{"id":16657,"date":"2022-09-14T13:04:15","date_gmt":"2022-09-14T16:04:15","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16657"},"modified":"2023-03-17T14:47:26","modified_gmt":"2023-03-17T17:47:26","slug":"success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/fi\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/","title":{"rendered":"XTALKDB: signaalireittien ristikk\u00e4isviestint\u00e4\u00e4 koskeva tietokanta Paperi Katsaus"},"content":{"rendered":"

T\u00e4m\u00e4 h\u00e4mm\u00e4stytt\u00e4v\u00e4 artikkeli tuo esiin tilastoja, joissa on yhteenveto XTALKDB:n tiedoista. Kirjoittaja loi muutamassa minuutissa infograafin, joka selitt\u00e4\u00e4 lajien jakautumisen XTALKDB:ss\u00e4.<\/p>\n\n\n\n

Tarkista alkuper\u00e4inen artikkeli t\u00e4\u00e4ll\u00e4<\/a>.<\/p>\n\n\n\n

Koska ihmiset ovat visuaalisia olentoja, kuvat ovat edelleen paras tapa selitt\u00e4\u00e4 tutkimuksesi niin yksityiskohtaisesti kuin haluat.<\/p>\n\n\n\n

Tutkijat ovat kehitt\u00e4neet tietokannan, joka dokumentoi tiettyjen signaalireittiparien ja niiden havaitsemien lajien ja kudosten v\u00e4liset ristikk\u00e4isvaikutukset.<\/strong><\/h2>\n\n\n\n

Biologisten tieteiden laitoksen Sarah Samin johtama tutkimusryhm\u00e4 (2016) raportoi, ett\u00e4 ulkoisen signaalin havaitseminen reseptoreissa saa v\u00e4liproteiinien toiminnan muuttumaan. <\/p>\n\n\n\n

T\u00e4m\u00e4 johtaa transkriptiotekij\u00f6iden s\u00e4\u00e4telyyn, mik\u00e4 muuttaa kohdegeenien ilmentymist\u00e4. XTalkDB tallentaa jokaisesta polkuparista yksityiskohtaiset tiedot, joissa kuvataan koeolosuhteet, joissa ristikk\u00e4isvaikutus havaittiin. <\/p>\n\n\n\n

Solut arvioivat ymp\u00e4rist\u00f6\u00e4\u00e4n ja reagoivat siihen signaalireittien avulla. Signaalireitit sis\u00e4lt\u00e4v\u00e4t tyypillisesti hyvin m\u00e4\u00e4ritellyn joukon reseptorien, v\u00e4litt\u00e4j\u00e4proteiinien, transkriptiotekij\u00f6iden ja kohdegeenien v\u00e4lisi\u00e4 s\u00e4\u00e4tely- ja fyysisi\u00e4 vuorovaikutuksia. <\/p>\n\n\n\n

XTalkDB-verkkosivusto tarjoaa tutkijoille helppok\u00e4ytt\u00f6isen k\u00e4ytt\u00f6liittym\u00e4n, jonka avulla he voivat selata ristikk\u00e4isviestint\u00e4\u00e4 koskevia tietoja tekem\u00e4ll\u00e4 kyselyn yhdest\u00e4 tai useammasta kiinnostavasta reitist\u00e4 tai molekyylist\u00e4.<\/p>\n\n\n\n

Tutkimuksessa oli mukana 650 paria.<\/strong><\/p>\n\n\n\n

Graafinen abstrakti, jonka taustalla on Mind the Graph<\/strong><\/h2>\n\n\n
\n
\"success-case-XTALKDB-a-database-of-signaling-pathway-crosstalk\"<\/a>
Valmistettu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Keskusteltaessa mahdollisista parannuksista: \"XTalkDB:n perustana olevalla manuaalisella kuratointiprosessilla on rajoituksensa, erityisesti kun pyrimme laajentamaan tietokannan kattavuutta. <\/p>\n\n\n\n

Aiomme kehitt\u00e4\u00e4 luonnollisen kielen k\u00e4sittelykehyksen, joka arvioi julkaisuja sen perusteella, miten todenn\u00e4k\u00f6isesti ne dokumentoivat ristikk\u00e4isviestint\u00e4\u00e4. Kuraattori voi sitten keskitty\u00e4 korkealle luokiteltuihin julkaisuihin\", he my\u00f6nt\u00e4v\u00e4t.<\/p>\n\n\n\n

Paperit Vaikutus ja suorituskyky<\/strong><\/h2>\n\n\n\n

Voimme analysoida Altmetric<\/a> tiedot, ett\u00e4 t\u00e4m\u00e4 paperi on kaikkien mittareiden ylin osa kaikissa NIH:n rahoittamissa artikkeleissa ulottuvuuksissa. <\/strong><\/p>\n\n\n

\n
\"\"<\/a>
L\u00e4hde: https:\/\/badge.dimensions.ai\/details\/id\/pub.1052462103<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Hy\u00f6dynn\u00e4 infografiikan voimaa my\u00f6s artikkelisi tehostamiseen. Kokeile Mind the Graph:t\u00e4!<\/p>\n\n\n\n

<\/div>\n\n\n\n
\n
Kokeile Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Opi niiden kanssa, jotka ovat jo l\u00f6yt\u00e4neet infografiikan voiman. T\u00e4ss\u00e4 artikkelissa on Mind the Graph:ll\u00e4 tehtyj\u00e4 graafisia tiivistelmi\u00e4. <\/p>","protected":false},"author":29,"featured_media":20046,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"\nXTALKDB: a database of signaling pathway crosstalk Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This amazing article brings out statistics summarizing data in XTALKDB with an infographic explaining the distribution of the species in XTALKDB.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/fi\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/\" \/>\n<meta property=\"og:locale\" content=\"fi_FI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"XTALKDB: a database of signaling pathway crosstalk Paper Review - 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