{"id":10456,"date":"2019-09-23T09:21:14","date_gmt":"2019-09-23T12:21:14","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10456"},"modified":"2022-10-14T11:21:45","modified_gmt":"2022-10-14T14:21:45","slug":"immune-cell-signalling","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/fi\/immuunisolujen-signaalinvalitys\/","title":{"rendered":"Uutta tieteellist\u00e4 tietoa: Aika on vastaus immuunisolujen signalointiin"},"content":{"rendered":"

Os gl\u00f3bulos brancos s\u00e3o respons\u00e1veis for defender nosso corpo contra amea\u00e7as, mantendo-nos vivos. <\/span>Mutta miten n\u00e4m\u00e4 maalit tunnistavat ameijan? <\/span>Ihmiskehon sis\u00e4ll\u00e4, jossa on kolmijalkaisia verisuonia, ne ovat erityisen tarkkoja ja t\u00e4sm\u00e4llisi\u00e4. <\/span>P\u00e4invastaisessa tapauksessa ne hy\u00f6kk\u00e4\u00e4v\u00e4t meit\u00e4 vastaan. <\/span>Essa responsabilidade recai sobre os ombros das c\u00e9lulas T, agentes especializados em identificar ant\u00edgenos nocivos e marc\u00e1-los para serem destru\u00eddos. <\/span>Uma das maiores quest\u00f5es sobre a sinaliza\u00e7\u00e3o das c\u00e9lulas imunes \u00e9 como as c\u00e9lulas T distinguem nossas pr\u00f3prias c\u00e9lulas saud\u00e1veis e o que \u00e9 prejudicial para n\u00f3s.<\/span><\/span><\/p>\n

\"ativa\u00e7\u00e3o<\/a><\/p>\n

Kehon kehittymisen aikana se tuottaa miljoonia T-soluja, jotka sis\u00e4lt\u00e4v\u00e4t erilaisia reseptorikategorioita. <\/span>Loppujen lopuksi meid\u00e4n ruumiimme ei tied\u00e4 tarkalleen, mit\u00e4 tulevaisuus tuo tullessaan. <\/span>T\u00e4ss\u00e4 strategiassa on kuitenkin ongelmia. <\/span>Tuotetaan soluja, joissa on reseptoreita, jotka tunnistavat elimist\u00f6\u00f6n kulkeutuvat peptidit. <\/span>Kehittymisen aikana eliminoidaan suuri osa T-tavoitteista, jotka reagoivat n\u00e4ihin \"ensisijaisiin\" mol\u00e9culas-molekyyleihin. <\/span>No entanto, alguns deles continuam circulando ao longo da vida, protegendo contra c\u00e9lulas infectadas e anormais sem prejudicar o organismo.<\/span><\/span><\/p>\n

O que impede as c\u00e9lulas T de marcar nossas c\u00e9lulas saud\u00e1veis?<\/span><\/span><\/h3>\n

Um novo artigo intitulado Controle optogen\u00e9tico mostra que a revis\u00e3o cin\u00e9tica regula a atividade do receptor de c\u00e9lulas T traz novas evid\u00eancias para essa quest\u00e3o. <\/span>Weiner, yksi artikkeleiden kirjoittajista, kertoi seuraavaa <\/span><\/span>Quanta Magazine<\/span><\/span><\/a> que \" <\/span><\/span>a c\u00e9lula poderia ter alguma maneira de tomar diferen\u00e7as muito, muito pequenas na dura\u00e7\u00e3o da liga\u00e7\u00e3o do receptor e amplificar isso para uma resposta celular muito maior\".<\/span><\/span><\/em><\/p>\n

A chave para a sinaliza\u00e7\u00e3o das c\u00e9lulas imunes \u00e9 o tempo. <\/span>As subst\u00e2ncias que se ligam aos receptores das c\u00e9lulas T por menos de cinco segundos s\u00e3o consideradas seguras, enquanto as mol\u00e9culas de liga\u00e7\u00e3o mais longa devem ser destru\u00eddas.<\/span><\/span><\/h3>\n

