{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/hu\/coronavirus-covid-19-is-hydroxychloroquine-the-uj-remeny-nyilvanvaloan-igen\/","title":{"rendered":"Koronav\u00edrus (Covid-19): a hidroxiklorokin az \u00faj rem\u00e9ny? \u00dagy t\u0171nik, igen."},"content":{"rendered":"<p>K\u00e9t nemr\u00e9giben megjelent tanulm\u00e1ny \u00f6sszegz\u00e9se egy in vitro kutat\u00e1s \u00e9s egy kis l\u00e9pt\u00e9k\u0171 klinikai vizsg\u00e1lat el\u00e9g volt Donald Trumpnak ahhoz, hogy az FDA \u00e9rv\u00e9nyes\u00edtse a hidroxiklorokin \u00faj gy\u00f3gyszer klinikai indik\u00e1ci\u00f3j\u00e1t: a koronav\u00edrus (Covid-19) \u00e1ltal \u00e9rintett betegek t\u00fcneteinek jav\u00edt\u00e1sa.<\/p>\n<p>Val\u00f3sz\u00edn\u0171leg ez a leggyorsabb gy\u00f3gyszerenged\u00e9lyez\u00e9si folyamat a modern t\u00f6rt\u00e9nelemben, \u00e9s az eln\u00f6knek nyilv\u00e1nval\u00f3an igaza van. Meglep\u0151 egy olyan glob\u00e1lis vezet\u0151t\u0151l, aki nem sok szeretetet t\u00e1pl\u00e1l a tudom\u00e1ny ir\u00e1nt.<\/p>\n<p><img decoding=\"async\" loading=\"lazy\" class=\"aligncenter size-full wp-image-10976\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2020\/03\/image-192.png\" alt=\"\" width=\"607\" height=\"480\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-192.png 607w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-192-300x237.png 300w\" sizes=\"(max-width: 607px) 100vw, 607px\" \/><\/p>\n<p>Az els\u0151 bizony\u00edt\u00e9k a hidroxiklorokinr\u00f3l a v\u00edrusra vonatkoz\u00f3an a k\u00f6vetkez\u0151b\u0151l sz\u00e1rmazik. <a href=\"https:\/\/www.nature.com\/articles\/s41421-020-0156-0\">ez a tegnap a Cell Discovery-n megjelent tanulm\u00e1ny<\/a>Ez csak in vitro, minden korl\u00e1toz\u00e1ssal egy\u00fctt, de vil\u00e1gosan mutatja a gy\u00f3gyszer potenci\u00e1lis k\u00e9pess\u00e9g\u00e9t a v\u00edrus elpuszt\u00edt\u00e1s\u00e1ra. Amikor beny\u00fajtott\u00e1k a tanulm\u00e1nyt, K\u00edn\u00e1ban 80 000 esetet er\u0151s\u00edtettek meg, k\u00f6zt\u00fck 2946 hal\u00e1lesetet, valamint t\u00f6bb mint 10 566 meger\u0151s\u00edtett esetet 72 m\u00e1sik orsz\u00e1gban. Akkoriban a legnagyobb rem\u00e9nyt a remdesivir nev\u0171 gy\u00f3gyszerre helyezt\u00e9k.<\/p>\n<figure id=\"attachment_10973\" aria-describedby=\"caption-attachment-10973\" style=\"width: 584px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"size-full wp-image-10973\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2020\/03\/image-191.png\" alt=\"a hidroklorokvin in vitro hat\u00e1sa a koronav\u00edrusra (Covid-19)\" width=\"584\" height=\"401\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-191.png 584w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-191-300x206.png 300w\" sizes=\"(max-width: 584px) 100vw, 584px\" \/><figcaption id=\"caption-attachment-10973\" class=\"wp-caption-text\">A hidroklorokvin in vitro hat\u00e1sa a koronav\u00edrusra (Covid-19). A jobb oldali oszlop a hat\u00e1sos gy\u00f3gyszer hat\u00e1sait mutatja, szemben a bal oldali klorokinnal vagy a kontrollcsoporttal. Ez azt mutatja, hogy a gy\u00f3gyszer jav\u00edtotta a sejtek azon k\u00e9pess\u00e9g\u00e9t, hogy ki\u0171zz\u00e9k a v\u00edrusokat... olyan, mintha seg\u00edtene kir\u00fagni a nemk\u00edv\u00e1natos szomsz\u00e9dot a h\u00e1zb\u00f3l. Ez seg\u00edt! \ud83d\ude42 .