{"id":12192,"date":"2021-01-27T10:46:16","date_gmt":"2021-01-27T12:46:16","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12192"},"modified":"2023-01-05T14:40:18","modified_gmt":"2023-01-05T17:40:18","slug":"cannabis-and-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/hu\/cannabis-and-alzheimers-disease\/","title":{"rendered":"Mi van odakint a kannabiszr\u00f3l \u00e9s az Alzheimer-k\u00f3rr\u00f3l?"},"content":{"rendered":"
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Az Alzheimer-k\u00f3r (AD) egy neurodegenerat\u00edv betegs\u00e9g, amely a jelenleg diagnosztiz\u00e1lt demenci\u00e1s esetek t\u00f6bb mint 50%-\u00e9\u00e9rt felel\u0151s, \u00e9s k\u00f6zvetlen\u00fcl \u00f6sszef\u00fcgg az \u00f6reged\u00e9ssel. Napjainkban a 85 \u00e9v feletti emberek 40%-\u00e9nek van valamilyen szint\u0171 demenci\u00e1ja.<\/p>\n\n\n\n

Kor\u00e1bban \u00fagy gondolt\u00e1k, hogy az Alzheimer-k\u00f3r t\u00fcnetei csak a r\u00f6vid t\u00e1v\u00fa mem\u00f3ri\u00e1t \u00e9rint\u0151 kognit\u00edv funkci\u00f3k cs\u00f6kken\u00e9s\u00e9hez kapcsol\u00f3dnak, m\u00edg a betegs\u00e9g el\u0151rehaladott st\u00e1dium\u00e1ban a beteg nyelvi k\u00e9pess\u00e9geit, s\u0151t a hossz\u00fa t\u00e1v\u00fa mem\u00f3ri\u00e1t is \u00e9rinti.<\/p>\n\n\n\n

Ma m\u00e1r azonban ismert, hogy az Alzheimer-k\u00f3rban szenved\u0151 betegek sz\u00e1mos m\u00e1s t\u00fcnetet is mutatnak, p\u00e9ld\u00e1ul depresszi\u00f3t, pszich\u00f3zist, agressz\u00edv viselked\u00e9st, ami tov\u00e1bb s\u00falyosb\u00edtja a betegs\u00e9get. <\/p>\n\n\n\n

Az elm\u00falt \u00e9vekben a kutat\u00f3k \u00e9s orvosok tanulm\u00e1nyaikban pozit\u00edv eredm\u00e9nyekr\u0151l sz\u00e1moltak be, amikor elkezdt\u00e9k kezelni Alzheimer-k\u00f3ros betegeiket kannabiszalap\u00fa gy\u00f3gyszerekkel, amelyekkel t\u00fcnetmentes\u00edt\u00e9st \u00e9rtek el.<\/p>\n\n\n\n

Az endokannabinoid rendszer alternat\u00edv megk\u00f6zel\u00edt\u00e9ss\u00e9 v\u00e1lt a k\u00fcl\u00f6nb\u00f6z\u0151 betegs\u00e9gek \u00e9s patol\u00f3gi\u00e1k kezel\u00e9s\u00e9ben, amellett, hogy sz\u00e1mos folyamatra, mint p\u00e9ld\u00e1ul a neuroplaszticit\u00e1s, neuroinflamm\u00e1ci\u00f3, viselked\u00e9si zavarok, alv\u00e1sszab\u00e1lyoz\u00e1s, immunol\u00f3giai funkci\u00f3k, gyullad\u00e1sos betegs\u00e9gek, sz\u00edv- \u00e9s \u00e9rrendszeri funkci\u00f3k, f\u00e1jdalom, motoros kontroll, energiaegyens\u00faly \u00e9s \u00e9tv\u00e1gy, hat\u00e1ssal van. <\/p>\n\n\n\n

\"\"<\/a>
F\u00e9nyk\u00e9pek Ravi Patel<\/a> a oldalon Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Sajnos m\u00e9g mindig kev\u00e9s olyan hivatalos tanulm\u00e1ny l\u00e9tezik, amely k\u00f6zvetlen\u00fcl elemzi az endokannabinoid rendszer \u00e9s az Alzheimer-k\u00f3r k\u00f6z\u00f6tti kapcsolatot.<\/p>\n\n\n\n

