{"id":8713,"date":"2019-04-18T18:07:31","date_gmt":"2019-04-18T21:07:31","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8713"},"modified":"2022-10-18T08:24:00","modified_gmt":"2022-10-18T11:24:00","slug":"brain-damage-pig-brains-alive-hours-death","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/hu\/brain-damage-pig-brains-alive-hours-death\/","title":{"rendered":"Agyk\u00e1rosod\u00e1s: infografika az \u00faj Nature-pap\u00edr meg\u00e9rt\u00e9s\u00e9hez"},"content":{"rendered":"

A Yale Egyetem tud\u00f3sai a hal\u00e1l ut\u00e1n \u00f3r\u00e1kig \u00e9letben tartott\u00e1k a sert\u00e9s agy\u00e1t a testen k\u00edv\u00fcl. A tanulm\u00e1ny Az agyi kering\u00e9s \u00e9s a sejtfunkci\u00f3k helyre\u00e1ll\u00edt\u00e1sa \u00f3r\u00e1kkal a hal\u00e1l ut\u00e1n<\/strong> elmagyar\u00e1zza a sert\u00e9sagyakkal v\u00e9gzett k\u00eds\u00e9rletet, amely f\u00e9nyt der\u00edthet az agyk\u00e1rosod\u00e1s kutat\u00e1s\u00e1ra. A Nature magazin\u00a0k\u00f6zz\u00e9tett <\/a>\u00e1prilis 17-\u00e9n.<\/p>\n

\"Az emberi t\u00f6rt\u00e9nelem nagy r\u00e9sz\u00e9ben a hal\u00e1l nagyon egyszer\u0171 volt.\"<\/em> mondja Christof Koch. \u0150 a washingtoni Seattle-ben tal\u00e1lhat\u00f3 Allen Institute for Brain Science eln\u00f6ke \u00e9s vezet\u0151 kutat\u00f3ja. \"Most meg kell k\u00e9rd\u0151jelezn\u00fcnk, hogy mi az, ami visszaford\u00edthatatlan.\"\u00a0<\/em><\/p>\n

Ezekben az agyakban nincs kommunik\u00e1ci\u00f3 az idegsejtek k\u00f6z\u00f6tt, \u00edgy nem volt tudatoss\u00e1g. De a sejtek \u00e9ltek - \u00e9s ez \u00f6nmag\u00e1ban is nagyon nagy felfedez\u00e9s.<\/p>\n

\"Kor\u00e1bbi eredm\u00e9nyek azt mutatt\u00e1k, hogy a sejtek alapvet\u0151en percek alatt mennek \u00e1t a sejthal\u00e1l folyamat\u00e1n.\"<\/em>\u00a0mondta Nenad Sestan, a Yale idegkutat\u00f3ja, a kutat\u00e1s vezet\u0151je egy sajt\u00f3t\u00e1j\u00e9koztat\u00f3n. \"Azt mutatjuk be, hogy a sejthal\u00e1l folyamata fokozatos, l\u00e9p\u00e9sr\u0151l l\u00e9p\u00e9sre halad\u00f3 folyamat, \u00e9s e folyamatok egy r\u00e9sze elhalaszthat\u00f3, meg\u0151rizhet\u0151 vagy ak\u00e1r vissza is ford\u00edthat\u00f3.\"<\/em><\/p>\n

Az agyk\u00e1rosod\u00e1si k\u00eds\u00e9rlet<\/strong><\/h3>\n

A Nature magazin szerint a kutat\u00f3k azt vizsg\u00e1lt\u00e1k, hogy az agyak mennyire j\u00f3l b\u00edrj\u00e1k hat \u00f3r\u00e1n kereszt\u00fcl. Azt tal\u00e1lt\u00e1k, hogy a neuronok \u00e9s m\u00e1s agysejtek \u00fajraind\u00edtott\u00e1k a norm\u00e1lis anyagcsere-funkci\u00f3kat, p\u00e9ld\u00e1ul a cukor fogyaszt\u00e1s\u00e1t \u00e9s a sz\u00e9n-dioxid termel\u00e9s\u00e9t. Emellett \u00fagy t\u0171nt, hogy az agyak immunrendszere is m\u0171k\u00f6dik. Az egyes sejtek \u00e9s az agy egyes r\u00e9szeinek szerkezete megmaradt. Ezzel szemben a kontroll agyakban, amelyek nem kaptak t\u00e1panyag- \u00e9s oxig\u00e9nd\u00fas oldatot, a sejtek \u00f6sszeomlottak. \u00c9s amikor a tud\u00f3sok elektromoss\u00e1got alkalmaztak a kezelt agyakb\u00f3l vett sz\u00f6vetmint\u00e1kra, azt tal\u00e1lt\u00e1k, hogy az egyes neuronok m\u00e9g mindig k\u00e9pesek jelet tov\u00e1bb\u00edtani.<\/p>\n

