{"id":12192,"date":"2021-01-27T10:46:16","date_gmt":"2021-01-27T12:46:16","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12192"},"modified":"2023-01-05T14:40:18","modified_gmt":"2023-01-05T17:40:18","slug":"cannabis-and-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/kanepi-ja-alzheimers-haigus\/","title":{"rendered":"Mis on seal kanepi ja Alzheimeri t\u00f5ve kohta v\u00e4lja toodud"},"content":{"rendered":"
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Alzheimeri t\u00f5bi (AD) on neurodegeneratiivne haigus, mis p\u00f5hjustab enam kui 50% praegu diagnoositud dementsuse juhtudest ja on otseselt seotud vananemisega. T\u00e4nap\u00e4eval on 40% \u00fcle 85-aastastest inimestest mingil tasemel dementsus.<\/p>\n\n\n\n

Varem arvati, et Alzheimeri t\u00f5ve s\u00fcmptomid on seotud vaid l\u00fchiajalisi m\u00e4lestusi m\u00f5jutava kognitiivse funktsiooni langusega, samas kui haiguse kaugelearenenud staadiumis m\u00f5jutavad need patsiendi keeleoskust ja isegi pikaajalisi m\u00e4lestusi.<\/p>\n\n\n\n

T\u00e4nap\u00e4eval on aga teada, et AD-ga patsientidel on mitmeid muid s\u00fcmptomeid, nagu depressioon, ps\u00fchhoos, agressiivne k\u00e4itumine, mis muudab haiguse veelgi hullemaks. <\/p>\n\n\n\n

Viimastel aastatel on teadlased ja arstid oma uuringutes teatanud positiivsetest tulemustest, kui nad on hakanud oma AD-patsiente ravima kanepip\u00f5histe ravimitega, saavutades s\u00fcmptomite leevendamise.<\/p>\n\n\n\n

Endokannabinoids\u00fcsteemist on saanud alternatiivne l\u00e4henemisviis erinevate haiguste ja patoloogiate raviks, lisaks selle m\u00f5jule mitmetes protsessides nagu neuroplastilisus, neuroinflammatsioon, k\u00e4itumish\u00e4ired, une reguleerimine, immunoloogilised funktsioonid, p\u00f5letikulised haigused, kardiovaskulaarsed funktsioonid, valu, motoorne kontroll, energiabilanss ja s\u00f6\u00f6giisu. <\/p>\n\n\n\n

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Foto: Ravi Patel<\/a> aadressil Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Kahjuks on veel v\u00e4he ametlikke uuringuid, milles anal\u00fc\u00fcsitakse otseselt endokannabinoids\u00fcsteemi ja Alzheimeri t\u00f5ve vahelisi seoseid.<\/p>\n\n\n\n

T\u00e4nap\u00e4eval on h\u00e4sti teada, et Alzheimeri t\u00f5bi on p\u00f5hjustatud geneetilistest ja vananemisega seotud teguritest. Haiguse peamised s\u00fc\u00fcdlased on omistatud haiguse seniilsed plaadid<\/strong> ja neurofibrillaarselt segunenud<\/strong>. <\/p>\n\n\n\n

Huvitav fakt on see, et Alzheimeri t\u00f5ve rottide mudelite abil avastasid teadlased, et Alzheimeri t\u00f5ve ajus on v\u00f5rreldes tervete ajudega v\u00e4hem CB1 retseptoreid - v\u00e4hem CB1 retseptoreid v\u00f5ib l\u00f5puks v\u00e4hendada ravimi terapeutilist toimet.<\/p>\n\n\n\n

Cannabinoidravi v\u00f5ib avaldada Alzheimeri t\u00f5vega patsientide ajus kaitsvat m\u00f5ju oks\u00fcdatiivse stressi ja neuroinflammatsiooni vastu, aidates v\u00e4hendada am\u00fcloidplaatide ja neurofibrillaarsete tongide moodustumist - see aeglustab patsientide kognitiivset langust. <\/p>\n\n\n\n

Kuigi am\u00fcloidplaate v\u00f5ib leida ka tervetest ajudest, on nende sagedus v\u00f5rreldes Alzheimeri t\u00f5ve ajudega \u00e4\u00e4rmiselt madal.<\/p>\n\n\n\n

Uuringud, mis on p\u00fchendatud selle m\u00f5istmisele, miks kannabinoididel on terapeutiline m\u00f5ju AD patsientidele, avastasid, et THC molekulil on v\u00f5ime suurendada neurotransmitteri biosaadavust, mida nimetatakse atset\u00fc\u00fclkoliin<\/strong> (Ach), inhibeerides selle lagundamise ens\u00fc\u00fcmi atset\u00fc\u00fclkoliinesteraas<\/strong> (AChE) - Ach vastutab sisuliselt n\u00e4rviimpulsi edasiandmise eest j\u00e4rgmisele neuronile. <\/p>\n\n\n\n

