{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/hu\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"A Zika-v\u00edrus szaporodik a feln\u0151tt emberi agysz\u00f6vetben, \u00e9s k\u00e1ros\u00edtja a szinapszisokat \u00e9s a mem\u00f3ri\u00e1t egerekben Paper Review"},"content":{"rendered":"

A ZIKV egy vesz\u00e9lyes v\u00edrus, amely puszt\u00edt a vil\u00e1gon. Ez\u00e9rt ebben az esetben a szerz\u0151 a feln\u0151tt emberi agyban val\u00f3 szaporod\u00e1s\u00e1t tanulm\u00e1nyozza.<\/p>\n\n\n\n

A Zika-v\u00edrus (ZIKV) megfert\u0151zi a feln\u0151tt agysz\u00f6vetet \u00e9s mem\u00f3riazavart okoz egerekben<\/strong><\/h2>\n\n\n\n

A Gy\u00f3gyszer\u00e9sztudom\u00e1nyi Kar Claudia Figueiredo (2019) \u00e1ltal vezetett csoportja azt vizsg\u00e1lta, hogyan szaporodik a zikav\u00edrus feln\u0151tt emberi agysz\u00f6vetben, \u00e9s hogyan k\u00e1ros\u00edtja a szinapszisokat \u00e9s a mem\u00f3ri\u00e1t egerekben. A zikav\u00edrus a Flaviviridae csal\u00e1dba tartoz\u00f3 arbov\u00edrus, amely a k\u00f6zelm\u00faltban Latin-Amerik\u00e1ban kit\u00f6rt nagy j\u00e1rv\u00e1ny\u00e9rt felel\u0151s. <\/p>\n\n\n\n

A ZIKV-t feln\u0151tt betegek agy\u00e1ban \u00e9s liquorj\u00e1ban is kimutatt\u00e1k. Az NS2B immunreaktivit\u00e1s kolokaliz\u00e1l\u00f3dott a NeuN-immunreakt\u00edv sejtekkel, de nem a GFAP-pal vagy az F4\/80-zal, ami arra utal, hogy a ZikV az \u00e9rett emberi sz\u00f6vetekben a neuronokat c\u00e9lozza meg. A ZIKV intracerebroventrikul\u00e1ris inf\u00fazi\u00f3j\u00e1val fert\u0151z\u00f6tt feln\u0151tt immunkompetens egerekben a ZikV RNS magas szintj\u00e9t mutatt\u00e1k ki a front\u00e1lis k\u00e9regben \u00e9s a hippokampuszban, \u00e9s az \u00e9rett neuronok a f\u0151 fert\u0151z\u00f6tt sejtt\u00edpus. <\/p>\n\n\n\n

A TNF-\u03b1 emelkedett agyi szintje, intenz\u00edv mikrogli\u00f3zis, a komplementrendszer feh\u00e9rj\u00e9inek (C1q \u00e9s C3) szab\u00e1lyozott expresszi\u00f3ja \u00e9s a hippokampusz szinapszisainak k\u00e1rosod\u00e1sa igazolt.<\/p>\n\n\n\n

A vizsg\u00e1lat 9 egyenl\u0151 kvadr\u00e1nsban zajlott.<\/strong><\/p>\n\n\n\n

Ellen\u0151rizze a eredeti cikk itt<\/a>.<\/p>\n\n\n\n

Grafikus \u00f6sszefoglal\u00f3k az Mind the Graph seg\u00edts\u00e9g\u00e9vel<\/strong><\/h2>\n\n\n\n
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K\u00e9sz\u00fclt Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Az els\u0151 \u00e1bra azt az esetet mutatja be, amikor a hum\u00e1n hal\u00e1nt\u00e9klebeny agyk\u00e9rgi sz\u00f6vetdarabokat 400 \u00b5m-es szeletekre v\u00e1gt\u00e1k, \u00e9s 4 napig tartott\u00e1k kult\u00far\u00e1ban, miel\u0151tt 1 \u00f3r\u00e1n kereszt\u00fcl ZIKV-vel (107 PFU) vagy mock m\u00e9diummal inkub\u00e1lt\u00e1k volna, majd ezt k\u00f6vet\u0151en kimost\u00e1k. <\/p>\n\n\n\n

