{"id":10456,"date":"2019-09-23T09:21:14","date_gmt":"2019-09-23T12:21:14","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10456"},"modified":"2022-10-14T11:21:45","modified_gmt":"2022-10-14T14:21:45","slug":"immune-cell-signalling","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/fr\/signalisation-des-cellules-immunitaires\/","title":{"rendered":"Nouvelles donn\u00e9es scientifiques : Le temps est la solution pour la signalisation des cellules immunitaires"},"content":{"rendered":"

Os gl\u00f3bulos brancos s\u00e3o respons\u00e1veis por defender nosso corpo contra amea\u00e7as, mantendo-nos vivos. <\/span>Mais comment ces cellules identifient-elles une maladie ? <\/span>Dans le corps humain, avec ses trois cellules, elles doivent \u00eatre sp\u00e9cifiques et pr\u00e9cises. <\/span>Caso contr\u00e1rio, eles come\u00e7am a nos atacar por dentro. <\/span>Cette responsabilit\u00e9 repose sur les ombres des cellules T, des agents sp\u00e9cialis\u00e9s dans l'identification d'antig\u00e8nes nocifs et leur marquage pour les d\u00e9truire. <\/span>Uma das maiores quest\u00f5es sobre a sinaliza\u00e7\u00e3o das c\u00e9lulas imunes \u00e9 como as c\u00e9lulas T distinguem nossas pr\u00f3prias c\u00e9lulas saud\u00e1veis e o que \u00e9 prejudicial para n\u00f3s.<\/span><\/span><\/p>\n

\"ativa\u00e7\u00e3o<\/a><\/p>\n

Au cours de son d\u00e9veloppement, le corps produit des millions de cellules T avec diff\u00e9rents types de r\u00e9cepteurs de fa\u00e7on al\u00e9atoire. <\/span>Afinal, our corpo n\u00e3o sabe exatamente o que o futuro reserva. <\/span>Mais il y a un probl\u00e8me avec cette strat\u00e9gie. <\/span>Nous produisons des cellules avec des r\u00e9cepteurs qui identifient les peptides qui se trouvent dans le corps. <\/span>Pendant le d\u00e9veloppement, nous \u00e9liminons la plupart des cellules T qui sont li\u00e9es \u00e0 ces mol\u00e9cules \"pr\u00e9f\u00e9r\u00e9es\". <\/span>No entanto, alguns deles continuam circulando ao longo da vida, protegendo contra c\u00e9lulas infectadas e anormais sem prejudicar o organismo.<\/span><\/span><\/p>\n

Qu'est-ce qui emp\u00eache les cellules T de marquer nos cellules saudes ?<\/span><\/span><\/h3>\n

Um novo artigo intitulado Controle optogen\u00e9tico mostra que a revis\u00e3o cin\u00e9tica regula a atividade do receptor de c\u00e9lulas T traz novas evid\u00eancias para essa quest\u00e3o. <\/span>Weiner, l'un des auteurs de l'un des articles, dit \u00e0 <\/span><\/span>Magazine Quanta<\/span><\/span><\/a> que \" <\/span><\/span>a c\u00e9lula poderia ter alguma maneira de tomar diferen\u00e7as muito, muito pequenas na dura\u00e7\u00e3o da liga\u00e7\u00e3o do receptor e amplificar isso para uma resposta celular muito maior\".<\/span><\/span><\/em><\/p>\n

Le temps est le meilleur moyen d'\u00e9liminer les cellules mortes. <\/span>As subst\u00e2ncias que se ligam aos receptores das c\u00e9lulas T por menos de cinco segundos s\u00e3o consideradas seguras, enquanto as mol\u00e9culas de liga\u00e7\u00e3o mais longa devem ser destru\u00eddas.<\/span><\/span><\/h3>\n

