{"id":12274,"date":"2021-02-10T09:13:00","date_gmt":"2021-02-10T11:13:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12274"},"modified":"2023-01-05T13:46:34","modified_gmt":"2023-01-05T16:46:34","slug":"cannabis-and-body-pain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/hu\/cannabis-and-body-pain\/","title":{"rendered":"Cannabis \u00e9s testf\u00e1jdalom"},"content":{"rendered":"

Az elm\u00falt \u00e9vtizedben sz\u00e1mos klinikai vizsg\u00e1lat sz\u00e1molt be pozit\u00edv \u00e9s \u00edg\u00e9retes eredm\u00e9nyekr\u0151l a kannabiszalap\u00fa gy\u00f3gyszerek neurop\u00e1ti\u00e1s f\u00e1jdalom kezel\u00e9s\u00e9re t\u00f6rt\u00e9n\u0151 alkalmaz\u00e1s\u00e1val kapcsolatban. <\/p>\n\n\n\n

A cukorbetegs\u00e9ggel, kemoter\u00e1pi\u00e1val, sclerosis multiplexszel, fibromyalgia, osteoarthritis \u00e9s sz\u00e1mos m\u00e1s betegs\u00e9ggel kapcsolatos f\u00e1jdalomcsillap\u00edt\u00e1st is kezeltek m\u00e1r Cannabisszal. <\/p>\n\n\n\n

\u00dagy t\u0171nik, hogy kapcsolat van az exog\u00e9n kannabinoidok \u00e9s az opioid receptorok k\u00f6z\u00f6tt, ami a betegek f\u00e1jdalom\u00e9rzet\u00e9nek n\u00f6veked\u00e9s\u00e9t eredm\u00e9nyezi - a f\u00e1jdalom\u00e9rz\u00e9s k\u00e9ptelens\u00e9g\u00e9t. <\/p>\n\n\n\n

Azokn\u00e1l a betegekn\u00e9l, akiket opioidokkal \u00e9s kannabiszalap\u00fa gy\u00f3gyszerekkel egy\u00fctt kezelnek, szinergikus gy\u00f3gyszerhat\u00e1s jelentkezik, ahol az opioidok hat\u00e9konys\u00e1g\u00e1t a kannabisz n\u00f6v\u00e9ny f\u0151 pszichoakt\u00edv molekul\u00e1ja, a tetrahidrokannabinol - THC - n\u00f6veli. <\/p>\n\n\n\n

A tud\u00f3sok pozit\u00edvan tekintenek ezekre az eredm\u00e9nyekre, mivel az opioidok gy\u00f3gyszeradagj\u00e1nak cs\u00f6kkent\u00e9s\u00e9re van lehet\u0151s\u00e9g, ami a f\u00e1jdalomt\u00f3l szenved\u0151 betegek \u00e9letmin\u0151s\u00e9g\u00e9nek javul\u00e1s\u00e1hoz vezet.<\/p>\n\n\n\n

Az endokannabinoid rendszer, hasonl\u00f3an m\u00e1s anyagcserep\u00e1ly\u00e1khoz, nem egy elszigetelt rendszere az emberi szervezetnek, befoly\u00e1solhatja \u00e9s befoly\u00e1solhat\u00f3 m\u00e1s jel\u00e1tviteli p\u00e1ly\u00e1k \u00e1ltal, ezek k\u00f6z\u00fcl az egyik nyilv\u00e1nval\u00f3an az opioidokhoz \u00e9s receptoraihoz kapcsol\u00f3dik. <\/p>\n\n\n\n

Az opioidreceptorok a f\u00e1jdalom\u00e9rzet jelz\u00e9se mellett szerepet j\u00e1tszanak a test bizonyos funkci\u00f3inak modul\u00e1l\u00e1s\u00e1ban is, mint p\u00e9ld\u00e1ul a h\u0151szab\u00e1lyoz\u00e1s, a hormon\u00e1lis stabilit\u00e1s, a f\u00e1jdalomcsillap\u00edt\u00f3 aktivit\u00e1s stb. <\/p>\n\n\n\n

Mind a kannabinoid-, mind az opioidreceptorok a G-feh\u00e9rje-csatolt receptorok csal\u00e1dj\u00e1ba tartoznak, amelyek olyan feh\u00e9rj\u00e9k, amelyek k\u00e9pesek befoly\u00e1solni a f\u00e1jdalom terjed\u00e9s\u00e9\u00e9rt felel\u0151s neurotranszmisszi\u00f3t az agyban \u00e9s a gerincvel\u0151ben. <\/p>\n\n\n\n

