{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/fi\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"Zika-virus lis\u00e4\u00e4ntyy aikuisen ihmisen aivokudoksessa ja heikent\u00e4\u00e4 synapseja ja muistia hiirill\u00e4 Paperikatsaus"},"content":{"rendered":"

ZIKV on vaarallinen virus, joka tuhoaa maailmaa. Siksi t\u00e4ss\u00e4 tapauksessa tekij\u00e4 tutkii sen replikaatiota aikuisen ihmisen aivoissa.<\/p>\n\n\n\n

Zikavirus (ZIKV) tarttuu aikuisten aivokudokseen ja aiheuttaa muistih\u00e4iri\u00f6it\u00e4 hiiriss\u00e4.<\/strong><\/h2>\n\n\n\n

Claudia Figueiredon (2019) johtama farmasian laitoksen ryhm\u00e4 tutki, miten zikavirus lis\u00e4\u00e4ntyy aikuisen ihmisen aivokudoksessa ja heikent\u00e4\u00e4 synapseja ja muistia hiiriss\u00e4. Zikavirus on Flaviviridae-heimoon kuuluva arbovirus, joka on vastuussa viimeaikaisesta suuresta taudinpurkauksesta Latinalaisessa Amerikassa. <\/p>\n\n\n\n

ZIKV:t\u00e4 on l\u00f6ydetty aikuispotilaiden aivoista ja aivoselk\u00e4ydinnesteest\u00e4. NS2B-immunoreaktiivisuus kolokalisoitui NeuN-immunoreaktiivisten solujen kanssa, mutta ei GFAP:n tai F4\/80:n kanssa, mik\u00e4 osoittaa, ett\u00e4 ZikV kohdistuu neuroneihin kyps\u00e4ss\u00e4 ihmiskudoksessa. Aikuisilla immunokompetenteilla hiirill\u00e4, jotka infektoitiin ZIKV:n intraserebroventrikulaarisella infuusiolla, havaittiin suuria m\u00e4\u00e4ri\u00e4 ZikV:n RNA:ta otsalohkon aivokuoressa ja hippokampuksessa, ja kyps\u00e4t neuronit ovat p\u00e4\u00e4asiallinen solutyyppi, joka sai tartunnan. <\/p>\n\n\n\n

Aivojen kohonneet TNF-\u03b1-pitoisuudet, voimakas mikroglioosi, komplementtij\u00e4rjestelm\u00e4n proteiinien (C1q ja C3) s\u00e4\u00e4nnelty ilmentyminen ja hippokampuksen synapsien vaurioituminen on varmistettu.<\/p>\n\n\n\n

Tutkimuksessa oli mukana 9 yht\u00e4 suurta kvadranttia.<\/strong><\/p>\n\n\n\n

Tarkista alkuper\u00e4inen artikkeli t\u00e4\u00e4ll\u00e4<\/a>.<\/p>\n\n\n\n

Mind the Graph:n k\u00e4ytt\u00e4m\u00e4t graafiset tiivistelm\u00e4t<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Valmistettu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Ensimm\u00e4isess\u00e4 kuvassa on tapaus, jossa ihmisen ohimolohkon aivokuoren kudosfragmentit leikattiin 400 \u00b5m:n viipaleiksi ja niit\u00e4 pidettiin viljelyss\u00e4 4 p\u00e4iv\u00e4\u00e4 ennen inkubointia ZIKV:ll\u00e4 (107 PFU) tai mock-mediumilla 1 tunnin ajan, mink\u00e4 j\u00e4lkeen ne huuhdeltiin pois. <\/p>\n\n\n\n

<\/div>\n\n\n
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Valmistettu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Toisessa n\u00e4ytet\u00e4\u00e4n, ett\u00e4 aikuiset hiiret saivat infuusiona 105 PFU ZIKV:t\u00e4, UV-inaktivoitua ZIKV:t\u00e4 tai mock-mediumia aivojen sivukammioon.<\/p>\n\n\n\n

Johtop\u00e4\u00e4t\u00f6kset n\u00e4ytt\u00e4v\u00e4t tukevan sit\u00e4, mit\u00e4 aiheesta on aiemmin tiedetty: \"ZIKV kohdistuu muistiin liittyville aivoalueille riippumatta siit\u00e4, onko tartuntareitti keskus- vai \u00e4\u00e4reisper\u00e4inen. Virusta on havaittu neurologisia komplikaatioita sairastavien aikuispotilaiden aivoselk\u00e4ydinnesteess\u00e4\", Figueiredo v\u00e4itti.<\/p>\n\n\n\n

He ehdottavat, ett\u00e4 tulevat tutkimukset, joilla pyrit\u00e4\u00e4n tutkimaan ZIKV-infektion pitk\u00e4aikaisia neurodegeneratiivisia vaikutuksia, ovat perusteltuja. Aivojen toimintah\u00e4iri\u00f6ihin johtavien signaalipoikkeavuuksien ehk\u00e4isemisen keinojen tunnistaminen voisi viitoittaa tiet\u00e4 interventiostrategioille, joilla voidaan viiv\u00e4stytt\u00e4\u00e4 tai ehk\u00e4ist\u00e4 vakavien neurologisten sairauksien kehittymist\u00e4.<\/p>\n\n\n\n

Paperit Vaikutus ja suorituskyky<\/strong><\/h2>\n\n\n\n

Voimme analysoida Altmetric<\/a> tiedot, joiden mukaan t\u00e4m\u00e4n asiakirjan verkkohuomion pistem\u00e4\u00e4r\u00e4 on korkeampi... kuin 95%<\/strong><\/strong> kaikista muista samanik\u00e4isist\u00e4 artikkeleista luonnossa.<\/strong> Lehdet.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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L\u00e4hde Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Hy\u00f6dynn\u00e4 infografiikan voimaa my\u00f6s artikkelisi tehostamiseen! Aloita luominen osoitteessa Mind the Graph.<\/p>\n\n\n\n

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Kokeile Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Tutkimus koskee ZIKV:t\u00e4 aikuisen ihmisen aivoissa, vaarallista virusta, joka riehuu maailmassa. Prosessissa k\u00e4ytet\u00e4\u00e4n Mind the Graph-kuvitusta.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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