{"id":12274,"date":"2021-02-10T09:13:00","date_gmt":"2021-02-10T11:13:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12274"},"modified":"2023-01-05T13:46:34","modified_gmt":"2023-01-05T16:46:34","slug":"cannabis-and-body-pain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/kanepi-ja-keha-valu\/","title":{"rendered":"Kanepi ja kehavalu"},"content":{"rendered":"

Viimase k\u00fcmne aasta jooksul on paljud kliinilised uuringud andnud positiivseid ja paljulubavaid tulemusi kanepip\u00f5histe ravimite kasutamisel neuropaatilise valu raviks. <\/p>\n\n\n\n

Kanepiga on ravitud diabeedi, keemiaravi, hulgiskleroosi, fibrom\u00fcalgia, osteoartriidi ja mitmete teiste haiguste valu. <\/p>\n\n\n\n

Ilmselt on eksogeensete kannabinoidide ja opioidiretseptorite vahel seos, mille tulemuseks on patsiendi analgeesia - v\u00f5imetus valu tunda - suurenemine. <\/p>\n\n\n\n

Patsientidel, keda ravitakse opioididega koos kanepip\u00f5histe ravimitega, ilmneb ravimi s\u00fcnergiline toime, kus opioidide efektiivsust suurendab tetrah\u00fcdrokannabinool - THC, mis on kanepitaimede peamine ps\u00fchhoaktiivne molekul. <\/p>\n\n\n\n

Teadlased vaatavad neid tulemusi positiivse perspektiiviga, sest opioidravimite annust on v\u00f5imalik v\u00e4hendada, mis toob kaasa parema elukvaliteedi valu all kannatavatele patsientidele.<\/p>\n\n\n\n

Endokannabinoids\u00fcsteem, nagu ka teised ainevahetusradad, ei ole inimkeha isoleeritud s\u00fcsteem, vaid seda v\u00f5ivad m\u00f5jutada ja m\u00f5jutada teised signaaliradadad, millest \u00fcks on ilmselt seotud opioidide ja nende retseptoritega. <\/p>\n\n\n\n

Opioidiretseptorite \u00fclesanne on lisaks valutunnetuse signaalimise funktsioonile moduleerida ka m\u00f5ningaid kehafunktsioone, nagu termiline regulatsioon, hormonaalne stabiilsus, valuvaigistav toime jmt. <\/p>\n\n\n\n

Nii kannabinoidide kui ka opioidide retseptorid kuuluvad G-valguga seotud perekonda, mis on valgud, millel on v\u00f5ime m\u00f5jutada neurotransmissiooni, mis vastutab valu leviku eest ajus ja seljaajus. <\/p>\n\n\n\n

Kroonilise valuga patsientide ravi h\u00f5lmab tavaliselt opioidide j\u00e4rk-j\u00e4rgult suurenevate annuste v\u00f5tmist, mis sageli p\u00f5hjustavad soovimatuid k\u00f5rvaltoimeid, nagu sedatsioon, hingamish\u00e4ired ja k\u00f5hukinnisus. <\/p>\n\n\n\n

M\u00f5ne aja p\u00e4rast hakkab patsientidel tekkima tolerantsus ja resistentsus opioidi annuse suhtes, mis ei avalda terapeutilist m\u00f5ju, mist\u00f5ttu arstid on sunnitud korduvalt suurendama annust, et saavutada sama valu leevendamistase.<\/p>\n\n\n\n

Ainult THC suurt annust peetakse valuvaigistavaks, kuid sellele j\u00e4rgnevad tavaliselt sellised ebasoovitavad k\u00f5rvaltoimed nagu \u00e4revus, peavalu, suukuivus, pearinglus, eufooria ja tahh\u00fckardia, samas kui v\u00e4ikesed annused ei tekita \u00fcldse valuvaigistavat toimet. <\/p>\n\n\n\n

Sellegipoolest v\u00f5ib see m\u00f5ju opioididega kombineerituna t\u00e4ielikult muutuda.<\/p>\n\n\n\n

Loomade mudelitel l\u00e4bi viidud uuringud on n\u00e4idanud, et eksogeensed kannabinoidid, nagu THC, v\u00f5ivad suurendada opioidravimite, nagu morfiin, t\u00f5husust. <\/p>\n\n\n\n

THC analgeetiline toime n\u00e4ib olevat opioidiretseptorite kaudu vahendatud, kusjuures kannabinoidide ja opioidide signaaliradade vahel on ristinteraktsioon. <\/p>\n\n\n\n

Kanepi uurijad teatavad, et THC manustamine v\u00f5ib stimuleerida endogeensete opioidpeptiidide tootmist organismis, mis l\u00f5puks seonduvad juba tuntud opioidiretseptoritega - delta ja kappa - vahendades kannabinoidide toimet. <\/p>\n\n\n\n

