{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/fr\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"Le virus Zika se r\u00e9plique dans le tissu c\u00e9r\u00e9bral humain adulte et alt\u00e8re les synapses et la m\u00e9moire chez la souris Paper Review"},"content":{"rendered":"

Le ZIKV est un virus dangereux qui fait des ravages dans le monde. C'est pourquoi, dans ce cas, l'auteur \u00e9tudie sa r\u00e9plication dans le cerveau humain adulte.<\/p>\n\n\n\n

Le virus Zika (ZIKV) infecte le tissu c\u00e9r\u00e9bral adulte et provoque des troubles de la m\u00e9moire chez la souris<\/strong><\/h2>\n\n\n\n

Un groupe de l'\u00c9cole de pharmacie dirig\u00e9 par Claudia Figueiredo (2019) a \u00e9tudi\u00e9 comment le virus zika se r\u00e9plique dans le tissu c\u00e9r\u00e9bral humain adulte et alt\u00e8re les synapses et la m\u00e9moire chez la souris. Le virus Zika est un arbovirus appartenant \u00e0 la famille des Flaviviridae responsable d'une r\u00e9cente \u00e9pid\u00e9mie majeure en Am\u00e9rique latine. <\/p>\n\n\n\n

Le ZIKV a \u00e9t\u00e9 trouv\u00e9 dans le cerveau et le LCR de patients adultes. L'immunor\u00e9activit\u00e9 du NS2B s'est retrouv\u00e9e en colocalisation avec les cellules immunor\u00e9actives au NeuN, mais pas avec le GFAP ou le F4\/80, ce qui indique que les neurones sont cibl\u00e9s par le ZikV dans le tissu humain mature. Chez des souris adultes immunocomp\u00e9tentes infect\u00e9es par perfusion intrac\u00e9r\u00e9broventriculaire de ZIKV, des niveaux \u00e9lev\u00e9s d'ARN de ZikV sont d\u00e9tect\u00e9s dans le cortex frontal et l'hippocampe, et les neurones matures sont le principal type cellulaire infect\u00e9. <\/p>\n\n\n\n

On v\u00e9rifie des niveaux c\u00e9r\u00e9braux \u00e9lev\u00e9s de TNF-\u03b1, une microgliose intense, une expression r\u00e9gul\u00e9e des prot\u00e9ines du syst\u00e8me du compl\u00e9ment (C1q et C3) et des dommages aux synapses de l'hippocampe.<\/p>\n\n\n\n

L'\u00e9tude portait sur 9 quadrants \u00e9gaux.<\/strong><\/p>\n\n\n\n

V\u00e9rifiez le article original ici<\/a>.<\/p>\n\n\n\n

R\u00e9sum\u00e9s graphiques propuls\u00e9s par Mind the Graph<\/strong><\/h2>\n\n\n\n
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Fabriqu\u00e9 avec Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

La premi\u00e8re figure repr\u00e9sente le cas o\u00f9 les fragments de tissu cortical du lobe temporal humain ont \u00e9t\u00e9 sectionn\u00e9s en tranches de 400 \u00b5m et maintenus en culture pendant 4 jours avant d'\u00eatre incub\u00e9s avec du ZIKV (107 PFU) ou du milieu simul\u00e9 pendant 1 h, puis lav\u00e9s. <\/p>\n\n\n\n

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Fabriqu\u00e9 avec Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

La seconde montre que des souris adultes ont re\u00e7u une perfusion de 105 UFP de ZIKV, de ZIKV inactiv\u00e9 par les UV ou de milieu simul\u00e9 dans le ventricule lat\u00e9ral c\u00e9r\u00e9bral.<\/p>\n\n\n\n

Les conclusions semblent confirmer ce que l'on savait d\u00e9j\u00e0 \u00e0 ce sujet : \"Le ZIKV cible les r\u00e9gions du cerveau li\u00e9es \u00e0 la m\u00e9moire, que la voie d'infection soit centrale ou p\u00e9riph\u00e9rique. Le virus a \u00e9t\u00e9 d\u00e9tect\u00e9 dans le LCR de patients adultes pr\u00e9sentant des complications neurologiques\", affirme Figueiredo.<\/p>\n\n\n\n

Ils estiment que de futures \u00e9tudes visant \u00e0 examiner l'impact neurod\u00e9g\u00e9n\u00e9ratif \u00e0 long terme de l'infection par le ZIKV sont justifi\u00e9es. L'identification des moyens de pr\u00e9venir les anomalies de signalisation conduisant \u00e0 un dysfonctionnement du cerveau pourrait ouvrir la voie \u00e0 des strat\u00e9gies d'intervention visant \u00e0 retarder ou \u00e0 pr\u00e9venir le d\u00e9veloppement de troubles neurologiques majeurs.<\/p>\n\n\n\n

Impact et performance des documents<\/strong><\/h2>\n\n\n\n

Nous pouvons analyser avec Altmetric<\/a> donn\u00e9es que le score d'attention en ligne de ce papier est plus \u00e9lev\u00e9 que 95%<\/strong><\/strong> de tous les autres articles d'un \u00e2ge similaire dans la Nature<\/strong> Journaux.<\/strong><\/p>\n\n\n\n

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Source : Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Utilisez le pouvoir des infographies pour booster votre article aussi ! Lancez une cr\u00e9ation sur Mind the Graph.<\/p>\n\n\n\n

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Essayez Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

L'\u00e9tude porte sur le ZIKV dans le cerveau humain adulte, un virus dangereux qui ravage le monde. Le processus utilise des illustrations Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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