{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/hu\/alzheimers-kor\/","title":{"rendered":"Alzheimer-k\u00f3r: Tudom\u00e1nyos infografika"},"content":{"rendered":"

Mindig nagy \u00f6r\u00f6m, amikor l\u00e1tjuk felhaszn\u00e1l\u00f3ink csod\u00e1latos munk\u00e1j\u00e1t.\u00a0M\u00e1r \u00edrtam<\/a> Dr. Alessandra Martini, dr.\u00a0Stefania Forner<\/a>\u00a0\u00e9s koll\u00e9g\u00e1ik. \u0150k a Kaliforniai Egyetem posztdoktori kutat\u00f3i, \u00e9s a grafikonhaszn\u00e1l\u00f3kkal t\u00f6r\u0151dnek. N\u00e9h\u00e1ny h\u00f3nappal ezel\u0151tt megmutattam az infografik\u00e1k<\/a>\u00a0Dr. Stefania Forner a Trends in Neurosciences c\u00edm\u0171 foly\u00f3iratban megjelent, Synaptic impairment in Alzheimer's Disease c\u00edm\u0171 \u00e1ttekint\u0151 cikkhez k\u00e9sz\u00edtett: A dysregulated symphony.<\/p>\n

Ma az \u00faj \u00e1ttekint\u0151 cikk\u00fckr\u0151l szeretn\u00e9k besz\u00e9lni, amelynek c\u00edme A m\u00faltb\u00f3l a j\u00f6v\u0151be: mit tanultunk az \u00e1llatmodellekb\u0151l az Alzheimer-k\u00f3rr\u00f3l.<\/a><\/p>\n

Az Alzheimer-k\u00f3r (Alzheimer-k\u00f3r) egy neurodegenerat\u00edv betegs\u00e9g, amely kognit\u00edv hi\u00e1nyoss\u00e1gokat \u00e9s mem\u00f3riaveszt\u00e9st okoz. A betegs\u00e9g mechanizmus\u00e1nak meg\u00e9rt\u00e9se fontos a betegek \u00e9letmin\u0151s\u00e9g\u00e9nek jav\u00edt\u00e1sa \u00e9s a hat\u00e9kony kezel\u00e9s megtal\u00e1l\u00e1sa \u00e9rdek\u00e9ben. Ma a tudom\u00e1nyos \u00e9s gy\u00f3gyszeriparon bel\u00fcli hatalmas er\u0151fesz\u00edt\u00e9sek ellen\u00e9re nem \u00e1ll rendelkez\u00e9sre hat\u00e9kony kezel\u00e9s. Az Alzheimer-k\u00f3r a hatodik vezet\u0151 hal\u00e1loz\u00e1si ok az USA-ban, \u00e9s vil\u00e1gszerte 35 milli\u00f3 embert \u00e9rint.<\/p>\n

Alzheimer-k\u00f3r infografika<\/h2>\n

 <\/p>\n

Az Alzheimer-k\u00f3rban szenved\u0151 betegek t\u00f6bbs\u00e9ge id\u0151sebb szem\u00e9ly, akik \u00e1ltal\u00e1ban sz\u00e1mos t\u00e1rsbetegs\u00e9gben szenvednek. A cukorbetegs\u00e9g, a csontritkul\u00e1s, a vesebetegs\u00e9g, az elh\u00edz\u00e1s, a magas v\u00e9rnyom\u00e1s \u00e9s a hiperkoleszterin\u00e9mia\/diszlipid\u00e9mia, a stroke \u00e9s a g\u00f6rcsrohamok a f\u0151 t\u00e1rsbetegs\u00e9gek, amelyek befoly\u00e1solj\u00e1k az Alzheimer-k\u00f3r kialakul\u00e1s\u00e1t \u00e9s progresszi\u00f3j\u00e1t, \u00e9s bonyolultabb\u00e1 teszik a betegs\u00e9g patogenezis\u00e9t.<\/p>\n

\"infografikus
Az Alzheimer-k\u00f3r t\u00e1rsbetegs\u00e9geit bemutat\u00f3 infografika. A m\u00faltb\u00f3l a j\u00f6v\u0151be: Alzheimer-k\u00f3r: Mit tanultak az \u00e1llatmodellek az Alzheimer-k\u00f3rr\u00f3l?<\/figcaption><\/figure>\n