Terves ajus on ens\u00fc\u00fcm AChE \u00fclesandeks Achi lagundamine, kuid Alzheimeri t\u00f5vega ajus on see ens\u00fc\u00fcm v\u00e4ga levinud, lagundades palju rohkem Achi, kui see peaks tegema, p\u00f5hjustades aju kognitiivsete funktsioonide langust aja jooksul.   <\/p>\n\n\n\n

Teadlased teatasid, et kanabinoidid v\u00f5ivad aidata t\u00e4nu selle ens\u00fc\u00fcmi AChE inhibeerivale toimele - see on n\u00e4idanud paremat toimet kui teised kaubanduslikult k\u00e4ttesaadavad ravimid. <\/p>\n\n\n\n

THC v\u00f5ib aidata v\u00e4hendada ka k\u00e4itumish\u00e4ireid ja reguleerib raske dementsusega patsientide \u00f6\u00f6p\u00e4evast ts\u00fcklit. M\u00f5ned teadlased kinnitavad isegi, et THC ja CBD kannabinoidid v\u00f5ivad olla Alzheimeri t\u00f5ve vastased ravimeetodid.<\/p>\n\n\n\n

2015. aastal ajakirjas Clinical Pharmacology and Therapeutics avaldatud artikkel<\/a>annab \u00fclevaate kanabinoidide potentsiaalist Alzheimeri t\u00f5ve ja sellega seotud neurops\u00fchhiaatriliste s\u00fcmptomite ravimisel eakatel inimestel, k\u00e4sitledes ka kanepip\u00f5histe ravimite aspekte seoses nende t\u00f5hususe, ohutuse ja farmakokineetikaga.<\/p>\n\n\n\n

72-aastasel Alzheimeri t\u00f5vega mehel oli k\u00e4itumish\u00e4ire nagu agiteeritus ja agressiivsus. Tema eelnev ravi ei n\u00e4idanud olulist paranemist. <\/p>\n\n\n\n

Kui patsiendile tutvustati Nabilone'i - s\u00fcnteetilist THC-ravimit - n\u00e4itas ta peagi oma k\u00e4itumish\u00e4ire ja muude s\u00fcmptomite paranemist, lisaks sellele ei olnud tal THC-baasravimi ravi ajal mingeid k\u00f5rvaltoimeid.<\/p>\n\n\n\n

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Foto: Louis Reed<\/a> aadressil Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Teine uurimisr\u00fchm, mis koosnes viieteistk\u00fcmnest Alzheimeri t\u00f5vega patsiendist - keskmine vanus 72 aastat - n\u00e4itas enne ravi k\u00e4itumish\u00e4ireid ja s\u00f6\u00f6misega seotud probleeme. <\/p>\n\n\n\n

Viisteist patsienti raviti kuue n\u00e4dala jooksul dronabinooliga (tuntud ka kui Marinol), mis on s\u00fcnteetiline THC-ravim. <\/p>\n\n\n\n

P\u00e4rast raviperioodi esitasid nad k\u00e4itumise paranemist, kaalut\u00f5usu ja agiteerituse v\u00e4henemist - v\u00f5rreldes platseeboga. T\u00e4heldati m\u00f5ningaid k\u00f5rvaltoimeid, nagu v\u00e4simus, unisus ja eufooria, mis k\u00f5ik on kinnitust leidnud, et on seotud dronabinooliga.<\/p>\n\n\n\n

Teine r\u00fchm, kuhu kuulus kuus patsienti, kelle keskmine vanus oli 81 aastat, kellest m\u00f5ned olid Alzheimeri t\u00f5vega ja teised raske dementsuse all kannatavad, alustasid kahen\u00e4dalast ravi dronabinooliga. <\/p>\n\n\n\n

Tulemused n\u00e4itasid nende patsientide \u00f6ise motoorse tegevuse olulist paranemist ja paremat k\u00e4itumist. Selles r\u00fchmas ei t\u00e4heldatud k\u00f5rvaltoimeid.<\/p>\n\n\n\n

\u00dches teises uuringur\u00fchmas, kuhu kuulus 40 erineva dementsuse tasemega patsienti, kellest 13-l oli Alzheimeri t\u00f5bi. <\/p>\n\n\n\n

K\u00f5igile alustati ravi dronabinooliga, et ravida k\u00e4itumisprobleeme ja s\u00f6\u00f6giisu h\u00e4ireid. <\/p>\n\n\n\n

Raviperiood oli 17 p\u00e4eva ja patsiendid paranesid m\u00f5lemas aspektis. Teatati sellistest k\u00f5rvaltoimetest nagu sedatsioon, deliirium, kuseteede infektsioonid ja segasus, kuid teadlaste s\u00f5nul ei olnud need otseselt seotud dronabinooli kasutamisega.<\/p>\n\n\n\n

Vaatamata mitmetele uuringutele, mille tulemused n\u00e4itavad positiivseid tulemusi kannabinoidide kasutamisel dementsusega patsientide ravis, v\u00e4idavad m\u00f5ned teadlased, et endiselt ei ole piisavalt t\u00f5endeid, mis t\u00f5estaksid, et kannabinoidid on k\u00e4itumish\u00e4irete ja dementsuse ravis t\u00f5esti head ja ohutud.<\/p>\n\n\n\n