T\u00e4m\u00e4 teoria, jota kutsutaan elokuvalliseksi tarkasteluksi, ei ole uusi. <\/span>Vuodesta 90 l\u00e4htien muutamat tutkijat ovat esitt\u00e4neet tempon tunnistamisen edellytyksen\u00e4. <\/span><\/span>No entanto, os testes da hip\u00f3tese encontraram correla\u00e7\u00f5es sugestivas entre o tempo de liga\u00e7\u00e3o e a ativa\u00e7\u00e3o das c\u00e9lulas T, exatamente como a revis\u00e3o cin\u00e9tica faria, mutta n\u00e4ill\u00e4 testimenetelmill\u00e4 ei pystyt\u00e4 erottamaan efeito do tempo dos efeitos de outros fatores biof\u00edsicos, como estruturas mudan\u00e7as nas mol\u00e9culas e diferen\u00e7as na for\u00e7a de liga\u00e7\u00e3o. <\/span><\/span><\/em>Lis\u00e4ksi tutkijat tiesiv\u00e4t, ett\u00e4 he ovat ottaneet huomioon monia potentiaalisesti t\u00e4rkeit\u00e4 tekij\u00f6it\u00e4, joita he eiv\u00e4t voi mitata tai analysoida.<\/span><\/span><\/p>\n

Uudet optogeneettiset tiedot imunalaisten maalien m\u00e4\u00e4rityksess\u00e4 (sinaliza\u00e7\u00e3o de c\u00e9lulas imunes)<\/span><\/span><\/h2>\n

\u00a0Optogenetiikka on tutkimusalue, jossa valoa k\u00e4ytet\u00e4\u00e4n tavoitteiden hallintaan. <\/span>Tutkijat k\u00e4ytt\u00e4v\u00e4t t\u00e4t\u00e4 menetelm\u00e4\u00e4 proteiini-proteiinien v\u00e4listen vuorovaikutusten valvontaan kaikissa tutkimuksissa. <\/span>Nyky\u00e4\u00e4n t\u00e4t\u00e4 teknologiaa k\u00e4ytt\u00e4v\u00e4t kaksi tutkimusryhm\u00e4\u00e4, joista yksi sijaitsee Alemmanhaassa ja toinen S\u00e3o Franciscossa. <\/span>N\u00e4iden tutkimusten v\u00e4lisist\u00e4 eroista huolimatta tutkijat saivat samansuuntaisia tuloksia: kun liga\u00e7\u00e3o-tapahtuma kesti kauemmin kuin cinco sekuntia, T-keh\u00e4 muuttui vilkkaaksi, mutta se ei onnistunut tekem\u00e4\u00e4n sit\u00e4, koska se ei ollut v\u00e4hemm\u00e4n kuin t\u00e4m\u00e4.<\/span><\/span><\/p>\n

Miksi n\u00e4in tapahtuu, ei ole selvill\u00e4. <\/span>Mutta tutkijoilla on yksi vastaus kysymykseen: \" <\/span><\/span>Siit\u00e4 hetkest\u00e4 l\u00e4htien, kun T-reseptori tarttuu johonkin soluun, tapahtuu useita biokemiallisia vaiheita, jotka eiv\u00e4t ole k\u00e4\u00e4nteentekevi\u00e4, ennen kuin solu aktivoituu. Se a mol\u00e9cula se desprender muito cedo durante esse cascata de sinaliza\u00e7\u00e3o , tudo tem que recome\u00e7ar desde o primeiro passo.\".\u00a0<\/span><\/span><\/em><\/p>\n

Kuten aina maailmassa, uusi vastaus her\u00e4tt\u00e4\u00e4 uusia kysymyksi\u00e4. <\/span>Tied\u00e4mme hieman enemm\u00e4n kuin aiemmin, mutta meill\u00e4 on silti koko universumi, jota on vaikea tutkia.<\/span><\/span><\/p>\n

\"cuidado<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Os gl\u00f3bulos brancos s\u00e3o respons\u00e1veis for defender nosso corpo contra amea\u00e7as, mantendo-nos vivos. Mutta miten n\u00e4m\u00e4 solut tunnistavat sairauden? Ihmiskehon sis\u00e4ll\u00e4, jossa on kolminkertainen m\u00e4\u00e4r\u00e4 soluja, niiden on oltava erityisi\u00e4 ja t\u00e4sm\u00e4llisi\u00e4. P\u00e4invastaisessa tapauksessa ne hy\u00f6kk\u00e4\u00e4v\u00e4t meihin sis\u00e4isesti. Essa responsabilidade recai sobre os ombros das c\u00e9lulas T, agentes especializados em [...]<\/p>","protected":false},"author":11,"featured_media":10461,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[302,361,360,299,318,354,256],"yoast_head":"\nNew scientific data: time is the immune cell response<\/title>\n<meta name=\"description\" content=\"One of the biggest questions on immune cell signalling is how the T cells distinguish our own healthy cells and what is harmful for us.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/fi\/immuunisolujen-signaalinvalitys\/\" \/>\n<meta property=\"og:locale\" content=\"fi_FI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New scientific data: time is the immune cell response\" 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