Ma m\u00e1r j\u00f3l ismert, hogy az Alzheimer-k\u00f3rt genetikai \u00e9s \u00f6reged\u00e9si t\u00e9nyez\u0151k okozz\u00e1k. A betegs\u00e9g f\u0151 okoz\u00f3i a k\u00f6vetkez\u0151kre vezethet\u0151k vissza szenilis plakkok<\/strong> \u00e9s a neurofibrill\u00e1ris kusza<\/strong>. <\/p>\n\n\n\n

\u00c9rdekes t\u00e9ny, hogy az Alzheimer-k\u00f3r patk\u00e1nymodellek felhaszn\u00e1l\u00e1s\u00e1val a kutat\u00f3k felfedezt\u00e9k, hogy az Alzheimer-k\u00f3r agy\u00e1ban kevesebb a CB1-receptorok sz\u00e1ma, mint az eg\u00e9szs\u00e9ges agyban - a kevesebb CB1-receptor v\u00e9gs\u0151 soron cs\u00f6kkentheti a gy\u00f3gyszer ter\u00e1pi\u00e1s hat\u00e1s\u00e1t.<\/p>\n\n\n\n

A kannabinoid-kezel\u00e9s v\u00e9d\u0151hat\u00e1st fejthet ki az oxidat\u00edv stressz \u00e9s a neuroinflamm\u00e1ci\u00f3 ellen az Alzheimer-k\u00f3rban szenved\u0151 betegek agy\u00e1ban, seg\u00edtve az amiloid plakkok \u00e9s a neurofibrill\u00e1ris csom\u00f3k kialakul\u00e1s\u00e1nak cs\u00f6kkent\u00e9s\u00e9t - k\u00e9sleltetve a betegek kognit\u00edv hanyatl\u00e1s\u00e1t. <\/p>\n\n\n\n

B\u00e1r az amiloid plakkok eg\u00e9szs\u00e9ges agyakban is megtal\u00e1lhat\u00f3k, gyakoris\u00e1guk rendk\u00edv\u00fcl alacsony az Alzheimer-k\u00f3ros agyakhoz k\u00e9pest.<\/p>\n\n\n\n

A kannabinoidok ter\u00e1pi\u00e1s hat\u00e1s\u00e1nak meg\u00e9rt\u00e9s\u00e9re ir\u00e1nyul\u00f3 tanulm\u00e1nyok felfedezt\u00e9k, hogy a THC molekula k\u00e9pes n\u00f6velni egy neurotranszmitter biol\u00f3giai hozz\u00e1f\u00e9rhet\u0151s\u00e9g\u00e9t. acetilkolin<\/strong> (Ach) lebont\u00f3 enzimj\u00e9nek g\u00e1tl\u00e1s\u00e1val acetilkolin-\u00e9szter\u00e1z<\/strong> (AChE) - Az Ach l\u00e9nyeg\u00e9ben az idegimpulzus tov\u00e1bb\u00edt\u00e1s\u00e1\u00e9rt felel\u0151s a k\u00f6vetkez\u0151 neuronhoz. <\/p>\n\n\n\n

Az AChE enzim feladata az eg\u00e9szs\u00e9ges agyban az Ach lebont\u00e1sa, azonban az Alzheimer-k\u00f3rban szenved\u0151 agyban az enzim nagym\u00e9rt\u00e9kben jelen van, \u00e9s sokkal t\u00f6bb Ach-ot bont le, mint amennyit kellene, ami id\u0151vel az agy kognit\u00edv funkci\u00f3inak hanyatl\u00e1s\u00e1t okozza.   <\/p>\n\n\n\n

A kutat\u00f3k arr\u00f3l sz\u00e1moltak be, hogy a kannabinoidok az AChE enzim g\u00e1tl\u00f3 hat\u00e1sa miatt seg\u00edthetnek - jobb v\u00e1laszokat mutattak, mint m\u00e1s, kereskedelmi forgalomban kaphat\u00f3 gy\u00f3gyszerek. <\/p>\n\n\n\n

A THC seg\u00edthet a viselked\u00e9si zavarok cs\u00f6kkent\u00e9s\u00e9ben is, \u00e9s szab\u00e1lyozza a s\u00falyos demenci\u00e1ban szenved\u0151 betegek cirkadi\u00e1n ciklus\u00e1t. Egyes tud\u00f3sok m\u00e9g azt is meger\u0151s\u00edtik, hogy a THC \u00e9s a CBD kannabinoidok potenci\u00e1lisan Alzheimer-ellenes ter\u00e1pi\u00e1k lehetnek.<\/p>\n\n\n\n

