{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/et\/coronavirus-covid-19-on-hudroksuklorokiin-uus-hoop-kuuldavasti-jah\/","title":{"rendered":"Koronaviirus (Covid-19): kas h\u00fcdroks\u00fcklorokiin on uus lootus? Ilmselt jah."},"content":{"rendered":"

Kaks hiljutist dokumenti, mis v\u00f5tsid kokku \u00fche in vitro uuringu ja v\u00e4ikese kliinilise uuringu, olid Donald Trumpile piisavad, et FDA j\u00f5ustaks uue ravimi kliinilise n\u00e4idustuse h\u00fcdroks\u00fcklorokiinile: parandada koronaviirusega (Covid-19) nakatunud patsientide s\u00fcmptomeid.<\/p>\n

See on t\u00f5en\u00e4oliselt k\u00f5ige kiirem ravimi heakskiitmise protsess t\u00e4nap\u00e4eva ajaloos ja presidendil on ilmselt \u00f5igus. \u00dcllatav globaalse liidri jaoks, kes ei tunne suurt kiindumust teadusesse.<\/p>\n

\"\"<\/p>\n

Esimesed t\u00f5endid h\u00fcdroks\u00fcklorokiini kohta viiruse kohta tulid see eile Cell Discovery's avaldatud artikkel<\/a>See on k\u00fcll ainult in vitro, koos k\u00f5igi piirangutega, kuid see n\u00e4itab selgelt ravimi potentsiaali viiruse tapmiseks. T\u00f6\u00f6 esitamisel oli Hiinas kinnitatud 80 000 juhtumit, sealhulgas 2946 surmajuhtumit, samuti \u00fcle 10 566 kinnitatud juhtumi 72 teises riigis. Tol ajal pandi suurim lootus ravimile nimega remdesivir.<\/p>\n

\"h\u00fcdroklorokiini
H\u00fcdroklorokiini in vitro m\u00f5ju koronaviirusele (Covid-19). Paremal asuvas veerus on n\u00e4idatud t\u00f5husa ravimi m\u00f5ju v\u00f5rreldes klorokviini v\u00f5i vasakul asuva kontrollr\u00fchmaga. See n\u00e4itab, et ravim parandas rakkude v\u00f5imet viirusi v\u00e4lja t\u00f5rjuda... see on nagu abi soovimatu naabri v\u00e4ljaajamiseks teie majast. See aitab! \ud83d\ude42 . <\/figcaption><\/figure>\n

Kuid suurim uudis tuli eelmisel p\u00e4eval avaldatud v\u00e4ikesemahulisest kliinilisest uuringust. Pealkiri on H\u00fcdroks\u00fcklorokiin ja asitrom\u00fctsiin COVID-19 raviks: avatud mitterandomiseeritud kliinilise uuringu tulemused ja saab alla laadida selle \"in press\" versioonis<\/a><\/p>\n

Ainult 20 patsiendiga tehtud uuringus n\u00e4itasid autorid, et h\u00fcdroks\u00fcklorokiin oli efektiivne koronaviiruse Covid-19 nakkuse vastu. Tegelikult v\u00e4hendas see 6 p\u00e4eva jooksul 75% nakatunute arvu, mis on vapustav. Veelgi parem on see, et kombinatsioon asitrom\u00fctsiiniga parandas ravi efektiivsust 95%-ni.<\/p>\n

\"H\u00fcdroklorokiini
H\u00fcdroh\u00fcklorokiini ja asitrom\u00fctsiini kombineeritud ravi on efektiivne koronaviiruse (Covid-19) infektsioonide vastu inimestel. Langus on dramaatiline ja annab uut lootust haigestunud patsientidele.<\/figcaption><\/figure>\n

Ravi parandas s\u00fcmptomeid, v\u00e4hendades samal ajal ka patsientide viiruskoormust. Ravim on varem heaks kiidetud malaaria puhul, mis t\u00e4hendab, et seda peetakse ohutuks. \"S\u00f5sarravim\" klorokiin oli v\u00e4hem t\u00f5hus. Hea, sest see on algo toksilisem.<\/p>\n

Uuring ei olnud randomiseeritud ja see on v\u00e4ikesemahuline, kuid tundub, et kuigi epideemia algas Hiinas, on lahendus p\u00e4rit \u00fclemaailmsest kogukonna j\u00f5upingutustest. In vitro t\u00f6\u00f6 on tegelikult Hiina, kliiniline aga Euroopa, t\u00e4psemalt Prantsusmaalt. Huvitav on see, et h\u00fcdroks\u00fcklorokiini originaalravimi registreeringud p\u00e4rinevad Prantsuse ravimifirmalt Sanofi ja hiljutine kliiniline uuring viidi l\u00e4bi Marseille's. Ale le bleu!<\/p>\n

Medscape'il on selle kohta suurep\u00e4rane artikkel, kui olete huvitatud \u00fcksikasjalikumast teabest.<\/a><\/p>\n

Please cite this work as Gautret et al. (2020) Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. International Journal of Antimicrobial Agents - In Press 17. m\u00e4rts 2020 - DOI : 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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