Cette th\u00e9orie, connue sous le nom de \"revis\u00e3o cin\u00e9tica\", n'est pas nouvelle. <\/span>Depuis la d\u00e9cennie 90, certains chercheurs ont propos\u00e9 le temps comme moyen d'identification. <\/span><\/span>No entanto, os testes da hip\u00f3tese encontraram correla\u00e7\u00f5es sugestivas entre o tempo de liga\u00e7\u00e3o e a ativa\u00e7\u00e3o das c\u00e9lulas T, exatamente como a revis\u00e3o cin\u00e9tica faria, mais ces m\u00e9thodes de test n'ont pas permis de s\u00e9parer l'effet du temps des effets d'autres facteurs biofysiques, tels que les modifications des mol\u00e9cules et les diff\u00e9rences dans la force de la liga\u00e7\u00e3o. <\/span><\/span><\/em>Pior, os pesquisadores sabiam que muitos par\u00e2metros potencialmente importantes em jogo que eles n\u00e3o podiam medir ou sequer haviam considerado.<\/span><\/span><\/p>\n

De nouvelles donn\u00e9es optog\u00e9n\u00e9tiques pour la d\u00e9termination des cellules mortes<\/span><\/span><\/h2>\n

\u00a0L'optog\u00e9n\u00e9tique est un domaine de recherche qui utilise la lumi\u00e8re pour contr\u00f4ler les cellules. <\/span>H\u00e1 cientistas utilizando o metodo para controlar as intera\u00e7\u00f5es prote\u00edna-prote\u00edna em todos os tipos de estudos. <\/span>Aujourd'hui, deux \u00e9quipes de recherche utilisent cette technologie pour \u00e9tudier la d\u00e9termination des cellules immunitaires, l'une ayant son si\u00e8ge en Allemagne et l'autre \u00e0 S\u00e3o Francisco. <\/span>Apesar das diferen\u00e7as entre esses dois estudos, os pesquisadores obtiveram resultados semelhantes : quando um evento de liga\u00e7\u00e3o durou plus de cinco segundos, a c\u00e9lula T se tornou ativa, mas n\u00e3o conseguiu faz\u00ea-lo por nada menos do que isso.<\/span><\/span><\/p>\n

La raison pour laquelle cela se produit n'est pas claire. <\/span>Mais les enqu\u00eateurs ont une id\u00e9e de ce que cela signifie : \" <\/span><\/span>\u00c0 partir du moment o\u00f9 un r\u00e9cepteur de c\u00e9lule T se lie \u00e0 une mol\u00e9cule, une s\u00e9rie d'\u00e9tapes biochimiques irr\u00e9versibles doivent se produire avant que la c\u00e9lule ne soit activ\u00e9e. Se a mol\u00e9cula se desprender muito cedo durante essa cascata de sinaliza\u00e7\u00e3o , tudo tem que recome\u00e7ar desde o primeiro passo\".\u00a0<\/span><\/span><\/em><\/p>\n

Comme toujours dans la vie, une nouvelle r\u00e9ponse entra\u00eene de nouvelles questions. <\/span>Nous savons un peu plus de choses qu'avant, mais nous avons toujours un univers m\u00e9connu \u00e0 explorer.<\/span><\/span><\/p>\n

\"le<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Les vaisseaux sanguins sont responsables de la d\u00e9fense de notre corps contre les agressions et nous maintiennent en vie. Mais comment ces cellules identifient-elles une maladie ? Dans le corps humain, qui compte trois cellules, ces derni\u00e8res doivent \u00eatre sp\u00e9cifiques et pr\u00e9cises. Dans le cas contraire, elles peuvent nous agresser de l'int\u00e9rieur. Essa responsabilidade recai sobre os ombros das c\u00e9lulas T, agentes especializados em [...]<\/p>","protected":false},"author":11,"featured_media":10461,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[302,361,360,299,318,354,256],"yoast_head":"\nNew scientific data: time is the immune cell response<\/title>\n<meta name=\"description\" content=\"One of the biggest questions on immune cell signalling is how the T cells distinguish our own healthy cells and what is harmful for us.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/fr\/signalisation-des-cellules-immunitaires\/\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New scientific data: time is the immune cell 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