{"id":16670,"date":"2022-09-16T19:40:00","date_gmt":"2022-09-16T22:40:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16670"},"modified":"2023-03-17T14:47:16","modified_gmt":"2023-03-17T17:47:16","slug":"success-case-nuclear-receptors-in-liver-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/fi\/success-case-nuclear-receptors-in-liver-fibrosis\/","title":{"rendered":"Ydinreseptorit maksan fibroosissa Paperikatsaus"},"content":{"rendered":"

T\u00e4ss\u00e4 tapauksessa kirjoittaja k\u00e4ytti Mind the Graph:t\u00e4 kootakseen eri l\u00e4hteist\u00e4 per\u00e4isin olevat luvut yhteen paikkaan. Parhaan tieteellisesti tarkan kuvituksen lis\u00e4ksi ty\u00f6tilassamme on yst\u00e4v\u00e4llinen k\u00e4ytt\u00f6liittym\u00e4 ja sit\u00e4 on eritt\u00e4in helppo k\u00e4ytt\u00e4\u00e4.<\/p>\n\n\n\n

Tarkista t\u00e4ydellinen alkuper\u00e4inen artikkeli<\/a>. <\/p>\n\n\n\n

Ydinreseptorien rooli maksan fibroosissa<\/strong><\/h2>\n\n\n\n

Philipp K\u00f6nigshofer ja muut (2021) raportoivat, ett\u00e4 ydinreseptorit ovat ligandien aktivoimia transkriptiotekij\u00f6it\u00e4, jotka s\u00e4\u00e4telev\u00e4t useiden maksan fibroosiin liittyvien keskeisten molekyylisignaalien geeniekspressiota. <\/p>\n\n\n\n

Maksan fibrogeneesin ensisijainen solutekij\u00e4 ovat aktivoituneet maksan stellatesolut. Erilaiset ydinreseptorit s\u00e4\u00e4telev\u00e4t maksan pro-inflammatoristen ja pro-fibrogeenisten sytokiinien ilmentymist\u00e4.<\/p>\n\n\n\n

Mind the Graph:n k\u00e4ytt\u00e4m\u00e4t graafiset tiivistelm\u00e4t<\/strong> t\u00e4ss\u00e4 artiklassa<\/strong><\/h2>\n\n\n\n
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Valmistettu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n
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T\u00e4m\u00e4 ensimm\u00e4inen kuva on yleiskatsaus ja ydinreseptorien luokittelu alaryhmien mukaan.<\/p>\n\n\n\n

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Valmistettu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Yll\u00e4 on esitetty erityyppisi\u00e4 ydinreseptoreiden efektoritoimintoja.<\/p>\n\n\n\n

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Valmistettu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Kolmannessa kuvassa on yleiskatsaus NR-modulaatioiden raportoituihin vaikutuksiin mahdollisina terapeuttisina l\u00e4hestymistapoina maksasairauksia vastaan. <\/p>\n\n\n\n

Nuolet osoittavat oletettuja suotuisia vaikutuksia maksasairauksissa. up- (tummanvihre\u00e4)<\/strong><\/span> tai alas- (vaaleanvihre\u00e4)<\/span><\/strong> sellaisten erityisten mekanismien s\u00e4\u00e4tely\u00e4, joiden on raportoitu tukevan maksan fibroosin taantumista tai v\u00e4hent\u00e4v\u00e4n maksan fibroosia. <\/p>\n\n\n\n

Oranssit nuolet<\/mark><\/strong> osoittavat NR-modulaation vaikutuksia ja mekanismeja, jotka ovat joko kiistanalaisia tai joita ei ole viel\u00e4 riitt\u00e4v\u00e4sti arvioitu.<\/p>\n\n\n\n

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Valmistettu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Viimeisess\u00e4 kuvassa esitet\u00e4\u00e4n NR-modulaattoreiden molekyylivaikutukset maksan fibroosin mahdollisena hoitomuotona, joiden on raportoitu tapahtuvan p\u00e4\u00e4asiassa HSC:ss\u00e4.<\/p>\n\n\n\n

K\u00f6nigshofer ja kollegat ehdottavat, ett\u00e4 ydinreseptoreihin liittyv\u00e4n signaloinnin lis\u00e4tutkimus voi johtaa tehokkaiden fibroottisten hoitojen kliiniseen kehitt\u00e4miseen maksasairauspotilaille.<\/p>\n\n\n\n

Paperit Vaikutus ja suorituskyky<\/strong><\/h2>\n\n\n\n

Valitsemalla yhden vuoden mittaustulosten vertailun muihin artikkeleihin\/katsauksiin, jotka on julkaistu samana kalenterivuonna kyseisess\u00e4 lehdess\u00e4, voidaan havaita, ett\u00e4 t\u00e4t\u00e4 artikkelia siteerattiin enemm\u00e4n kuin 57%:t\u00e4 niist\u00e4.<\/strong>.<\/p>\n\n\n

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L\u00e4hde PlumX<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Hy\u00f6dynn\u00e4 infografiikan voimaa my\u00f6s artikkelisi tehostamiseen. Kokeile Mind the Graph:t\u00e4!<\/p>\n\n\n\n

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Kokeile Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

T\u00e4ss\u00e4 artikkelissa on tieteellisi\u00e4 kuvia, jotka on tehty Mind the Graph:ll\u00e4 ja jotka kuvaavat ydinreseptoreita maksan fibroosissa.<\/p>","protected":false},"author":29,"featured_media":20044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nNuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/fi\/success-case-nuclear-receptors-in-liver-fibrosis\/\" \/>\n<meta property=\"og:locale\" content=\"fi_FI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/fi\/success-case-nuclear-receptors-in-liver-fibrosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-16T22:40:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nuclear receptors in liver fibrosis Paper Review - 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