{"id":9012,"date":"2019-06-03T11:07:17","date_gmt":"2019-06-03T14:07:17","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=9012"},"modified":"2022-10-18T08:23:58","modified_gmt":"2022-10-18T11:23:58","slug":"award-zika-virus-infection","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/auhind-zika-viirusinfektsioon\/","title":{"rendered":"Zika viirus: Pikaajalised tagaj\u00e4rjed: auhinnatud uuring, mis toob uut valgust pikaajalistele tagaj\u00e4rgedele"},"content":{"rendered":"

Meie kasutajate teaduslikku t\u00f6\u00f6d on alati h\u00e4mmastav n\u00e4idata. Nii et t\u00e4na tutvustan teile Brasiilia teadlast Isis de Souza ja tema t\u00f6\u00f6d zikaviirusega. Isis ja tema kolleegid uurivad Zika-viiruse varajase nakatumise m\u00f5ju hiirtel. Ta on ka Mind the graphi kasutaja ja v\u00f5itja esitlusel on visuaalsed vahendid Mind the graphist. Noh, me ei saakski rohkem uhked olla.<\/p>\n

Mis on zikaviirus?<\/strong><\/h3>\n

Zika viirus kuulub Flaviviridae perekonda. Sellesse r\u00fchma kuuluvad mitmed patogeensed viirused. K\u00f5ige tuntum on kollapalaviku viirus, mis on perekonna t\u00fc\u00fcpviirus ja ka perekonna nime p\u00f5hjuseks, sest s\u00f5na flavus t\u00e4hendab ladina keeles \"kollast\". Peale selle on teised flaviviirused L\u00e4\u00e4ne-Niiluse viirus, dengue'i viirus ja puukentsefaliidi viirus.<\/p>\n

Flaviviridae perekonnal on \u00fchine suurus (40-65 nm) ja viiruse \u00fcmbrik, mis katab nende kaitsvat ikosaedrilist nukleokapsidi. Samuti on geneetiline materjal RNA ja nad ilmuvad elektronmikroskoobis.<\/p>\n

Allpool olev infograafika n\u00e4itab zikaviiruse p\u00f5histruktuuri:<\/p>\n

\"preview_90481\"<\/a><\/p>\n

 Zika levib peamiselt naissoost Stegomya aegypti<\/em> s\u00e4\u00e4sk, kes toitub verest, et muneda. S\u00e4\u00e4sk on aktiivne peamiselt p\u00e4evasel ajal.<\/p>\n

V\u00f5itja paber<\/strong><\/h2>\n

Viimasel ajal uurivad paljud teadlased neuroloogilisi h\u00e4ireid, mis on seotud kaasas\u00fcndinud kokkupuutega zikaviirusega (ZIKV).<\/p>\n

Lisaks sellele on kaasas\u00fcndinud mikrotsefaalia \u00fcks k\u00f5ige m\u00e4rgatavam m\u00f5ju, millest on teatatud ZIKV-ga nakatunud vasts\u00fcndinutel. Seet\u00f5ttu keskenduvad teadusuuringud ZIKV-st p\u00f5hjustatud kaasas\u00fcndinud mikrotsefaalia mehhanismide m\u00f5istmisele.<\/p>\n

Kuid ainult 1-13% kokkupuutunud lootel ilmnevad s\u00fcnni ajal f\u00fc\u00fcsilised v\u00e4\u00e4rarengud. Lisaks sellele puudub teave perinataalse nakatumise pikaajaliste tagaj\u00e4rgede kohta.<\/p>\n

Nii kasutasid Isis de Souza ja tema kolleegid hiired, et uurida k\u00e4itumuslikke ja neuropatoloogilisi tingimusi ning l\u00fchi- ja pikaajalisi tagaj\u00e4rgi, ning avaldasid tulemused dokumendis pealkirjaga Zika-viiruse varajase infektsiooni \u00e4gedad ja kroonilised neuroloogilised tagaj\u00e4rjed hiirtel.<\/strong><\/p>\n