A Clinical Pharmacology and Therapeutics foly\u00f3iratban 2015-ben megjelent cikk<\/a>\u00e1ttekint\u00e9st ny\u00fajt a kannabinoidokban rejl\u0151 lehet\u0151s\u00e9gekr\u0151l a k\u00e9s\u0151i Alzheimer-k\u00f3r \u00e9s a kapcsol\u00f3d\u00f3 neuropszichi\u00e1triai t\u00fcnetek kezel\u00e9s\u00e9ben az id\u0151sekn\u00e9l, \u00e9s kit\u00e9r a kannabiszalap\u00fa gy\u00f3gyszerek hat\u00e1soss\u00e1gi, biztons\u00e1gi \u00e9s farmakokinetikai szempontjaira is.<\/p>\n\n\n\n

Egy 72 \u00e9ves Alzheimer-k\u00f3ros f\u00e9rfinak viselked\u00e9si zavara volt, mint p\u00e9ld\u00e1ul agit\u00e1ci\u00f3 \u00e9s agresszivit\u00e1s. Kor\u00e1bbi kezel\u00e9se nem mutatott jelent\u0151s javul\u00e1st. <\/p>\n\n\n\n

Amikor a p\u00e1ciens a Nabilone-t - egy szintetikus THC-gy\u00f3gyszert - kapta, hamarosan javul\u00e1st mutatott viselked\u00e9si zavaraiban \u00e9s egy\u00e9b t\u00fcneteiben, r\u00e1ad\u00e1sul a THC-alap\u00fa gy\u00f3gyszerrel val\u00f3 kezel\u00e9s sor\u00e1n nem voltak mell\u00e9khat\u00e1sai.<\/p>\n\n\n\n

\"\"<\/a>
F\u00e9nyk\u00e9pek Louis Reed<\/a> a oldalon Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Egy m\u00e1sik, tizen\u00f6t Alzheimer-k\u00f3ros betegb\u0151l \u00e1ll\u00f3 vizsg\u00e1lati csoport - \u00e1tlag\u00e9letkoruk 72 \u00e9v - a kezel\u00e9s el\u0151tt viselked\u00e9si zavarokat \u00e9s \u00e9tkez\u00e9si probl\u00e9m\u00e1kat mutatott. <\/p>\n\n\n\n

A tizen\u00f6t beteget hat h\u00e9ten kereszt\u00fcl dronabinollal - m\u00e1s n\u00e9ven Marinol - egy szintetikus THC hat\u00f3anyaggal kezelt\u00e9k. <\/p>\n\n\n\n

A kezel\u00e9s id\u0151tartama ut\u00e1n a viselked\u00e9s javul\u00e1s\u00e1t, s\u00falygyarapod\u00e1st \u00e9s a nyugtalans\u00e1g cs\u00f6kken\u00e9s\u00e9t mutatt\u00e1k be - a placeb\u00f3hoz k\u00e9pest. N\u00e9h\u00e1ny mell\u00e9khat\u00e1st is \u00e9szleltek, mint p\u00e9ld\u00e1ul f\u00e1radts\u00e1g, \u00e1lmoss\u00e1g \u00e9s euf\u00f3ria, amelyek mindegyike igazoltan a dronabinollal hozhat\u00f3 \u00f6sszef\u00fcgg\u00e9sbe.<\/p>\n\n\n\n

Egy m\u00e1sik, hat betegb\u0151l \u00e1ll\u00f3, \u00e1tlagosan 81 \u00e9ves, r\u00e9szben Alzheimer-k\u00f3rban, r\u00e9szben s\u00falyos demenci\u00e1ban szenved\u0151 csoportban k\u00e9t hetes dronabinol-kezel\u00e9st kezdtek. <\/p>\n\n\n\n

Az eredm\u00e9nyek jelent\u0151s javul\u00e1st mutattak ezen betegek \u00e9jszakai motoros tev\u00e9kenys\u00e9geiben \u00e9s jobb viselked\u00e9st. Ebben a csoportban nem \u00e9szleltek mell\u00e9khat\u00e1sokat.<\/p>\n\n\n\n

Egy m\u00e1sik vizsg\u00e1latban 40, k\u00fcl\u00f6nb\u00f6z\u0151 szint\u0171 demenci\u00e1ban szenved\u0151 betegcsoportban, k\u00f6z\u00fcl\u00fck 13 Alzheimer-k\u00f3rban szenvedett. <\/p>\n\n\n\n

