{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/fi\/autofagia-voittaa-nobel-palkinnon-laaketieteen-alalla\/","title":{"rendered":"Autofagia saa l\u00e4\u00e4ketieteen Nobel-palkinnon"},"content":{"rendered":"

Autofagiaprosessi on mukana useissa sairauksissa, kuten sy\u00f6v\u00e4ss\u00e4 ja neurologisissa sairauksissa. Se toimii elimist\u00f6n sis\u00e4isen\u00e4 kierr\u00e4tysohjelmana. Autofagian toimintah\u00e4iri\u00f6t on kuitenkin yhdistetty Parkinsonin tautiin, diabetekseen, sy\u00f6p\u00e4\u00e4n ja muihin ik\u00e4\u00e4n liittyviin sairauksiin.<\/p>\n

T\u00e4m\u00e4n autofagiaprosessin merkityst\u00e4 k\u00e4sittelev\u00e4n pienen esittelyn j\u00e4lkeen ei ole mik\u00e4\u00e4n yll\u00e4tys, ett\u00e4 alan uudet l\u00f6yd\u00f6t voivat johtaa Nobel-palkinnon saamiseen. Viime maanantaina tutkija Yoshino Ohsumi voitti nimitt\u00e4in Nobelin l\u00e4\u00e4ketieteen palkinto<\/a> ensimm\u00e4isten autofagian kannalta olennaisten geenien tunnistamiseen.<\/p>\n

\"Minusta ei ole mukava kilpailla monien ihmisten kanssa, ja sen sijaan minusta on nautinnollisempaa tehd\u00e4 jotain, mit\u00e4 kukaan muu ei tee. Tavallaan juuri siit\u00e4 tieteess\u00e4 on kyse, ja ilo siit\u00e4, ett\u00e4 l\u00f6yd\u00e4n jotain, inspiroi minua.\" Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Miten Ohsumi teki sen?<\/h3>\n

Ohsumi oli laboratoriossaan kehitt\u00e4nyt hiivakantoja, jotka ker\u00e4siv\u00e4t autofagosomeja n\u00e4lk\u00e4kuoleman aikana. T\u00e4m\u00e4 kertyminen olisi voinut tapahtua vain, jos autofagian kannalta olennaiset geenit olisivat olleet toimimattomia. Niinp\u00e4 Ohsumi alkoi manipuloida soluja useilla geenimutaatioilla ja onnistui saamaan aikaan autofagian.<\/p>\n

\"Autofagia<\/a><\/p>\n

Autofagia on ollut olemassa<\/h3>\n

Vaikka autofagia on tunnettu jo 50 vuoden ajan, vasta 1990-luvulla Ohsumin tutkimusten my\u00f6t\u00e4 t\u00e4m\u00e4n prosessin merkitys tunnustettiin.
\nTy\u00f6st\u00e4\u00e4n Ohsumi on jo ansainnut joitakin faneja:<\/p>\n

\"Autofagia<\/a><\/p>\n

\n

\"Olen hyvin iloinen siit\u00e4, ett\u00e4 h\u00e4n sai t\u00e4m\u00e4n vuoden Nobel-palkinnon, se on hyvin ansaittu. H\u00e4nen laboratorionsa ty\u00f6skentelee p\u00e4\u00e4asiassa hiivan parissa. He tekiv\u00e4t ensimm\u00e4iset seulonnat, joiden avulla l\u00f6ydettiin autofagiaan osallistuvat avaingeenit. Niin monet muut laboratoriot ovat hy\u00f6dynt\u00e4neet h\u00e4nen l\u00f6yt\u00f6j\u00e4\u00e4n suoraan tai ep\u00e4suorasti n\u00e4hd\u00e4kseen, miksi se on t\u00e4rke\u00e4\u00e4 sairauksissa.\"<\/p>\n

David Rubinsztein<\/a> - Cambridgen l\u00e4\u00e4ketieteellisen tutkimuslaitoksen varajohtaja.<\/p>\n<\/blockquote>\n

\"Autofagia<\/a><\/p>\n

\n

\"Mielest\u00e4ni on eritt\u00e4in t\u00e4rke\u00e4\u00e4, ett\u00e4 t\u00e4m\u00e4 tieteenala tunnustetaan. T\u00e4rke\u00e4 periaate on, ett\u00e4 sairauksien yhteisi\u00e4 mekanismeja etsit\u00e4\u00e4n. Se avaa n\u00e4iden sairauksien hoitoon keinoja, jotka eroavat perinteisemmist\u00e4 sairauskohtaisista l\u00e4hestymistavoista.\"<\/p>\n

Giovanna Mallucci<\/a> - kliinisen neurotieteen professori Cambridgen yliopistossa.<\/p>\n<\/blockquote>\n

\"Autofagia<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Autofagiaprosessi on mukana useissa sairauksissa, kuten sy\u00f6v\u00e4ss\u00e4 ja neurologisissa sairauksissa. Se toimii elimist\u00f6n sis\u00e4isen\u00e4 kierr\u00e4tysohjelmana. Autofagian toimintah\u00e4iri\u00f6t on kuitenkin yhdistetty Parkinsonin tautiin, diabetekseen, sy\u00f6p\u00e4\u00e4n ja muihin ik\u00e4\u00e4n liittyviin sairauksiin. T\u00e4m\u00e4n autofagiaprosessin merkityst\u00e4 k\u00e4sittelev\u00e4n pienen johdannon j\u00e4lkeen ei ole yll\u00e4tt\u00e4v\u00e4\u00e4, ett\u00e4 uudet l\u00f6yd\u00f6t [...].<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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