A kr\u00f3nikus f\u00e1jdalommal k\u00fczd\u0151 betegek kezel\u00e9se \u00e1ltal\u00e1ban fokozatosan n\u00f6vekv\u0151 opioidd\u00f3zisok szed\u00e9s\u00e9t jelenti, ami gyakran nemk\u00edv\u00e1natos mell\u00e9khat\u00e1sokkal j\u00e1r, mint p\u00e9ld\u00e1ul nyugtat\u00e1s, l\u00e9gz\u00e9si zavarok \u00e9s sz\u00e9kreked\u00e9s. <\/p>\n\n\n\n

Egy id\u0151 ut\u00e1n a betegekn\u00e9l tolerancia \u00e9s rezisztencia alakul ki az opioid adagol\u00e1ssal szemben, nem \u00e9rik el a ter\u00e1pi\u00e1s hat\u00e1st, \u00edgy az orvosok k\u00e9nytelenek ism\u00e9telten n\u00f6velni az adagot, hogy ugyanazt a f\u00e1jdalomcsillap\u00edt\u00e1si szintet \u00e9rj\u00e9k el.<\/p>\n\n\n\n

A THC magas d\u00f3zisa \u00f6nmag\u00e1ban f\u00e1jdalomcsillap\u00edt\u00f3 hat\u00e1s\u00fanak tekinthet\u0151, de \u00e1ltal\u00e1ban nemk\u00edv\u00e1natos mell\u00e9khat\u00e1sok k\u00f6vetik, mint p\u00e9ld\u00e1ul szorong\u00e1s, fejf\u00e1j\u00e1s, sz\u00e1jsz\u00e1razs\u00e1g, sz\u00e9d\u00fcl\u00e9s, euf\u00f3ria \u00e9s tachycardia, m\u00edg az alacsony d\u00f3zisok egy\u00e1ltal\u00e1n nem fejtenek ki f\u00e1jdalomcsillap\u00edt\u00f3 hat\u00e1st. <\/p>\n\n\n\n

Opioidokkal kombin\u00e1lva azonban ez a hat\u00e1s teljesen megv\u00e1ltozhat.<\/p>\n\n\n\n

\u00c1llatmodelleken v\u00e9gzett vizsg\u00e1latok kimutatt\u00e1k, hogy az exog\u00e9n kannabinoidok, mint p\u00e9ld\u00e1ul a THC, n\u00f6velhetik az opioid gy\u00f3gyszerek, p\u00e9ld\u00e1ul a morfium hat\u00e9konys\u00e1g\u00e1t. <\/p>\n\n\n\n

\u00dagy t\u0171nik, hogy a THC f\u00e1jdalomcsillap\u00edt\u00f3 hat\u00e1sa az opioidreceptorokon kereszt\u00fcl k\u00f6zvet\u00edt, a kannabinoidok \u00e9s az opioidok jel\u00e1tviteli \u00fatvonalai k\u00f6z\u00f6tti keresztk\u00f6lcs\u00f6nhat\u00e1s r\u00e9v\u00e9n. <\/p>\n\n\n\n

A kannabiszkutat\u00f3k arr\u00f3l sz\u00e1molnak be, hogy a THC bead\u00e1sa serkentheti a szervezetben az endog\u00e9n opioid peptidek termel\u00e9s\u00e9t, amelyek v\u00e9g\u00fcl a m\u00e1r ismert opioid receptorokhoz - delta \u00e9s kappa - k\u00f6t\u0151dnek, k\u00f6zvet\u00edtve a kannabinoid hat\u00e1st. <\/p>\n\n\n\n

Egy harmadik opioid receptor, a mu szint\u00e9n aktiv\u00e1l\u00f3dik, amikor morfiumot adnak neki. E h\u00e1rom opioidreceptor aktiv\u00e1l\u00e1sa lehet a magyar\u00e1zata az antinocicept\u00edv hat\u00e1s - a f\u00e1jdalomcsillap\u00edt\u00e1s azon folyamata, amely blokkolja a f\u00e1jdalmas inger \u00e9szlel\u00e9s\u00e9t - hat\u00e9konys\u00e1g\u00e1nak n\u00f6veked\u00e9s\u00e9nek a csak morfiummal vagy THC-vel v\u00e9gzett kezel\u00e9sek eredm\u00e9nyeihez k\u00e9pest.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

A a Life Sciences foly\u00f3iratban 2004-ben megjelent tanulm\u00e1ny<\/a> meger\u0151s\u00edtette a THC \u00e9s a morfium k\u00f6z\u00f6tti kapcsolatot az opioidreceptor g\u00e1tl\u00e1s\u00e1val, specifikus molekul\u00e1k seg\u00edts\u00e9g\u00e9vel. <\/p>\n\n\n\n

