{"id":5346,"date":"2016-03-03T13:41:11","date_gmt":"2016-03-03T16:41:11","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=5346"},"modified":"2022-10-18T08:29:24","modified_gmt":"2022-10-18T11:29:24","slug":"zika-virus-graphical-abstract","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/zika-viiruse-graafiline-kokkuvote\/","title":{"rendered":"Zika viiruse graafiline kokkuv\u00f5te mikrotsefaalia kohta"},"content":{"rendered":"

M\u00f5ista Zika viiruse graafilist kokkuv\u00f5tet: kuidas see v\u00e4hendab aju suurust<\/h3>\n

T\u00e4na lisati \u00fches uurimuses huvitavaid t\u00f5endeid Zika-viiruse rolli kohta n\u00e4rvikoe v\u00e4\u00e4rarengutes. Ah, jah, enne kui k\u00fcsite, inimese n\u00e4rvikude.<\/p>\n

Seda tegi elegantselt dr Stevens Reheni r\u00fchm, kes on rahvusvaheliselt tuntud teadlane t\u00fcvirakkude uurimise ja hiljuti ka rakkude \u00fcmberprogrammeerimise valdkonnas.<\/p>\n

Allj\u00e4rgnevas joonises on kokkuv\u00f5tlikult esitatud paber<\/a>, kuid ma p\u00fc\u00fcan seda l\u00fchidalt selgitada.<\/p>\n

 <\/p>\n

\"blogi<\/p>\n

See l\u00e4bin\u00e4gelik Zika-viiruse graafiline kokkuv\u00f5te tehti Mind the graphiaga. Kas pole mitte lahe?<\/em><\/p>\n

 <\/p>\n

 <\/p>\n

Nagu \u00fclaltoodud pildil n\u00e4ha, kasutati selles uuringus kolme erinevat l\u00e4henemisviisi. K\u00f5ik need kinnitavad, et Zika-viirusel on otsene m\u00f5ju sellele, kuidas ajurakud arenevad, et moodustada korralik neuronaalne kude, ehk siis \"intsidentne aju v\u00e4\u00e4rareng\".\"zikaviiruse<\/a>Mikrotsefaalia on vaid \u00fcks aju v\u00e4\u00e4rareng. See, millele paber viitab, on midagi veelgi p\u00f5him\u00f5ttelisemat.<\/p>\n

Nad n\u00e4itavad, kuidas Zika viirus:<\/p>\n

    \n
  1. Soodustab rakusurma<\/li>\n
  2. Indutseerib morfoloogilisi muutusi (neurosf\u00e4\u00e4rides).<\/li>\n
  3. V\u00e4hendab ajuorganoidide (miniaju) kasvu\/suurust.<\/li>\n<\/ol>\n

    K\u00f5ik need on viisid, kuidas Zika viirus m\u00f5jutab neurogeneesi inimese aju arengu ajal ja p\u00f5hjustab allpool kirjeldatud fenot\u00fc\u00fcbi.<\/p>\n

    \"zikaviiruse<\/a><\/p>\n

    <\/h3>\n

    Miks seda varem ei tehtud?<\/h3>\n

    Murranguline l\u00e4henemisviis oli indutseeritud pluripotentsusega t\u00fcvirakkude (iPS-rakkude) kasutamine, et uurida viirusinfektsiooni inimrakkudes.<\/p>\n

    Selle protsessi abil programmeeritakse inimeselt v\u00f5etud somaatiline rakk \u00fcmber algse pluripotentse raku olekusse ja seda saab seej\u00e4rel diferentseerida erinevateks rakkudeks, kudedeks ja hiljuti ka organiteks. See on \"inimkoetehnoloogia\" algus.<\/p>\n

    Uuringus ei kasutanud autorid mitte ainult iPS rakke, vaid genereerisid ka aju organoidid<\/a>, mida tuntakse ka kui \"miniaju\", et m\u00f5ista, kuidas Zika viiruse olemasolu m\u00f5jutab selle neuronaalse koe moodustumist.<\/p>\n

    Selliseid rakukultuure peetakse kolmem\u00f5\u00f5tmelisteks (3D) struktuurideks ja need annavad rohkem vihjeid elundite arhitektuuri kohta. See on organoidi aasta vastavalt Majandusteadlane<\/a>. Selle uuendusliku l\u00e4henemisviisi abil said teadlased aru, kuidas zikaviirus on suunatud inimese ajurakkudele, v\u00e4hendades nende eluj\u00f5ulisust ja kasvu neurosf\u00e4\u00e4ridena ja ajuorganoididena.<\/p>\n