Mindannyian dronabinollal kezdt\u00e9k el a kezel\u00e9st viselked\u00e9si probl\u00e9m\u00e1k \u00e9s \u00e9tv\u00e1gytalans\u00e1gok kezel\u00e9s\u00e9re. <\/p>\n\n\n\n

A kezel\u00e9s id\u0151tartama 17 nap volt, \u00e9s a betegek mindk\u00e9t szempontb\u00f3l javultak. Olyan mell\u00e9khat\u00e1sokr\u00f3l sz\u00e1moltak be, mint a szed\u00e1ci\u00f3, del\u00edrium, h\u00fagy\u00fati fert\u0151z\u00e9sek \u00e9s zavarts\u00e1g, de a kutat\u00f3k szerint ezek nem voltak k\u00f6zvetlen\u00fcl \u00f6sszef\u00fcgg\u00e9sben a dronabinol alkalmaz\u00e1s\u00e1val.<\/p>\n\n\n\n

Annak ellen\u00e9re, hogy sz\u00e1mos tanulm\u00e1ny, eredm\u00e9ny pozit\u00edv eredm\u00e9nyeket mutat a kannabinoidok alkalmaz\u00e1sa a demenci\u00e1ban szenved\u0151 betegek kezel\u00e9s\u00e9ben, egyes kutat\u00f3k azt \u00e1ll\u00edtj\u00e1k, hogy m\u00e9g mindig nincs elegend\u0151 bizony\u00edt\u00e9k annak bizony\u00edt\u00e1s\u00e1ra, hogy a kannabinoidok val\u00f3ban j\u00f3k \u00e9s biztons\u00e1gosak a viselked\u00e9si zavarok \u00e9s a demencia kezel\u00e9s\u00e9ben.<\/p>\n\n\n\n

A kutat\u00f3k egy\u00e9bk\u00e9nt egyre gyakrabban sz\u00e1molnak be a kannabiszalap\u00fa gy\u00f3gyszerek alkalmaz\u00e1s\u00e1r\u00f3l az Alzheimer-k\u00f3rban szenved\u0151 betegek kezel\u00e9s\u00e9re, \u00e9s nem csak ezt, hanem a Parkinson-k\u00f3r \u00e9s az autizmus kezel\u00e9s\u00e9ben is alkalmazz\u00e1k, az orvosok \u00e9s a tud\u00f3sok pedig arr\u00f3l sz\u00e1moltak be, hogy a kannabiszalap\u00fa gy\u00f3gyszerek szed\u00e9se ut\u00e1n javult a betegek \u00e9letmin\u0151s\u00e9ge. De ez m\u00e1r a k\u00f6vetkez\u0151 cikk t\u00e9m\u00e1ja.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

\u00d6n a neurol\u00f3gia ter\u00fclet\u00e9n dolgozik? Az Mind the Graph-ben van egy nagy neurol\u00f3giai illusztr\u00e1ci\u00f3s kateg\u00f3ria, ahol mindent megtal\u00e1l, amire sz\u00fcks\u00e9ge van neurol\u00f3giai dolgozat\u00e1hoz vagy prezent\u00e1ci\u00f3j\u00e1hoz. N\u00e9zze meg itt<\/a>.  <\/strong><\/p>\n\n\n\n

Vagy <\/strong>amit keres biok\u00e9mia <\/a>\u00e9s molekul\u00e1ris biol\u00f3gia<\/a> illusztr\u00e1ci\u00f3kat az Mind the Graph-ben is tal\u00e1lsz. <\/p>\n\n\n\n

\u00c9s mi itt vagyunk, hogy seg\u00edts\u00fcnk, ha b\u00e1rmi m\u00e1sra van sz\u00fcks\u00e9ge, csak bejelentkez\u00e9s a fi\u00f3kj\u00e1ba<\/a> \u00e9s k\u00fcldj\u00f6n nek\u00fcnk \u00fczenetet a IKON K\u00c9R\u00c9SE<\/strong>. <\/p>\n\n\n\n

Hivatkoz\u00e1sok<\/strong><\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoidok a k\u00e9s\u0151i Alzheimer-k\u00f3rban. Klinikai farmakol\u00f3gia \u00e9s ter\u00e1pia<\/strong>, v. 97, n. 6, p. 597-606, 2015.<\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoidok a k\u00e9s\u0151i Alzheimer-k\u00f3rban. Klinikai farmakol\u00f3gia \u00e9s ter\u00e1pia<\/strong>, v. 97, n. 6, p. 597-606, 2015.<\/p>\n\n\n\n

