{"id":16670,"date":"2022-09-16T19:40:00","date_gmt":"2022-09-16T22:40:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16670"},"modified":"2023-03-17T14:47:16","modified_gmt":"2023-03-17T17:47:16","slug":"success-case-nuclear-receptors-in-liver-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/hu\/success-case-nuclear-receptors-in-liber-fibrosis\/","title":{"rendered":"Nukle\u00e1ris receptorok a m\u00e1jfibr\u00f3zisban Paper Review"},"content":{"rendered":"<p>Ebben az esetben a szerz\u0151 az Mind the Graph-t arra haszn\u00e1lta, hogy a k\u00fcl\u00f6nb\u00f6z\u0151 forr\u00e1sokb\u00f3l sz\u00e1rmaz\u00f3 adatokat egyetlen helyen \u00f6sszegy\u0171jtse. A legjobb tudom\u00e1nyos pontoss\u00e1g\u00fa illusztr\u00e1ci\u00f3k mellett a munkater\u00fclet\u00fcnk bar\u00e1ts\u00e1gos fel\u00fclettel rendelkezik, \u00e9s nagyon k\u00f6nnyen haszn\u00e1lhat\u00f3.<\/p>\n\n\n\n<p>Ellen\u0151rizze a teljes <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S092544392100168X?via%3Dihub\" target=\"_blank\" rel=\"noreferrer noopener\">eredeti cikk<\/a>. <\/p>\n\n\n\n<h2><strong>A nukle\u00e1ris receptorok szerepe a m\u00e1jfibr\u00f3zisban<\/strong><\/h2>\n\n\n\n<p>Philipp K\u00f6nigshofer \u00e9s munkat\u00e1rsai (2021) arr\u00f3l sz\u00e1molnak be, hogy a nukle\u00e1ris receptorok olyan ligandum-aktiv\u00e1lt transzkripci\u00f3s faktorok, amelyek a m\u00e1jfibr\u00f3zisban szerepet j\u00e1tsz\u00f3 sz\u00e1mos kulcsfontoss\u00e1g\u00fa molekul\u00e1ris jel g\u00e9nexpresszi\u00f3j\u00e1t szab\u00e1lyozz\u00e1k. <\/p>\n\n\n\n<p>A m\u00e1jfibrogenezis els\u0151dleges sejtszint\u0171 mozgat\u00f3rug\u00f3ja az aktiv\u00e1lt m\u00e1j csillagsejtek. K\u00fcl\u00f6nb\u00f6z\u0151 nukle\u00e1ris receptorok szab\u00e1lyozz\u00e1k a pro-inflammatorikus \u00e9s pro-fibrog\u00e9n citokinek m\u00e1jbeli expresszi\u00f3j\u00e1t.<\/p>\n\n\n\n<h2><strong>Grafikus \u00f6sszefoglal\u00f3k az Mind the Graph seg\u00edts\u00e9g\u00e9vel<\/strong> <strong>ebben a cikkben<\/strong><\/h2>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1.jpg\"><img decoding=\"async\" loading=\"lazy\" width=\"800\" height=\"389\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1.jpg\" alt=\"\" class=\"wp-image-20242\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1.jpg 800w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1-300x146.jpg 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1-768x373.jpg 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1-18x9.jpg 18w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr1-100x49.jpg 100w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>K\u00e9sz\u00fclt <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p>Ez az els\u0151 \u00e1bra a nukle\u00e1ris receptorok \u00e1ttekint\u00e9se \u00e9s alcsal\u00e1dok szerinti oszt\u00e1lyoz\u00e1sa.<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2.jpg\"><img decoding=\"async\" loading=\"lazy\" width=\"800\" height=\"468\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2.jpg\" alt=\"\" class=\"wp-image-20246\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2.jpg 800w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2-300x176.jpg 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2-768x449.jpg 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2-18x12.jpg 18w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr2-100x59.jpg 100w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>K\u00e9sz\u00fclt <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Fentebb l\u00e1thatjuk a nukle\u00e1ris receptorok k\u00fcl\u00f6nb\u00f6z\u0151 t\u00edpus\u00fa effektor funkci\u00f3it.<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s2.0-S092544392100168X-gr3.jpg\"><img decoding=\"async\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s2.0-S092544392100168X-gr3.jpg\" alt=\"\" class=\"wp-image-20245\"\/><\/a><figcaption class=\"wp-element-caption\"><em>K\u00e9sz\u00fclt <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>A harmadik \u00e1br\u00e1n \u00e1ttekint\u00e9st kaphatunk a m\u00e1jbetegs\u00e9gek elleni potenci\u00e1lis ter\u00e1pi\u00e1s megk\u00f6zel\u00edt\u00e9sekk\u00e9nt jelentett NR-modul\u00e1ci\u00f3k hat\u00e1sair\u00f3l. <\/p>\n\n\n\n<p>A nyilak a m\u00e1jbetegs\u00e9gben felt\u00e9telezett kedvez\u0151 hat\u00e1sokat jelzik a