Igal juhul on teadlased \u00fcha enam teatanud kanepip\u00f5histe ravimite kasutamisest Alzheimeri t\u00f5vega patsientide raviks ning lisaks sellele on seda kasutatud ka Parkinsoni t\u00f5ve ja autismi raviks, kusjuures arstid ja teadlased on teatanud oma patsientide elukvaliteedi paranemisest p\u00e4rast kanepip\u00f5histe ravimite v\u00f5tmise alustamist. Kuid see on j\u00e4rgmise artikli teema.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Kas te olete neuroloogia valdkonnas? Mind the Graph-s on suur neuroloogia illustratsioonide kategooria, kust leiate k\u00f5ik, mida vajate oma neuroloogia-alase t\u00f6\u00f6 v\u00f5i esitluse jaoks. Vaadake siin<\/a>.  <\/strong><\/p>\n\n\n\n

V\u00f5i <\/strong>mida te otsite biokeemia <\/a>ja molekulaarbioloogia<\/a> illustratsioonid leiad ka Mind the Graph-st. <\/p>\n\n\n\n

Ja me oleme siin, et aidata teid, kui vajate midagi muud, lihtsalt logige oma kontole sisse<\/a> ja saatke meile s\u00f5num TAOTLEDA IKOONI<\/strong>. <\/p>\n\n\n\n

Viited<\/strong><\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoidid Alzheimeri t\u00f5ve hilisema alguse korral. Kliiniline farmakoloogia ja teraapia<\/strong>, v. 97, n. 6, lk. 597-606, 2015.<\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoidid Alzheimeri t\u00f5ve hilisema alguse korral. Kliiniline farmakoloogia ja teraapia<\/strong>, v. 97, n. 6, lk. 597-606, 2015.<\/p>\n\n\n\n

BALASH, Y. et al. Medical Cannabis in Parkinson Disease: Real-Life Patients' Experience. Kliiniline neurofarmakoloogia<\/strong>, v. 40, n. 6, lk. 268-272, dets. 2017.<\/p>\n\n\n\n

BENITO, C. et al. Endokannabinoids\u00fcsteem ja Alzheimeri t\u00f5bi. Molekulaarne neurobioloogia<\/strong>, v. 36, nr. 1, lk. 75-81, 1 tagasi. 2007.<\/p>\n\n\n\n

DE FARIA, S. M. et al. Akuutse kannabidiooli manustamise m\u00f5ju \u00e4revusele ja v\u00e4rinatele, mis on esile kutsutud avaliku r\u00e4\u00e4kimise simuleeritud testiga Parkinsoni t\u00f5vega patsientidel. Ps\u00fchhofarmakoloogia ajakiri<\/strong>, v. 34, nr. 2, lk. 189-196, 1. veebr. 2020.<\/p>\n\n\n\n

FALCO, A. D. et al. DOEN\u00c7A DE ALZHEIMER: HIP\u00d3TES ETIOL\u00d3GICAS E PERSPECTIVAS DE TRATAMENTO. Qu\u00edmica Nova<\/strong>, v. 39, n. 1, lk. 63-80, jan. 2016.<\/p>\n\n\n\n

LEEHEY, M. A. et al. Cannabidioli ohutus ja talutavus Parkinsoni t\u00f5ve korral: An Open Label, Dose-Escalation Study. Kanepi ja kannabinoidide uuringud<\/strong>, 19. m\u00e4rts. 2020.<\/p>\n\n\n\n

POLEG, S. et al. Cannabidiol kui soovituslik kandidaat autismispektrih\u00e4ire raviks. Neurops\u00fchhofarmakoloogia ja bioloogilise ps\u00fchhiaatria edusammud<\/strong>, v. 89, lk. 90-96, 8 m\u00e4rts. 2019.YOO, K.-Y.; PARK, S.-Y. Terpenoidid kui potentsiaalsed Alzheimeri t\u00f5ve ravimid. Molekulid<\/strong>, v. 17, nr. 3, lk. 3524-3538, m\u00e4rts. 2012.<\/p>","protected":false},"excerpt":{"rendered":"

Alzheimeri t\u00f5bi (AD) on neurodegeneratiivne haigus, mis p\u00f5hjustab enam kui 50% praegu diagnoositud dementsuse juhtudest ja on otseselt seotud vananemisega. T\u00e4nap\u00e4eval on 40% \u00fcle 85-aastastest inimestest mingil tasemel dementsus. Varem arvati, et Alzheimeri t\u00f5ve s\u00fcmptomid olid seotud vaid l\u00fchiajalist m\u00e4lu m\u00f5jutava kognitiivse funktsiooni langusega, samas kui [...]<\/p>","protected":false},"author":4,"featured_media":12193,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959],"tags":[213,819,554],"yoast_head":"\nWhat is Out There About Cannabis and Alzheimer\u2019s Disease - MTG<\/title>\n<meta name=\"description\" content=\"Do you know Cannabis and Alzheimer's Disease can be related? 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. 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