 <\/p>\n

\n

Az elm\u00falt \u00e9vtizedek intenz\u00edv kutat\u00e1si er\u0151fesz\u00edt\u00e9sei ellen\u00e9re a betegs\u00e9g leggyakoribb form\u00e1j\u00e1t jelent\u0151 sporadikus Alzheimer-k\u00f3r (sAD) etiol\u00f3gi\u00e1j\u00e1nak h\u00e1tter\u00e9ben \u00e1ll\u00f3 mechanizmusok tov\u00e1bbra sem ismertek. Ez legal\u00e1bbis r\u00e9szben annak k\u00f6sz\u00f6nhet\u0151, hogy a sAD-betegek t\u00f6bbs\u00e9ge id\u0151sebb szem\u00e9ly, akik \u00e1ltal\u00e1ban sz\u00e1mos t\u00e1rsbetegs\u00e9gben szenvednek (pl. stroke, stressz, cukorbetegs\u00e9g, g\u00f6rcsrohamok, csontritkul\u00e1s \u00e9s vesebetegs\u00e9g).<\/em><\/p>\n<\/blockquote>\n

A k\u00f6vetkez\u0151 infografika a tau \u00e9s a b\u00e9ta-amiloid oligomerek szinaptikus toxicit\u00e1s\u00e1nak kialakul\u00e1s\u00e1t \u00e9s mechanizmusait mutatja be.<\/p>\n

 <\/p>\n

\"infografico
A m\u00faltb\u00f3l a j\u00f6v\u0151be: Alzheimer-k\u00f3r: Mit tanultak az \u00e1llatmodellek az Alzheimer-k\u00f3rr\u00f3l?<\/figcaption><\/figure>\n

 <\/p>\n

\n

A tauop\u00e1ti\u00e1k sor\u00e1n a dendritikus gerincek sz\u00e1ma cs\u00f6kken. A tau nem jut be a neuron magj\u00e1ba, ami DNS-k\u00e1rosod\u00e1st eredm\u00e9nyez. Cs\u00f6kken a mitokondriumok sz\u00e1ma \u00e9s a preszinaptikus vezikul\u00e1k sz\u00e1ma is, ami szinaptikus vesztes\u00e9ghez vezet. Ez a vesztes\u00e9g a tau dendritekbe \u00e9s posztszinaptikus ter\u00fcletekre val\u00f3 bejut\u00e1s\u00e1nak is k\u00f6sz\u00f6nhet\u0151. A tau extracellul\u00e1risan is aggreg\u00e1l\u00f3dik, ami lehet\u0151v\u00e9 teszi, hogy m\u00e1s neuronok befogj\u00e1k.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

Egy infografik\u00e1t is k\u00e9sz\u00edtett az Alzheimer-k\u00f3rhoz (AD) kapcsol\u00f3d\u00f3 gyullad\u00e1sos mechanizmusok bemutat\u00e1s\u00e1ra.<\/p>\n

 <\/p>\n

\"infografico<\/p>\n

 <\/p>\n

\n

Az elm\u00falt n\u00e9h\u00e1ny \u00e9vben k\u00fcl\u00f6n\u00f6sen \u00e9rdekelt benn\u00fcnket annak meg\u00e9rt\u00e9se, hogy a gyullad\u00e1s hogyan befoly\u00e1solja a b\u00e9ta-amiloid \u00e9s a tau patol\u00f3gi\u00e1j\u00e1t. Az id\u0151sek fog\u00e9konyak a v\u00edrusos \u00e9s bakteri\u00e1lis fert\u0151z\u00e9sekre, \u00e9s ezek a mikrobi\u00e1lis \u00e1gensek s\u00falyosb\u00edthatj\u00e1k az agyban megl\u00e9v\u0151 gyullad\u00e1sos \u00e1llapotot, felgyors\u00edtva a kognit\u00edv hanyatl\u00e1st.<\/em><\/p>\n<\/blockquote>\n

Gratul\u00e1lunk Dr. Forner Stef\u00e1ni\u00e1nak a nagyszer\u0171 munk\u00e1j\u00e1hoz!<\/p>\n

Ha tud\u00f3s vagy, \u00e9s szeretn\u00e9l sz\u00e9p \u00e1br\u00e1kat k\u00e9sz\u00edteni a dolgozatodhoz, akkor m\u00e1r most a mind the graph felhaszn\u00e1l\u00f3j\u00e1v\u00e1 v\u00e1lhatsz.<\/p>\n

\"c\u00edm<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Mindig nagy \u00f6r\u00f6m, amikor l\u00e1tjuk felhaszn\u00e1l\u00f3ink csod\u00e1latos munk\u00e1j\u00e1t. Dr. Alessandra Martini, Dr. Stefania Forner \u00e9s koll\u00e9g\u00e1ik kutat\u00e1s\u00e1r\u00f3l m\u00e1r \u00edrtam. \u0150k a Kaliforniai Egyetem posztdoktori kutat\u00f3i, \u00e9s a grafikon felhaszn\u00e1l\u00f3ira figyelnek. N\u00e9h\u00e1ny h\u00f3nappal ezel\u0151tt megmutattam azokat az infografik\u00e1kat, amelyeket Dr. Stefania Forner k\u00e9sz\u00edtett a Trends c\u00edm\u0171 foly\u00f3iratban megjelent \u00e1ttekint\u0151 cikkhez [...]<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/hu\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - 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