{"id":16636,"date":"2022-09-10T18:27:00","date_gmt":"2022-09-10T21:27:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16636"},"modified":"2023-03-17T14:47:45","modified_gmt":"2023-03-17T17:47:45","slug":"success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/es\/caso-de-exito-senalizacion-fgf-en-la-autorrenovacion-de-organoides-del-cancer-del-colon\/","title":{"rendered":"Se\u00f1alizaci\u00f3n del FGF en la autorrenovaci\u00f3n de los organoides de c\u00e1ncer de colon Revisi\u00f3n de art\u00edculos"},"content":{"rendered":"

La formaci\u00f3n de esferoides y organoides deshabilitados por la inhibici\u00f3n del FGFR en c\u00e9lulas de CCR derivadas de pacientes es mucho m\u00e1s f\u00e1cil de entender utilizando las ilustraciones de Mind the Graph. <\/p>\n\n\n\n

El esquema creado por el autor muestra que las biopsias quir\u00fargicas fueron digeridas enzim\u00e1ticamente para obtener una suspensi\u00f3n de c\u00e9lulas individuales. Las c\u00e9lulas ingenuas sin clasificar se cultivaron en un medio de CSC que conten\u00eda FGF2 o con el inhibidor del FGFR SU-5402.<\/p>\n\n\n\n

Se ha investigado el papel del factor de crecimiento de fibroblastos 2 (FGF2) en la autorrenovaci\u00f3n de las c\u00e9lulas madre del c\u00e1ncer colorrectal<\/strong><\/h2>\n\n\n\n

En \"FGF Signalling in the Self-Renewal of Colon Cancer Organoids\", J\u00f6rg Otte y sus colegas (2019) informaron de que cuando las c\u00e9lulas individuales ingenuas se incrustaron en Matrigel y se cultivaron en el medio CSC, se observ\u00f3 una autoorganizaci\u00f3n m\u00e1s compleja en todos los pacientes analizados. <\/p>\n\n\n\n

Los genes directamente asociados a la EMT junto con un fenotipo mesenquimal y de autorrenovaci\u00f3n (TGFB3, ID1, ID2 e ID4) resultaron estar sobreexpresados en los organoides. <\/p>\n\n\n\n

Mientras que la inhibici\u00f3n del FGFR condujo a un aumento de la se\u00f1alizaci\u00f3n MAPK, observaron una diferenciaci\u00f3n inducida, una p\u00e9rdida de la mayor\u00eda de los marcadores de c\u00e9lulas madre y un fenotipo epitelial. <\/p>\n\n\n\n

Las c\u00e9lulas madre del c\u00e1ncer son una subpoblaci\u00f3n de c\u00e9lulas malignas capaces de autorrenovarse y de servir como fuente continua de c\u00e9lulas tumorales diferenciadas. En algunos protocolos de cultivo de CSC, el factor de crecimiento de fibroblastos 2 es un ingrediente importante para mantener la condici\u00f3n de c\u00e9lulas madre. <\/p>\n\n\n\n

Por otro lado, en los organoides cultivados con CSC, detectaron la inducci\u00f3n de TGF-\u03b2 y de los cuatro miembros de la familia de genes inhibidores de la diferenciaci\u00f3n.<\/p>\n\n\n\n

En la investigaci\u00f3n participaron 9 pacientes consecutivos de CCR no seleccionados.<\/strong><\/p>\n\n\n\n

Compruebe el art\u00edculo original aqu\u00ed<\/a>.<\/p>\n\n\n\n

Resumen gr\u00e1fico con tecnolog\u00eda Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Hecho con Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Algunas de sus conclusiones refuerzan potencialmente lo que se sab\u00eda hasta ahora sobre este campo: \"Los genes asociados a la pluripotencia NANOG, LIN28 y SALL1 fueron expresados exclusivamente por las hESC. Los t\u00e9rminos GO \"regulaci\u00f3n negativa de la v\u00eda de se\u00f1alizaci\u00f3n BMP\" y \"transducci\u00f3n de se\u00f1ales de la prote\u00edna SMAD\" se detectaron en nuestro cultivo de hESC\", sugiri\u00f3 Otte.<\/p>\n\n\n\n

Los autores admiten que \"el an\u00e1lisis de los t\u00e9rminos GO de este conjunto de genes arroj\u00f3 s\u00f3lo unos pocos resultados significativos debido al bajo n\u00famero de genes com\u00fanmente regulados. La mayor\u00eda de estos t\u00e9rminos GO para la condici\u00f3n de CSC-medio estaban asociados con la transcripci\u00f3n activa, la proliferaci\u00f3n celular o el aumento de la captaci\u00f3n de glucosa. <\/p>\n\n\n\n

Tras la inhibici\u00f3n del FGFR, encontramos reguladores del ciclo celular as\u00ed como muchos genes anotados con \"diferenciaci\u00f3n de c\u00e9lulas epiteliales\", \"digesti\u00f3n\" o \"transporte de \u00e1cidos biliares y sales biliares\".\"<\/p>\n\n\n\n

Papeles Impacto y rendimiento<\/strong><\/h2>\n\n\n\n

Podemos analizar con Altmetric<\/a> datos que la puntuaci\u00f3n de la atenci\u00f3n en l\u00ednea de este documento es mayor que 68%<\/strong><\/strong> de todos los dem\u00e1s art\u00edculos de edad similar en Scientific Reports.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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Fuente Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Mejore la accesibilidad de su art\u00edculo tambi\u00e9n con el poder de la infograf\u00eda.<\/p>\n\n\n\n

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Prueba Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

La formaci\u00f3n de esferoides y organoides deshabilitados por la inhibici\u00f3n del FGFR en c\u00e9lulas de CCR derivadas de pacientes es m\u00e1s f\u00e1cil de entender con nuestras ilustraciones.<\/p>","protected":false},"author":29,"featured_media":20014,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,1],"tags":[96,554,775,963],"yoast_head":"\nFGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/es\/caso-de-exito-senalizacion-fgf-en-la-autorrenovacion-de-organoides-del-cancer-del-colon\/\" \/>\n<meta property=\"og:locale\" content=\"es_MX\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - 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