{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/autofaagia-voidab-nobel-preemia-meditsiini\/","title":{"rendered":"Autofagia saab Nobeli meditsiinipreemia"},"content":{"rendered":"

Autofaagia protsess on seotud mitmete seisundite, n\u00e4iteks v\u00e4hi ja neuroloogiliste haiguste puhul. See toimib keha sisemise ringlussev\u00f5tu programmina. Autofaagia h\u00e4ireid on aga seostatud Parkinsoni t\u00f5ve, diabeedi, suhkruhaiguse ja muude vanusega seotud h\u00e4iretega.<\/p>\n

P\u00e4rast seda v\u00e4ikest sissejuhatust autofaagia protsessi t\u00e4htsuse kohta ei ole \u00fcllatav, et uued avastused selles valdkonnas v\u00f5ivad viia Nobeli preemia saamiseni. T\u00f5epoolest, m\u00f6\u00f6dunud esmasp\u00e4eval sai teadlane Yoshino Ohsumi teadlase Nobeli meditsiinipreemia<\/a> esimeste autofaagia jaoks oluliste geenide tuvastamiseks.<\/p>\n

\"Ma ei tunne end mugavalt paljude inimestega konkureerides, selle asemel on mulle meeldivam teha midagi, mida keegi teine ei tee. M\u00f5nes m\u00f5ttes ongi see teadustegevus just selline, ja r\u00f5\u00f5m millegi leidmisest inspireerib mind.\" Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Kuidas Ohsumi seda tegi?<\/h3>\n

Ohsumi oli oma laboris loonud p\u00e4rmit\u00fcvesid, mis kogusid n\u00e4lgimise ajal autofagosoomi. See akumuleerumine v\u00f5is toimuda ainult siis, kui autofaagia jaoks olulised geenid olid mitteaktiivsed. Seega hakkas Ohsumi manipuleerima rakke mitmete geenimuutustega ja tal \u00f5nnestus autofaagia esile kutsuda.<\/p>\n

\"Autofagia<\/a><\/p>\n

Autofaagia on olnud umbes<\/h3>\n

Kuigi autofaagia on olnud teada juba 50 aastat, tunnustati selle protsessi t\u00e4htsust alles 1990ndatel Ohsumi uuringutega.
\nOma t\u00f6\u00f6 eest teenis Ohsumi juba m\u00f5ned f\u00e4nnid:<\/p>\n

\"Autofagia<\/a><\/p>\n

\n

\"Mul on v\u00e4ga hea meel, et ta sai t\u00e4navuse Nobeli preemia, see on v\u00e4ga h\u00e4sti \u00e4ra teenitud. Tema labor t\u00f6\u00f6tab peamiselt p\u00e4rmidega. Nad tegid esialgsed skriinid, mis v\u00f5imaldasid avastada autofaagias osalevaid v\u00f5tmegeene. Nii paljud teised laborid on tema avastusi otseselt v\u00f5i kaudselt \u00e4ra kasutanud, et n\u00e4ha, miks see on haiguste puhul oluline.\"<\/p>\n

David Rubinsztein<\/a> - Cambridge'i meditsiiniuuringute instituudi direktori aset\u00e4itja<\/p>\n<\/blockquote>\n

\"Autofagia<\/a><\/p>\n

\n

\"Minu arvates on v\u00e4ga oluline, et seda teadusvaldkonda tunnustataks. Oluline p\u00f5him\u00f5te siin on otsida haiguste \u00fchiseid mehhanisme. See avab nende haiguste raviks v\u00f5imalusi, mis erinevad tavalisematest haigusspetsiifilistest l\u00e4henemisviisidest.\"<\/p>\n

Giovanna Mallucci<\/a> - Cambridge'i \u00fclikooli kliinilise neuroteaduse professor<\/p>\n<\/blockquote>\n

\"Autofagia<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Autofaagia protsess on seotud mitmete haiguste, n\u00e4iteks v\u00e4hi ja neuroloogiliste haiguste puhul. See toimib keha sisemise ringlussev\u00f5tu programmina. Autofaagia h\u00e4ireid on aga seostatud Parkinsoni t\u00f5ve, diabeedi, suhkruhaiguse ja muude vanusega seotud h\u00e4iretega. P\u00e4rast seda v\u00e4ikest sissejuhatust autofaagia protsessi t\u00e4htsuse kohta ei ole \u00fcllatav, et uued avastused [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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