&nbsp;<\/figcaption><\/figure>\n<p>A legnagyobb h\u00edr azonban egy el\u0151z\u0151 nap k\u00f6zz\u00e9tett kis l\u00e9pt\u00e9k\u0171 klinikai tanulm\u00e1nyb\u00f3l sz\u00e1rmazik. A c\u00edm <a href=\"https:\/\/www.mediterranee-infection.com\/wp-content\/uploads\/2020\/03\/Hydroxychloroquine_final_DOI_IJAA.pdf\">Hydroxychloroquine \u00e9s azithromycin a COVID-19 kezel\u00e9s\u00e9ben: egy ny\u00edlt, nem randomiz\u00e1lt klinikai vizsg\u00e1lat eredm\u00e9nyei, \u00e9s let\u00f6lthet\u0151 a \"sajt\u00f3ban\" v\u00e1ltozat\u00e1ban<\/a><\/p>\n<p>Egy mind\u00f6ssze 20 beteggel v\u00e9gzett vizsg\u00e1latban a szerz\u0151k kimutatt\u00e1k, hogy a hidroxiklorokvin hat\u00e1sos a Covid-19 koronav\u00edrus fert\u0151z\u00e9se ellen. Val\u00f3j\u00e1ban a fert\u0151z\u00f6ttek 75%-j\u00e9t cs\u00f6kkentette a 6 napos id\u0151szakban, ami f\u00e9lelmetes. Enn\u00e9l is jobb, hogy az azitromicinnel val\u00f3 kombin\u00e1ci\u00f3 95%-re jav\u00edtotta a kezel\u00e9s hat\u00e9konys\u00e1g\u00e1t.<\/p>\n<figure id=\"attachment_10975\" aria-describedby=\"caption-attachment-10975\" style=\"width: 668px\" class=\"wp-caption aligncenter\"><img decoding=\"async\" loading=\"lazy\" class=\"wp-image-10975\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2020\/03\/Hydroxychloroquine_final_DOI_IJAA-24-1024x546-1.jpg\" alt=\"A hidroklorokvin \u00e9s az azitromicin kombin\u00e1lt ter\u00e1pia hat\u00e9kony a koronav\u00edrus (Covid-19) fert\u0151z\u00e9sek ellen hum\u00e1n betegekn\u00e9l\" width=\"668\" height=\"356\"><figcaption id=\"caption-attachment-10975\" class=\"wp-caption-text\">A hidroklorokin \u00e9s az azitromicin kombin\u00e1lt ter\u00e1pia hat\u00e9kony a koronav\u00edrus (Covid-19) fert\u0151z\u00e9sek ellen hum\u00e1n betegekn\u00e9l. A cs\u00f6kken\u00e9s dr\u00e1mai, \u00e9s \u00faj rem\u00e9nyt ad az \u00e9rintett betegek sz\u00e1m\u00e1ra.<\/figcaption><\/figure>\n<p>A kezel\u00e9s jav\u00edtotta a t\u00fcneteket, mik\u00f6zben cs\u00f6kkentette a betegek v\u00edrusterhel\u00e9s\u00e9t is. A gy\u00f3gyszert kor\u00e1bban mal\u00e1ria kezel\u00e9s\u00e9re m\u00e1r enged\u00e9lyezt\u00e9k, ami azt jelenti, hogy biztons\u00e1gosnak tekinthet\u0151. A \"testv\u00e9r\" gy\u00f3gyszer, a klorokin kev\u00e9sb\u00e9 volt hat\u00e9kony. J\u00f3 nek\u00fcnk, mert az algo m\u00e9rgez\u0151bb.<\/p>\n<p>A vizsg\u00e1lat nem volt randomiz\u00e1lt \u00e9s kis l\u00e9pt\u00e9k\u0171, azonban \u00fagy t\u0171nik, hogy b\u00e1r a j\u00e1rv\u00e1ny K\u00edn\u00e1b\u00f3l indult, a megold\u00e1s egy glob\u00e1lis k\u00f6z\u00f6ss\u00e9gi er\u0151fesz\u00edt\u00e9sb\u0151l ered. Az in vitro tanulm\u00e1ny val\u00f3j\u00e1ban k\u00ednai, m\u00edg a klinikai eur\u00f3pai, pontosabban franciaorsz\u00e1gi. \u00c9rdekes, hogy a hidroxiklorokin eredeti gy\u00f3gyszer-regisztr\u00e1ci\u00f3ja a francia Sanofi gy\u00f3gyszerc\u00e9gt\u0151l sz\u00e1rmazik, \u00e9s a k\u00f6zelm\u00faltbeli klinikai vizsg\u00e1latot Marseille-ben v\u00e9gezt\u00e9k. Ale le bleu!<\/p>\n<p style=\"text-align: center;\"><a href=\"https:\/\/www.medscape.com\/viewarticle\/927033#vp_1\">A Medscape egy kiv\u00e1l\u00f3 cikket k\u00f6z\u00f6l err\u0151l, ha r\u00e9szletesebb inform\u00e1ci\u00f3kra k\u00edv\u00e1ncsiak.<\/a><\/p>\n<p>Please cite this work as Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents - In Press 2020. m\u00e1rcius 17. - DOI : 10.1016\/j.ijantimicag.2020.105949.<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Coronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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Apparently, yes."}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"hu-HU"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3","name":"Fabricio Pamplona","image":{"@type":"ImageObject","inLanguage":"hu-HU","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","caption":"Fabricio Pamplona"},"description":"Fabricio Pamplona is the founder of Mind the Graph - a tool used by over 400K users in 60 countries. He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. 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