{"id":16670,"date":"2022-09-16T19:40:00","date_gmt":"2022-09-16T22:40:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16670"},"modified":"2023-03-17T14:47:16","modified_gmt":"2023-03-17T17:47:16","slug":"success-case-nuclear-receptors-in-liver-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/success-case-nuclear-receptors-in-liber-fibrosis\/","title":{"rendered":"Tuumaretseptorid maksafibroosis Paberi \u00fclevaade"},"content":{"rendered":"

Antud juhul kasutas autor Mind the Graph, et koondada erinevatest allikatest saadud arvud \u00fchte kohta. Peale parimate teaduslike t\u00e4psete illustratsioonide on meie t\u00f6\u00f6ruumil s\u00f5bralik kasutajaliides ja seda on v\u00e4ga lihtne kasutada.<\/p>\n\n\n\n

Kontrollige t\u00e4ielikku originaalartikkel<\/a>. <\/p>\n\n\n\n

Tuumaretseptorite roll maksafibroosis<\/strong><\/h2>\n\n\n\n

Philipp K\u00f6nigshofer jt (2021) teatavad, et tuumaretseptorid on ligandiga aktiveeritud transkriptsioonifaktorid, mis reguleerivad mitmesuguste maksafibroosiga seotud v\u00f5tmemolekulaarsete signaalide geeniekspressiooni. <\/p>\n\n\n\n

Maksa fibrogeneesi peamine rakuline mootor on aktiveeritud maksastellaatrakud. Erinevad tuumaretseptorid reguleerivad p\u00f5letikuvastaste ja fibrogeenseid toimeid soodustavate ts\u00fctokiinide ekspressiooni maksas.<\/p>\n\n\n\n

Graafilised kokkuv\u00f5tted, mille aluseks on Mind the Graph<\/strong> k\u00e4esolevas artiklis<\/strong><\/h2>\n\n\n\n
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Valmistatud koos Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n
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See esimene joonis on \u00fclevaade ja tuumaretseptorite klassifikatsioon alamperekondade kaupa.<\/p>\n\n\n\n

<\/div>\n\n\n
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Valmistatud koos Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Eespool n\u00e4eme erinevaid tuumaretseptori efektori funktsioone.<\/p>\n\n\n\n

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Valmistatud koos Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Kolmandal joonisel saame kontrollida \u00fclevaadet NR-modulatsioonide kui potentsiaalsete maksahaiguste ravimeetodite teatatud m\u00f5judest. <\/p>\n\n\n\n

Nooltega on n\u00e4idatud eeldatavalt kasulikud m\u00f5jud maksahaiguste puhul, mida up- (tumeroheline)<\/strong><\/span> v\u00f5i alla- (heleroheline)<\/span><\/strong> spetsiifiliste mehhanismide reguleerimine, mis v\u00e4idetavalt toetavad maksafibroosi taandarengut v\u00f5i v\u00e4hendavad maksafibroosi. <\/p>\n\n\n\n

Oran\u017eid nooled<\/mark><\/strong> viitavad NR-modulatsiooni m\u00f5jule ja mehhanismidele, mis on kas vastuolulised v\u00f5i veel ebapiisavalt hinnatud.<\/p>\n\n\n\n

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Valmistatud koos Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Viimane joonis kujutab NR-modulaatorite molekulaarseid m\u00f5jusid kui potentsiaalset ravi maksafibroosi puhul, mis ilmnevad peamiselt HSC-des.<\/p>\n\n\n\n

K\u00f6nigshofer ja kolleegid teevad ettepaneku, et tuumaretseptoritega seotud signaali\u00fclekannete edasine uurimine v\u00f5ib viia t\u00f5husate fibroosiavastaste ravimeetodite kliinilise v\u00e4ljat\u00f6\u00f6tamiseni maksahaigusega patsientide jaoks.<\/p>\n\n\n\n

Paberi m\u00f5ju ja tulemuslikkus<\/strong><\/h2>\n\n\n\n

Valides 1-aastase valikuv\u00f5imaluse meetrikate v\u00f5rdluse teiste artiklitega\/\u00fclevaadetega, mis samuti avaldati samal kalendriaastal selles ajakirjas, v\u00f5ime m\u00e4rgata, et seda artiklit tsiteeriti rohkem kui 57% neist<\/strong>.<\/p>\n\n\n

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Allikas PlumX<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Kasutage infograafiate j\u00f5udu ka oma artikli edendamiseks. Proovige Mind the Graph!<\/p>\n\n\n\n

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Proovige Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Selles artiklis on teaduslikud illustratsioonid, mis on tehtud Mind the Graph-ga, et kujutada tuumaretseptoreid maksafibroosis.<\/p>","protected":false},"author":29,"featured_media":20044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nNuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/et\/success-case-nuclear-receptors-in-liber-fibrosis\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/et\/success-case-nuclear-receptors-in-liber-fibrosis\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-16T22:40:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nuclear receptors in liver fibrosis Paper Review - 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