{"id":13008,"date":"2021-06-21T18:09:00","date_gmt":"2021-06-21T21:09:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=13008"},"modified":"2023-01-05T14:38:06","modified_gmt":"2023-01-05T17:38:06","slug":"napping-time-genetics","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/napping-time-genetics\/","title":{"rendered":"Nokitsemise aeg geneetika: Kuidas l\u00f5unapaus v\u00f5ib m\u00f5jutada geneetilist varieeruvust"},"content":{"rendered":"

P\u00e4evane nokitsemine on enamiku inimeste s\u00fc\u00fcdi.<\/p>\n\n\n

\n
\"Garfield<\/a><\/figure><\/div>\n\n\n

Enamasti on see ka igap\u00e4evaelu sissejuurdunud harjumus. See on v\u00e4ga tavaline paljudel liikidel alates k\u00e4rbestest kuni imetajateni.<\/p>\n\n\n\n

Uinumine on seotud ka t\u00e4helepanuv\u00f5ime parandamisega, mis on oluline neile, kes t\u00f6\u00f6tavad \u00f6\u00f6sel hilja v\u00f5i kes on tavaliselt unepuuduses.<\/p>\n\n\n\n

Samuti on \u00f6eldud, et see aitab parandada j\u00f5udlust, m\u00e4lu ja leevendada stressi. <\/p>\n\n\n\n

Kuid lisaks nendele eelistele v\u00f5ivad nokitsemise pikaajalised tagaj\u00e4rjed olla inimese heaolule kroonilised.<\/p>\n\n\n\n

Kuigi see on vastuoluline teema ja p\u00f5hjuseks v\u00f5ivad olla mitmed m\u00e4hkmetega seotud tegurid, nagu ebapiisav unets\u00fckkel, halb toitumine v\u00f5i halb tervislik seisund.<\/p>\n\n\n\n

Kas nokitsemine p\u00e4eva jooksul on teie \u00f5nnelik tund? Teadlased v\u00e4idavad vastupidist. <\/strong><\/p>\n\n\n\n

Uurimisr\u00fchm anal\u00fc\u00fcsis nokitsemise m\u00f5ju geneetilise varieerumise kaudu.<\/p>\n\n\n\n

Nende uurimus seisnes erinevate inimeste geneetilise varieeruvuse m\u00f5istmises nende eelistuste ja uinakute kestuse kaudu.<\/p>\n\n\n\n

Praegu on kogu genoomi h\u00f5lmava assotsiatsiooniuuringu k\u00e4igus avastatud umbes seitse geneetilist lokatsiooni, mis vastavad p\u00e4eva jooksul nokitsemisele.<\/p>\n\n\n\n

Teadlased kasutasid \u00dchendkuningriigi biopanga Euroopa p\u00e4ritolu osalejaid (n=452 633), kellest umbes 38,2% osalejatest nokitsesid m\u00f5nikord ja 5,3% osalejatest nokitsesid alati p\u00e4eva jooksul.<\/p>\n\n\n\n

Need nokitsevad ajad olid peaaegu alati vanemad mehed, kellel oli k\u00f5rge kehamassiindeks v\u00f5i kehamassiindeks, kellel oli diagnoositud uneh\u00e4ired, kes suitsetasid v\u00f5i olid pension\u00e4rid. Nad viisid l\u00e4bi kogu genoomi h\u00f5lmava assotsiatsiooniuuringu (GWAS) kvaliteetsete omistatud geneetiliste variantidega, mis h\u00f5lmas umbes neli lakh osalejaid. Seda tehti erinevate varem leitud tegurite muutmise teel.<\/p>\n\n\n\n

Nad tuvastasid edukalt 123 geneetilist loci koos \u00fcksiknukleotiidipol\u00fcmorfismil p\u00f5hineva p\u00e4rilikkusega, mis on ligikaudu 11,9%.<\/p>\n\n\n\n

Nad kitsendasid oma GWASi k\u00f5rgema kehamassiindeksiga isikutega. <\/p>\n\n\n\n

Leiti, et 123 lokaalist 110 olid kogu genoomi h\u00f5lmava t\u00e4htsusega.<\/p>\n\n\n\n

Nad anal\u00fc\u00fcsisid ka nokitsemisviiside erinevust eri sugupoolte vahel X-kromosoomi assotsieerumisel. <\/p>\n\n\n\n

Lisaks j\u00e4reldasid nad ka geenide kohta, mis vastutavad rasvumise h\u00fcpersomnolentsuse raja eest: PNOC (prepronotsitseptiin), <\/em>ja PATJ (pururakkude polaarsuse komponent).<\/em><\/p>\n\n\n\n

Lisaks sellele, FADS1 (Fatty Acid Desaturase) geeni ekspressioon, mis oli koloniseeritud, esitas lipiidide ainevahetuse pleiotroopse m\u00f5ju unemustrile.<\/p>\n\n\n\n

Teised korrelatsioonid, mida tajuti seoses kogu genoomi h\u00f5lmava geneetilise ja selliste tunnustega nagu gl\u00fckeemiline indeks, antropomeetriline ja kardiometaboolne indeks, millest paljud korrelatsioonid v\u00e4henesid p\u00e4rast kehamassiindeksi arvestamist. <\/p>\n\n\n\n

Veelgi enam on see, et skoor anal\u00fc\u00fcsitud fenoomi h\u00f5lmava assotsiatsiooni kasutades p\u00e4evase uinumise genoomi h\u00f5lmava pol\u00fcgeeni aitas korrelatsiooni haiguste seotud rasvumise, h\u00fcpertensiooni ja k\u00f5ige t\u00e4htsam teatud kardiometaboolsete haiguste samuti. <\/p>\n\n\n\n

Kokkuv\u00f5tteks v\u00f5ib \u00f6elda, et nende j\u00e4reldused avavad silmad. M\u00f5nikord on just sellised harjumused need, mis p\u00f5hjustavad meie kehas mitmeid soovimatuid t\u00fcsistusi. Tuleb j\u00e4rgida tervislikku rutiini ja h\u00e4id eluviise. <\/p>\n\n\n

\n
\"mees<\/a><\/figure><\/div>\n\n\n

Et rohkem teada saada nende uuringute kohta, vaadake allpool toodud viidet.<\/p>\n\n\n\n

Dashti, H.S., Daghlas, I., Lane, J.M. et al.<\/em> P\u00e4evase uinumise geneetilised tegurid ja m\u00f5ju kardiometaboolsele tervisele. Nat Commun<\/em> 12, 900 (2021). DOI : https:\/\/doi.org\/10.1038\/s41467-020-20585-3<\/a><\/p>\n\n\n\n

Mind the Graph galeriist leiate palju geneetikaga seotud illustratsioone. Kl\u00f5psake alloleval pildil, et vaadata.<\/p>\n\n\n

\n
\"\"\/<\/a><\/figure><\/div>","protected":false},"excerpt":{"rendered":"

P\u00e4evane nokitsemine on enamiku inimeste s\u00fc\u00fcdi. Enamasti on see ka igap\u00e4evarutiini sissejuurdunud harjumus. See on v\u00e4ga tavaline paljudel liikidel alates k\u00e4rbestest kuni imetajateni. Uinumine on seotud ka valvsuse parandamisega, mis on oluline neile, kes t\u00f6\u00f6tavad hilis\u00f5htul v\u00f5i [...]<\/p>","protected":false},"author":18,"featured_media":13012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nDid you know that taking that nap can influence genetic - MTG<\/title>\n<meta name=\"description\" content=\"Is napping time your happy hour? 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