A blokkol\u00f3 molekul\u00e1k jelenl\u00e9te a morfium hat\u00e9konys\u00e1g\u00e1nak cs\u00f6kken\u00e9s\u00e9t eredm\u00e9nyezte, \u00e9s ezzel egy\u00fctt a morfium ter\u00e1pi\u00e1s hat\u00e1s\u00e1t is. <\/p>\n\n\n\n

Ez az eredm\u00e9ny meger\u0151s\u00edti, hogy e receptorok el\u00e9rhet\u0151s\u00e9ge \u00e9s aktiv\u00e1l\u00e1sa mennyire fontos a morfium - \u00e9s a THC - kezel\u00e9s hat\u00e9konys\u00e1ga szempontj\u00e1b\u00f3l. Egy m\u00e1sik k\u00eds\u00e9rlet, amelyet Naloxonnal - egy opioid antagonist\u00e1val - v\u00e9geztek, blokkolta a THC aktivit\u00e1s\u00e1t az agy k\u00fcl\u00f6nb\u00f6z\u0151 r\u00e9gi\u00f3iban, mint a ventr\u00e1lis tegment\u00e1lis ter\u00fclet, a hipotalamusz \u00e9s a periaqueductalis sz\u00fcrke\u00e1llom\u00e1ny (PAG), ami arra utal, hogy ezek a r\u00e9gi\u00f3k valamilyen m\u00f3don fontosak az opioid-kannabinoid k\u00f6lcs\u00f6nhat\u00e1s szempontj\u00e1b\u00f3l. <\/p>\n\n\n\n

A tanulm\u00e1ny arr\u00f3l is besz\u00e1mol, hogy az egerek alacsony d\u00f3zis\u00fa THC-vel \u00e9s morfinnal t\u00f6rt\u00e9n\u0151 egy\u00fcttes kezel\u00e9se nem vezetett opioid-toleranci\u00e1hoz.<\/p>\n\n\n\n

Ez a tanulm\u00e1ny \u00e9s sz\u00e1mos m\u00e1s tanulm\u00e1ny is megjelent, amelyek al\u00e1t\u00e1masztj\u00e1k azt az elk\u00e9pzel\u00e9st, hogy a kannabinoidok kombin\u00e1ci\u00f3ban n\u00f6velhetik az opioidok hat\u00e1s\u00e1t. <\/p>\n\n\n\n

A kannabinoidok nyilv\u00e1nval\u00f3an megv\u00e1ltoztathatj\u00e1k az opioidok toleranci\u00e1j\u00e1t \u00e9s f\u00fcgg\u0151s\u00e9g\u00e9t is. <\/p>\n\n\n\n

Az opioidok hossz\u00fa t\u00e1v\u00fa haszn\u00e1lata \u00e1ltal\u00e1ban a betegek f\u00fcgg\u0151s\u00e9g\u00e9vel j\u00e1r, ami az eredetileg csak ter\u00e1pi\u00e1s c\u00e9llal haszn\u00e1lt anyaggal val\u00f3 vissza\u00e9l\u00e9shez vezet. <\/p>\n\n\n\n

Ez\u00e9rt a kannabinoid-opioid - p\u00e9ld\u00e1ul a THC \u00e9s a morfium - kombin\u00e1ci\u00f3ja a kombin\u00e1lt ter\u00e1pia \u00faj f\u00e1jdalomcsillap\u00edt\u00e1si strat\u00e9gi\u00e1j\u00e1v\u00e1 v\u00e1lhat, lehet\u0151v\u00e9 t\u00e9ve az orvosok sz\u00e1m\u00e1ra, hogy cs\u00f6kkents\u00e9k betegeik magas opioidd\u00f3zis\u00e1t, \u00e9s cs\u00f6kkents\u00e9k a betegek opioidokkal val\u00f3 vissza\u00e9l\u00e9s\u00e9t \u00e9s f\u00fcgg\u0151s\u00e9g\u00e9t. <\/p>\n\n\n\n

Az endog\u00e9n opioidokat stimul\u00e1l\u00f3 kannabinoidok elm\u00e9lete mellett a kannabinoid-opioid k\u00f6lcs\u00f6nhat\u00e1si rendszer r\u00e9szletes mechanizmusa m\u00e9g mindig tiszt\u00e1zatlan. <\/p>\n\n\n\n