    The paber<\/a> on eelv\u00e4ljaanne innovaatilises ajakirjas PeerJ. Saate isegi kommenteerida ja aidata autoritel seda protsessi k\u00e4igus parandada. Te v\u00f5ite n\u00e4ha allpool olevat kokkuv\u00f5tet ja saada t\u00e4ieliku juurdep\u00e4\u00e4su, kui kl\u00f5psate j\u00e4rgmisel lingil siin<\/a>.<\/p>\n

    \"zikaviiruse<\/a><\/p>\n

    M\u00e4rkus: Kaks kuud p\u00e4rast 2016. aasta m\u00e4rtsis PeerJ-s avaldatud eelpublikatsiooni avaldati l\u00f5plik paber ja meie \u00fcllatuseks oli see avaldatud veebilehel Science <\/a>Magazine, mis on \u00fcks maailma mainekamaid teadusajakirju.<\/p>\n

    -> Lugege Garcezi jt artiklid Science'is <-<\/a><\/p>\n

    \"zikaviiruse<\/a><\/p>\n

    Laske rohkem inimesi sellest teada, jagades seda postitust. See on \u00fclemaailmse rahvatervise k\u00fcsimus, nagu juba m\u00e4rkis Maailma Terviseorganisatsioon<\/a>\u00a0(WHO).<\/p>\n

    \n

     <\/p>\n

    Tea, mida WHO annab n\u00f5u Zika-viiruse kohta<\/a>\u00a0\u00fclekandumine ja nakatumine:<\/p>\n

    \n

    Edastamine<\/h3>\n

    Zika-viirus kandub inimestele peamiselt hammustuste kaudu, mida teevad Aedes<\/i> s\u00e4\u00e4sed, mis elavad sageli linnapiirkondade hoonete \u00fcmbruses ja on tavaliselt aktiivsed p\u00e4evasel ajal (hammustus on k\u00f5ige aktiivsem varahommikul ja hilis\u00f5htul).<\/p>\n

    M\u00f5ned t\u00f5endid viitavad sellele, et Zika viirus v\u00f5ib inimesele \u00fcle kanduda ka vere\u00fclekande, perinataalse \u00fclekande ja seksuaalse \u00fclekande kaudu. Need viisid on siiski v\u00e4ga haruldased.<\/p>\n

    Inkubatsiooniperiood on tavaliselt 2-7 p\u00e4eva.<\/p>\n

    M\u00e4rgid ja s\u00fcmptomid<\/h3>\n

    Zika-viirusnakkust iseloomustab madal palavik (alla 38,5 \u00b0C), millega sageli kaasneb makulopapuloosne l\u00f6\u00f6ve. Muud sagedased s\u00fcmptomid on lihasvalu, liigesevalu koos v\u00f5imaliku turse (eelk\u00f5ige k\u00e4te ja jalgade v\u00e4ikestes liigestes), peavalu, valu silmade taga ja konjunktiviit. Kuna s\u00fcmptomid on sageli kerged, v\u00f5ib nakkus j\u00e4\u00e4da m\u00e4rkamata v\u00f5i diagnoositakse v\u00e4\u00e4ralt dengue'ks.<\/p>\n

    Sarnaselt teiste flaviviirustega, nagu dengue- ja L\u00e4\u00e4ne-Niiluse viirus, on Zika-viiruse puhul oodata suurt as\u00fcmptomaatilise nakatumise m\u00e4\u00e4ra. Enamik inimesi paraneb t\u00e4ielikult ilma raskete t\u00fcsistusteta ja haiglaravi on v\u00e4ike. Siiani ei ole teatatud \u00fchestki Zika-viirusega seotud surmajuhtumist.<\/p><\/blockquote>\n

     <\/p>\n

    Uuendatud 3. mail 2016.<\/p>","protected":false},"excerpt":{"rendered":"

    M\u00f5ista Zika viiruse graafilist kokkuv\u00f5tet: kuidas see v\u00e4hendab aju suurust T\u00e4na lisati uuringus huvitavaid t\u00f5endeid Zika viiruse rolli kohta n\u00e4rvikoe v\u00e4\u00e4rarengutes. Ah, jah, enne kui k\u00fcsite, inimese n\u00e4rvikude. Seda tegi elegantselt dr Stevens Reheni r\u00fchm, rahvusvaheliselt tuntud teadlane [...]<\/p>","protected":false},"author":4,"featured_media":7136,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[956],"tags":[96,201,200,203,202,205,554,71,250,204,199],"yoast_head":"\nZika virus graphical abstract on microcephaly - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This insightful Zika virus graphical abstract was done with Mind the graph. 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