{"id":16636,"date":"2022-09-10T18:27:00","date_gmt":"2022-09-10T21:27:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16636"},"modified":"2023-03-17T14:47:45","modified_gmt":"2023-03-17T17:47:45","slug":"success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/fr\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/","title":{"rendered":"La signalisation du FGF dans l'auto-renouvellement des organo\u00efdes du cancer du c\u00f4lon : revue de presse"},"content":{"rendered":"

La formation de sph\u00e9ro\u00efdes et d'organo\u00efdes invalides par l'inhibition du FGFR dans les cellules CRC d\u00e9riv\u00e9es de patients est beaucoup plus facile \u00e0 comprendre gr\u00e2ce aux illustrations de Mind the Graph. <\/p>\n\n\n\n

Le sch\u00e9ma cr\u00e9\u00e9 par l'auteur montre que les biopsies chirurgicales ont \u00e9t\u00e9 dig\u00e9r\u00e9es par voie enzymatique pour obtenir une suspension de cellules uniques. Les cellules na\u00efves non tri\u00e9es ont \u00e9t\u00e9 cultiv\u00e9es dans un milieu CSC contenant du FGF2 ou avec l'inhibiteur de FGFR SU-5402.<\/p>\n\n\n\n

Le r\u00f4le du facteur de croissance des fibroblastes 2 (FGF2) dans l'autorenouvellement des cellules souches du cancer colorectal a \u00e9t\u00e9 \u00e9tudi\u00e9.<\/strong><\/h2>\n\n\n\n

Dans \" FGF Signalling in the Self-Renewal of Colon Cancer Organoids \", J\u00f6rg Otte et ses coll\u00e8gues (2019) ont rapport\u00e9 que lorsque des cellules uniques na\u00efves \u00e9taient int\u00e9gr\u00e9es dans du Matrigel et cultiv\u00e9es dans le milieu CSC, une auto-organisation plus complexe \u00e9tait observ\u00e9e chez tous les patients analys\u00e9s. <\/p>\n\n\n\n

Les g\u00e8nes directement associ\u00e9s \u00e0 l'EMT ainsi qu'\u00e0 un ph\u00e9notype m\u00e9senchymateux et autorenouvelable (TGFB3, ID1, ID2 et ID4) se sont r\u00e9v\u00e9l\u00e9s surexprim\u00e9s dans les organo\u00efdes. <\/p>\n\n\n\n

Alors que l'inhibition du FGFR a entra\u00een\u00e9 une augmentation de la signalisation MAPK, ils ont observ\u00e9 une diff\u00e9renciation induite, une perte de la plupart des marqueurs de cellules souches et un ph\u00e9notype \u00e9pith\u00e9lial. <\/p>\n\n\n\n

Les cellules souches canc\u00e9reuses sont une sous-population de cellules malignes capables de s'auto-renouveler et de servir de source permanente de cellules tumorales diff\u00e9renci\u00e9es. Dans certains protocoles de culture de CSC, le facteur de croissance des fibroblastes 2 est un ingr\u00e9dient important pour le maintien de l'\u00e9tat de souche. <\/p>\n\n\n\n

Dans les organo\u00efdes cultiv\u00e9s par les CSC, en revanche, ils ont d\u00e9tect\u00e9 une induction du TGF-\u03b2 et des quatre membres de la famille des g\u00e8nes inhibiteurs de la diff\u00e9renciation.<\/p>\n\n\n\n

9 patients cons\u00e9cutifs non s\u00e9lectionn\u00e9s atteints de CRC ont particip\u00e9 \u00e0 la recherche.<\/strong><\/p>\n\n\n\n

V\u00e9rifiez le article original ici<\/a>.<\/p>\n\n\n\n

Abr\u00e9g\u00e9 graphique aliment\u00e9 par Mind the Graph<\/strong><\/h2>\n\n\n\n
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Fabriqu\u00e9 avec Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Certaines de leurs conclusions renforcent potentiellement ce qui \u00e9tait pr\u00e9c\u00e9demment connu dans ce domaine : \"Les g\u00e8nes associ\u00e9s \u00e0 la pluripotence NANOG, LIN28 et SALL1 \u00e9taient exclusivement exprim\u00e9s par les CSEh. Les termes GO \"r\u00e9gulation n\u00e9gative de la voie de signalisation BMP\" et \"transduction du signal de la prot\u00e9ine SMAD\" ont \u00e9t\u00e9 d\u00e9tect\u00e9s dans notre culture de CSEh\", sugg\u00e8re Otte.<\/p>\n\n\n\n

Les auteurs admettent que \"l'analyse GO-terme de cet ensemble de g\u00e8nes n'a donn\u00e9 que quelques r\u00e9sultats significatifs en raison du faible nombre de g\u00e8nes couramment r\u00e9gul\u00e9s. La plupart de ces GO-termes pour la condition CSC-medium \u00e9taient associ\u00e9s \u00e0 une transcription active, \u00e0 la prolif\u00e9ration cellulaire ou \u00e0 une augmentation de l'absorption du glucose. <\/p>\n\n\n\n

Apr\u00e8s l'inhibition du FGFR, nous avons trouv\u00e9 des r\u00e9gulateurs du cycle cellulaire ainsi que de nombreux g\u00e8nes annot\u00e9s avec \"diff\u00e9renciation des cellules \u00e9pith\u00e9liales\", \"digestion\" ou \"transport des acides biliaires et des sels biliaires\".\"<\/p>\n\n\n\n

Impact et performance des documents<\/strong><\/h2>\n\n\n\n

Nous pouvons analyser avec Altmetric<\/a> donn\u00e9es que le score d'attention en ligne de ce papier est plus \u00e9lev\u00e9 que 68%<\/strong><\/strong> de tous les autres articles de m\u00eame \u00e2ge dans Scientific Reports.<\/strong><\/p>\n\n\n\n

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Source : Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Am\u00e9liorez l'accessibilit\u00e9 de votre article gr\u00e2ce \u00e0 la puissance des infographies.<\/p>\n\n\n\n

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Essayez Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

La formation de sph\u00e9ro\u00efdes et d'organo\u00efdes d\u00e9sactiv\u00e9s par l'inhibition du FGFR dans les cellules CRC d\u00e9riv\u00e9es de patients est plus facile \u00e0 comprendre gr\u00e2ce \u00e0 nos illustrations.<\/p>","protected":false},"author":29,"featured_media":20014,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,1],"tags":[96,554,775,963],"yoast_head":"\nFGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/fr\/success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - 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