9nyek \u00e9s \u00e1llatok genomjaiban vannak jelen. A n\u00f6v\u00e9nyekben azonban gyakrabban fordulnak el\u0151. A Schrick<\/a>, a START-dom\u00e9nek jelenl\u00e9te az evol\u00faci\u00f3san t\u00e1voli fajokn\u00e1l, p\u00e9ld\u00e1ul az \u00e1llatokn\u00e1l \u00e9s a n\u00f6v\u00e9nyekn\u00e9l, a feh\u00e9rj\u00e9k \u00e9s a lipidek\/szterolok k\u00f6lcs\u00f6nhat\u00e1s\u00e1nak konzerv\u00e1lt mechanizmus\u00e1ra utal.<\/p>\n

A tanulm\u00e1ny megjelent a The Plant Journal<\/a> a PYR\/PYL\/RCARs ABA-receptorokra \u00f6sszpontos\u00edt. A kutat\u00f3k \u00fagy d\u00f6nt\u00f6ttek, hogy optimaliz\u00e1lnak egy olyan m\u00f3dszert, amely lehet\u0151v\u00e9 teszi a START dom\u00e9n \u00e9s a START dom\u00e9nnel rokon feh\u00e9rje ligandumok azonos\u00edt\u00e1s\u00e1t n\u00f6v\u00e9nyekben, mert \"a START-dom\u00e9n feh\u00e9rje ligandumok n\u00e9lk\u00fcl\u00f6zhetetlenek feh\u00e9rj\u00e9ik megfelel\u0151 m\u0171k\u00f6d\u00e9s\u00e9hez mind az \u00e1llatokban, mind a n\u00f6v\u00e9nyekben, \u00e9s a n\u00f6v\u00e9nyi START-dom\u00e9n feh\u00e9rj\u00e9kr\u0151l bebizonyosodott, hogy alapvet\u0151 \u00e9lettani folyamatokban j\u00e1tszanak szerepet\".<\/em><\/p>\n

A m\u00f3dszertan vizu\u00e1lis \u00f6sszefoglal\u00f3ja<\/strong><\/h2>\n

 <\/p>\n

M\u00f3dszertanuk magyar\u00e1zat\u00e1hoz a tud\u00f3sok egy infografik\u00e1t k\u00e9sz\u00edtettek a grafikonok illusztr\u00e1ci\u00f3ival. Ez szemet gy\u00f6ny\u00f6rk\u00f6dtet\u0151 \u00e9s k\u00f6nnyebben \u00e9rthet\u0151. <\/strong><\/h4>\n

 <\/p>\n

Az al\u00e1bbi infografika a k\u00eds\u00e9rleti munkafolyamatot mutatja be. Mint l\u00e1that\u00f3, n\u00e9gy START-feh\u00e9rj\u00e9t expressz\u00e1ltak \u00e9s tiszt\u00edtottak meg. A nat\u00edv oldhat\u00f3 frakci\u00f3t tartalmaz\u00f3 fel\u00fcl\u00fasz\u00f3t sztreptavidin-szefar\u00f3zzal, a megb\u00edzhat\u00f3 \u00e9s magas sz\u00ednvonal\u00fa, affinit\u00e1st biztos\u00edt\u00f3 affinit\u00e1sgyant\u00e1val sz\u0171rt\u00e9k \u00e9s inkub\u00e1lt\u00e1k.-felbont\u00e1s\u00fa biomolekul\u00e1k tiszt\u00edt\u00e1sa. Ezut\u00e1n western blot seg\u00edts\u00e9g\u00e9vel elemezt\u00e9k az aliquotokat. A ligand azonos\u00edt\u00e1s\u00e1hoz el\u00fasztatt\u00e1k a felt\u00e9telezett ligandumokat, \u00e9s LC -MS (folyad\u00e9kkromatogr\u00e1fia \u00e9s t\u00f6megspektrometria) rendszer\u0171 elemz\u00e9snek vetett\u00e9k al\u00e1. Az \u00e9rdekl\u0151d\u00e9sre sz\u00e1mot tart\u00f3 putat\u00edv ligandumok molekulaszerkezet\u00e9t tandem t\u00f6megspektrometri\u00e1val hat\u00e1rozt\u00e1k meg.<\/p>\n

 <\/p>\n

\"vizu\u00e1lis<\/p>\n

A szerz\u0151k egy j\u00f3 technik\u00e1t mutattak be a feh\u00e9rje ligandumok kezdeti szond\u00e1z\u00e1s\u00e1ra a n\u00f6v\u00e9nyekben. A megk\u00f6zel\u00edt\u00e9st a START ligandumok felfedez\u00e9s\u00e9hez igaz\u00edtott\u00e1k. A m\u00f3dszert azonban az analitikai felt\u00e9telek be\u00e1ll\u00edt\u00e1s\u00e1val m\u00e1s k\u00e9miai term\u00e9szet\u0171 ligandumokhoz is \u00e1t lehet adapt\u00e1lni.<\/p>\n

Ha tudom\u00e1nyos illusztr\u00e1ci\u00f3kkal \u00e9s vizu\u00e1lis \u00f6sszefoglal\u00f3kkal szeretn\u00e9 bemutatni kutat\u00e1sait, akkor is haszn\u00e1lhatja az Mind the Graph-t. K\u00e9szen \u00e1llsz teh\u00e1t arra, hogy jav\u00edtsd a tudom\u00e1nyos kommunik\u00e1ci\u00f3dat?<\/p>\n

\"preview_250\"<\/a><\/p>","protected":false},"excerpt":{"rendered":"

A vizu\u00e1lis absztraktot nem k\u00f6nny\u0171 l\u00e9trehozni, de itt van, hogy maradjon. Ez\u00e9rt mindig sz\u00edvesen mutatjuk be felhaszn\u00e1l\u00f3ink csod\u00e1latos munk\u00e1it, mint a vizu\u00e1lis absztrakci\u00f3 inspir\u00e1l\u00f3 p\u00e9ld\u00e1j\u00e1t. Szeretn\u00e9nk k\u00e9pess\u00e9 tenni a tud\u00f3sokat arra, hogy vizu\u00e1lisabb \u00e9s el\u00e9rhet\u0151bb tudom\u00e1nyt tegyenek lehet\u0151v\u00e9. A bejegyz\u00e9sben megmutatom egy kicsit a [...]<\/p>","protected":false},"author":11,"featured_media":8741,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[193,40],"tags":[291,96,292,245,294,295,554,775,293,382],"yoast_head":"\nVisual abstract created by Mind the Graph user. Attractive scientific figure!<\/title>\n<meta name=\"description\" content=\"See the visual abstract created by the MindtheGraph subscriber Yelena Sterling to explain her research in an attractive and instructive way. 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Awesome job!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/hu\/vizualis-absztrakt\/visual-abstract-example\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2019-04-23T19:35:01+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-18T11:23:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/04\/cover-yelena.png\" \/>\n\t<meta property=\"og:image:width\" content=\"622\" \/>\n\t<meta property=\"og:image:height\" content=\"379\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabiola Soares\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabiola Soares\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Visual abstract created by Mind the Graph user. 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