{"id":5346,"date":"2016-03-03T13:41:11","date_gmt":"2016-03-03T16:41:11","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=5346"},"modified":"2022-10-18T08:29:24","modified_gmt":"2022-10-18T11:29:24","slug":"zika-virus-graphical-abstract","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/hu\/zika-virus-graphical-abstract\/","title":{"rendered":"Zikav\u00edrus grafikus \u00f6sszefoglal\u00f3 a mikrokef\u00e1li\u00e1r\u00f3l"},"content":{"rendered":"

A Zika-v\u00edrus grafikus kivonat\u00e1nak meg\u00e9rt\u00e9se: Hogyan cs\u00f6kkenti az agy m\u00e9ret\u00e9t?<\/h3>\n

Egy mai kutat\u00e1s \u00e9rdekes bizony\u00edt\u00e9kkal szolg\u00e1lt a Zika-v\u00edrusnak az idegsz\u00f6vetek fejl\u0151d\u00e9si rendelleness\u00e9g\u00e9ben j\u00e1tszott szerep\u00e9re. \u00c1, igen, miel\u0151tt megk\u00e9rdezn\u00e9d, az emberi idegsz\u00f6vet.<\/p>\n

Ezt Dr. Stevens Rehen, az \u0151ssejtkutat\u00e1s \u00e9s \u00fajabban a sejtek \u00fajraprogramoz\u00e1s\u00e1nak nemzetk\u00f6zileg ismert kutat\u00f3ja, Dr. Stevens Rehen csoportja eleg\u00e1nsan v\u00e9gezte el.<\/p>\n

Az al\u00e1bbi \u00e1bra \u00f6sszefoglalja az al\u00e1bbi meg\u00e1llap\u00edt\u00e1sokat a pap\u00edr<\/a>, de megpr\u00f3b\u00e1lom r\u00f6viden elmagyar\u00e1zni.<\/p>\n

 <\/p>\n

\"blog<\/p>\n

Ez az \u00e9lesl\u00e1t\u00f3 Zika-v\u00edrus grafikus \u00f6sszefoglal\u00f3 a Mind the graph seg\u00edts\u00e9g\u00e9vel k\u00e9sz\u00fclt. H\u00e1t nem kir\u00e1ly?<\/em><\/p>\n

 <\/p>\n

 <\/p>\n

Amint a fenti k\u00e9pen l\u00e1that\u00f3, a kutat\u00e1s sor\u00e1n h\u00e1rom k\u00fcl\u00f6nb\u00f6z\u0151 megk\u00f6zel\u00edt\u00e9st alkalmaztunk. Mindegyik meger\u0151s\u00edti, hogy a Zika-v\u00edrus k\u00f6zvetlen hat\u00e1ssal van arra, hogy az agysejtek hogyan fejl\u0151dnek ki megfelel\u0151 neuron\u00e1lis sz\u00f6vetet, m\u00e1s n\u00e9ven \"inkub\u00e1lt agyi malform\u00e1ci\u00f3t\" alkotva.\"zikav\u00edrus<\/a>A mikrokef\u00e1lia csak egy agyi rendelleness\u00e9g. A tanulm\u00e1ny enn\u00e9l sokkal alapvet\u0151bb dologra utal.<\/p>\n

Megmutatj\u00e1k, hogyan terjed a Zika-v\u00edrus:<\/p>\n

    \n
  1. El\u0151seg\u00edti a sejthal\u00e1lt<\/li>\n
  2. Morfol\u00f3giai v\u00e1ltoz\u00e1sokat id\u00e9z el\u0151 (neuroszf\u00e9r\u00e1kban)<\/li>\n
  3. Cs\u00f6kkenti az agyi organoidok (mini agyak) n\u00f6veked\u00e9s\u00e9t\/m\u00e9ret\u00e9t.<\/li>\n<\/ol>\n

    Ezek mind-mind olyan m\u00f3djai annak, hogy a Zika-v\u00edrus hogyan befoly\u00e1solja a neurogenezist az emberi agy fejl\u0151d\u00e9se sor\u00e1n, \u00e9s hogyan okozza az al\u00e1bb l\u00e1that\u00f3 fenot\u00edpust.<\/p>\n

    \"zikav\u00edrus<\/a><\/p>\n

    <\/h3>\n

    Mi\u00e9rt nem tett\u00e9k meg kor\u00e1bban?<\/h3>\n

    Az \u00fatt\u00f6r\u0151 megk\u00f6zel\u00edt\u00e9s az induk\u00e1lt pluripotenci\u00e1j\u00fa \u0151ssejtek (iPS-sejtek) felhaszn\u00e1l\u00e1s\u00e1val lehet\u0151v\u00e9 tette a v\u00edrusfert\u0151z\u00e9s tanulm\u00e1nyoz\u00e1s\u00e1t emberi sejtekben.<\/p>\n