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K\u00e9sz\u00fclt Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

A m\u00e1sodik azt mutatja, hogy a feln\u0151tt egerek 105 PFU ZIKV, UV-inaktiv\u00e1lt ZIKV vagy mock m\u00e9dium inf\u00fazi\u00f3j\u00e1t kapt\u00e1k az agyi oldalkamr\u00e1ba.<\/p>\n\n\n\n

A k\u00f6vetkeztet\u00e9sek al\u00e1t\u00e1masztani l\u00e1tszanak azt, amit kor\u00e1bban m\u00e1r tudtunk err\u0151l a t\u00e9m\u00e1r\u00f3l: \"A ZIKV a mem\u00f3ri\u00e1val kapcsolatos agyi ter\u00fcleteket veszi c\u00e9lba, f\u00fcggetlen\u00fcl att\u00f3l, hogy a fert\u0151z\u00e9s \u00fatja centr\u00e1lis vagy perif\u00e9ri\u00e1s. A v\u00edrust kimutatt\u00e1k a neurol\u00f3giai sz\u00f6v\u0151dm\u00e9nyekkel j\u00e1r\u00f3 feln\u0151tt betegek liquorj\u00e1ban\" - \u00e1ll\u00edtotta Figueiredo.<\/p>\n\n\n\n

Azt javasolj\u00e1k, hogy a ZIKV-fert\u0151z\u00e9s hossz\u00fa t\u00e1v\u00fa neurodegenerat\u00edv hat\u00e1s\u00e1nak vizsg\u00e1lat\u00e1ra ir\u00e1nyul\u00f3 j\u00f6v\u0151beli tanulm\u00e1nyok indokoltak. Az agyi diszfunkci\u00f3hoz vezet\u0151 jel\u00e1tviteli rendelleness\u00e9gek megel\u0151z\u00e9s\u00e9nek m\u00f3djainak azonos\u00edt\u00e1sa utat nyithat a s\u00falyos neurol\u00f3giai \u00e1llapotok kialakul\u00e1s\u00e1nak k\u00e9sleltet\u00e9s\u00e9re vagy megel\u0151z\u00e9s\u00e9re ir\u00e1nyul\u00f3 beavatkoz\u00e1si strat\u00e9gi\u00e1k fel\u00e9.<\/p>\n\n\n\n

Pap\u00edrok hat\u00e1sa \u00e9s teljes\u00edtm\u00e9nye<\/strong><\/h2>\n\n\n\n

Elemezhetj\u00fck a Altmetric<\/a> adatok, hogy a lap online figyelem pontsz\u00e1ma magasabb mint a 95%<\/strong><\/strong> a term\u00e9szetben tal\u00e1lhat\u00f3 \u00f6sszes t\u00f6bbi hasonl\u00f3 kor\u00fa cikkre vonatkoz\u00f3an<\/strong> Foly\u00f3iratok.<\/strong><\/p>\n\n\n\n

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Forr\u00e1s Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Haszn\u00e1lja ki az infografik\u00e1k erej\u00e9t a cikkei fellend\u00edt\u00e9s\u00e9re is! Ind\u00edtson el egy alkot\u00e1st az Mind the Graph-n\u00e9l.<\/p>\n\n\n\n

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Pr\u00f3b\u00e1lja ki az Mind the Graph-t<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

A tanulm\u00e1ny a ZIKV-r\u0151l sz\u00f3l a feln\u0151tt emberi agyban, a vesz\u00e9lyes v\u00edrusr\u00f3l, amely a vil\u00e1gon puszt\u00edt. Az elj\u00e1r\u00e1s Mind the Graph illusztr\u00e1ci\u00f3kat haszn\u00e1l.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/hu\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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