{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/fi\/coronavirus-covid-19-on-hydroksiklorokiini-uusi-toivo-ilmeisesti-kylla\/","title":{"rendered":"Koronavirus (Covid-19): onko hydroksiklorokiini uusi toivo? Ilmeisesti kyll\u00e4."},"content":{"rendered":"

Kaksi viimeaikaista artikkelia, joissa tiivistettiin yksi in vitro -tutkimus ja pienimuotoinen kliininen tutkimus, riitti Donald Trumpille, jotta FDA saattoi voimaan uuden l\u00e4\u00e4kkeen kliinisen k\u00e4ytt\u00f6aiheen hydroksiklorokiinille: koronaviruksen (Covid-19) tartunnan saaneiden potilaiden oireiden parantaminen.<\/p>\n

T\u00e4m\u00e4 on luultavasti nopein l\u00e4\u00e4kkeen hyv\u00e4ksymisprosessin eteneminen nykyaikaisessa historiassa, ja presidentti on ilmeisesti oikeassa. Yll\u00e4tt\u00e4v\u00e4\u00e4 globaalilta johtajalta, joka ei juurikaan pid\u00e4 tieteest\u00e4.<\/p>\n

\"\"<\/p>\n

Ensimm\u00e4iset todisteet hydroksiklorokiinin vaikutuksesta virukseen saatiin tutkimuksesta. t\u00e4m\u00e4 eilen Cell Discoveryss\u00e4 julkaistu artikkeli<\/a>Kyseess\u00e4 on vain in vitro -koe kaikkine rajoituksineen, mutta se osoittaa selv\u00e4sti l\u00e4\u00e4kkeen potentiaalin tappaa virus. Kun he toimittivat artikkelin, Kiinassa oli vahvistettu 80 000 tapausta, joihin sis\u00e4ltyi 2946 kuolemantapausta, sek\u00e4 yli 10 566 vahvistettua tapausta 72 muussa maassa. Tuolloin suurin toivo kohdistui remdesivir-nimiseen l\u00e4\u00e4kkeeseen.<\/p>\n

\"hydrokloorikiinin
Hydrokloorikiinin in vitro -vaikutukset koronavirukseen (Covid-19). Oikeanpuoleisessa sarakkeessa n\u00e4kyv\u00e4t tehokkaan l\u00e4\u00e4kkeen vaikutukset verrattuna klorokiiniin tai vasemmanpuoleiseen kontrolliryhm\u00e4\u00e4n. Se osoittaa, ett\u00e4 l\u00e4\u00e4ke paransi solujen kyky\u00e4 ulostaa viruksia... se on kuin auttaisi potkimaan ei-toivotun naapurin ulos talostasi. Se auttaa! \ud83d\ude42 <\/figcaption><\/figure>\n

Suurin uutinen tuli kuitenkin edellisen\u00e4 p\u00e4iv\u00e4n\u00e4 julkaistusta pienimuotoisesta kliinisest\u00e4 tutkimuksesta. Tutkimuksen nimi on Hydroksiklorokiini ja atsitromysiini COVID-19:n hoitona: avoimen, ei-satunnaistetun kliinisen tutkimuksen tulokset, ja se on ladattavissa sen \"in press\" -versiosta.<\/a><\/p>\n

Tutkimuksessa, johon osallistui vain 20 potilasta, kirjoittajat osoittivat, ett\u00e4 hydroksiklorokiini oli tehokas Covid-19-koronaviruksen aiheuttamaa infektiota vastaan. Itse asiassa se v\u00e4hensi 75% tartunnan saaneiden henkil\u00f6iden m\u00e4\u00e4r\u00e4\u00e4 6 p\u00e4iv\u00e4n aikana, mik\u00e4 on mahtavaa. Viel\u00e4 parempaa oli, ett\u00e4 yhdistelm\u00e4 atsitromysiinin kanssa paransi hoidon tehoa 95%:iin.<\/p>\n

\"Hydrohiklorokiinin
Hydrohiklorokiinin ja atsitromysiinin yhdistelm\u00e4hoito tehoaa koronaviruksen (Covid-19) aiheuttamiin infektioihin ihmispotilailla. Pudotus on dramaattinen ja tuo uutta toivoa sairastuneille potilaille.<\/figcaption><\/figure>\n

Hoito paransi oireita ja v\u00e4hensi samalla potilaiden viruskuormaa. L\u00e4\u00e4ke on aiemmin hyv\u00e4ksytty malariaan, mik\u00e4 tarkoittaa, ett\u00e4 sit\u00e4 pidet\u00e4\u00e4n turvallisena. \"Sisarl\u00e4\u00e4ke\" klorokiini ei ollut yht\u00e4 tehokas. Hyv\u00e4 meille, koska se on algo myrkyllisempi.<\/p>\n