    Ezzel a folyamattal egy szem\u00e9lyb\u0151l kinyert szomatikus sejtet \u00fajraprogramoznak a pluripotens sejtek eredeti \u00e1llapot\u00e1ba, \u00e9s ezt k\u00f6vet\u0151en k\u00fcl\u00f6nb\u00f6z\u0151 sejtekk\u00e9, sz\u00f6vetekk\u00e9, \u00e9s \u00fajabban szervv\u00e9 differenci\u00e1l\u00f3dhatnak. Ez a \"hum\u00e1n sz\u00f6vettechnol\u00f3gia\" kezdete.<\/p>\n

    A tanulm\u00e1nyban a szerz\u0151k nem csak az iPS sejteket haszn\u00e1lt\u00e1k, hanem gener\u00e1ltak agyi organoidok<\/a>, m\u00e1s n\u00e9ven \"miniagyakat\", hogy meg\u00e9rts\u00fck, hogyan befoly\u00e1solja a Zika-v\u00edrus jelenl\u00e9te ennek az idegsz\u00f6vetnek a kialakul\u00e1s\u00e1t.<\/p>\n

    Az ilyen sejtkult\u00far\u00e1kat h\u00e1romdimenzi\u00f3s (3D) strukt\u00far\u00e1knak tekintik, \u00e9s t\u00f6bb utal\u00e1st adnak a szerv fel\u00e9p\u00edt\u00e9s\u00e9r\u0151l. Ez az organoid \u00e9ve az organoidok szerint K\u00f6zgazd\u00e1sz<\/a>. Ezzel az innovat\u00edv megk\u00f6zel\u00edt\u00e9ssel a tud\u00f3sok meg\u00e9rtett\u00e9k, hogy a zikav\u00edrus hogyan t\u00e1madja meg az emberi agysejteket, cs\u00f6kkentve azok \u00e9letk\u00e9pess\u00e9g\u00e9t \u00e9s n\u00f6veked\u00e9s\u00e9t neurog\u00f6mb\u00f6k \u00e9s agyi organoidok form\u00e1j\u00e1ban.<\/p>\n

    A pap\u00edr<\/a> a PeerJ c\u00edm\u0171 innovat\u00edv foly\u00f3irat el\u0151nyomtat\u00e1sban van. A folyamat sor\u00e1n m\u00e9g megjegyz\u00e9seket is f\u0171zhet hozz\u00e1, \u00e9s seg\u00edthet a szerz\u0151knek jav\u00edtani rajta. Az al\u00e1bbiakban megtekintheti az \u00f6sszefoglal\u00f3t, a teljes hozz\u00e1f\u00e9r\u00e9s pedig a k\u00f6vetkez\u0151 linkre kattintva \u00e9rhet\u0151 el itt<\/a>.<\/p>\n

    \"zikav\u00edrus<\/a><\/p>\n

    Megjegyz\u00e9s: K\u00e9t h\u00f3nappal a PeerJ-n 2016 m\u00e1rcius\u00e1ban megjelent el\u0151nyomtat\u00e1s ut\u00e1n megjelent a v\u00e9gleges tanulm\u00e1ny, \u00e9s meglepet\u00e9s\u00fcnkre a k\u00f6vetkez\u0151 volt megjelent a Science <\/a>Magazine, a bolyg\u00f3 egyik legrangosabb tudom\u00e1nyos foly\u00f3irata.<\/p>\n

    -> Olvassa el a teljes cikket Garcez et al. a Science <-<\/a><\/p>\n

    \"zikav\u00edrus<\/a><\/p>\n

    Hadd tudjanak r\u00f3la min\u00e9l t\u00f6bben megosztva ezt a bejegyz\u00e9st. Ez egy glob\u00e1lis k\u00f6zeg\u00e9szs\u00e9g\u00fcgyi k\u00e9rd\u00e9s, ahogyan azt m\u00e1r a Eg\u00e9szs\u00e9g\u00fcgyi Vil\u00e1gszervezet<\/a>\u00a0(WHO).<\/p>\n

    \n

     <\/p>\n

    Tudja, hogy mi a A WHO tan\u00e1csai a Zika-v\u00edrusr\u00f3l<\/a>\u00a0\u00e1tvitel \u00e9s fert\u0151z\u00e9s:<\/p>\n