Morfiini manustamisel aktiveerub ka kolmas opioidiretseptor mu. Nende kolme opioidiretseptori aktiveerimine v\u00f5ib olla selgituseks antinotsitseptiva efekti - valuvaigistava stiimuli tuvastamist blokeeriva analgeesia protsessi - t\u00f5hususe suurenemisele v\u00f5rreldes ainult morfiini v\u00f5i THC ravi tulemustega.<\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

A 2004. aastal ajakirjas Life Sciences avaldatud uuring<\/a> kinnitas THC ja morfiini vahelist seost, inhibeerides opioidiretseptorit spetsiifiliste molekulide abil. <\/p>\n\n\n\n

Blokeerivate molekulide olemasolu p\u00f5hjustas morfiini t\u00f5hususe v\u00e4henemise, mis omakorda v\u00e4hendas selle terapeutilist toimet. <\/p>\n\n\n\n

See tulemus kinnitab, kui oluline on nende retseptorite k\u00e4ttesaadavus ja nende aktiveerimine morfiini ja THC ravi t\u00f5hususe seisukohalt. Teine katse, mis viidi l\u00e4bi naloksooniga - opioidi antagonistiga - blokeeris THC aktiivsust erinevates ajupiirkondades, nagu ventraalne tegmentaalne piirkond, h\u00fcpotalamus ja periaqueductal gray (PAG), mis viitab sellele, et need piirkonnad on kuidagi olulised opioidi-kannabinoidi koostoimes. <\/p>\n\n\n\n

Lisaks sellele teatatakse uuringus ka, et hiirte ravi THC ja morfiini v\u00e4ikeste annustega koos ei p\u00f5hjustanud opioiditaluvust.<\/p>\n\n\n\n

See uuring ja paljud teised on avaldatud, mis toetavad ideed, et kanabinoidid v\u00f5ivad kombineerituna suurendada opioidide toimet. <\/p>\n\n\n\n

Ilmselt v\u00f5ivad kannabinoidid muuta ka opioidide taluvust ja s\u00f5ltuvust. <\/p>\n\n\n\n

Opioidide pikaajaline kasutamine on tavaliselt seotud patsientide s\u00f5ltuvusega, mis viib algselt ainult terapeutilise eesm\u00e4rgiga aine kuritarvitamiseni. <\/p>\n\n\n\n

Seet\u00f5ttu v\u00f5ib kanabinoidi-opioidi - n\u00e4iteks THC ja morfiini - kombinatsioon kujuneda uueks kombineeritud valuvaigistamise strateegiaks, mis v\u00f5imaldab arstidel v\u00e4hendada oma patsientide k\u00f5rgeid opioiddoseid ja v\u00e4hendada ka patsientide opioidide kuritarvitamist ja s\u00f5ltuvust. <\/p>\n\n\n\n

Lisaks teooriale, et kannabinoidid stimuleerivad endogeenseid opioide, on kannabinoidide ja opioidide koostoime s\u00fcsteemi \u00fcksikasjalik mehhanism endiselt ebaselge. <\/p>\n\n\n\n

H\u00fcpotees, millega p\u00fc\u00fctakse seletada v\u00f5imalikku toimemehhanismi, on, et kannabinoidid v\u00f5ivad indutseerida opioidpeptiidide s\u00fcnteesi v\u00f5i vabanemist - m\u00f5lemat -, suurendades opioidiretseptorite arvu, mis aktiveerib opioidiretseptoreid, mille tulemuseks on valuvaigistav tase. <\/p>\n\n\n\n

Samuti ei ole selge ega teada, millised peptiidid selles protsessis osalevad, seega oleks teadlastele v\u00e4ga oluline m\u00f5ista t\u00e4ielikult nende molekulide struktuuri ja seda, kuidas kannabinoide saab kasutada analgeetilise toime tekitamiseks, lisaks opioids\u00f5ltuvuse abistamisele. <\/p>\n\n\n\n

Kuid kanabinoidid \u00fcldiselt on n\u00e4idanud \u00fcllatavaid tulemusi, mis on meditsiinit\u00f6\u00f6tajate seas pidevalt suurenenud, t\u00f5estades selle potentsiaali alternatiivse ravimina. <\/p>\n\n\n\n

Teadlastel on vaja veel mitmeid uuringuid, et m\u00f5ista t\u00e4ielikult kanepip\u00f5histe ravimite tegelikku kasu ja v\u00f5imalusi inimkehale ning seda, kuidas on parim v\u00f5imalik variant kanepitaime raviks kasutada.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Kas sulle meeldis selles artiklis olev infograafika? K\u00f5ik ikoonid<\/a> mida k\u00e4esolevas artiklis kasutatakse - ja palju muud - on saadaval Mind the Graph-s. Olemasolevaid illustratsioone saate vaadata meie galerii<\/a>.<\/p>\n\n\n\n