Inimestel on zikaviirusega kokkupuutega seotud palju kliinilisi haigusi, mis ilmnevad kuid v\u00f5i aastaid p\u00e4rast s\u00fcndi. Seega, isegi kui lapsed ei s\u00fcnni mikrotsefaalia t\u00f5ttu, v\u00f5ivad neil esineda motoorseid kahjustusi, krambihoogudega seotud kortikaalset d\u00fcsplaasiat ja muid neuroloogilisi h\u00e4ireid.<\/p>\n

Autorite s\u00f5nul on nad \"nakatasid vasts\u00fcndinud metsikut t\u00fc\u00fcpi hiired s\u00fcsteemselt ZIKV-ga ja viisid l\u00e4bi nakatumise k\u00e4itumuslike, neuropatoloogiliste ja molekulaarsete tagaj\u00e4rgede pikaajalise j\u00e4lgimise. Me teatame l\u00fchi- ja pikaajalistest t\u00fcsistustest p\u00e4rast ZIKV-infektsiooni hiirtel ja n\u00e4itame, et varajane tuumornekroosifaktor-\u03b1 (TNF-\u03b1) neutraliseerimine hoiab need kahjulikud m\u00f5jud osaliselt \u00e4ra. Meie leiud paljastavad vajaduse p\u00f6\u00f6rata erilist t\u00e4helepanu neuropatoloogiliste t\u00fcsistuste v\u00f5imalikule koormusele lastel ja noorukitel p\u00e4rast kaasas\u00fcndinud kokkupuudet ZIKV-ga ja viitavad sellele, et neuroinflammatsiooni varajane inhibeerimine v\u00f5ib olla potentsiaalne ravi, et v\u00e4ltida pikaajalisi neuroloogilisi tagaj\u00e4rgi ZIKV-ga nakatunud imikutel.\"<\/em><\/p>\n

 GE Healthcare Life Sciences'i poolt edendatav auhind<\/strong><\/h2>\n

\"Pr\u00eamio Jovem Talento em Ci\u00eancias da Vida\" ehk Noore Talendi auhind bioteaduste valdkonnas on Brasiilia Biokeemia ja Molekulaarbioloogia \u00dchingu ja GE Healthcare Life Sciences'i poolt v\u00e4lja pandud. Teaduskomitee valis v\u00e4lja viis kandidaati, kes esitlevad oma t\u00f6\u00f6d aastakongressil, mis \u00fchendab professoreid ja \u00fcli\u00f5pilasi kogu Ladina-Ameerikast.<\/p>\n

Komitee valis v\u00e4lja Isis de Oliveira, kes tutvustas oma uuringut zikaviirusega kokkupuute tagaj\u00e4rgede kohta.<\/p>\n

\"teaduslik
Isis de Oliveira esitleb oma tulemusi<\/figcaption><\/figure>\n

Ta kirjutas postituse, milles t\u00e4nas oma \u00fclikooli ja stipendiumi, mis v\u00f5imaldas tema \u00f5pinguid. Lisaks avaldas ta lootust, et tulevane p\u00f5lvkond saab teha samasugust teadlaskarj\u00e4\u00e4ri nagu tema.<\/p>\n

Nii et me tahame \u00f5nnitleda Isist tema h\u00e4mmastava t\u00f6\u00f6 eest! Loodan, et ta inspireerib oma t\u00f6\u00f6ga rohkem inimesi teadlaseks hakkama.<\/p>\n

Ja kui soovite oma andmeid visuaalsemaks muuta, et teaduses paremini suhelda, v\u00f5ite proovida Mind the Graph:<\/p>\n

\"meeles<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Meie kasutajate teaduslikku t\u00f6\u00f6d on alati h\u00e4mmastav n\u00e4idata. Nii et t\u00e4na tutvustan teile Brasiilia teadlast Isis de Souza ja tema t\u00f6\u00f6d zikaviirusega. Isis ja tema kolleegid uurivad Zika-viiruse varajase nakatumise m\u00f5ju hiirtel. Ta on ka mind the graph kasutaja ja v\u00f5itja esitlus on [...]<\/p>","protected":false},"author":11,"featured_media":9080,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[40],"tags":[299,282,554,71,775,293,316,315],"yoast_head":"\nZika virus: the award-winning study that sheds light on the future<\/title>\n<meta name=\"description\" content=\"Microcephaly is a known effect related to congenital exposure to zika virus. 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