    \n

    \u00c1tvitel<\/h3>\n

    A Zika-v\u00edrus els\u0151sorban a k\u00f6vetkez\u0151 v\u00edrusok cs\u00edp\u00e9se r\u00e9v\u00e9n terjed az emberre Aedes<\/i> sz\u00fanyogok, amelyek gyakran \u00e9lnek a v\u00e1rosi ter\u00fcleteken az \u00e9p\u00fcletek k\u00f6r\u00fcl, \u00e9s \u00e1ltal\u00e1ban nappali \u00f3r\u00e1kban akt\u00edvak (a cs\u00edp\u00e9si aktivit\u00e1s cs\u00facspontja kora reggel \u00e9s k\u00e9s\u0151 d\u00e9lut\u00e1n van).<\/p>\n

    Bizonyos bizony\u00edt\u00e9kok arra utalnak, hogy a Zika-v\u00edrus v\u00e9r\u00e1t\u00f6mleszt\u00e9s, perinat\u00e1lis \u00e1tvitel \u00e9s szexu\u00e1lis \u00e1tvitel \u00fatj\u00e1n is \u00e1tvihet\u0151 az emberre. Ezek a m\u00f3dok azonban nagyon ritk\u00e1k.<\/p>\n

    A lappang\u00e1si id\u0151 \u00e1ltal\u00e1ban 2 \u00e9s 7 nap k\u00f6z\u00f6tt van.<\/p>\n

    Jelek \u00e9s t\u00fcnetek<\/h3>\n

    A zikav\u00edrus-fert\u0151z\u00e9st alacsony fok\u00fa l\u00e1z (38,5 \u00b0C alatti), gyakran makulopapul\u00f3zus ki\u00fct\u00e9sekkel k\u00eds\u00e9rt l\u00e1z jellemzi. Egy\u00e9b gyakori t\u00fcnetek k\u00f6z\u00e9 tartozik az izomf\u00e1jdalom, \u00edz\u00fcleti f\u00e1jdalom, esetleges duzzanattal (k\u00fcl\u00f6n\u00f6sen a k\u00e9z \u00e9s a l\u00e1b kis \u00edz\u00fcleteiben), fejf\u00e1j\u00e1s, szem m\u00f6g\u00f6tti f\u00e1jdalom \u00e9s k\u00f6t\u0151h\u00e1rtya-gyullad\u00e1s. Mivel a t\u00fcnetek gyakran enyh\u00e9k, a fert\u0151z\u00e9st nem ismerik fel, vagy t\u00e9vesen dengue-k\u00f3rk\u00e9nt diagnosztiz\u00e1lj\u00e1k.<\/p>\n

    A zikav\u00edrus okozta t\u00fcnetmentes fert\u0151z\u00e9s magas ar\u00e1nya v\u00e1rhat\u00f3, hasonl\u00f3an m\u00e1s flaviv\u00edrusokhoz, p\u00e9ld\u00e1ul a dengue-v\u00edrushoz \u00e9s a nyugat-n\u00edlusi v\u00edrushoz. A legt\u00f6bb ember teljesen fel\u00e9p\u00fcl s\u00falyos sz\u00f6v\u0151dm\u00e9nyek n\u00e9lk\u00fcl, \u00e9s a k\u00f3rh\u00e1zi kezel\u00e9sek ar\u00e1nya alacsony. Eddig nem jelentettek a Zika-v\u00edrussal \u00f6sszef\u00fcgg\u00e9sbe hozhat\u00f3 hal\u00e1lesetet.<\/p><\/blockquote>\n

     <\/p>\n

    Friss\u00edtve 2016. m\u00e1jus 3-\u00e1n.<\/p>","protected":false},"excerpt":{"rendered":"