k\u00f6vetkez\u0151kkel <span style=\"color:#0d880f\" class=\"has-inline-color\"><strong>up- (s\u00f6t\u00e9tz\u00f6ld)<\/strong><\/span> vagy<strong><span class=\"has-inline-color has-vivid-green-cyan-color\"> lefel\u00e9 (vil\u00e1gosz\u00f6ld)<\/span><\/strong> olyan specifikus mechanizmusok szab\u00e1lyoz\u00e1sa, amelyek a jelent\u00e9sek szerint t\u00e1mogatj\u00e1k a m\u00e1jfibr\u00f3zis regresszi\u00f3j\u00e1t vagy cs\u00f6kkentik a m\u00e1jfibr\u00f3zist. <\/p>\n\n\n\n<p><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-luminous-vivid-orange-color\">Narancss\u00e1rga nyilak<\/mark><\/strong> az NR-modul\u00e1ci\u00f3 olyan hat\u00e1saira \u00e9s mechanizmusaira utalnak, amelyek vagy ellentmond\u00e1sosak, vagy m\u00e9g nem el\u00e9gg\u00e9 \u00e9rt\u00e9keltek.<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5.jpg\"><img decoding=\"async\" loading=\"lazy\" width=\"800\" height=\"431\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5.jpg\" alt=\"\" class=\"wp-image-20244\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5.jpg 800w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5-300x162.jpg 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5-768x414.jpg 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5-18x10.jpg 18w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/1-s20-s092544392100168x-gr5-100x54.jpg 100w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>K\u00e9sz\u00fclt <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Az utols\u00f3 \u00e1bra az NR-modul\u00e1torok molekul\u00e1ris hat\u00e1sait mutatja be, mint a m\u00e1jfibr\u00f3zis lehets\u00e9ges kezel\u00e9s\u00e9t, amelyek a jelent\u00e9sek szerint els\u0151sorban a HSC-kben jelentkeznek.<\/p>\n\n\n\n<p>K\u00f6nigshofer \u00e9s munkat\u00e1rsai azt javasolj\u00e1k, hogy a nukle\u00e1ris receptorokkal kapcsolatos jel\u00e1tvitel tov\u00e1bbi kutat\u00e1sa a m\u00e1jbetegs\u00e9gben szenved\u0151 betegek sz\u00e1m\u00e1ra hat\u00e9kony antifibrotikus ter\u00e1pi\u00e1k klinikai kifejleszt\u00e9s\u00e9hez vezethet.<\/p>\n\n\n\n<h2><strong>Pap\u00edrok hat\u00e1sa \u00e9s teljes\u00edtm\u00e9nye<\/strong><\/h2>\n\n\n\n<p>Ha a metrik\u00e1k 1 \u00e9ves \u00f6sszehasonl\u00edt\u00e1s\u00e1t v\u00e1lasztjuk m\u00e1s olyan cikkekkel\/\u00e9rt\u00e9kel\u00e9sekkel, amelyeket ugyanabban a napt\u00e1ri \u00e9vben szint\u00e9n az adott foly\u00f3iratban tettek k\u00f6zz\u00e9, akkor meg\u00e1llap\u00edthatjuk, hogy <strong>ezt a cikket t\u00f6bbsz\u00f6r id\u00e9zt\u00e9k, mint 57% k\u00f6z\u00fcl\u00fck<\/strong>.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/Nuclear-receptors.png\"><img decoding=\"async\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/Nuclear-receptors.png\" alt=\"\" class=\"wp-image-20247\"\/><\/a><figcaption class=\"wp-element-caption\"><em>Forr\u00e1s <a href=\"https:\/\/plu.mx\/plum\/a\/?doi=10.1016\/j.bbadis.2021.166235&amp;theme=plum-sciencedirect-theme&amp;hideUsage=true\" target=\"_blank\" rel=\"noreferrer noopener\">PlumX<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Haszn\u00e1lja ki az infografik\u00e1k erej\u00e9t a cikkei fellend\u00edt\u00e9s\u00e9re is. Pr\u00f3b\u00e1lja ki az Mind the Graph-t!<\/p>\n\n\n\n<div class=\"is-layout-flex wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"https:\/\/mindthegraph.com\/app\/auth\/register?from_url=\/\" style=\"border-radius:100px;background-color:#dc1866\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Pr\u00f3b\u00e1lja ki az Mind the Graph-t<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Ez a cikk tudom\u00e1nyos illusztr\u00e1ci\u00f3kat tartalmaz az Mind the Graph seg\u00edts\u00e9g\u00e9vel a nukle\u00e1ris receptorok m\u00e1jfibr\u00f3zisban val\u00f3 \u00e1br\u00e1zol\u00e1s\u00e1ra.<\/p>","protected":false},"author":29,"featured_media":20044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Nuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/hu\/success-case-nuclear-receptors-in-liber-fibrosis\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/hu\/success-case-nuclear-receptors-in-liber-fibrosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-16T22:40:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nuclear receptors in liver fibrosis Paper Review - 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