A tud\u00f3sok l\u00e9trehoztak egy BrainEx nev\u0171 rendszert, amelyet kifejezetten arra terveztek, hogy m\u00e9rs\u00e9kelje a hal\u00e1l ut\u00e1ni agyakban a sz\u00f6vetek leboml\u00e1s\u00e1\u00e9rt felel\u0151s folyamatok egy r\u00e9sz\u00e9t. A rendszer egy BEx perfuz\u00e1tum nev\u0171 oldat pump\u00e1l\u00e1s\u00e1val m\u0171k\u00f6dik. Az oldat v\u00e9d\u0151, stabiliz\u00e1l\u00f3 \u00e9s kontrasztanyagokat tartalmaz\u00f3, szabadalmaztatott kever\u00e9k, amely a v\u00e9r helyettes\u00edt\u00e9s\u00e9re szolg\u00e1l. A perfuz\u00e1tum olyan vegyi anyagokat is tartalmaz, amelyek meg\u00e1ll\u00edtj\u00e1k a testsz\u00f6vet oxid\u00e1ci\u00f3j\u00e1t, azaz az apopt\u00f3zist. Tartalmaz tov\u00e1bb\u00e1 egy idegi aktivit\u00e1st g\u00e1tl\u00f3 anyagot is, amelynek c\u00e9lja kett\u0151s. Az oldatot norm\u00e1l testh\u0151m\u00e9rs\u00e9kleten pump\u00e1lt\u00e1k az izol\u00e1lt agy f\u0151art\u00e9ri\u00e1iba.<\/p>\n

 <\/p>\n

\"diszn\u00f3k\"<\/a>
A cikk \u00e1br\u00e1ja azt mutatja, hogyan csatlakoztattak egy eg\u00e9sz agyat a BEx k\u00e9sz\u00fcl\u00e9khez. A sert\u00e9sagy csatlakoztat\u00e1sa a perf\u00fazi\u00f3s rendszerhez art\u00e9ri\u00e1s vezet\u00e9keken kereszt\u00fcl t\u00f6rt\u00e9nt.\u00a0<\/strong><\/figcaption><\/figure>\n

 <\/p>\n

A kutat\u00f3k az Egyes\u00fclt \u00c1llamok Mez\u0151gazdas\u00e1gi Miniszt\u00e9rium\u00e1nak egyik v\u00e1g\u00f3h\u00eddj\u00e1r\u00f3l sz\u00e1rmaz\u00f3 mintegy 300 sert\u00e9sfejet haszn\u00e1ltak fel. A technol\u00f3gia optimaliz\u00e1l\u00e1sa ut\u00e1n a csapat 32 sert\u00e9sagyat csatlakoztatott a BrainEx rendszerhez. A csatlakoztat\u00e1st 4 \u00f3r\u00e1val a sert\u00e9sek le\u00f6l\u00e9se ut\u00e1n v\u00e9gezt\u00e9k el, miut\u00e1n elt\u00e1vol\u00edtott\u00e1k az agyakat a kopony\u00e1kb\u00f3l. A szivatty\u00fak, f\u0171t\u0151berendez\u00e9sek \u00e9s sz\u0171r\u0151k sz\u00e1m\u00edt\u00f3g\u00e9pes h\u00e1l\u00f3zata hat \u00f3r\u00e1n kereszt\u00fcl szab\u00e1lyozta az \u00e1raml\u00e1st, a h\u0151m\u00e9rs\u00e9kletet \u00e9s a szabadalmaztatott perfuz\u00e1toldatot.<\/p>\n

Egy infografika a k\u00eds\u00e9rlet meg\u00e9rt\u00e9s\u00e9hez<\/strong><\/h2>\n

 <\/p>\n

\"preview_77833<\/a><\/p>\n

 <\/p>\n

Az infografik\u00e1t az Mind the Graph seg\u00edts\u00e9g\u00e9vel k\u00e9sz\u00edtettem. Ha szeretn\u00e9l vonz\u00f3 tudom\u00e1nyos illusztr\u00e1ci\u00f3kkal t\u00f6bb embert el\u00e9rni a kutat\u00e1soddal, haszn\u00e1lhatod a mind the Graph-ot is!<\/p>\n

\"preview_250\"<\/a><\/p>","protected":false},"excerpt":{"rendered":"

A Yale Egyetem tud\u00f3sai a hal\u00e1l ut\u00e1n \u00f3r\u00e1kig tartott\u00e1k \u00e9letben a sert\u00e9s agy\u00e1t a testen k\u00edv\u00fcl. Az agyi kering\u00e9s \u00e9s a sejtfunkci\u00f3k helyre\u00e1ll\u00edt\u00e1sa \u00f3r\u00e1kkal a hal\u00e1l ut\u00e1n c\u00edm\u0171 tanulm\u00e1ny a sert\u00e9sagyakkal v\u00e9gzett k\u00eds\u00e9rletet magyar\u00e1zza, amely f\u00e9nyt der\u00edthet az agyk\u00e1rosod\u00e1s kutat\u00e1s\u00e1ra. A Nature magazin \u00e1prilis 17-\u00e9n k\u00f6z\u00f6lte a tanulm\u00e1nyt. \"Az emberi t\u00f6rt\u00e9nelem nagy r\u00e9sz\u00e9ben a hal\u00e1l nagyon egyszer\u0171 volt\" [...].<\/p>","protected":false},"author":11,"featured_media":8721,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[54,288,287,286,282,554,71,964,775,70],"yoast_head":"\nBrain damage: an infographic to understand the new Nature paper - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Scientists from Yale University kept pig brains alive for hours after death. The experiment using pigs brains brings light to brain damage research.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/hu\/brain-damage-pig-brains-alive-hours-death\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brain damage: an infographic to understand the new Nature paper - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Scientists from Yale University kept pig brains alive for hours after death. 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