BALASH, Y. et al. Medical Cannabis in Parkinson Disease: A betegek val\u00f3s tapasztalatai. Klinikai neurofarmakol\u00f3gia<\/strong>, v. 40, n. 6, p. 268-272, 2017. december.<\/p>\n\n\n\n

BENITO, C. et al. Az endokannabinoid rendszer \u00e9s az Alzheimer-k\u00f3r. Molekul\u00e1ris neurobiol\u00f3gia<\/strong>, 36. \u00e9vfolyam, 1. sz\u00e1m, 75-81. o., 1 \u00e9vvel ezel\u0151tt. 2007.<\/p>\n\n\n\n

DE FARIA, S. M. et al. Az akut kannabidiol-adagol\u00e1s hat\u00e1sa a szorong\u00e1sra \u00e9s a remeg\u00e9sre, amelyet a szimul\u00e1lt nyilv\u00e1nos besz\u00e9dteszt v\u00e1lt ki Parkinson-k\u00f3ros betegekn\u00e9l. Journal of Psychopharmacology<\/strong>, 34. \u00e9vfolyam, 2. sz\u00e1m, 189-196. o., 2020. febru\u00e1r 1.<\/p>\n\n\n\n

FALCO, A. D. et al. DOEN\u00c7A DE ALZHEIMER: HIP\u00d3TESES ETIOL\u00d3GICAS E PERSPECTIVAS DE TRATAMENTO. Qu\u00edmica Nova<\/strong>, 39. \u00e9vf. 39. sz\u00e1m, 1. sz. 63-80. o., 2016. jan.<\/p>\n\n\n\n

LEEHEY, M. A. et al. A Cannabidiol biztons\u00e1goss\u00e1ga \u00e9s toler\u00e1lhat\u00f3s\u00e1ga Parkinson-k\u00f3rban: Egy ny\u00edlt c\u00edmk\u00e9s, d\u00f3zis-sk\u00e1l\u00e1z\u00e1si vizsg\u00e1lat. Cannabis \u00e9s kannabinoid kutat\u00e1s<\/strong>, m\u00e1rcius 19. 2020.<\/p>\n\n\n\n

POLEG, S. et al. Cannabidiol mint az autizmus spektrumzavar kezel\u00e9s\u00e9nek javasolt jel\u00f6ltje. Fejlem\u00e9nyek az idegpszichofarmakol\u00f3gi\u00e1ban \u00e9s a biol\u00f3giai pszichi\u00e1tri\u00e1ban<\/strong>, 89. \u00e9vfolyam, 90-96. o., 8 m\u00e1rc. 2019.YOO, K.-Y.; PARK, S.-Y. Terpenoidok mint potenci\u00e1lis Alzheimer-k\u00f3r elleni ter\u00e1pi\u00e1s szerek. Molekul\u00e1k<\/strong>, v. 17, n. 3, p. 3524-3538, m\u00e1rcius. 2012.<\/p>","protected":false},"excerpt":{"rendered":"

Az Alzheimer-k\u00f3r (AD) egy neurodegenerat\u00edv betegs\u00e9g, amely a jelenleg diagnosztiz\u00e1lt demenci\u00e1s esetek t\u00f6bb mint 50%-\u00e9\u00e9rt felel\u0151s, \u00e9s k\u00f6zvetlen\u00fcl \u00f6sszef\u00fcgg az \u00f6reged\u00e9ssel. Napjainkban a 85 \u00e9v feletti emberek 40%-\u00e9nek van valamilyen szint\u0171 demenci\u00e1ja. Kor\u00e1bban \u00fagy gondolt\u00e1k, hogy az Alzheimer-k\u00f3r t\u00fcnetei csak a r\u00f6vid t\u00e1v\u00fa mem\u00f3ri\u00e1t \u00e9rint\u0151 kognit\u00edv funkci\u00f3k cs\u00f6kken\u00e9s\u00e9hez kapcsol\u00f3dnak, m\u00edg [...]<\/p>","protected":false},"author":4,"featured_media":12193,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959],"tags":[213,819,554],"yoast_head":"\nWhat is Out There About Cannabis and Alzheimer\u2019s Disease - MTG<\/title>\n<meta name=\"description\" content=\"Do you know Cannabis and Alzheimer's Disease can be related? 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