{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"Zika-viirus paljuneb t\u00e4iskasvanud inimese ajukoes ja kahjustab hiirte s\u00fcnapsi ja m\u00e4lu Paper Review"},"content":{"rendered":"

ZIKV on ohtlik viirus, mis laastab maailma. Seet\u00f5ttu uurib autor antud juhul selle replikatsiooni t\u00e4iskasvanud inimese ajus.<\/p>\n\n\n\n

Zika-viirus (ZIKV) nakatab t\u00e4iskasvanute ajukude ja p\u00f5hjustab hiirtel m\u00e4luh\u00e4ireid<\/strong><\/h2>\n\n\n\n

Claudia Figueiredo (2019) juhitud farmaatsia teaduskonna t\u00f6\u00f6r\u00fchm uuris, kuidas zikaviirus paljuneb t\u00e4iskasvanud inimese ajukoes ning kahjustab hiirtel s\u00fcnapsi ja m\u00e4lu. Zikaviirus on Flaviviridae perekonda kuuluv arboviirus, mis vastutab hiljutise suure puhangu eest Ladina-Ameerikas. <\/p>\n\n\n\n

ZIKV on leitud t\u00e4iskasvanud patsientide ajus ja ajukelmest. NS2B immunoreaktiivsus kolokaliseerus NeuN-immunoreaktiivsete rakkudega, kuid mitte GFAP v\u00f5i F4\/80, mis n\u00e4itab, et ZikV sihtm\u00e4rgiks on inimese k\u00fcpses koes neuronid. T\u00e4iskasvanud immunokompetentsetel hiirtel, kes on nakatunud ZIKV intratserebroventrikulaarse infusiooni teel, on ZikV RNA k\u00f5rge tase tuvastatud frontaalses ajukoores ja hipokampuses ning peamised nakatunud rakut\u00fc\u00fcbid on k\u00fcpsed neuronid. <\/p>\n\n\n\n

T\u00f5estatud on aju TNF-\u03b1 taseme t\u00f5us, intensiivne mikrogl\u00fcoos, komplemendis\u00fcsteemi valkude (C1q ja C3) reguleeritud ekspressioon ja hipokampuse s\u00fcnapsi kahjustus.<\/p>\n\n\n\n

Uuringus osales 9 v\u00f5rdset kvadranti.<\/strong><\/p>\n\n\n\n

Kontrollige originaalartikkel siin<\/a>.<\/p>\n\n\n\n

Graafilised kokkuv\u00f5tted, mille aluseks on Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
\n
\"\"<\/a>
Valmistatud koos Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Esimesel joonisel on kujutatud juhtum, kus inimese ajukoorekoe fragmendid l\u00f5igati 400 \u00b5m suurusteks viiludeks ja hoiti kultuuris 4 p\u00e4eva enne inkubeerimist ZIKV-ga (107 PFU) v\u00f5i mock-keskkonnaga 1 h jooksul, millele j\u00e4rgnes pesemine. <\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
Valmistatud koos Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Teine n\u00e4itab, et t\u00e4iskasvanud hiired said 105 PFU ZIKV, UV-inaktiveeritud ZIKV v\u00f5i mock-keskkonna infusiooni aju k\u00fclgventriklisse.<\/p>\n\n\n\n

J\u00e4reldused n\u00e4ivad kinnitavat seda, mida varem selle teema kohta teada oli: \"ZIKV on suunatud m\u00e4luga seotud ajupiirkondadele s\u00f5ltumata sellest, kas nakatumise tee on tsentraalne v\u00f5i perifeerne. Viirus on avastatud neuroloogiliste t\u00fcsistustega t\u00e4iskasvanud patsientide CSF-is,\" v\u00e4itis Figueiredo.<\/p>\n\n\n\n

Nad teevad ettepaneku, et tulevased uuringud, mille eesm\u00e4rk on uurida ZIKV-infektsiooni pikaajalist neurodegeneratiivset m\u00f5ju, on \u00f5igustatud. Aju talitlush\u00e4irete tekkimist p\u00f5hjustavate signaalih\u00e4irete ennetamise viiside tuvastamine v\u00f5ib sillutada teed sekkumisstrateegiatele, et l\u00fckata edasi v\u00f5i ennetada raskete neuroloogiliste seisundite teket.<\/p>\n\n\n\n

Paberi m\u00f5ju ja tulemuslikkus<\/strong><\/h2>\n\n\n\n

Me saame anal\u00fc\u00fcsida koos Altmetric<\/a> andmed, et selle paberi online t\u00e4helepanu skoor on k\u00f5rgem kui 95%<\/strong><\/strong> k\u00f5ikidest teistest samavanuselistest artiklitest looduses<\/strong> Ajakirjad.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
Allikas Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Kasuta infograafiate j\u00f5udu ka oma artikli \u00fclesehitamiseks! Alusta loomist aadressil Mind the Graph.<\/p>\n\n\n\n

\n
Proovige Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Uuring k\u00e4sitleb ZIKV-d t\u00e4iskasvanud inimese ajus, ohtlikku viirust, mis laastab maailma. Protsessis kasutatakse Mind the Graph illustratsioone.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/et\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/et\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-06T20:57:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:48:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog-image-0008.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog-image-0008.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog","description":"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/et\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","og_locale":"et_EE","og_type":"article","og_title":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog","og_description":"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.","og_url":"https:\/\/mindthegraph.com\/blog\/et\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","og_site_name":"Mind the Graph Blog","article_published_time":"2022-09-06T20:57:00+00:00","article_modified_time":"2023-03-17T17:48:05+00:00","og_image":[{"width":1125,"height":614,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog-image-0008.jpg","type":"image\/jpeg"}],"author":"Artur Zignani","twitter_card":"summary_large_image","twitter_image":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog-image-0008.jpg","twitter_misc":{"Written by":"Artur Zignani","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","url":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","name":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2022-09-06T20:57:00+00:00","dateModified":"2023-03-17T17:48:05+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02"},"description":"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/#breadcrumb"},"inLanguage":"et","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"et"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02","name":"Artur Zignani","image":{"@type":"ImageObject","inLanguage":"et","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","caption":"Artur Zignani"},"url":"https:\/\/mindthegraph.com\/blog\/et\/author\/artur\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/et\/wp-json\/wp\/v2\/posts\/16621"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/et\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/et\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/et\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/et\/wp-json\/wp\/v2\/comments?post=16621"}],"version-history":[{"count":5,"href":"https:\/\/mindthegraph.com\/blog\/et\/wp-json\/wp\/v2\/posts\/16621\/revisions"}],"predecessor-version":[{"id":27199,"href":"https:\/\/mindthegraph.com\/blog\/et\/wp-json\/wp\/v2\/posts\/16621\/revisions\/27199"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/et\/wp-json\/wp\/v2\/media\/20048"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/et\/wp-json\/wp\/v2\/media?parent=16621"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/et\/wp-json\/wp\/v2\/categories?post=16621"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/et\/wp-json\/wp\/v2\/tags?post=16621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}