{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/hu\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/","title":{"rendered":"Nagy felbont\u00e1s\u00fa szinkrotron-alap\u00fa r\u00f6ntgen-mikrotomogr\u00e1fia, mint az agy h\u00e1romdimenzi\u00f3s neuron\u00e1lis architekt\u00far\u00e1j\u00e1nak felt\u00e1r\u00e1s\u00e1nak eszk\u00f6ze Paper Review"},"content":{"rendered":"

A r\u00f6ntgen-mikrotomogr\u00e1fia \u00faj m\u00f3dszerr\u00e9 v\u00e1lt az agy citoarchitekt\u00far\u00e1j\u00e1nak \u00e9s konnektivit\u00e1s\u00e1nak megfejt\u00e9s\u00e9re, \u00e9s itt bemutatunk egy olyan m\u00f3dszert, amellyel teljes neuronok k\u00e9palkot\u00e1sa lehets\u00e9ges.<\/p>\n\n\n\n

Nagy felbont\u00e1s\u00fa szinkrotron-alap\u00fa r\u00f6ntgen-mikrotomogr\u00e1fia, mint az agy h\u00e1romdimenzi\u00f3s neuron\u00e1lis architekt\u00far\u00e1j\u00e1nak felt\u00e1r\u00e1s\u00e1nak eszk\u00f6ze<\/strong><\/h2>\n\n\n\n

A \"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain\" (Nagyfelbont\u00e1s\u00fa szinkrotron-alap\u00fa r\u00f6ntgen-mikro-tomogr\u00e1fia mint az agy h\u00e1romdimenzi\u00f3s neuron\u00e1lis architekt\u00far\u00e1j\u00e1nak felt\u00e1r\u00e1s\u00e1nak eszk\u00f6ze) c\u00edm\u0171 tanulm\u00e1ny\u00e1ban Matheus de Castro Fonseca \u00e9s munkat\u00e1rsai (2018) megjegyezt\u00e9k, hogy a neuronok mint individualiz\u00e1lt egys\u00e9gek tanulm\u00e1nyoz\u00e1sa a 19. sz\u00e1zadban kezd\u0151d\u00f6tt a neuron-tan megalkot\u00e1s\u00e1val. <\/p>\n\n\n\n

Az elm\u00falt n\u00e9h\u00e1ny \u00e9vben nagy er\u0151fesz\u00edt\u00e9seket tettek a neuron\u00e1lis szervez\u0151d\u00e9s \u00e9s \u00f6sszekapcsol\u00f3d\u00e1s meg\u00e9rt\u00e9s\u00e9re \u00e9p agyi mint\u00e1kban. A Golgi-Cox jel\u00f6l\u00e9si technika megfelel\u0151 kontrasztot k\u00edn\u00e1l az idegsejtek specifikus jel\u00f6l\u00e9s\u00e9re a r\u00f6ntgen-mikrotomogr\u00e1fi\u00e1hoz. <\/p>\n\n\n\n

Az idegsejteknek hat\u00e1rozott morfol\u00f3gi\u00e1juk \u00e9s specifikus kapcsol\u00f3d\u00e1si mint\u00e1ik vannak, amelyek elengedhetetlenek a megfelel\u0151 m\u0171k\u00f6d\u00e9s\u00fckh\u00f6z. A kutat\u00f3k egy olyan k\u00e9palkot\u00e1si m\u00f3dszert mutatnak be, amely a szinkrotron-alap\u00fa r\u00f6ntgen-mikrotomogr\u00e1fi\u00e1t a Golgi-Cox impregn\u00e1l\u00e1si protokollal kombin\u00e1lja. <\/p>\n\n\n\n

A m\u00f3dszer nagyobb \u00e9s homog\u00e9nebb kontrasztot biztos\u00edt a sz\u00f6veten bel\u00fcl viszonylag ritk\u00e1n eloszl\u00f3 teljes neuronok sz\u00e1m\u00e1ra.<\/p>\n\n\n\n

Az agyakat f\u00e9nyt\u0151l v\u00e9dve 14 napig Golgi-Cox fest\u0151oldatban inkub\u00e1ltuk. Az inkub\u00e1ci\u00f3s id\u0151szakot k\u00f6vet\u0151en az agyakat vibrat\u00f3m seg\u00edts\u00e9g\u00e9vel sorozatosan metszett\u00fck.<\/strong><\/p>\n\n\n\n

Ellen\u0151rizze a eredeti cikk itt<\/a>.<\/p>\n\n\n\n

Grafikus absztrakt az Mind the Graph seg\u00edts\u00e9g\u00e9vel<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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\"\"<\/a>
K\u00e9sz\u00fclt Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

A szerz\u0151 a Mind the Graph<\/a> egy olyan sematikus \u00e1bra elk\u00e9sz\u00edt\u00e9s\u00e9hez, amely egy feln\u0151tt egeret \u00e1br\u00e1zol, amelybe i.p. s\u00f3oldatot vagy pilokarpin oldatot (280 mg\/kg) fecskendeznek. Az \u00f6sszetett folyamatok infografik\u00e1kkal val\u00f3 \u00e1br\u00e1zol\u00e1sa j\u00f3 m\u00f3dja annak, hogy k\u00f6nnyen \u00e9rthet\u0151v\u00e9 tegy\u00fck azokat, an\u00e9lk\u00fcl, hogy a r\u00e9szleteket \u00e9s a d\u00f6nt\u0151 fontoss\u00e1g\u00fa inform\u00e1ci\u00f3kat f\u00e9lretenn\u00e9nk.<\/p>\n\n\n\n

A kutat\u00f3k egyes eredm\u00e9nyei meger\u0151s\u00edteni l\u00e1tszanak azt, amit kor\u00e1bban m\u00e1r tudtak err\u0151l a ter\u00fcletr\u0151l: \"Az itt bemutatott higanyalap\u00fa neuronimpregn\u00e1l\u00e1s lehet\u0151v\u00e9 tette sz\u00e1munkra, hogy egy\u00e9rtelm\u0171en meghat\u00e1rozzuk a teljes neuronokat, els\u0151sorban a sejtek folyamatosabb \u00e9s homog\u00e9nebb impregn\u00e1l\u00e1sa \u00e9s a m\u0171term\u00e9kek sokkal kisebb s\u0171r\u0171s\u00e9ge miatt\" - javasolta de Castro Fonseca.<\/p>\n\n\n\n

Pap\u00edrok hat\u00e1sa \u00e9s teljes\u00edtm\u00e9nye<\/strong><\/h2>\n\n\n\n

Elemezhetj\u00fck a Altmetric<\/a> adatok, hogy a lap online figyelem pontsz\u00e1ma magasabb mint a 64%<\/strong><\/strong> a Scientific Reports \u00f6sszes t\u00f6bbi hasonl\u00f3 kor\u00fa cikk\u00e9t.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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Forr\u00e1s Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Jav\u00edtsa cikke el\u00e9rhet\u0151s\u00e9g\u00e9t az infografik\u00e1k erej\u00e9vel is.<\/p>\n\n\n\n

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Pr\u00f3b\u00e1lja ki az Mind the Graph-t<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Tekintse meg az agy citoarchitekt\u00far\u00e1j\u00e1nak \u00e9s konnektivit\u00e1s\u00e1nak megfejt\u00e9s\u00e9re szolg\u00e1l\u00f3 \u00faj m\u00f3dszert, amelyet az Mind the Graph illusztr\u00e1ci\u00f3i mutatnak be.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/hu\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/hu\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-08T21:14:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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