A hipot\u00e9zis, amely a lehets\u00e9ges hat\u00e1smechanizmust pr\u00f3b\u00e1lja megmagyar\u00e1zni, az, hogy a kannabinoidok tal\u00e1n az opioid peptidek szint\u00e9zis\u00e9t vagy felszabadul\u00e1s\u00e1t - mindkett\u0151t - induk\u00e1lj\u00e1k, n\u00f6velve az aktiv\u00e1lt opioid receptorok sz\u00e1m\u00e1t, ami a f\u00e1jdalomcsillap\u00edt\u00f3 szinteket eredm\u00e9nyezi. <\/p>\n\n\n\n

Annak tiszt\u00e1z\u00e1sa, hogy mely peptidek vesznek r\u00e9szt ebben a folyamatban, szint\u00e9n nem egy\u00e9rtelm\u0171 vagy ismert, ez\u00e9rt a tud\u00f3sok sz\u00e1m\u00e1ra kulcsfontoss\u00e1g\u00fa lenne, hogy teljes m\u00e9rt\u00e9kben meg\u00e9rts\u00e9k e molekul\u00e1k szerkezet\u00e9t, \u00e9s hogy a kannabinoidok hogyan haszn\u00e1lhat\u00f3k f\u00e1jdalomcsillap\u00edt\u00f3 hat\u00e1s kiv\u00e1lt\u00e1s\u00e1ra, az opioidf\u00fcgg\u0151s\u00e9g kezel\u00e9s\u00e9n t\u00falmen\u0151en. <\/p>\n\n\n\n

A kannabinoidok azonban \u00e1ltal\u00e1ban v\u00e9ve meglep\u0151 eredm\u00e9nyeket mutatnak, \u00e9s folyamatosan teret nyernek az eg\u00e9szs\u00e9g\u00fcgyi szakemberek k\u00f6r\u00e9ben, bizony\u00edtva alternat\u00edv gy\u00f3gy\u00e1szati potenci\u00e1ljukat. <\/p>\n\n\n\n

Sz\u00e1mos tov\u00e1bbi tanulm\u00e1nyra van sz\u00fcks\u00e9g ahhoz, hogy a kutat\u00f3k teljes m\u00e9rt\u00e9kben meg\u00e9rts\u00e9k a kannabisz-alap\u00fa gy\u00f3gyszerek val\u00f3di el\u0151nyeit \u00e9s lehet\u0151s\u00e9geit az emberi szervezet sz\u00e1m\u00e1ra, \u00e9s hogy hogyan lehet a kannabisz n\u00f6v\u00e9nyt a lehet\u0151 legjobban alkalmazni kezel\u00e9sk\u00e9nt.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Tetszett a cikkben tal\u00e1lhat\u00f3 infografika? Minden ikonok<\/a> az ebben a cikkben haszn\u00e1lt - \u00e9s m\u00e9g sok m\u00e1s - az Mind the Graph-ben \u00e9rhet\u0151 el. A rendelkez\u00e9sre \u00e1ll\u00f3 illusztr\u00e1ci\u00f3kat megtekintheti a gal\u00e9ria<\/a>.<\/p>\n\n\n\n

\u00c9s nem kell a null\u00e1r\u00f3l kezdenie az infografik\u00e1t, szerkeszthet\u0151 infografika-sablonokat k\u00edn\u00e1lunk felhaszn\u00e1l\u00f3inknak, \u00edgy nem kell \u00fcres v\u00e1szonr\u00f3l kezdeni\u00fck. Itt l\u00e1that infografikai sablonokat.<\/a><\/p>\n\n\n\n

Lehet szenior el\u0151fizet\u00e9sed is, \u00e9s korl\u00e1tlan sz\u00e1mokat hozhatsz l\u00e9tre, kattintson ide az indul\u00e1shoz<\/a>!<\/p>\n\n\n\n

Hivatkoz\u00e1sok <\/strong><\/p>\n\n\n\n

BROWN, J. D.; WINTERSTEIN, A. G. Az orvosi \u00e9s fogyaszt\u00f3i kannabidiol (CBD) haszn\u00e1lat\u00e1nak lehets\u00e9ges mell\u00e9khat\u00e1sai \u00e9s gy\u00f3gyszer-gy\u00f3gyszer k\u00f6lcs\u00f6nhat\u00e1sai. Journal of Clinical Medicine, v. 8, n. 7, 2019. j\u00fal. 8.<\/p>\n\n\n\n

