{"id":16657,"date":"2022-09-14T13:04:15","date_gmt":"2022-09-14T16:04:15","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16657"},"modified":"2023-03-17T14:47:26","modified_gmt":"2023-03-17T17:47:26","slug":"success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/","title":{"rendered":"XTALKDB: signaaliradade ristsidumise andmebaas Paberi \u00fclevaade"},"content":{"rendered":"

See h\u00e4mmastav artikkel toob v\u00e4lja statistika, mis v\u00f5tab kokku XTALKDB andmed. M\u00f5ne minutiga l\u00f5i autor infograafika, mis selgitab liikide levikut XTALKDB-s.<\/p>\n\n\n\n

Kontrollige originaalartikkel siin<\/a>.<\/p>\n\n\n\n

Kuna inimesed on visuaalsed olendid, on pildid ikka veel parim viis oma uurimist\u00f6\u00f6 selgitamiseks nii paljude \u00fcksikasjadega, kui soovite.<\/p>\n\n\n\n

Teadlased on v\u00e4lja t\u00f6\u00f6tanud andmebaasi, mis dokumenteerib konkreetsete signaaliradade paaride ning liikide ja kudede vahelist ristm\u00f5ju, milles neid t\u00e4heldatakse.<\/strong><\/h2>\n\n\n\n

Bioloogiateaduskonna Sarah Sami juhitud uurimisr\u00fchm (2016) teatas, et v\u00e4lise signaali tajumine retseptorite poolt p\u00f5hjustab vahepealsete valkude aktiivsuse muutumise. <\/p>\n\n\n\n

Selle tulemuseks on transkriptsioonifaktorite regulatsioon, mis moduleerib sihtgeenide ekspressiooni. XTalkDB salvestab iga teepaari kohta \u00fcksikasjaliku teabe, mis kirjeldab eksperimentaalseid tingimusi, mille puhul ristm\u00f5ju avastati. <\/p>\n\n\n\n

Rakud hindavad oma keskkonda ja reageerivad sellele signaaliradade kaudu. Signaaltee sisaldab tavaliselt h\u00e4sti m\u00e4\u00e4ratletud regulatiivsete ja f\u00fc\u00fcsikaliste vastastikm\u00f5jude kogumit retseptorite, vahepealsete signaalivalkude, transkriptsioonifaktorite ja sihtgeenide vahel. <\/p>\n\n\n\n

XTalkDB veebisait pakub teadlastele h\u00f5lpsasti kasutatavat kasutajaliidest, et sirvida ristmolekulide teavet, tehes p\u00e4ringuid \u00fche v\u00f5i mitme huvipakkuva tee v\u00f5i molekuli kohta.<\/p>\n\n\n\n

Uuringus osales 650 paari.<\/strong><\/p>\n\n\n\n

Graafiline kokkuv\u00f5te, mille aluseks on Mind the Graph<\/strong><\/h2>\n\n\n
\n
\"success-case-XTALKDB-a-database-of-signaling-pathway-crosstalk\"<\/a>
Valmistatud koos Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Arutledes v\u00f5imalike paranduste \u00fcle: \"XTalkDB aluseks oleval k\u00e4sitsi kureerimisprotsessil on omad piirangud, eriti kui me p\u00fc\u00fcame laiendada andmebaasi ulatust. <\/p>\n\n\n\n

Me kavatseme v\u00e4lja t\u00f6\u00f6tada loomuliku keele t\u00f6\u00f6tlemise raamistiku, mis hindab v\u00e4ljaandeid selle alusel, kui t\u00f5en\u00e4oline on, et need dokumenteerivad ristkasutust. Seej\u00e4rel saab kuraator keskenduda k\u00f5rgelt reastatud v\u00e4ljaannetele,\" tunnistavad nad.<\/p>\n\n\n\n

Paberi m\u00f5ju ja tulemuslikkus<\/strong><\/h2>\n\n\n\n

Me saame anal\u00fc\u00fcsida koos Altmetric<\/a> andmed, et see paber on k\u00f5igi m\u00f5\u00f5dikute \u00fclemine osa k\u00f5igis NIHi rahastatud artiklites m\u00f5\u00f5tmete raames. <\/strong><\/p>\n\n\n

\n
\"\"<\/a>
Allikas: https:\/\/badge.dimensions.ai\/details\/id\/pub.1052462103<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Kasutage infograafiate j\u00f5udu ka oma artikli edendamiseks. Proovige Mind the Graph!<\/p>\n\n\n\n

<\/div>\n\n\n\n
\n
Proovige Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

\u00d5ppige koos nendega, kes on juba avastanud infograafiate j\u00f5u. Selles artiklis on Mind the Graph abil tehtud graafilised kokkuv\u00f5tted. <\/p>","protected":false},"author":29,"featured_media":20046,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"\nXTALKDB: a database of signaling pathway crosstalk Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This amazing article brings out statistics summarizing data in XTALKDB with an infographic explaining the distribution of the species in XTALKDB.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/et\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"XTALKDB: a database of signaling pathway crosstalk Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"This amazing article brings out statistics summarizing data in XTALKDB with an infographic explaining the distribution of the species in XTALKDB.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/et\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-14T16:04:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_5.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_5.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"XTALKDB: a database of signaling pathway crosstalk Paper Review - 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