Tutkimus ei ollut satunnaistettu ja se on pienimuotoinen, mutta n\u00e4ytt\u00e4\u00e4 silt\u00e4, ett\u00e4 vaikka epidemia alkoi Kiinassa, ratkaisu on maailmanlaajuisen yhteis\u00f6n ponnistelujen tulosta. In vitro -tutkimus on itse asiassa kiinalainen, kun taas kliininen tutkimus on eurooppalainen, tarkemmin sanottuna Ranskasta. Mielenkiintoista on, ett\u00e4 hydroksiklorokiinin alkuper\u00e4iset l\u00e4\u00e4kerekister\u00f6innit ovat ranskalaiselta l\u00e4\u00e4keyhti\u00f6lt\u00e4 Sanofilta, ja \u00e4skett\u00e4inen kliininen tutkimus tehtiin Marseillessa. Ale le bleu!<\/p>\n

Medscape-sivustolla on siit\u00e4 erinomainen artikkeli, jos haluat lis\u00e4tietoja.<\/a><\/p>\n

Please cite this work as Gautret et al. (2020) Hydroksiklorokiini ja atsitromysiini COVID-19:n hoitona: avoimen, satunnaistamattoman kliinisen tutkimuksen tulokset. International Journal of Antimicrobial Agents - In Press 17. maaliskuuta 2020 - DOI : 10.1016\/j.ijantimicag.2020.105949.<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. New paper shows exciting clinical results from a small scale study done in France.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/fi\/coronavirus-covid-19-on-hydroksiklorokiini-uusi-toivo-ilmeisesti-kylla\/\" \/>\n<meta property=\"og:locale\" content=\"fi_FI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Is Hydroxycholoquine the new hope for coronavirus (Covid-19) infected patients? Apparently, yes.\" \/>\n<meta property=\"og:description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. New paper shows exciting clinical results from a small scale study done in France.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/fi\/coronavirus-covid-19-on-hydroksiklorokiini-uusi-toivo-ilmeisesti-kylla\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-20T11:22:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-18T11:09:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-192.png\" \/>\n\t<meta property=\"og:image:width\" content=\"607\" \/>\n\t<meta property=\"og:image:height\" content=\"480\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"Is Hydroxycholoquine the new hope for coronavirus (Covid-19) infected patients? Apparently, yes.\" \/>\n<meta name=\"twitter:description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. New paper shows exciting clinical results from a small scale study done in France.\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-192.png\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Coronavirus Covid-19: hydroxychloroquine, the new hope?","description":"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. New paper shows exciting clinical results from a small scale study done in France.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/fi\/coronavirus-covid-19-on-hydroksiklorokiini-uusi-toivo-ilmeisesti-kylla\/","og_locale":"fi_FI","og_type":"article","og_title":"Is Hydroxycholoquine the new hope for coronavirus (Covid-19) infected patients? Apparently, yes.","og_description":"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. New paper shows exciting clinical results from a small scale study done in France.","og_url":"https:\/\/mindthegraph.com\/blog\/fi\/coronavirus-covid-19-on-hydroksiklorokiini-uusi-toivo-ilmeisesti-kylla\/","og_site_name":"Mind the Graph Blog","article_published_time":"2020-03-20T11:22:00+00:00","article_modified_time":"2022-10-18T11:09:52+00:00","og_image":[{"width":607,"height":480,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-192.png","type":"image\/png"}],"author":"Fabricio Pamplona","twitter_card":"summary_large_image","twitter_title":"Is Hydroxycholoquine the new hope for coronavirus (Covid-19) infected patients? Apparently, yes.","twitter_description":"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. New paper shows exciting clinical results from a small scale study done in France.","twitter_image":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2020\/03\/image-192.png","twitter_misc":{"Written by":"Fabricio Pamplona","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes\/","url":"https:\/\/mindthegraph.com\/blog\/coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes\/","name":"Coronavirus Covid-19: hydroxychloroquine, the new hope?","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2020-03-20T11:22:00+00:00","dateModified":"2022-10-18T11:09:52+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3"},"description":"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. New paper shows exciting clinical results from a small scale study done in France.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes\/#breadcrumb"},"inLanguage":"fi","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Coronavirus (Covid-19): is hydroxychloroquine the new hope? Apparently, yes."}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"fi"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3","name":"Fabricio Pamplona","image":{"@type":"ImageObject","inLanguage":"fi","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","caption":"Fabricio Pamplona"},"description":"Fabricio Pamplona is the founder of Mind the Graph - a tool used by over 400K users in 60 countries. He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/fi\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/posts\/10972"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/comments?post=10972"}],"version-history":[{"count":11,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/posts\/10972\/revisions"}],"predecessor-version":[{"id":16041,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/posts\/10972\/revisions\/16041"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/media\/11134"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/media?parent=10972"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/categories?post=10972"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/fi\/wp-json\/wp\/v2\/tags?post=10972"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}