{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/fr\/coronavirus-covid-19-est-hydroxychloroquine-le-nouveau-espoir-apparemment-oui\/","title":{"rendered":"Coronavirus (Covid-19) : l'hydroxychloroquine est-elle le nouvel espoir ? Apparemment, oui."},"content":{"rendered":"

Deux articles r\u00e9cents r\u00e9sumant une recherche in vitro et une \u00e9tude clinique \u00e0 petite \u00e9chelle ont suffi \u00e0 Donald Trump pour que la FDA mette en application une nouvelle indication clinique pour l'hydroxychloroquine : am\u00e9liorer les sympt\u00f4mes des patients affect\u00e9s par le Coronavirus (Covid-19).<\/p>\n

Il s'agit probablement du processus d'approbation d'un m\u00e9dicament le plus rapide de l'histoire moderne, et le pr\u00e9sident a apparemment raison. Surprenant pour un leader mondial qui n'a pas beaucoup d'affection pour la science.<\/p>\n

\"\"<\/p>\n

Les premi\u00e8res preuves de l'action de l'hydroxychloroquine sur le virus proviennent de cet article publi\u00e9 hier sur Cell Discovery<\/a>Ce n'est qu'une \u00e9tude in vitro, avec toutes ses limites, mais elle montre clairement le potentiel du m\u00e9dicament pour tuer le virus. Au moment o\u00f9 ils ont soumis le document, 80 000 cas ont \u00e9t\u00e9 confirm\u00e9s en Chine, dont 2946 d\u00e9c\u00e8s, ainsi que plus de 10 566 cas confirm\u00e9s dans 72 autres pays. \u00c0 cette \u00e9poque, les plus grands espoirs reposaient sur un m\u00e9dicament appel\u00e9 remdesivir.<\/p>\n

\"effets
Effets in vitro de l'hydrochloroquine sur le coronavirus (Covid-19). La colonne de droite montre les effets du m\u00e9dicament efficace, par opposition \u00e0 la chloroquine ou au groupe t\u00e9moin de gauche. Elle montre que le m\u00e9dicament a am\u00e9lior\u00e9 la capacit\u00e9 des cellules \u00e0 extruder les virus... c'est comme aider \u00e0 chasser un voisin ind\u00e9sirable de votre maison. C'est utile ! \ud83d\ude42 . <\/figcaption><\/figure>\n

Mais la plus grande nouvelle est venue d'une \u00e9tude clinique \u00e0 petite \u00e9chelle publi\u00e9e la veille. Le titre est Hydroxychloroquine et azithromycine comme traitement du COVID-19 : r\u00e9sultats d'un essai clinique ouvert non randomis\u00e9 et t\u00e9l\u00e9chargeable sur sa version \"in press\".<\/a><\/p>\n

Dans une \u00e9tude portant sur seulement 20 patients, les auteurs ont montr\u00e9 que l'hydroxychloroquine \u00e9tait efficace contre l'infection par le coronavirus Covid-19. En fait, elle a permis de r\u00e9duire 75% des individus infect\u00e9s au cours de la p\u00e9riode de 6 jours, ce qui est impressionnant. Mieux encore, l'association avec l'azithromycine a am\u00e9lior\u00e9 l'efficacit\u00e9 du traitement \u00e0 95%.<\/p>\n

\"La
La th\u00e9rapie combin\u00e9e d'hydrochloroquine et d'azithromycine est efficace contre les infections \u00e0 coronavirus (Covid-19) chez les patients humains. La baisse est spectaculaire et apporte un nouvel espoir aux patients touch\u00e9s.<\/figcaption><\/figure>\n

Le traitement a am\u00e9lior\u00e9 les sympt\u00f4mes, tout en r\u00e9duisant la charge virale des patients. Le m\u00e9dicament a d\u00e9j\u00e0 \u00e9t\u00e9 approuv\u00e9 pour le paludisme, ce qui signifie qu'il est consid\u00e9r\u00e9 comme s\u00fbr. Le m\u00e9dicament \"fr\u00e8re\", la chloroquine, \u00e9tait moins efficace. Tant mieux pour nous, parce qu'il est beaucoup plus toxique.<\/p>\n

Il s'agit d'une \u00e9tude non randomis\u00e9e et \u00e0 petite \u00e9chelle, mais il semble que si l'\u00e9pid\u00e9mie a commenc\u00e9 en Chine, la solution provienne d'un effort communautaire mondial. L'\u00e9tude in vitro est en fait chinoise, tandis que l'\u00e9tude clinique est europ\u00e9enne, plus pr\u00e9cis\u00e9ment fran\u00e7aise. Il est int\u00e9ressant de noter que les enregistrements originaux de l'hydroxychloroquine proviennent de la soci\u00e9t\u00e9 pharmaceutique fran\u00e7aise Sanofi, et que l'\u00e9tude clinique r\u00e9cente a \u00e9t\u00e9 men\u00e9e \u00e0 Marseille. Ale le bleu !<\/p>\n

Medscape propose un excellent article \u00e0 ce sujet, pour ceux qui souhaitent obtenir des informations plus d\u00e9taill\u00e9es.<\/a><\/p>\n

Veuillez citer ce travail comme Gautret et al. (2020) Hydroxychloroquine et azithromycine comme traitement du COVID-19 : r\u00e9sultats d'un essai clinique ouvert non randomis\u00e9. International Journal of Antimicrobial Agents - In Press 17 mars 2020 - DOI : 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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