Ja te ei pea alustama oma infograafiat nullist, me pakume oma kasutajatele redigeeritavaid infograafiamalle, nii et nad ei pea alustama t\u00fchjalt l\u00f5uendilt. Siin n\u00e4ete infograafia malle.<\/a><\/p>\n\n\n\n

Teil v\u00f5ib olla ka vanemate tellimus ja luua piiramatu arvud, kliki siia, et alustada<\/a>!<\/p>\n\n\n\n

Viited <\/strong><\/p>\n\n\n\n

BROWN, J. D.; WINTERSTEIN, A. G. Potentsiaalsed k\u00f5rvaltoimed ja ravimite koostoimed meditsiinilise ja tarbijale m\u00f5eldud Cannabidioli (CBD) kasutamisel. Journal of Clinical Medicine, v. 8, n. 7, 8. juuli 2019.<\/p>\n\n\n\n

CICHEWICZ, D. L. Kanabinoidide ja opioidanalgeetikumide s\u00fcnergistlikud koostoimed. Life Sciences, v. 74, n. 11, lk. 1317-1324, 30. jan. 2004.<\/p>\n\n\n\n

HANEY, M.; BISAGA, A.; FOLTIN, R. W. Naltreksooni ja suukaudse THC koostoime tugevate marihuaanasuitsetajate puhul. Psychopharmacology, v. 166, n. 1, lk. 77-85, 1 fev. 2003.<\/p>\n\n\n\n

KUHLEN, M. et al. Spastilisuse t\u00f5hus ravi dronabinooliga pediaatrilise palliatiivravi puhul. European Journal of Paediatric Neurology, v. 20, n. 6, lk. 898-903, 1 nov. 2016.<\/p>\n\n\n\n

L\u00d6TSCH, J. et al. Ravimite koostoimed patsiendi kontrollitava valuvaigistiga. Clinical Pharmacokinetics, v. 41, n. 1, lk. 31-57, 1. jan. 2002.<\/p>\n\n\n\n

LYNCH, M. E.; CLARK, A. J. Cannabis v\u00e4hendab opioidide annust kroonilise mittekantseroosse valu ravis. Journal of Pain and Symptom Management, v. 25, n. 6, lk. 496-498, 1. juuni 2003.<\/p>\n\n\n\n

MANZANARES, J. et al. Farmakoloogilised ja biokeemilised koostoimed opioidide ja kannabinoidide vahel. Trends in Pharmacological Sciences, v. 20, n. 7, lk. 287-294, 1. juuli 1999.<\/p>\n\n\n\n

WAKLEY, A. A.; CRAFT, R. M. THC-metadooni ja THC-naltreksooni koostoimed diskrimineerimise, antinotsitseptsiooni ja lokomotsiooni suhtes rottidel. Behavioural Pharmacology, v. 22, nr. 5 ja 6, lk. 489-497, kogum. 2011.<\/p>\n\n\n\n

WELCH, S. P. Kanabinoidide ja opioidide s\u00fcsteemi koostoime nokitseptsiooni moduleerimisel. International Review of Psychiatry, v. 21, n. 2, lk. 143-151, 1. jan. 2009.<\/p>","protected":false},"excerpt":{"rendered":"

Viimase k\u00fcmne aasta jooksul on paljud kliinilised uuringud andnud positiivseid ja paljulubavaid tulemusi kanepip\u00f5histe ravimite kasutamisel neuropaatilise valu raviks. Kanepiga on ravitud diabeedi, keemiaravi, hulgiskleroosi, fibrom\u00fcalgia, osteoartriidi ja mitmete teiste haigustega seotud valu. Ilmselt on eksogeensete kannabinoidide ja opioidiretseptorite vahel seos, mille tulemuseks on [...]<\/p>","protected":false},"author":4,"featured_media":12276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[819,51,554],"yoast_head":"\nCannabis and Body Pain - MTG<\/title>\n<meta name=\"description\" content=\"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/et\/kanepi-ja-keha-valu\/\" \/>\n<meta property=\"og:locale\" content=\"et_EE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cannabis and Body Pain - MTG\" \/>\n<meta property=\"og:description\" content=\"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/et\/kanepi-ja-keha-valu\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-10T11:13:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-05T16:46:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/02\/cannabis-and-body-pain.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1123\" \/>\n\t<meta property=\"og:image:height\" content=\"612\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cannabis and Body Pain - MTG","description":"Do you want to know cannabis can impact the body pain? 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. 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