    A Zika-v\u00edrus grafikus \u00f6sszefoglal\u00f3ja: Hogyan cs\u00f6kkenti az agy m\u00e9ret\u00e9t Egy mai kutat\u00e1s \u00e9rdekes bizony\u00edt\u00e9kkal szolg\u00e1lt a Zika-v\u00edrusnak az idegsz\u00f6vetek fejl\u0151d\u00e9si rendelleness\u00e9g\u00e9ben j\u00e1tszott szerepe fel\u00e9. \u00c1, igen, miel\u0151tt megk\u00e9rdezn\u00e9d, az emberi idegsz\u00f6vetek. Ezt eleg\u00e1nsan Dr. Stevens Rehen csoportja v\u00e9gezte el, aki nemzetk\u00f6zileg ismert kutat\u00f3 a [...]<\/p>","protected":false},"author":4,"featured_media":7136,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[956],"tags":[96,201,200,203,202,205,554,71,250,204,199],"yoast_head":"\nZika virus graphical abstract on microcephaly - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This insightful Zika virus graphical abstract was done with Mind the graph. Isn't is cool?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/hu\/zika-virus-graphical-abstract\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Understand how Zika virus reduces brain size\" \/>\n<meta property=\"og:description\" content=\"Today a research study added interesting evidence towards the role of Zika virus in the malformation of nervous tissues. Ah, yes, before you ask, human nervous tissue. This was elegantly done by the group of Dr. Stevens Rehen, an internationally-known researcher in the field of stem cell research and, more recently, cell reprogramming. The figure below summarizes the findings of the paper.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/hu\/zika-virus-graphical-abstract\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2016-03-03T16:41:11+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-18T11:29:24+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/03\/captura-de-tela-2016-03-03-as-114609.png\" \/>\n\t<meta property=\"og:image:width\" content=\"492\" \/>\n\t<meta property=\"og:image:height\" content=\"333\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Understand how Zika virus reduces brain size\" \/>\n<meta name=\"twitter:description\" content=\"Zike virus and microcephaly studied in human tissues for the first time in history! Published in Science\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2016\/03\/Captura-de-Tela-2016-03-03-a\u0300s-11.46.09.png\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Zika virus graphical abstract on microcephaly - Mind the Graph Blog","description":"This insightful Zika virus graphical abstract was done with Mind the graph. Isn't is cool?","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/hu\/zika-virus-graphical-abstract\/","og_locale":"hu_HU","og_type":"article","og_title":"Understand how Zika virus reduces brain size","og_description":"Today a research study added interesting evidence towards the role of Zika virus in the malformation of nervous tissues. Ah, yes, before you ask, human nervous tissue. This was elegantly done by the group of Dr. Stevens Rehen, an internationally-known researcher in the field of stem cell research and, more recently, cell reprogramming. The figure below summarizes the findings of the paper.","og_url":"https:\/\/mindthegraph.com\/blog\/hu\/zika-virus-graphical-abstract\/","og_site_name":"Mind the Graph Blog","article_published_time":"2016-03-03T16:41:11+00:00","article_modified_time":"2022-10-18T11:29:24+00:00","og_image":[{"width":492,"height":333,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2016\/03\/captura-de-tela-2016-03-03-as-114609.png","type":"image\/png"}],"author":"Fabricio Pamplona","twitter_card":"summary_large_image","twitter_title":"Understand how Zika virus reduces brain size","twitter_description":"Zike virus and microcephaly studied in human tissues for the first time in history! Published in Science","twitter_image":"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2016\/03\/Captura-de-Tela-2016-03-03-a\u0300s-11.46.09.png","twitter_misc":{"Written by":"Fabricio Pamplona","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/zika-virus-graphical-abstract\/","url":"https:\/\/mindthegraph.com\/blog\/zika-virus-graphical-abstract\/","name":"Zika virus graphical abstract on microcephaly - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2016-03-03T16:41:11+00:00","dateModified":"2022-10-18T11:29:24+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3"},"description":"This insightful Zika virus graphical abstract was done with Mind the graph. Isn't is cool?","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/zika-virus-graphical-abstract\/#breadcrumb"},"inLanguage":"hu-HU","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/zika-virus-graphical-abstract\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/zika-virus-graphical-abstract\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Zika virus graphical abstract on microcephaly"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"hu-HU"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3","name":"Fabricio Pamplona","image":{"@type":"ImageObject","inLanguage":"hu-HU","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","caption":"Fabricio Pamplona"},"description":"Fabricio Pamplona is the founder of Mind the Graph - a tool used by over 400K users in 60 countries. He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/hu\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/hu\/wp-json\/wp\/v2\/posts\/5346"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/hu\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/hu\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/hu\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/hu\/wp-json\/wp\/v2\/comments?post=5346"}],"version-history":[{"count":19,"href":"https:\/\/mindthegraph.com\/blog\/hu\/wp-json\/wp\/v2\/posts\/5346\/revisions"}],"predecessor-version":[{"id":23389,"href":"https:\/\/mindthegraph.com\/blog\/hu\/wp-json\/wp\/v2\/posts\/5346\/revisions\/23389"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/hu\/wp-json\/wp\/v2\/media\/7136"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/hu\/wp-json\/wp\/v2\/media?parent=5346"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/hu\/wp-json\/wp\/v2\/categories?post=5346"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/hu\/wp-json\/wp\/v2\/tags?post=5346"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}