CICHEWICZ, D. L. A kannabinoid \u00e9s az opioid analgetikumok k\u00f6z\u00f6tti szinergisztikus k\u00f6lcs\u00f6nhat\u00e1sok. Life Sciences, v. 74, n. 11, p. 1317-1324, 2004. jan. 30.<\/p>\n\n\n\n

HANEY, M.; BISAGA, A.; FOLTIN, R. W. A naltrexon \u00e9s az or\u00e1lis THC k\u00f6lcs\u00f6nhat\u00e1sa er\u0151s marihu\u00e1na doh\u00e1nyosokn\u00e1l. Psychopharmacology, v. 166, n. 1, p. 77-85, 2003. fev. 1.<\/p>\n\n\n\n

KUHLEN, M. et al. A spaszticit\u00e1s hat\u00e9kony kezel\u00e9se dronabinollal a gyermekpalliat\u00edv ell\u00e1t\u00e1sban. European Journal of Paediatric Neurology, v. 20, n. 6, p. 898-903, 2016. nov. 1.<\/p>\n\n\n\n

L\u00d6TSCH, J. et al. Gy\u00f3gyszerk\u00f6lcs\u00f6nhat\u00e1sok a betegvez\u00e9relt f\u00e1jdalomcsillap\u00edt\u00e1ssal. Clinical Pharmacokinetics, v. 41, n. 1, p. 31-57, 2002. jan. 1.<\/p>\n\n\n\n

LYNCH, M. E.; CLARK, A. J. A kannabisz cs\u00f6kkenti az opioidd\u00f3zist a kr\u00f3nikus, nem r\u00e1kos f\u00e1jdalom kezel\u00e9s\u00e9ben. Journal of Pain and Symptom Management, v. 25, n. 6, p. 496-498, 2003. j\u00fan. 1.<\/p>\n\n\n\n

MANZANARES, J. et al. Az opioidok \u00e9s a kannabinoidok k\u00f6z\u00f6tti farmakol\u00f3giai \u00e9s biok\u00e9miai k\u00f6lcs\u00f6nhat\u00e1sok. Trends in Pharmacological Sciences, v. 20, n. 7, p. 287-294, 1999. j\u00fal. 1.<\/p>\n\n\n\n

WAKLEY, A. A.; CRAFT, R. M. THC-metadon \u00e9s THC-naltrexon k\u00f6lcs\u00f6nhat\u00e1sok a megk\u00fcl\u00f6nb\u00f6ztet\u00e9sre, az antinocicepci\u00f3ra \u00e9s a mozg\u00e1sra patk\u00e1nyokban. Behavioural Pharmacology, v. 22, n. 5 \u00e9s 6, p. 489-497, set. 2011.<\/p>\n\n\n\n

WELCH, S. P. A kannabinoid- \u00e9s az opioidrendszer k\u00f6lcs\u00f6nhat\u00e1sa a nocicepci\u00f3 modul\u00e1ci\u00f3j\u00e1ban. International Review of Psychiatry, v. 21, n. 2, p. 143-151, 1 jan. 2009. jan. 1.<\/p>","protected":false},"excerpt":{"rendered":"

Az elm\u00falt \u00e9vtizedben sz\u00e1mos klinikai vizsg\u00e1lat sz\u00e1molt be pozit\u00edv \u00e9s \u00edg\u00e9retes eredm\u00e9nyekr\u0151l a kannabiszalap\u00fa gy\u00f3gyszerek neurop\u00e1ti\u00e1s f\u00e1jdalom kezel\u00e9s\u00e9re t\u00f6rt\u00e9n\u0151 alkalmaz\u00e1s\u00e1val kapcsolatban. A cukorbetegs\u00e9ggel, kemoter\u00e1pi\u00e1val, szkler\u00f3zis multiplexszel, fibromyalgi\u00e1val, osteoarthritisszel \u00e9s sz\u00e1mos m\u00e1s betegs\u00e9ggel kapcsolatos f\u00e1jdalomcsillap\u00edt\u00e1st is kezeltek m\u00e1r Cannabisszal. \u00dagy t\u0171nik, hogy kapcsolat van az exog\u00e9n kannabinoidok \u00e9s az opioid receptorok k\u00f6z\u00f6tt, ami [...]<\/p>","protected":false},"author":4,"featured_media":12276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[819,51,554],"yoast_head":"\nCannabis and Body Pain - MTG<\/title>\n<meta name=\"description\" content=\"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/hu\/cannabis-and-body-pain\/\" \/>\n<meta property=\"og:locale\" content=\"hu_HU\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cannabis and Body Pain - MTG\" \/>\n<meta property=\"og:description\" content=\"Do you want to know cannabis can impact the body pain? 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