{"id":8713,"date":"2019-04-18T18:07:31","date_gmt":"2019-04-18T21:07:31","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8713"},"modified":"2022-10-18T08:24:00","modified_gmt":"2022-10-18T11:24:00","slug":"brain-damage-pig-brains-alive-hours-death","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/fi\/brain-damage-pig-brains-brains-alive-hours-death\/","title":{"rendered":"Aivovauriot: infografiikka uuden Nature-lehden ymm\u00e4rt\u00e4miseksi"},"content":{"rendered":"

Yalen yliopiston tutkijat pitiv\u00e4t sian aivoja elossa ruumiin ulkopuolella tunteja kuoleman j\u00e4lkeen. Lehti Aivojen verenkierron ja solutoimintojen palauttaminen tunteja kuoleman j\u00e4lkeen.<\/strong> selitt\u00e4\u00e4 sian aivoja k\u00e4ytt\u00e4v\u00e4n kokeen, joka voi tuoda valoa aivovaurioiden tutkimukseen. Nature-lehti\u00a0julkaistu <\/a>huhtikuun 17. p\u00e4iv\u00e4n\u00e4.<\/p>\n

\"Suurimman osan ihmiskunnan historiasta kuolema oli hyvin yksinkertaista.\"<\/em> sanoo Christof Koch. H\u00e4n on Seattlessa, Washingtonissa sijaitsevan Allen Institute for Brain Science -instituutin puheenjohtaja ja johtava tutkija. \"Nyt meid\u00e4n on kyseenalaistettava se, mik\u00e4 on peruuttamatonta.\"\u00a0<\/em><\/p>\n

N\u00e4iden aivojen neuronien v\u00e4lill\u00e4 ei ole mink\u00e4\u00e4nlaista viestint\u00e4\u00e4, joten niiss\u00e4 ei ollut tietoisuutta. Mutta solut olivat elossa - ja se yksin\u00e4\u00e4n on eritt\u00e4in suuri l\u00f6yt\u00f6.<\/p>\n

\"Aikaisemmat havainnot ovat osoittaneet, ett\u00e4 solut k\u00e4yv\u00e4t l\u00e4pi solukuolemaprosessin periaatteessa minuuteissa\", sanoo h\u00e4n.<\/em>\u00a0sanoi tutkimusta johtanut Yalen neurotieteilij\u00e4 Nenad Sestan lehdist\u00f6tilaisuudessa. \"Osoitamme, ett\u00e4 solukuolema on asteittainen, vaiheittainen prosessi, ja joitakin n\u00e4ist\u00e4 prosesseista voidaan joko lyk\u00e4t\u00e4, s\u00e4ilytt\u00e4\u00e4 tai jopa k\u00e4\u00e4nt\u00e4\u00e4.\"<\/em><\/p>\n

Aivovauriokokeilu<\/strong><\/h3>\n

Nature Magazinen mukaan tutkijat testasivat, miten hyvin aivot p\u00e4rj\u00e4siv\u00e4t kuuden tunnin aikana. He havaitsivat, ett\u00e4 neuronit ja muut aivosolut olivat k\u00e4ynnist\u00e4neet uudelleen normaalit aineenvaihduntatoiminnot, kuten sokerin kulutuksen ja hiilidioksidin tuotannon. My\u00f6s aivojen immuunij\u00e4rjestelm\u00e4 n\u00e4ytti toimivan. Yksitt\u00e4isten solujen ja aivojen osien rakenteet s\u00e4ilyiv\u00e4t. Sen sijaan vertailuaivojen solut, jotka eiv\u00e4t saaneet ravinne- ja happirikasta liuosta, luhistuivat. Ja kun tutkijat k\u00e4yttiv\u00e4t s\u00e4hk\u00f6\u00e4 k\u00e4sitellyist\u00e4 aivoista otettuihin kudosn\u00e4ytteisiin, he havaitsivat, ett\u00e4 yksitt\u00e4iset neuronit pystyiv\u00e4t edelleen v\u00e4litt\u00e4m\u00e4\u00e4n signaalia.<\/p>\n

Tutkijat loivat BrainEx-nimisen j\u00e4rjestelm\u00e4n, joka on erityisesti suunniteltu vaimentamaan joitakin kuolemanj\u00e4lkeisten aivojen kudosten hajoamisesta vastuussa olevia prosesseja. J\u00e4rjestelm\u00e4\u00e4n kuuluu BEx-perfuusaatiksi kutsutun liuoksen pumppaaminen. Liuos on suojaavien, stabiloivien ja kontrastiaineiden patentoitu seos, joka toimii veren korvikkeena. Perfusaatti sis\u00e4lt\u00e4\u00e4 my\u00f6s kemikaaleja, jotka pys\u00e4ytt\u00e4v\u00e4t kudoksen hapettumisen, eli apoptoosin. Se sis\u00e4lt\u00e4\u00e4 my\u00f6s hermotoiminnan est\u00e4j\u00e4\u00e4, jonka tarkoitus on kaksijakoinen. He pumppasivat liuosta eristettyjen aivojen p\u00e4\u00e4valtimoihin normaalissa ruumiinl\u00e4mm\u00f6ss\u00e4.<\/p>\n

 <\/p>\n

\"siat\"<\/a>
Artikkelin kuvassa n\u00e4ytet\u00e4\u00e4n, miten kokonaiset aivot liitettiin BEx-laitteeseen. Sian aivot liitettiin perfuusioj\u00e4rjestelm\u00e4\u00e4n valtimolinjojen kautta.\u00a0<\/strong><\/figcaption><\/figure>\n

