{"id":16651,"date":"2022-09-12T18:50:00","date_gmt":"2022-09-12T21:50:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16651"},"modified":"2023-03-17T14:47:35","modified_gmt":"2023-03-17T17:47:35","slug":"success-case-immunotherapeutic-potential-of-crotoxin-anti-inflammatory-and-immunosuppressive-properties","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/success-case-immunotherapeutic-potential-of-crotoxin-anti-inflammatory-and-immunosuppressive-properties\/","title":{"rendered":"Krotoksiini immunoteraapiline potentsiaal: p\u00f5letikuvastased ja immunosupressiivsed omadused."},"content":{"rendered":"<p>Ilma korralike piltideta v\u00f5ib olla veidi raske selgitada krotoksiini p\u00f5letikuvastast modulatsiooni, kuid sellep\u00e4rast ongi Mind the Graph olemas!<\/p>\n\n\n\n<h2><strong>\u00dclevaade teaduslikest uuringutest, mis on seotud klapikum\u00fcrgi krotoksiiniga.<\/strong><\/h2>\n\n\n\n<p>Marco Sartim et al. (2018) m\u00e4rkisid teoses \"Immunotherapeutic potential of Crotoxin\", et viimase 80 aasta jooksul on krotoksiinist saanud \u00fcks enim uuritud isoleeritud madu m\u00fcrkide toksiine. <\/p>\n\n\n\n<p>Krotoksiin on peamine m\u00fcrgine komponent L\u00f5una-Ameerika klapikumadu Crotalus durissus terrificus m\u00fcrgis. Uuringud on n\u00e4idanud, et C.d.t. immunomoduleeriv toime on seotud p\u00f5letikuvastaste mediaatorite tootmisega. <\/p>\n\n\n\n<p>Krotoksiini ja selle all\u00fcksuste v\u00f5ime moduleerida immuuns\u00fcsteemi t\u00f5i kaasa uued v\u00e4ljavaated potentsiaalsete raviainetena.<\/p>\n\n\n\n<p><strong>Uurijad vaatasid l\u00e4bi 161 artiklit.<\/strong><\/p>\n\n\n\n<p>Kontrollige <a href=\"https:\/\/jvat.biomedcentral.com\/articles\/10.1186\/s40409-018-0178-3\" target=\"_blank\" rel=\"noreferrer noopener\">originaalartikkel siin<\/a>.<\/p>\n\n\n\n<h2><strong>Graafilised kokkuv\u00f5tted, mille aluseks on Mind the Graph<\/strong><\/h2>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html.webp\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"1003\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-1024x1003.webp\" alt=\"\" class=\"wp-image-20251\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-1024x1003.webp 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-300x294.webp 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-768x752.webp 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-12x12.webp 12w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-100x98.webp 100w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html.webp 1418w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>Valmistatud koos <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Autor kasutas Mind the Graph platvormi, et luua skemaatiline joonis tsirkulatsiooni, kudede ja rakkude s\u00fcndmuste kohta, mida Crotoxin ja selle all\u00fchikud moduleerivad p\u00f5letikulise stiimuli ajal.<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_Fig3_HTML.webp\"><img decoding=\"async\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_Fig3_HTML-839x1024.webp\" alt=\"\" class=\"wp-image-20252\"\/><\/a><figcaption class=\"wp-element-caption\"><em>Valmistatud koos <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Autor kirjeldas \u00fcksikasjalikult ka vereringet, l\u00fcmfis\u00f5lmede l\u00fcmfots\u00fc\u00fctide kodustumist ja rakus\u00fcndmusi, mis on seotud krotoksiini ja selle all\u00fchendite immunosupressiivse toimega.<\/p>\n\n\n\n<p><strong>See ongi infograafiate j\u00f5ud!<\/strong><\/p>\n\n\n\n<p>Autorite j\u00e4reldused n\u00e4ivad konsolideerivat varasemat t\u00f6\u00f6d selles valdkonnas: \"Krotoksiin suutis p\u00e4rssida spetsiifilist anti-HSA IgG1 ja IgG2a antikehade tootmist HAS-immuniseeritud hiirtel, mis n\u00e4itab selle v\u00f5imet moduleerida Th1- ja Th2-vastuseid,\" v\u00e4itis Sartim.<\/p>\n\n\n\n<h2><strong>Paberi m\u00f5ju ja tulemuslikkus<\/strong><\/h2>\n\n\n\n<p>Me saame anal\u00fc\u00fcsida koos <a href=\"https:\/\/mindthegraph.com\/blog\/altmetric\/\" target=\"_blank\" rel=\"noreferrer noopener\">Altmetric<\/a> andmed, et sellel dokumendil oli rohkem tsiteeringuid <strong>kui <strong>84%<\/strong><\/strong> <strong>muud artiklid Springer Nature'ist.<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1.png\"><img decoding=\"async\" loading=\"lazy\" width=\"322\" height=\"578\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1.png\" alt=\"\" class=\"wp-image-20254\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1.png 322w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1-167x300.png 167w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1-7x12.png 7w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1-56x100.png 56w\" sizes=\"(max-width: 322px) 100vw, 322px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>Allikas <a href=\"https:\/\/citations.springernature.com\/item?doi=10.1186\/s40409-018-0178-3&amp;start=11&amp;years=&amp;journals=&amp;books=&amp;authors=\" target=\"_blank\" rel=\"noreferrer noopener\">Crossref<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Kasutage infograafiate j\u00f5udu, et suurendada ja <a href=\"https:\/\/mindthegraph.com\/blog\/research-journal-impact-factor\/\">m\u00f5jutada teie artiklit<\/a> samuti. Proovige Mind the Graph!<\/p>\n\n\n\n<div class=\"is-layout-flex wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"https:\/\/mindthegraph.com\/app\/auth\/register?from_url=\/\" style=\"border-radius:100px;background-color:#dc1866\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Proovige Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Krotoksiini p\u00f5letikuvastast modulatsiooni v\u00f5ib olla veidi raske selgitada ilma korralike piltideta, kuid Mind the Graph on olemas!<\/p>","protected":false},"author":29,"featured_media":20047,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"It could be a little difficult to explain the crotoxin\u2019s anti-inflammatory modulation without the proper images, but Mind the Graph exists!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/et\/success-case-immunotherapeutic-potential-of-crotoxin-anti-inflammatory-and-immunosuppressive-properties\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"It could be a little difficult to explain the crotoxin\u2019s anti-inflammatory modulation without the proper images, but Mind the Graph exists!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/et\/success-case-immunotherapeutic-potential-of-crotoxin-anti-inflammatory-and-immunosuppressive-properties\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-12T21:50:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:35+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_6.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_6.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Immunotherapeutic potential of Crotoxin: anti-inflammatory and immunosuppressive properties Paper Review - 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