{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/alzheimeri-tobi\/","title":{"rendered":"Alzheimeri t\u00f5bi: Teaduslik infograafika"},"content":{"rendered":"

See on alati r\u00f5\u00f5mustav, kui me n\u00e4eme oma kasutajate h\u00e4mmastavat t\u00f6\u00f6d.\u00a0Ma juba kirjutasin<\/a> Dr. Alessandra Martini, dr.\u00a0Stefania Forner<\/a>\u00a0ja nende kolleegid. Nad on California \u00dclikooli j\u00e4reldoktorid ja j\u00e4lgivad graafiku kasutajaid. Paar kuud tagasi n\u00e4itasin ma infograafia<\/a>\u00a0Dr. Stefania Forner l\u00f5i ajakirjas Trends in Neurosciences avaldatud \u00fclevaateartikli \"Synaptic impairment in Alzheimer's Disease\" jaoks: A dysregulated symphony.<\/p>\n

T\u00e4na tahan r\u00e4\u00e4kida nende uuest \u00fclevaatlikust artiklist pealkirjaga Minevikust tulevikku: mida loomamudelid on meile Alzheimeri t\u00f5ve kohta \u00f5petanud.<\/a><\/p>\n

Alzheimeri t\u00f5bi on neurodegeneratiivne haigus, mis p\u00f5hjustab kognitiivseid puuduj\u00e4\u00e4ke ja m\u00e4lukaotust. Haiguse mehhanismi m\u00f5istmine on oluline, et parandada patsientide elukvaliteeti ja leida t\u00f5hus ravi. Vaatamata tohututele j\u00f5upingutustele akadeemiliste ringkondade ja farmaatsiat\u00f6\u00f6stuse raames ei ole t\u00e4nap\u00e4eval t\u00f5husaid ravimeetodeid saadaval. Alzheimeri t\u00f5bi on USAs kuues peamine surmap\u00f5hjus ja m\u00f5jutab 35 miljonit inimest kogu maailmas.<\/p>\n

Alzheimeri t\u00f5ve infograafika<\/h2>\n

 <\/p>\n

Enamik Alzheimeri t\u00f5vega patsientidest on eakad, kellel on tavaliselt mitmeid kaasuvaid haigusi. Diabeet, osteoporoos, neeruhaigused, rasvumine, h\u00fcpertensioon ja h\u00fcperkooli-teroleemia\/d\u00fcslipideemia, insult ja krambid on peamised kaasuvad haigused, mis m\u00f5jutavad Alzheimeri t\u00f5ve teket ja progresseerumist ning muudavad haiguse patogeneesi keerulisemaks.<\/p>\n

\"infograafiline
Infograafik, mis n\u00e4itab Alzheimeri t\u00f5ve (AD) kaasuvaid haigusi. Minevikust tulevikku: Alzheimeri t\u00f5ve kohta.<\/figcaption><\/figure>\n

 <\/p>\n

\n

Vaatamata viimastel aastak\u00fcmnetel tehtud intensiivsetele uuringutele, on haiguse k\u00f5ige levinumaks vormiks oleva sporaadilise Alzheimeri t\u00f5ve (sAD) etioloogia aluseks olevad mehhanismid endiselt teadmata. Selle p\u00f5hjuseks on v\u00e4hemalt osaliselt asjaolu, et enamik sAD-patsiente on eakad isikud, kes kannatavad tavaliselt mitmesuguste kaasnevate haiguste all (nt insult, stress, diabeet, krambid, osteoporoos ja neeruhaigused).<\/em><\/p>\n<\/blockquote>\n

J\u00e4rgmine infograafika n\u00e4itab tau ja beeta-am\u00fcloidi oligomeeride s\u00fcnaptilist toksilisust ja selle tekkemehhanisme.<\/p>\n

 <\/p>\n

\"infografico
Minevikust tulevikku: Alzheimeri t\u00f5ve kohta: Mida loomamudelid on meile \u00f5petanud Alzheimeri t\u00f5ve kohta.<\/figcaption><\/figure>\n

 <\/p>\n

\n

Tauopaatia ajal v\u00e4heneb dendriitiliste okulaaride arv. Tau ei p\u00e4\u00e4se neuroni tuumasse, mille tulemuseks on DNA-kahjustus. V\u00e4heneb mitokondrite ja ka pres\u00fcnaptiliste vesiklite arv, mis viib s\u00fcnapsi kadumiseni. Selline kaotus on tingitud ka tau sisenemisest dendritesse ja posts\u00fcnaptilistesse piirkondadesse. Tau koondub ka rakuv\u00e4liselt, v\u00f5imaldades seda teiste neuronite poolt kinni p\u00fc\u00fcda.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

Ta l\u00f5i ka infograafika, et n\u00e4idata Alzheimeri t\u00f5vega (AD) seotud p\u00f5letikulisi mehhanisme.<\/p>\n

 <\/p>\n

\"infografico<\/p>\n

 <\/p>\n

\n

Viimastel aastatel oleme olnud eriti huvitatud sellest, kuidas p\u00f5letik m\u00f5jutab beeta-am\u00fcloidi ja tau patoloogiat. Eakad inimesed on vastuv\u00f5tlikud viirus- ja bakteriaalsetele infektsioonidele ning need mikroobsed ained v\u00f5ivad olemasolevat p\u00f5letikulist seisundit ajus s\u00fcvendada, kiirendades kognitiivset langust.<\/em><\/p>\n<\/blockquote>\n

\u00d5nnitlused dr Stefania Fornerile suurep\u00e4rase t\u00f6\u00f6 eest!<\/p>\n

Kui olete teadlane ja soovite luua oma t\u00f6\u00f6 jaoks ilusaid jooniseid, v\u00f5ite kohe hakata mind the graphi kasutajaks.<\/p>\n

\"untitled-creation63724<\/a><\/p>","protected":false},"excerpt":{"rendered":"

See on alati r\u00f5\u00f5mustav, kui me n\u00e4eme oma kasutajate h\u00e4mmastavat t\u00f6\u00f6d. Ma juba kirjutasin dr Alessandra Martini, dr Stefania Forneri ja nende kolleegide uuringutest. Nad on California \u00dclikooli j\u00e4reldoktorid ja m\u00f5tlevad graafikute kasutajatele. M\u00f5ni kuu tagasi n\u00e4itasin Dr. Stefania Forneri koostatud infograafikat, mis on avaldatud ajakirjas Trends avaldatud \u00fclevaateartikli jaoks [...]<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/et\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - 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