{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/es\/la-autofagia-gana-el-premio-nobel-de-medicina\/","title":{"rendered":"La autofagia gana el Premio Nobel de Medicina"},"content":{"rendered":"

El proceso de autofagia est\u00e1 implicado en varias afecciones, como el c\u00e1ncer y las enfermedades neurol\u00f3gicas. Funciona como un programa de reciclaje interno del organismo. Sin embargo, la autofagia disfuncional se ha relacionado con la enfermedad de Parkinson, la diabetes, el c\u00e1ncer y otros trastornos relacionados con la edad.<\/p>\n

Despu\u00e9s de esta peque\u00f1a introducci\u00f3n sobre la importancia del proceso de autofagia, no es de extra\u00f1ar que los nuevos descubrimientos en este campo puedan dar lugar a un Premio Nobel. De hecho, el pasado lunes, la investigadora Yoshino Ohsumi gan\u00f3 el Premio Nobel de Medicina<\/a> para identificar los primeros genes esenciales para la autofagia.<\/p>\n

\"No me siento c\u00f3modo compitiendo con mucha gente, y en cambio me resulta m\u00e1s agradable hacer algo que nadie m\u00e1s est\u00e1 haciendo. En cierto modo, en eso consiste la ciencia, y la alegr\u00eda de encontrar algo me inspira\". Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

\u00bfC\u00f3mo lo hizo Ohsumi?<\/h3>\n

En su laboratorio, Ohsumi hab\u00eda dise\u00f1ado cepas de levadura que acumulaban autofagosomas durante la inanici\u00f3n. Esta acumulaci\u00f3n s\u00f3lo pod\u00eda producirse si los genes esenciales para la autofagia estaban inactivos. As\u00ed, Ohsumi empez\u00f3 a manipular las c\u00e9lulas con varias mutaciones gen\u00e9ticas y consigui\u00f3 inducir la autofagia.<\/p>\n

\"La<\/a><\/p>\n

La autofagia ha existido<\/h3>\n

Aunque la autofagia se conoce desde hace 50 a\u00f1os, no fue hasta los a\u00f1os 90 con los estudios de Ohsumi cuando se reconoci\u00f3 la importancia de este proceso.
\nPor su trabajo, Ohsumi ya se ha ganado algunos fans:<\/p>\n

\"La<\/a><\/p>\n

\n

\"Estoy muy contento de que haya recibido el premio Nobel de este a\u00f1o, es muy merecido. Su laboratorio trabaja principalmente en levaduras. Hicieron las pruebas iniciales que permitieron descubrir los genes clave que intervienen en la autofagia. Muchos otros laboratorios han aprovechado sus descubrimientos, directa o indirectamente, para ver su importancia en las enfermedades\".<\/p>\n

David Rubinsztein<\/a> - director adjunto del Instituto de Investigaci\u00f3n M\u00e9dica de Cambridge<\/p>\n<\/blockquote>\n

\"La<\/a><\/p>\n

\n

\"Creo que es muy importante que se reconozca esta \u00e1rea de la ciencia. El principio importante aqu\u00ed es buscar mecanismos comunes en la enfermedad. Abre v\u00edas para el tratamiento de estos trastornos que son diferentes de los enfoques m\u00e1s convencionales para enfermedades espec\u00edficas.\"<\/p>\n

Giovanna Mallucci<\/a> - profesor de neurociencia cl\u00ednica en la Universidad de Cambridge<\/p>\n<\/blockquote>\n

\"La<\/a><\/p>","protected":false},"excerpt":{"rendered":"

El proceso de autofagia est\u00e1 implicado en varias afecciones, como el c\u00e1ncer y las enfermedades neurol\u00f3gicas. Funciona como un programa de reciclaje interno del organismo. Sin embargo, la autofagia disfuncional se ha relacionado con la enfermedad de Parkinson, la diabetes, el c\u00e1ncer y otros trastornos relacionados con la edad. Tras esta peque\u00f1a introducci\u00f3n sobre la importancia del proceso de autofagia, no es de extra\u00f1ar que los nuevos descubrimientos [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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