 <\/p>\n

Tutkijat k\u00e4yttiv\u00e4t noin 300 sian p\u00e4\u00e4t\u00e4 Yhdysvaltain maatalousministeri\u00f6n teurastamosta. Tekniikan optimoinnin j\u00e4lkeen tutkimusryhm\u00e4 liitti 32 sian aivoa BrainEx-j\u00e4rjestelm\u00e4\u00e4n. He tekiv\u00e4t kytkenn\u00e4n 4 tuntia sen j\u00e4lkeen, kun siat oli lopetettu, ja sen j\u00e4lkeen, kun aivot oli poistettu kalloista. T\u00e4m\u00e4 tietokoneistettu pumppujen, l\u00e4mmittimien ja suodattimien verkosto ohjasi virtausta, l\u00e4mp\u00f6tilaa ja omaa perfuusioliuosta kuuden tunnin ajan.<\/p>\n

Infografiikka kokeen ymm\u00e4rt\u00e4miseksi<\/strong><\/h2>\n

 <\/p>\n

\"preview_77833<\/a><\/p>\n

 <\/p>\n

Loin infograafin k\u00e4ytt\u00e4m\u00e4ll\u00e4 Mind the Graph:t\u00e4. Jos haluat k\u00e4ytt\u00e4\u00e4 houkuttelevia tieteellisi\u00e4 kuvituksia tavoittaaksesi enemm\u00e4n ihmisi\u00e4 tutkimuksellasi, voit k\u00e4ytt\u00e4\u00e4 my\u00f6s mind the Graphia!<\/p>\n

\"preview_250\"<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Yalen yliopiston tutkijat pitiv\u00e4t sian aivoja elossa ruumiin ulkopuolella tunteja kuoleman j\u00e4lkeen. The paper Restoration of brain circulation and cellular functions hours post mortem selitt\u00e4\u00e4 sian aivoja k\u00e4ytt\u00e4v\u00e4n kokeen, joka voi tuoda valoa aivovauriotutkimukseen. Nature-lehti julkaisi artikkelin 17. huhtikuuta. \"Suurimman osan ihmiskunnan historiasta kuolema oli hyvin yksinkertainen\", [...].<\/p>","protected":false},"author":11,"featured_media":8721,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[54,288,287,286,282,554,71,964,775,70],"yoast_head":"\nBrain damage: an infographic to understand the new Nature paper - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Scientists from Yale University kept pig brains alive for hours after death. The experiment using pigs brains brings light to brain damage research.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/fi\/brain-damage-pig-brains-brains-alive-hours-death\/\" \/>\n<meta property=\"og:locale\" content=\"fi_FI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Brain damage: an infographic to understand the new Nature paper - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Scientists from Yale University kept pig brains alive for hours after death. The experiment using pigs brains brings light to brain damage research.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/fi\/brain-damage-pig-brains-brains-alive-hours-death\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2019-04-18T21:07:31+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-18T11:24:00+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/04\/cover-pigs.png\" \/>\n\t<meta property=\"og:image:width\" content=\"607\" \/>\n\t<meta property=\"og:image:height\" content=\"352\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabiola Soares\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabiola Soares\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Brain damage: an infographic to understand the new Nature paper - Mind the Graph Blog","description":"Scientists from Yale University kept pig brains alive for hours after death. The experiment using pigs brains brings light to brain damage research.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/fi\/brain-damage-pig-brains-brains-alive-hours-death\/","og_locale":"fi_FI","og_type":"article","og_title":"Brain damage: an infographic to understand the new Nature paper - Mind the Graph Blog","og_description":"Scientists from Yale University kept pig brains alive for hours after death. The experiment using pigs brains brings light to brain damage research.","og_url":"https:\/\/mindthegraph.com\/blog\/fi\/brain-damage-pig-brains-brains-alive-hours-death\/","og_site_name":"Mind the Graph Blog","article_published_time":"2019-04-18T21:07:31+00:00","article_modified_time":"2022-10-18T11:24:00+00:00","og_image":[{"width":607,"height":352,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/04\/cover-pigs.png","type":"image\/png"}],"author":"Fabiola Soares","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabiola Soares","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/brain-damage-pig-brains-alive-hours-death\/","url":"https:\/\/mindthegraph.com\/blog\/brain-damage-pig-brains-alive-hours-death\/","name":"Brain damage: an infographic to understand the new Nature paper - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2019-04-18T21:07:31+00:00","dateModified":"2022-10-18T11:24:00+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132"},"description":"Scientists from Yale University kept pig brains alive for hours after death. The experiment using pigs brains brings light to brain damage research.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/brain-damage-pig-brains-alive-hours-death\/#breadcrumb"},"inLanguage":"fi","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/brain-damage-pig-brains-alive-hours-death\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/brain-damage-pig-brains-alive-hours-death\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Brain damage: an infographic to understand the new Nature paper"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fi"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132","name":"Fabiola Soares","image":{"@type":"ImageObject","inLanguage":"fi","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","caption":"Fabiola Soares"},"url":"https:\/\/mindthegraph.com\/blog\/fi\/author\/fabiola\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/posts\/8713"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/comments?post=8713"}],"version-history":[{"count":10,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/posts\/8713\/revisions"}],"predecessor-version":[{"id":23429,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/posts\/8713\/revisions\/23429"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/media\/8721"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/media?parent=8713"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/categories?post=8713"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/tags?post=8713"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}