{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/hu\/autofagia-nyertes-nobel-dij-gyogyaszat\/","title":{"rendered":"Az autof\u00e1gia elnyerte az orvosi Nobel-d\u00edjat"},"content":{"rendered":"

Az autof\u00e1gia folyamata sz\u00e1mos betegs\u00e9gben, p\u00e9ld\u00e1ul a r\u00e1kban \u00e9s a neurol\u00f3giai betegs\u00e9gekben is szerepet j\u00e1tszik. A szervezet bels\u0151 \u00fajrahasznos\u00edt\u00e1si programjak\u00e9nt m\u0171k\u00f6dik. A nem megfelel\u0151en m\u0171k\u00f6d\u0151 autof\u00e1gi\u00e1t azonban \u00f6sszef\u00fcgg\u00e9sbe hozt\u00e1k a Parkinson-k\u00f3rral, a cukorbetegs\u00e9ggel, a r\u00e1kbetegs\u00e9ggel \u00e9s m\u00e1s, az \u00e9letkorral \u00f6sszef\u00fcgg\u0151 rendelleness\u00e9gekkel.<\/p>\n

Az autof\u00e1gia folyamat\u00e1nak fontoss\u00e1g\u00e1t bemutat\u00f3 kis bevezet\u0151 ut\u00e1n nem meglep\u0151, hogy az ezen a ter\u00fcleten tett \u00faj felfedez\u00e9sek Nobel-d\u00edjhoz vezethetnek. Val\u00f3ban, m\u00falt h\u00e9tf\u0151n Yoshino Ohsumi kutat\u00f3 nyerte el a Orvosi Nobel-d\u00edj<\/a> az autof\u00e1gia els\u0151 esszenci\u00e1lis g\u00e9njeinek azonos\u00edt\u00e1s\u00e1\u00e9rt.<\/p>\n

\"Nem \u00e9rzem j\u00f3l magam, ha sok emberrel kell versenyeznem, ehelyett sokkal \u00e9lvezetesebbnek tal\u00e1lom, ha olyasmit csin\u00e1lok, amit senki m\u00e1s nem csin\u00e1l. Bizonyos \u00e9rtelemben err\u0151l sz\u00f3l a tudom\u00e1ny, \u00e9s a felfedez\u00e9s \u00f6r\u00f6me inspir\u00e1l engem.\" Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Hogyan csin\u00e1lta Ohsumi?<\/h3>\n

Ohsumi laborat\u00f3rium\u00e1ban olyan \u00e9leszt\u0151t\u00f6rzseket fejlesztett ki, amelyek \u00e9hez\u00e9s sor\u00e1n autof\u00e1gosz\u00f3m\u00e1kat halmoztak fel. Ez a felhalmoz\u00f3d\u00e1s csak akkor t\u00f6rt\u00e9nhetett volna meg, ha az autof\u00e1gi\u00e1hoz n\u00e9lk\u00fcl\u00f6zhetetlen g\u00e9nek inakt\u00edvak lenn\u00e9nek. \u00cdgy Ohsumi elkezdte manipul\u00e1lni a sejteket t\u00f6bb g\u00e9nmut\u00e1ci\u00f3val, \u00e9s siker\u00fclt autof\u00e1gi\u00e1t induk\u00e1lnia.<\/p>\n

\"Az<\/a><\/p>\n

Az autof\u00e1gia m\u00e1r l\u00e9tezik<\/h3>\n

B\u00e1r az autof\u00e1gia m\u00e1r 50 \u00e9ve ismert, csak az 1990-es \u00e9vekben, Ohsumi tanulm\u00e1nyaival ismert\u00e9k fel ennek a folyamatnak a fontoss\u00e1g\u00e1t.
\nMunk\u00e1j\u00e1\u00e9rt Ohsumi m\u00e1ris szerzett n\u00e9h\u00e1ny rajong\u00f3t:<\/p>\n

\"Az<\/a><\/p>\n

\n

\"Nagyon \u00f6r\u00fcl\u00f6k, hogy \u0151 kapta az idei Nobel-d\u00edjat, nagyon meg\u00e9rdemelte. A laborat\u00f3riuma f\u0151leg \u00e9leszt\u0151vel foglalkozik. \u0150k v\u00e9gezt\u00e9k a kezdeti sz\u0171r\u00e9seket, amelyek lehet\u0151v\u00e9 tett\u00e9k az autof\u00e1gi\u00e1ban szerepet j\u00e1tsz\u00f3 kulcsfontoss\u00e1g\u00fa g\u00e9nek felfedez\u00e9s\u00e9t. Nagyon sok m\u00e1s laborat\u00f3rium haszn\u00e1lta fel k\u00f6zvetlen\u00fcl vagy k\u00f6zvetve az \u0151 felfedez\u00e9seit, hogy megl\u00e1ss\u00e1k, mi\u00e9rt fontos ez a betegs\u00e9gekn\u00e9l.\"<\/p>\n

David Rubinsztein<\/a> - a Cambridge-i Orvosi Kutat\u00f3int\u00e9zet igazgat\u00f3helyettese<\/p>\n<\/blockquote>\n

\"Az<\/a><\/p>\n

\n

\"Nagyon fontosnak tartom, hogy a tudom\u00e1nynak ezt a ter\u00fclet\u00e9t elismerj\u00e9k. A fontos elv itt az, hogy a betegs\u00e9gekben k\u00f6z\u00f6s mechanizmusokat keress\u00fcnk. Ez olyan utakat nyit meg e rendelleness\u00e9gek kezel\u00e9s\u00e9re, amelyek elt\u00e9rnek a hagyom\u00e1nyosabb, betegs\u00e9gspecifikusabb megk\u00f6zel\u00edt\u00e9sekt\u0151l.\"<\/p>\n

Giovanna Mallucci<\/a> - a Cambridge-i Egyetem klinikai idegtudom\u00e1nyok professzora<\/p>\n<\/blockquote>\n

\"Az<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Az autof\u00e1gia folyamata sz\u00e1mos betegs\u00e9gben, p\u00e9ld\u00e1ul a r\u00e1kban \u00e9s a neurol\u00f3giai betegs\u00e9gekben is szerepet j\u00e1tszik. A szervezet bels\u0151 \u00fajrahasznos\u00edt\u00e1si programjak\u00e9nt m\u0171k\u00f6dik. A nem megfelel\u0151en m\u0171k\u00f6d\u0151 autof\u00e1gi\u00e1t azonban \u00f6sszef\u00fcgg\u00e9sbe hozt\u00e1k a Parkinson-k\u00f3rral, a cukorbetegs\u00e9ggel, a r\u00e1kbetegs\u00e9ggel \u00e9s m\u00e1s, az \u00e9letkorral \u00f6sszef\u00fcgg\u0151 rendelleness\u00e9gekkel. Az autof\u00e1gia folyamat\u00e1nak fontoss\u00e1g\u00e1r\u00f3l sz\u00f3l\u00f3 kis bevezet\u0151 ut\u00e1n nem meglep\u0151, hogy az \u00faj felfedez\u00e9sek [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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